In the past decades, urban villages proliferate in major cities of China. These marginalised places not only are home to many local villagers, but also host millions of rural migrants. This paper ...provides an ethnographic account of the spatial and social production of Chinese urban villages. It discusses urban village residents’ detailed tactics in developing/participating in the informal housing market, service market and labour market. By so doing, it emphasises people’s agency in making their own living spaces and further challenges the marginalisation paradigm that either victimises or disparages urban village residents. It shows peasants, who are commonly assumed to be the antithesis of modernisation and urbanisation, are major actors and urbanise their living spaces. This paper also elaborates on the types of governing strategies at the village and municipal levels. It points out that the contradictions and loopholes in state power have left space for the formation of informal markets and contribute to the making of urban villages in contemporary China.
过去几十年中，城中村在中国大城市繁衍。这些边缘化的地方不仅是许多当地村民的家，也聚 集了数百万农村进城务工人员。本文报告了中国城中村空间和社会生产的一项民族志研宄。文 章讨论了城中村居民在开发〖参与非正规住房市场、服务市场和劳动力市场时的具体方式。讨论 强调了人们在打造自身生存空间时的能动性，并进一步质疑了牺牲或蔑视城中村居民的边缘化 范式。本文显示，通常被认为是现代化和城市化之反题的农民，是实现其生存空间城市化的主 角。本文也详细讨论了村庄和城市层面的治理策略，指出政府权力的矛盾和漏洞为非正规市场 的形成留下了空间，并促成了当代中国城中村的形成。
Since the early 2000s, scholars have proposed the notion of “world anthropologies” to expose the pluralistic nature of anthropology, and to counter the colonial legacy embedded in knowledge ...production. This paper discusses how anthropological knowledge in and of China contributes to, is distant from, and challenges, such intellectual movement at both intellectual and institutional levels. First, unlike Western anthropology which shifts from colonialism to liberalism and then to postcolonialism, anthropology in China began with a progressive agenda of anti-colonialism, and then leaned toward liberalism. In the context of China’s rise, “China” has been further embroiled in a puzzle of imperialism. This reversed ideological tendency contributes to the disorientation of the critical energy in anthropology focused on China. Second, just as China has taken an active role in the competition for education and research in a globalized, yet uneven academia through discipline construction, anthropology in the West, particularly the United States, has become provincialized in terms of its intellectual agendas. Many of the younger generation of Chinese anthropologists have become stuck in the disjuncture, struggling to channel their critical energy through engaged scholarship, both within and beyond academic institutions. The epistemic politics in and of China, at both the intellectual and institutional levels, reveals that the post-socialist condition deserves to be reference points in world anthropologies. If decolonization posits treating plural standpoints as equal, then being counted in the decolonizing efforts necessitates subscribing to the dominant framework. Thus, more attention to the post-socialist condition, and ultimately the pluralization of the reference points of political potency, should truly pluralize, and ultimately decolonize, anthropology.
In this letter, we propose a novel supervised change detection method based on a deep siamese convolutional network for optical aerial images. We train a siamese convolutional network using the ...weighted contrastive loss. The novelty of the method is that the siamese network is learned to extract features directly from the image pairs. Compared with hand-crafted features used by the conventional change detection method, the extracted features are more abstract and robust. Furthermore, because of the advantage of the weighted contrastive loss function, the features have a unique property: the feature vectors of the changed pixel pair are far away from each other, while the ones of the unchanged pixel pair are close. Therefore, we use the distance of the feature vectors to detect changes between the image pair. Simple threshold segmentation on the distance map can even obtain good performance. For improvement, we use a k-nearest neighbor approach to update the initial result. Experimental results show that the proposed method produces results comparable, even better, with the two state-of-the-art methods in terms of F-measure.
Severe influenza remains unusual in its virulence for humans. Complications or ultimately death arising from these infections are often associated with hyperinduction of proinflammatory cytokine ...production, which is also known as ＇cytokine storm＇. For this disease, it has been proposed that immunomodulatory therapy may improve the outcome, with or without the combination of antiviral agents. Here, we review the current literature on how various effectors of the immune system initiate the cytokine storm and exacerbate pathological damage in hosts. We also review some of the current immunomodulatory strategies for the treatment of cytokine storms in severe influenza, including corticosteroids, peroxisome proliferator-activated receptor agonists, sphingosine-l-phosphate receptor 1 agonists, cyclooxygenase-2 inhibitors, antioxidants, anti-tumour-necrosis factor therapy, intravenous immunoglobulin therapy, statins, arbidol, herbs, and other potential therapeutic strategies.
Heteroaromatic‐conjugated aromatic molecules have inspired numerous interests in rechargeable batteries like Li‐ion batteries, but were limited by low conductivity and easy dissolution in ...electrolytes. Herein, we immobilize a nitrogen‐rich aromatic molecule tricycloquinazoline (TQ) and CuO4 unit into a two‐dimensional (2D) conductive metal–organic framework (MOF) to unlock their potential for Li+ storage. TQ was identified redox activity with Li+ for the first time. With a synergistic effect of TQ and CuO4 unit, the 2D conductive MOF, named Cu‐HHTQ (HHTQ=2,3,7,8,12,13‐hexahydroxytricycloquinazoline), can facilitate the Li+/e− transport and ensure a resilient electrode, resulting in a high capacity of 657.6 mAh g−1 at 600 mA g−1 with extraordinary high‐rate capability and impressive cyclability. Our findings highlight an efficient strategy of constructing electrode materials for energy storage with combining multiple redox‐active moieties into conductive MOFs.
