Driver fatigue evaluation is of great importance for traffic safety and many intricate factors would exacerbate the difficulty. In this paper, based on the spatial-temporal structure of multichannel ...electroencephalogram (EEG) signals, we develop a novel EEG-based spatial-temporal convolutional neural network (ESTCNN) to detect driver fatigue. First, we introduce the core block to extract temporal dependencies from EEG signals. Then, we employ dense layers to fuse spatial features and realize classification. The developed network could automatically learn valid features from EEG signals, which outperforms the classical two-step machine learning algorithms. Importantly, we carry out fatigue driving experiments to collect EEG signals from eight subjects being alert and fatigue states. Using 2800 samples under within-subject splitting, we compare the effectiveness of ESTCNN with eight competitive methods. The results indicate that ESTCNN fulfills a better classification accuracy of 97.37% than these compared methods. Furthermore, the spatial-temporal structure of this framework advantages in computational efficiency and reference time, which allows further implementations in the brain-computer interface online systems.
Nitrogen-doped (N-doped) hierarchical porous carbon was widely utilized as an efficient volatile organic compounds (VOCs) adsorbent. In this work, a series of N-doped hierarchical porous carbons were ...successfully prepared from the direct pyrolysis process of three food waste components. The porous biochar that derived from bone showed a high specific surface area (1405.06 m2/g) and sizable total pore volume (0.97 cm3/g). The developed hierarchical porous structure was fabricated by the combined effect of self-activation (Carbon dioxide (CO2) and water vapor (H2O)) and self-template. The emission characteristics of activation gas analyzed by Thermogravimetric-Fourier transform infrared spectrometer (TG-FTIR) and the transformation of ash composition in the biochar help to illustrate the pore-forming mechanism. Calcium oxide (CaO) and hydroxylapatite were confirmed as the major templates for mesopores, while the decomposition processes of calcium carbonate (CaCO3) and hydroxylapatite provided a large amount of activation gas (CO2 and H2O) to form micropores. The materials also obtained abundant N-containing surface functional groups (up to 7.84 atomic%) from pyrolysis of protein and chitin. Finally, the porous biochar showed excellent performance for VOCs adsorption with a promising uptake of 288 mg/g for toluene and a high adsorption rate of 0.189 min−1. Aplenty of mesopores distributed in the materials effectively improved the mass transfer behaviors, the adsorption rate got a noticeable improvement (from 0.118 min−1 to 0.189 min−1) benefited from mesopores. Reusable potentials of the hierarchical porous carbons were also satisfying. After four thermal regeneration cycles, the materials still occupied 84.8%–87.4% of the original adsorption capacities.
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•N-doped hierarchical porous biochar was prepared from direct pyrolysis process.•The combined self-activation and self-templated effect was studied.•CO2 generation had an exclusive influence on micropores' production.•N-doped hierarchical porous biochar could remove toluene effectively (288 mg/g).
Reducing maternal mortality ratio (MMR) has been a worldwide public health challenge for a long time. Utilization of maternal health services including antenatal care (ANC), institutional delivery ...(ID), and postnatal care (PNC) is vital to prevent maternal mortality. China has made significant improvements in maternal health during the past 30 years, however, disparities in maternal health service utilization still exist among regions and the western rural areas had the lowest utilization rate. This study aims to assess the inequality and determinants of maternal health service utilization in western poverty-stricken rural areas based on Anderson's Behavioral Model of Health Service Use and provide evidence-based suggestions to improve equity and coverage of maternal service utilization in China.
A cross-sectional study was conducted in Gansu and Yunnan Province, Western China using primary data (n = 996) collected by the research team. A multistage, judgment, quota sampling procedure was employed to select the participants of the survey. Trained local health staff formed an interview team to help respondents answer a structured, pre-tested questionnaire designed based on Anderson's model. Data collected through interviews were used for descriptive analysis, range analysis, and univariate and multivariate binary logistic analysis to identify influencing factors of 5 + ANC, 8 + ANC, ID, and 2 + PNC utilization.
Place of residence, age, education level, annual income, and health education during ANC were influencing factors of 5 + ANC; place of residence, education level, per capita household income, conditional cash transfer (CCT) participation, and distance to health facilities were influencing factors of 8 + ANC; place of residence, education level, and availability of financial incentive programs were influencing factors of ID; number of children, health education during ANC, CCT projects participation, and self-rated health status were influencing factors of 2 + PNC.
