The COVID-19 pandemic has exposed the many broken fragments of US health care and social service systems, reinforcing extant health and socioeconomic inequities faced by structurally marginalized ...immigrant communities. Throughout the pandemic, even during the most critical period of rising cases in different epicenters, immigrants continued to work in high-risk-exposure environments while simultaneously having less access to health care and economic relief and facing discrimination. We describe systemic factors that have adversely affected low-income immigrants, including limiting their work opportunities to essential jobs, living in substandard housing conditions that do not allow for social distancing or space to safely isolate from others in the household, and policies that discourage access to public resources that are available to them or that make resources completely inaccessible. We demonstrate that the current public health infrastructure has not improved health care access or linkages to necessary services, treatments, or culturally competent health care providers, and we provide suggestions for how the Public Health 3.0 framework could advance this. We recommend the following strategies to improve the Public Health 3.0 public health infrastructure and mitigate widening disparities: (1) address the social determinants of health, (2) broaden engagement with stakeholders across multiple sectors, and (3) develop appropriate tools and technologies. (
2021;111(S3):S224-S231. https://doi.org/10.2105/AJPH.2021.306433).
Immunoglobulin (Ig)G4-related sclerosing disease (ISD) (also called IgG4-related systemic disease, IgG4-related disease or hyper-IgG4 disease) is a recently described systemic fibroinflammatory ...disease associated with elevated circulating levels of IgG4. Although initial descriptions of this disorder focused on its pancreatic presentation (autoimmune pancreatitis), it has become apparent that ISD is a systemic disease with many facets. The lesion of ISD is characterised by lymphoplasmacytic inflammation, fibrosis, phlebitis and increased numbers of IgG4-positive plasma cells. The disease can either be localised to one or two organs, or be present with diffuse multi-organ disease. Furthermore, lesions in different organs can present simultaneously or metachronously. In the thorax, lesions associated with ISD have been described in the lung parenchyma, airways and pleura, as well as the mediastinum. Data published to date suggest that ISD may account for a portion of various fibroinflammatory conditions of unknown cause encountered in the chest, including inflammatory pseudotumours, idiopathic interstitial pneumonias, fibrosing mediastinitis, inflammatory pleural lesions and, occasionally, airway disease. Some aspects of pulmonary manifestations attributed to ISD remain controversial and additional studies are needed to clarify the relationship along with the increasing relevance of this disorder to pulmonary medicine.
Objective
To investigate clinical and pathologic aspects of IgG4‐related disease (IgG4‐RD) in non‐Asian populations.
Methods
We conducted a retrospective review of the medical records of patients ...with IgG4‐RD who presented to an academic medical center from January 1994 to September 2012.
Results
Among 166 patients identified, the median age at diagnosis was 61 years (interquartile range IQR 49–70 years), 75% were male, and 80% were white. The median number of organs involved was 2 (IQR 2–3). When organs were grouped according to anatomic system, the hepatopancreaticobiliary system was most commonly involved (77%). The median highest serum IgG4 level during the clinical course was 215 mg/dl (IQR 122–466). Forty‐three patients (26%) had a normal serum IgG4 level. Seventy‐nine pathology specimens were available for immunostaining. The median number of IgG4+ cells was 37 (IQR 25–82) per high‐power field, with an IgG4+:IgG+ ratio of 0.50 (IQR 0.32–0.68). Among 151 patients who received medical therapy, 72 (48%) received steroid‐sparing agents because of relapse, recurrence, or corticosteroid intolerance. Of the 66 patients who were newly diagnosed, started on corticosteroid monotherapy as the initial treatment, and followed up at our institution, 30 (45%) experienced relapse or recurrence despite an initial favorable response. The number of organs involved had a significant impact on time to relapse or recurrence, with a hazard ratio of 1.48 (95% confidence interval 95% CI 1.12–1.93) (P < 0.01) in multivariate analysis. The standardized incidence ratio of malignancy was 4.5 (95% CI 1.5–7.5).
Conclusion. IgG4‐RD is a multisystem disorder that commonly affects older men and has a propensity for relapse, recurrence, and malignancy.
ABSTRACT
We use the NewHorizon simulation to study the redshift evolution of bar properties and fractions within galaxies in the stellar masses range M⋆ = 107.25–1011.4$\, \rm {M}_\odot$ over the ...redshift range of z = 0.25–1.3. We select disc galaxies using stellar kinematics as a proxy for galaxy morphology. We employ two different automated bar detection methods, coupled with visual inspection, resulting in observable bar fractions of fbar = 0.070$_{{-0.012}}^{{+0.018}}$ at z ∼ 1.3, decreasing to fbar = 0.011$_{{-0.003}}^{{+0.014}}$ at z ∼ 0.25. Only one galaxy is visually confirmed as strongly barred in our sample. This bar is hosted by the most massive disc and only survives from z = 1.3 down to z = 0.7. Such a low bar fraction, in particular amongst Milky Way-like progenitors, highlights a missing bars problem, shared by literally all cosmological simulations with spatial resolution <100 pc to date. The analysis of linear growth rates, rotation curves, and derived summary statistics of the stellar, gas and dark matter components suggest that galaxies with stellar masses below 109.5−1010$\, \rm {M}_\odot$ in NewHorizon appear to be too dominated by dark matter relative to stellar content to form a bar, while more massive galaxies typically have formed large bulges that prevent bar persistence at low redshift. This investigation confirms that the evolution of the bar fraction puts stringent constraints on the assembly history of baryons and dark matter on to galaxies.