The 2D conductive metal–organic framework Cu‐HHTQ with multiple redox‐active sites originating from a nitrogen‐rich aromatic molecule tricycloquinazoline (TQ) and a CuO4 unit was designed for Li‐ion batteries with high capacity, extraordinary high‐rate capability and impressive cyclability. TQ was identified as redox‐active with Li+ for the first time.
This article conceptualizes storytelling as epistemic labor that is critical to the everyday meaning-making and future-making of Chinese rural migrants. Compared to stories told by scholars and ...migrants turned writers and artists, those told by migrants in a quotidian setting are largely overlooked because of their lack of representational value. However, narratives of success, fortune, and the future that circulate on China's urban fringe are essential in three ways: (1) stories, rather than numbers and calculations, help rural migrants make sense of their economic reality; (2) storytelling allows rural migrants to cope with unexpected events; and (3) stories are often imbued with moral sentiment through which moral boundaries and group identities are established. Overall, epistemic labor makes the present sensible, reality tolerable, and the future imaginable under conditions of hyper-uncertainty in which spatial instability negates routinized time and linear accumulation is denied by dramatic market fluctuations and unpredictable displacement. Epistemic labor proves that migrant agency not only resides in eventful resistance but also in constant negotiations.
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase ...(PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor. In this study, we confirmed that expression of PKM2 is heterogeneous in CRC cells, namely high in oxaliplatin‐resistant cells but relatively low in sensitive cells, and found that chemoresistant cells had enhanced glycolysis and ATP production. In addition, we report a PKM2‐dependent mechanism through which chemosensitive cells may gradually transform into chemoresistant cells. The circular RNA hsa_circ_0005963 (termed ciRS‐122 in this study), which was determined to be a sponge for the PKM2‐targeting miR‐122, was positively correlated with chemoresistance. In vitro and in vivo studies showed that exosomes from oxaliplatin‐resistant cells delivered ciRS‐122 to sensitive cells, thereby promoting glycolysis and drug resistance through miR‐122 sponging and PKM2 upregulation. Moreover, si‐ciRS‐122 transported by exosomes could suppress glycolysis and reverse resistance to oxaliplatin by regulating the ciRS‐122–miR‐122–PKM2 pathway in vivo. Exosomes derived from chemoresistant CRC cells could transfer ciRS‐122 across cells and promote glycolysis to reduce drug susceptibility in chemosensitive cells. This intercellular signal delivery suggests a potential novel therapeutic target and establishes a foundation for future clinical applications in drug‐resistant CRC.
Exosomes from oxaliplatin‐resistant colorectal cancer (CRC) cells transferred ciRS‐122 to oxaliplatin‐sensitive cells, enhancing glycolysis and drug resistance by promoting PKM2 expression. Furthermore, ciRS‐122 targeting through exosome‐delivered small interfering (si)RNA in vivo enhanced the drug response, indicating a novel potential approach for the reversion of oxaliplatin resistance in CRC.
Mental strength and history of winning play an important role in the determination of social dominance. However, the neural circuits mediating these intrinsic and extrinsic factors have remained ...unclear. Working in mice, we identified a dorsomedial prefrontal cortex (dmPFC) neural population showing “effort”-related firing during moment-to-moment competition in the dominance tube test. Activation or inhibition of the dmPFC induces instant winning or losing, respectively. In vivo optogenetic-based long-term potentiation and depression experiments establish that the mediodorsal thalamic input to the dmPFC mediates long-lasting changes in the social dominance status that are affected by history of winning. The same neural circuit also underlies transfer of dominance between different social contests. These results provide a framework for understanding the circuit basis of adaptive and pathological social behaviors.
For decades, Chinese rural migrants have been understood as engaging in dagong 打工 (working for a boss), or the selling of their waged labor, conditioned by the global production chain, dormitory ...regimes, and exploitive labor relations within and beyond factories. Meanwhile, chuangdang 闯荡 (venturing) as a life project that either opposes or extends dagong has been neglected in scholarly studies. Venturing refers to a spatiotemporal condition defined by the uniqueness of urban villages where rural migrants participate in the informal economy on the urban fringes and attach themselves to entrepreneurship and mobility. It is also a multifaceted presentism produced out of the following spatiotemporal conditions: (1) the sense of urgency to get ahead in spatial temporality; (2) an optimistic relationship with unpredictability; and (3) the technologies of mobility in the name of freedom. By highlighting the dilemmas that propel and hinder rural migrants, this article argues that the cultural politics of venturing are a condition that renders rural migrants economically aggressive, yet politically passive. Thereby, it not only prolongs rural migrants’ mobile lives on the urban fringes, but also dampens political actions that claim space through resistance.
Two early Late Pleistocene (~105,000- to 125,000-year-old) crania from Lingjing, Xuchang, China, exhibit a morphological mosaic with differences from and similarities to their western contemporaries. ...They share pan–Old World trends in encephalization and in supraorbital, neurocranial vault, and nuchal gracilization. They reflect eastern Eurasian ancestry in having low, sagittally flat, and inferiorly broad neurocrania. They share occipital (suprainiac and nuchal torus) and temporal labyrinthine (semicircular canal) morphology with the Neandertals. This morphological combination reflects Pleistocene human evolutionary patterns in general biology, as well as both regional continuity and interregional population dynamics.
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