Supramolecular polymers have received considerable attention during the last few decades due to their scientific value in polymer chemistry and profound implications for future developments of ...advanced materials. Discrete supramolecular coordination complexes (SCCs) with well-defined size, shape, and geometry have been widely employed to construct hierarchical systems by coordination-driven self-assembly with the spontaneous formation of metal-ligand bonds, which results in the formation of well-defined two-dimensional (2D) metallacycles or three-dimensional (3D) metallacages with high functionalities. The incorporation of discrete SCCs into supramolecular polymers by the orthogonal combination of metal-ligand coordination and other noncovalent interactions or covalent bonding could further facilitate the construction of novel supramolecular polymers with hierarchical architectures and multiple functions including controllable uptake and release of guest molecules, providing a flexible platform for the development of smart materials. In this review, the recent progress in metallacycle/metallacage-cored supramolecular polymers that were constructed by the combination of metal-ligand interactions and other orthogonal interactions (including hydrophobic or hydrophilic interactions, hydrogen bonding, van der Waals forces, π-π stacking, electrostatic interactions, host-guest interactions and covalent bonding) has been discussed. In addition, the potential applications of metallacycle/metallacage-cored supramolecular polymers in the areas of light emitting, sensing, bio-imaging, delivery and release, etc., are also presented.
Pluronic polymers (pluronics) are a unique class of synthetic triblock copolymers containing hydrophobic polypropylene oxide (PPO) and hydrophilic polyethylene oxide (PEO) arranged in the PEO-PPO-PEO ...manner. Due to their excellent biocompatibility and amphiphilic properties, pluronics are an ideal and promising biological material, which is widely used in drug delivery, disease diagnosis, and treatment, among other applications. Through self-assembly or in combination with other materials, pluronics can form nano carriers with different morphologies, representing a kind of multifunctional pharmaceutical excipients. In recent years, the utilization of pluronic-based multi-functional drug carriers in tumor treatment has become widespread, and various responsive drug carriers are designed according to the characteristics of the tumor microenvironment, resulting in major progress in tumor therapy. This review introduces the specific role of pluronic-based polymer drug delivery systems in tumor therapy, focusing on their physical and chemical properties as well as the design aspects of pluronic polymers. Finally, using newer literature reports, this review provides insights into the future potential and challenges posed by different pluronic-based polymer drug delivery systems in tumor therapy.
Surface modification is an important technique in fields, such as, self‐cleaning, surface patterning, sensing, and detection. The diselenide bond was shown to be a dynamic covalent bond that can ...undergo a diselenide metathesis reaction simply under visible light irradiation. Herein we develop this diselenide dynamic chemistry into a versatile surface modification method with a fast response and reversibility. The diselenide bond could be modified onto various substrates, such as, PDMS, quartz, and ITO conductive film glass. Different functional diselenide molecules could then be immobilized onto the surface via diselenide metathesis reaction. We demonstrated that by using this modification method we could achieve liquid motion in a capillary tube under light illumination. We also show that this approach has the potential to serve as an efficient modification method for surface bioconjugation, which has practical applications in clinical usage.
Se‐ing and doing: Diselenide dynamic chemistry gives a versatile, reversible, surface modification method with fast response (30 s). Different functional diselenide molecules can then be immobilized onto the surface via diselenide metathesis reactions under visible light irradiation. This approach gives liquid motion in a capillary tube under light illumination and is an efficient tool for surface bioconjugation.
A new colorimetric and NIR fluorescent chemosensor (1) for Cu(2+) based on BODIPY is reported, displaying a highly sensitive and selective fluorescent enhancement with Cu(2+) among various metal ...ions, upon excitation at 620 nm in CH(3)CN.
Transfer request: A self‐assembled supramolecular charge‐transfer complex of 1‐(11‐oxo‐11‐pyren‐1‐ylmethoxy)undecyl)pyridinium bromide (PYR) and ethane‐1,2‐diyl bis(3,5‐dinitrobenzoate) (DNB) is ...shown to form vesicular aggregates in aqueous solution, in contrast to the tubular aggregates of pure PYR (see picture). A curvature‐dependent mechanism for this change is proposed.
Cancer has become a common disease that seriously endangers human health and life. Up to now, the essential treatment method has been drug therapy, and drug delivery plays an important role in cancer ...therapy. To improve the efficiency of drug therapy, researchers are committed to improving drug delivery methods to enhance drug pharmacokinetics and cancer accumulation. Supramolecular coordination complexes (SCCs) with well-defined shapes and sizes are formed through the coordination between diverse functional organic ligands and metal ions, and they have emerged as potential components in drug delivery and cancer therapy. In particular, micelles or vesicles with the required biocompatibility and stability are synthesized using SCC-containing polymeric systems to develop novel carriers for drug delivery that possess combined properties and extended system tunability. In this study, the research status of SCC-containing polymeric systems as drug carriers and adjuvants for cancer treatment is reviewed, and a special focus is given to their design and preparation.
Conjugated polymers generally contain conjugated backbone structures with benzene, heterocycle, double bond, or triple bond, so that they have properties similar to semiconductors and even ...conductors. Their energy band gap is very small and can be adjusted via chemical doping, allowing for excellent photoelectric properties. To obtain prominent conjugated materials, numerous well-designed polymer backbones have been reported, such as polyphenylenevinylene, polyphenylene acetylene, polycarbazole, and polyfluorene. 4,4'-Difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based conjugated polymers have also been prepared owing to its conjugated structure and intriguing optical properties, including high absorption coefficients, excellent thermal/photochemical stability, and high quantum yield. Most importantly, the properties of BODIPYs can be easily tuned by chemical modification on the dipyrromethene core, which endows the conjugated polymers with multiple functionalities. In this paper, BODIPY-based conjugated polymers are reviewed, focusing on their structures and applications. The forms of BODIPY-based conjugated polymers include linear, coiled, and porous structures, and their structure-property relationship is explored. Also, typical applications in optoelectronic materials, sensors, gas/energy storage, biotherapy, and bioimaging are presented and discussed in detail. Finally, the review provides an insight into the challenges in the development of BODIPY-based conjugated polymers.
A cross-linked supramolecular network was prepared by the orthogonal self-assembly of metal-coordination and host–guest interactions. Due to the incorporation of two fluorophores, coumarin and ...tetraphenylethene, into the network as well as the abundant stimuli-responsiveness of the two non-covalent interactions, it can be used for the ratiometric sensing of pH, cyclen and Cl − .
Supramolecular polymers based on supramolecular coordination complexes (SCCs) have received extensive attention because of their good stimulus responsiveness, processability and other properties. ...Herein, we report metallacycle-crosslinked supramolecular polymers via amino–yne click reaction, which were employed as well-performing elastomer materials. The supramolecular polymers cross-linked by the metallacycle not only maintained the aggregation induced emission (AIE) properties of the metallacycle, which were used to detect nitroaromatic explosives, but also had enhanced mechanical strength and toughness and exhibited elastomeric properties. This study provides a feasible strategy for the preparation of metallacycle-based supramolecular polymers with better mechanical properties.
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