Investigating the association between red cell distribution width (RDW) and all-cause mortality in patients with breast cancer, to evaluate the potential clinical prognostic value of RDW.
Based on ...the RDW index, patients with breast cancer in the Medical Information Mart for Intensive Care (MIMIC-IV) database were categorized into quartiles. The primary outcomes included in-hospital mortality from all causes during the first six months, the first year, and the first three years. Cox hazards regression and restricted cubic spline (RCS) models were developed to investigate the effects of RDW on primary outcomes.
The study included 939 patients (female). The 6-month, 1-year, and 3-year mortality rates were 14.0%, 21.4%, and 28.4%, respectively. Multivariate Cox proportional hazards analyses demonstrated that RDW exhibited an autonomous association with an increased risk of all-cause mortality. After adjusting for confounders, higher RDW quartiles were significantly associated with 6-month mortality (adjusted hazard ratio (HR), 3.197; 95% confidence interval (CI), 1.745-5.762; P < 0.001), 1-year mortality (adjusted HR, 2.978; 95% CI, 1.867-4.748; P < 0.001), and 3-year mortality (adjusted HR, 2.526; 95% CI, 1.701-3.750; P < 0.001). The RCS curves demonstrated that high RDW (> 14.6) was associated with a greater risk of all-cause mortality. Subgroup analyses revealed no statistically significant differences in the interactions between the subgroups.
The study revealed a highly pronounced relationship between RDW and overall mortality, indicating its potential as an autonomous prognostic factor for increased mortality among patients with breast cancer.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Drought has become one of the environmental threats to agriculture and food security. Applications of melatonin (MT) serve as an effective way to alleviate drought stress, but the underlying ...mechanism remains poorly understood. Here, we found that foliar spray of 100-µM MT greatly mitigated the severe drought stress-induced damages in rice seedlings, including improved survival rates, enhanced antioxidant system, and adjusted osmotic balance. However, mutation of the
(
) and
(
) abolished the effects of MT. Furthermore, the upregulated expression of
was detected in wild type (WT) under drought stress, irrespective of MT treatment, whereas
was significantly downregulated in
and
mutants. In contrast, no change of the
expression level was detected in
. Moreover, mutation of
and
significantly suppressed the expression of genes associated with the antioxidant system. These results suggested that the functions of
in the MT-mediated alleviation of drought stress were associated with the ABI5-mediated signals. Collectively, we demonstrated that OsSGT1 was involved in the drought response of rice and that melatonin promoted SGT1-involved signals to ameliorate drought stress adaption.
Albedo/reflectance is of great importance for glaciers’ mass balance and energy budget. Elevation could be a major factor of influence for glacier reflectance, and therefore when studying glacier ...reflectance, the altitude ranges should be considered. However, due to the limitations of traditional earth observation systems, conventional analyses usually consider the spatial and temporal patterns of the reflectance average, which is severely restricted. The launch of Landsat-8 gives us the opportunity to study the seasonal glacier reflectance–elevation relationship. We have obtained the monthly near-nadir reflectance per 100 m for twelve glaciers in western China based on 372 scenes of Landsat 8 images acquired from April 2013 to December 2015. Variations of monthly broadband reflectance, reflectance–elevation relationships and reflectance gradients are analyzed and discussed. The results show that the linear trend of the reflectance–elevation relationship (when the altitude is less than 6100 m) is very significant; elevation has greater influence than location on seasonal reflectance variations; and the level of glacier reflectance gradient may relate with its climate. This may be the first work that has used remote-sensing data to analyze seasonal glacier reflectance–elevation patterns.