Carbon (C) dynamics of boreal forest ecosystems have substantial implications for efforts to mitigate the rise of atmospheric CO
2
and may be substantially influenced by warming and changing wildfire ...regimes. In this study we applied a large-scale ecosystem model that included dynamics of organic soil horizons and soil organic matter characteristics of multiple pools to assess forest C stock changes of the Yukon River Basin (YRB) in Alaska, USA, and Canada from 1960 through 2006, a period characterized by substantial climate warming and increases in wildfire. The model was calibrated for major forests with data from long-term research sites and evaluated using a forest inventory database. The regional assessment indicates that forest vegetation C storage increased by 46 Tg C, but that total soil C storage did not change appreciably during this period. However, further analysis suggests that C has been continuously lost from the mineral soil horizon since warming began in the 1970s, but has increased in the amorphous organic soil horizon. Based on a factorial experiment, soil C stocks would have increased by 158 Tg C if the YRB had not undergone warming and changes in fire regime. The analysis also identified that warming and changes in fire regime were approximately equivalent in their effects on soil C storage, and interactions between these two suggests that the loss of organic horizon thickness associated with increases in wildfire made deeper soil C stocks more vulnerable to loss via decomposition. Subbasin analyses indicate that C stock changes were primarily sensitive to the fraction of burned forest area within each subbasin and that boreal forest ecosystems in the YRB are currently transitioning from being sinks to sources at ∼0.7% annual area burned. We conclude that it is important for international mitigation efforts focused on controlling atmospheric CO
2
to consider how climate warming and changes in fire regime may concurrently affect the CO
2
sink strength of boreal forests. It is also important for large-scale biogeochemical and earth system models to include organic soil dynamics in applications to assess regional C dynamics of boreal forests responding to warming and changes in fire regime.
We investigate how environment affects satellite galaxies using their location within the projected phase space of their host haloes from the Wang et al.'s group catalogue. Using the Yonsei Zoom-in ...Cluster Simulations, we derive zones of constant mean infall time \overline{T}_inf in projected phase space, and catalogue in which zone each observed galaxy falls. Within each zone, we compute the mean observed galaxy properties including specific star formation rate, luminosity-weighted age, stellar metallicity, and α/Fe abundance ratio. By comparing galaxies in different zones, we inspect how shifting the mean infall time from recent infallers (\overline{T}_inf < 3 Gyr) to ancient infallers (\overline{T}_{inf}> 5 Gyr) impacts galaxy properties at fixed stellar and halo mass. Ancient infallers are more quenched, and the impact of environmental quenching is visible down to low host masses (≤group masses). Meanwhile, the quenching of recent infallers is weakly dependent on host mass, indicating they have yet to respond strongly to their current environment. α/Fe and especially metallicity are less dependent on host mass, but show a dependence on \overline{T}_{inf}. We discuss these results in the context of longer exposure times for ancient infallers to environmental effects, which grow more efficient in hosts with a deeper potential well and a denser intracluster medium. We also compare our satellites with a control field sample, and find that even the most recent infallers (\overline{T}_{inf} < 2 Gyr) are more quenched than field galaxies, in particular for cluster mass hosts. This supports the role of pre-processing and/or faster quenching in satellites.
This paper describes the Magnetic Electron Ion Spectrometer (MagEIS) instruments aboard the RBSP spacecraft from an instrumentation and engineering point of view. There are four magnetic ...spectrometers aboard each of the two spacecraft, one low-energy unit (20–240 keV), two medium-energy units (80–1200 keV), and a high-energy unit (800–4800 keV). The high unit also contains a proton telescope (55 keV–20 MeV).
The magnetic spectrometers focus electrons within a selected energy pass band upon a focal plane of several silicon detectors where pulse-height analysis is used to determine if the energy of the incident electron is appropriate for the electron momentum selected by the magnet. Thus each event is a two-parameter analysis, an approach leading to a greatly reduced background.
The physics of these instruments are described in detail followed by the engineering implementation. The data outputs are described, and examples of the calibration results and early flight data presented.
ABSTRACT
Low-surface-brightness galaxies (LSBGs) – defined as systems that are fainter than the surface-brightness limits of past wide-area surveys – form the overwhelming majority of galaxies in the ...dwarf regime (M⋆ < 109 M⊙). Using NewHorizon, a high-resolution cosmological simulation, we study the origin of LSBGs and explain why LSBGs at similar stellar mass show the large observed spread in surface brightness. NewHorizon galaxies populate a well-defined locus in the surface brightness–stellar mass plane, with a spread of ∼3 mag arcsec−2, in agreement with deep Sloan Digital Sky Survey (SDSS) Stripe 82 data. Galaxies with fainter surface brightnesses today are born in regions of higher dark matter density. This results in faster gas accretion and more intense star formation at early epochs. The stronger resultant supernova feedback flattens gas profiles at a faster rate, which, in turn, creates shallower stellar profiles (i.e. more diffuse systems) more rapidly. As star formation declines towards late epochs ( z < 1), the larger tidal perturbations and ram pressure experienced by these systems (due to their denser local environments) accelerate the divergence in surface brightness, by increasing their effective radii and reducing star formation, respectively. A small minority of dwarfs depart from the main locus towards high surface brightnesses, making them detectable in past wide surveys (e.g. standard-depth SDSS images). These systems have anomalously high star formation rates, triggered by recent fly-by or merger-driven starbursts. We note that objects considered extreme or anomalous at the depth of current data sets, e.g. ‘ultra-diffuse galaxies’, actually dominate the predicted dwarf population and will be routinely visible in future surveys like the Legacy Survey of Space and Time (LSST).
Rare earth elements or yttrium can weaken the strong basal textures of magnesium sheets and are of interest for the improvement of sheet formability. The weakening of magnesium sheet textures with ...increasing content of Ce, Nd and Y is connected to the solid solubility of the respective element. A relationship is drawn between the weak textures and the appearance of deformation bands with compression and double twins during rolling and a grain growth restriction during annealing of the sheets.
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