Inequalities in maternal service utilization exist between Yunnan and Gansu provinces. This study shows a strong association between both predisposing and enabling factors and maternal services utilization. Predisposing factors such as place of residence, education level, and number of children, enabling factors such as CCT participation, annual income, health education during ANC, and distance to health facilities along with need factor self-rated health status all contribute to maternal services utilization. We conclude that many factors influence maternal service utilization and interventions targeted at various levels should be considered. Therefore, we suggest more health resources should be invested in underutilized areas, financial incentive projects targeting pregnant women should be implemented, and health education should be provided to improve women's health literacy.
Long-term care insurance (LTCI) is garnering attention internationally and is being considered a public policy in a growing number of countries. Previous research has focused on the effects of LTCI ...in developed countries, ignoring the health outcomes of developing countries, especially in rural regions. Therefore, this study investigates whether different impact on health outcomes is present in the effects of LTCI between urban and rural residents in China. We employed a quasi-experimental design with data from the China Health and Retirement Longitudinal Survey. The specific implementation time of each pilot city was sorted according to the LTCI policy texts, dividing these pilot cities into the treatment group and control group. Finally, difference-in-differences analyses were utilized to evaluate the health effects of LTCI between urban and rural residents, and the health effect in urban areas was further tested. The implementation of LTCI has effectively enhanced the self-rating health (SRH) of the entire group of residents; however, this effect may only be significant for the urban group. In particular, LTCI can increase the SRH of urban residents by 0.377 units compared to the urban residents without LTCI (P < 0.01). The result of the placebo effect test further verifies that LTCI could improve the health of residents to some extent. In China, LTCI may have triggered different impacts on health outcomes between urban and rural residents, and may not improve the SRH of rural residents and only prove efficacious for urban residents. Government and policy-makers should give more attention to the rural group as it needs long-term care the most.
Abstract
Osteoarthritis is a worldwide prevalent disease that imposes a significant socioeconomic burden on individuals and healthcare systems. Achieving cartilage regeneration in patients with ...osteoarthritis remains challenging clinically. In this work, we construct a multiple hydrogen-bond crosslinked hydrogel loaded with tannic acid and Kartogenin by polyaddition reaction as a cell-free scaffold for in vivo cartilage regeneration, which features ultra-durable mechanical properties and stage-dependent drug release behavior. We demonstrate that the hydrogel can withstand 28000 loading-unloading mechanical cycles and exhibits fast shape memory at body temperature (30 s) with the potential for minimally invasive surgery. We find that the hydrogel can also alleviate the inflammatory reaction and regulate oxidative stress in situ to establish a microenvironment conducive to healing. We show that the sequential release of tannic acid and Kartogenin can promote the migration of bone marrow mesenchymal stem cells into the hydrogel scaffold, followed by the induction of chondrocyte differentiation, thus leading to full-thickness cartilage regeneration in vivo. This work may provide a promising solution to address the problem of cartilage regeneration.
Curcumin is known to exhibit anticancer effects on various cancers with selective cytotoxicity in tumor cells. In the present study, the effects of curcumin‑induced multiple PCDs on human non‑small ...cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co‑culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002. The anti‑proliferation effect of different stimulus was measured by MTT assay. Apoptosis was detected by flow cytometry. Autophagy induction was detected by MDC labeling and western blotting of Beclin1, LC3, and p62 expression. The mRNA and protein expression levels of Akt and mTOR were assayed by real‑time fluorescence quantitative (qRT‑PCR) technique and western blotting. Our results showed that curcumin inhibited the viability of A549 cells time‑ and dose‑dependently. In addition, a dosage-dependent A549 cell apoptosis‑induction phenomena was observed by the curcumin intervention. Moreover, obvious autophagy was induced after curcumin‑treatment, characterized by the formation of fluorescent particles autophagic vesicles (AVs) and significant increase in ratio of LC3‑Ⅱ/LC3‑Ⅰ and Beclin1 as well as decreased p62 expression. Furthermore, the effect of curcumin on a substantial downregulation of phosphatidylinositol 3‑kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was observed. It is worth noting that the inhibition of mTOR by rapamycin or of PI3K/Akt by LY294002 augmented curcumin‑induced apoptosis and autophagy, leading to significant inhibition of cell proliferation. From these findings, it can be speculated that curcumin potently inhibit the cell growth of NSCLC A549 cells through inducing both apoptosis and autophagy by inhibition of the PI3K/Akt/mTOR pathway. These results support the potential use of curcumin as a novel candidate in treatment of human lung cancer.