In this paper, a semantic analysis approach to children’s emotional disorder intervention and education is thoroughly analyzed and discussed, and a corresponding educational system is designed for ...application in real life. This paper acquires video data by deploying a common camera acquisition and transforms, annotates, frames, and processes the data with the help of feature engineering methods. In addition, this paper proposes a fine-grained action decomposition strategy to solve the problem of extreme imbalance in the dataset to improve the performance of the model and proposes an iterative sampling data fusion strategy, which aims to integrate and fuse data from multiple sources to make them more effective and further improve the robustness and generalization ability of the model. Since it is difficult for families to improve the emotional management skills of migrant children, and it is also difficult to obtain professional help and support from the community or schools, it is important to take advantage of the professional strengths of social work to provide professional support for migrant children and their families. From the perspective of theoretical research, most of the existing studies focus on individual migrant children and cannot give global guidance from the perspective of the family system. The comparison results show that T-SVR trained using data from all subjects outperforms the inductive method based on individual training of trainees, validating the effectiveness of the proposed adaptive emotion recognition model. Therefore, from the perspective of system integration, it is important to explore social work interventions to improve the emotional management skills of migrant children. The system network structure design is determined according to the actual situation; then from the system requirements, the system is abstracted with the help of UML entity-relationship diagram, and the database table design is completed; so far, the overall system can be divided into independent functional modules, and the boundaries of each module and the participating roles are gradually clarified, and the detailed design within each functional module is illustrated by UML timing diagram and class diagram to clarify the classes used. Finally, the system is tested end-to-end to verify whether the results of the view layer meet the design guidelines, whether the system modules work together properly, and whether the functional development meets the requirements.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, OILJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
This study investigates the effects of moisture content control on the characteristics, properties, and in vitro starch digestion of roasted rice powder made from natural high-resistant starch (RS) ...rice varieties. The results demonstrate that adjusting the moisture content before roasting significantly affects the RS content of the roasted rice powder. Among various moisture levels tested, the addition of 15% water (rice-to-water ratio of 85:15) before roasting resulted in the highest RS content, reaching 22.61%. Several key parameters of the rice samples before and after optimal moisture control were analyzed, including thermal stability, chain length distribution, volatile flavor composition, and scanning electron microscopy. Additionally, in vitro digestion properties were measured. The findings revealed that the volatile flavor compounds in the high-RS roasted rice significantly increased compared to non-roasted rice. Moreover, the thermal stability of the rice samples improved, and the chain length distribution exhibited significant changes. The water absorption and expansion properties were significantly lower in the high-RS roasted rice. Furthermore, the in vitro starch digestion of the roasted flour made from high-RS rice showed a significantly lower digestion rate compared to common rice, indicating a lower starch hydrolysis index in high-RS rice with the sbe-rs genotype. Overall, the roasting process of natural high-RS rice modifies its characteristics, increases the RS content, enhances the flavor, and results in a lower starch digestion rate compared to common rice. This study provides valuable data for the food industry to promote the application of high-RS rice varieties with mutations in the SBEIIb gene, such as Youtangdao2 (YTD2).
Abstract
Background
To compare the clinical efficacy of vacuum sealing drainage, eggshell-like debridement combined with antibiotic calcium sulphate implantation and conventional debridement combined ...with antibiotic calcium sulphate implantation in the treatment of calcaneal osteomyelitis.
Methods
Sixty-six patients with calcaneal osteomyelitis who were treated in our department between January 2017 and August 2021 were included in this study. Thirty-one patients underwent VSD and eggshell-like debridement combined with antibiotic calcium sulphate implantation. Thirty-five patients underwent conventional debridement combined with antibiotic calcium sulphate implantation. The inflammatory markers, operation time, wound healing time, hospital stay, full weight bearing time after operation, recurrence rate of infection, complications, and American Orthopedic Foot and Ankle Society (AOFAS) scores were compared between the two groups.
Results
The operation time and full weight bearing time after operation of observation group were longer than that of control group. Compared with preoperative results, WBC, ESR, CRP and PCT in both groups were significantly decreased at 14 days after operation, and there was no statistical significance between the two groups. The wound healing time and hospital stay in the observation group were shorter than those in the control group (
P
< 0.05). There were four patients with aseptic exudation in the observation group and ten patients with aseptic exudation in the control group, and the wounds healed well after multiple dressing changes. Seven patients in the observation group underwent secondary bone grafting due to bone defects, and four patients in the control group received secondary bone grafting due to bone defects. In the observation group, three patients received debridement combined with antibiotic calcium sulphate implantation again due to recurrent infection, compared with seven patients in the control group. One year after operation, the observation group had a better AOFAS scores than the control group, especially in terms of foot function (
P
< 0.05).
Conclusion
Compared with conventional debridement and antibiotic calcium sulphate implantation, VSD and eggshell-like debridement combined with antibiotic calcium sulphate implantation in the treatment of calcaneal osteomyelitis can shorten the wound healing and hospital stay of patients, reduce postoperative aseptic exudation complications and infection recurrence rate, and better preserve the foot function, which is a simple and effective method.
In this paper, we construct all the indecomposable modules of a class of non-pointed Hopf algebras, which are quotient Hopf algebras of a class of prime Hopf algebras of GK-dimension one. Then the ...decomposition formulas of the tensor product of any two indecomposable modules are established. Based on these results, the representation ring of the Hopf algebras is characterized by generators and some relations.
•An oil swellable polymer (OSP) with oil absorptivity as high as 700% is synthesized.•Addition of OSP decreases the total porosity of the hardened cement paste (HCP).•Addition of OSP reduces the ...water adsorption rate and increases the oil absorptivity of HCP.•Incorporation of OSP significantly increases the expandability of HCP upon oil absorption.•A novel technique to achieve a crack self-healing property is developed.
This paper proposes a novel approach to achieve self-healing property of cement sheath in the oil well triggered by oil leakage through cracks. An oil swellable polymer (OSP) with oil absorptivity as high as 700% was synthesized through emulsion polymerization. The OSP dispersion was added into the Portland cement paste. It is found that the oil absorption and the linear expansion of the OSP modified hardened cement paste (MHCP) are greatly increased compared to the blank hardened cement paste (BHCP). Pore structure measurements by N2 adsorption show that the addition of OSP decreases the total porosity of MHCP which confirms that the formation of the polymeric film in MHCP. The self-healing ability of MHCP was evaluated by the oil flow test through a single crack in the cylindrical specimen. The oil flow tests indicate that the leakage of oil through the crack is gradually mitigated due to the expansion of the MHCP and thus the self-healing ability is successfully achieved.
In view of the adverse effects of CDOM (chromophoric or colored dissolved organic matter) on in vivo algal pigment concentration measurements in natural water bodies, a CDOM influence correction ...method for algal concentration measurements based on three-dimensional fluorescence spectra is investigated. The three-dimensional fluorescence spectra of five common species of algae belonging to five categories, HA (humic acid), and natural water sampled from the Dongpu reservoir, Hefei were analyzed, and the spectral similarity of endogenous/exogenous CDOM in the algal fluorescence spectra region was compared. HA was selected to represent the CDOM spectrum group. The CDOM modified algal pigment concentration measurement method was developed using three-dimensional fluorescence spectra coupled with non-negative weighted least squares linear regression analysis. The results show that under the presence of CDOM interference factors, the recognition accuracy rate of Pyrrophyta, Bacillariophyta, Cyanophyta, and Chlorophyta increased 100%, 100%, 40%, and 40%, respectively. The average recovery rate of Cryptomonas, Pyrrophyta, Bacillariophyta, and Chlorophyta increased 162.7%, 50.3%, 106.4%, and 19.1%, respectively. In addition, the classification accuracy of Pyrrophyta, Bacillariophyta, Cyanophyta, Chlorophyta increased 83.9%, 100%, 38.2%, and 48%, respectively. This was concluded by comparing these results with the results of the algal pigment concentration measurement method without the CDOM modification. This study provides an experimental basis for the development of accurate phytoplankton fluorescence classification monitoring technology.
Display omitted
•The three-dimensional fluorescence spectra of five common species of algae belonging to five categories, HA (humic acid), and natural water sampled from the Dongpu reservoir, Hefei were analyzed, and the spectral similarity of endogenous/exogenous CDOM in the algal fluorescence spectra region was compared.•Based on the discussion of spectral similarity, CDOM is used as a separate component in spectral analysis without considering its source.•The non-negative weighted least squares linear regression analysis algorithm was used to analyze the aliasing three-dimensional fluorescence spectrum in the CDOM modified algal pigment concentration measurement method.
Background:
Intellectual disability (ID) is defined by cognitive and social adaptation defects. Variants in the
SYNGAP1
gene, which encodes the brain-specific cytoplasmic protein SYNGAP1, are ...commonly associated with ID. The aim of this study was to identify novel
SYNGAP1
gene variants in Chinese individuals with ID and evaluate the pathogenicity of the detected variants.
Methods:
Whole exome sequencing (WES) was performed on 113 patients diagnosed with ID. In the study, two
de novo
variants in
SYNGAP1
were identified. Sanger sequencing was used to confirm these variants. Minigene assays were used to verify whether the
de novo
intronic variant in
SYNGAP1
influenced the normal splicing of mRNA.
Results:
Two
de novo
heterozygous pathogenic variants in
SYNGAP1,
c.333del and c.664-2A>G, were identified in two ID patients separately. The c.333del variant has been reported previously as a
de novo
finding in a child with ID, while the c.664-2A>G variant was novel
de novo
intronic variant, which has not been reported in the literature. Functional studies showed that c.664-2A>G could cause aberrant splicing, resulting in exon 7 skipping and a 16bp deletion within exon 7.
Conclusion:
We identified two
de novo
pathogenic heterozygous variants in
SYNGAP1
in two patients with ID, among which the c.664-2A>G variant was a novel
de novo
pathogenic variant. Our findings further enrich the variant spectrum of the
SYNGAP1
gene and provide a research basis for the genetic diagnosis of ID.
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