Lockdowns were issued to medium and high-risk areas. Since precise and differentiated epidemic control strategies were encouraged, local governments had the authority to set their risk identification ...standards under the central CDC’s supervision. Some shelter hospitals (temporary hospitals built by converting existing public venues) and civilian hotels were taken over as quarantine spaces. Since only regional outbreaks happened occasionally, the demand gap for healthcare workers decreased and only civilian medics travelled around the country to offer support at epicentres. China expected the number of confirmed cases and severe cases to rise, putting significant pressure on its health system and challenging its resilience 18. ...the focus of governance, capacity, and resource shifted from prevention to treatment. According to Dr Zunyou Wu, the Chief Expert of Epidemiology of China CDC, three years of strict COVID-19 containment strategy were critical for protecting people’s lives, since the occurrence of severe cases dropped from 16.47% in 2020 to 0.18% in 2022 and the death rate dropped from 5.18% to 0.04% 20.
Measuring water holdup and characterizing the flow behavior of an oil-water two-phase flow is a contemporary and challenging problem of significant importance in industry. To address this problem, we ...develop a new method to design a new four-sector distributed conductance sensor. Specifically, we first use the finite-element method (FEM) to investigate the sensitivity distribution of the electric field and then calculate its response on the measurement electrodes. Based on the FEM analysis results, we extract two optimizing indexes to describe and find the optimum geometry for the four-sector distributed conductance sensor. We carry out oil-water two-phase flow experiments in a vertical upward pipe to validate the designed sensor implemented in the measurement of water holdup. In addition, we use the multivariate pseudo Wigner distribution (MPWD) method to analyze the multivariate signals from the four-sector distributed sensor. Our analytical and experimental results indicate that the four-sector distributed conductance sensor enables measuring water holdup and the MPWD allows uncovering local flow behavior revealing different oil-water flow patterns.
China has a lot of wastelands that are usually overly contaminated as a result of the relocation of industrial enterprises. Given that long-term threats are thus generated, safe and effective ...treatment routines are urgently needed. Due to its low carbon footprint and environmental protection benefits, the microwave heating treatment of contaminated soil has generated substantial academic interest. Nevertheless, wave-absorbing materials must be added during the treatment process to holistically enhance the effectiveness of heating the contaminated soil. Therefore, this study selects three typical wave-absorbing materials, i.e., Fe
O
, SiC and activated carbon, to explore the influence of the addition of wave-absorbing materials on the microwave heating efficiency for contaminated soil. Moreover, the changes in the mineral phases and microscopic morphology of the contaminated soil and wave-absorbing materials after heating at different temperatures are analyzed. It is concluded that the heating rate would reach 39.5 °C/min when the amount of additive Fe
O
reaches 8%; when the temperature exceeds 300 °C, the Fe
O
will be gradually oxidized to Fe
O
. Activated carbon is a wave-absorbing material that has a higher thermal stability than Fe
O
, although it has less impact on the heating rate. The ability of SiC to absorb waves has a limited impact on the heating rate. During microwave heating, the microscopic morphology of the contaminated soil and wave-absorbing materials do not change significantly.
The treatment of diabetic chronic wounds remains a global challenge due to the up-regulated inflammation response, oxidant stress, and persistent infection during healing process. Developing wound ...dressing materials with ideal biocompatibility, adequate mechanical strength, considerable under-water adhesion, sufficient anti-inflammation, antioxidant, and antibacterial properties is on-demand for clinical applications. In this study, we developed a bioactive skin-mimicking hydrogel band-aid through the combination of tannic acid (TA) and imidazolidinyl urea reinforced polyurethane (PMI) (TAP hydrogel) and explored its potentials in various medical applications, including hemostasis, normal skin incision, full-thickness skin wounds, and bacterial-infection skin incision on diabetic mice. TA was loaded into PMI hydrogel network to enhance the mechanical properties of TAP hydrogels through multiple non-covalent interactions (break strength: 0.28–0.64 MPa; elongation at break: 650–930%), which could resist the local stress and maintain the structural integrity of wound dressings during applications. Moreover, owing to the promising moisture-resistant adhesiveness and organ hemostasis, outstanding anti-inflammation, antibacterial, and antioxidant properties, TAP hydrogels could efficiently promote the recovery of skin incision and defects on diabetic mice. To further simulate the practical situation and explore the potential in clinical application, we also verified the treatment efficiency of TAP hydrogel in S. aureus-infected skin incision model on diabetic mice.
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•Bioactive skin-mimicking hydrogels were developed through the combination of tannic acid and polyurethane.•The wound healing and infected skin incision closure by the bioactive skin-mimicking hydrogels were studied on diabetic mice.
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