Replanting obstacles of
caused by complex factors, including pathogens, have received great attention. In this study, essential oils (EOs) from either
Hance or
(Zingiberaceae) were found to inhibit ...the growth of
-associated pathogenic fungi in vitro. Subsequent GC-MS analysis revealed the chemical profiles of two plant derived EOs. Linalool and eucalyptol were found to be abundant in the EOs and tested for their antifungal activities. In addition, the synergistic effects of
EOs and hymexazol were also examined. These findings suggested that Zingiberaceae EOs might be a good source for developing new green natural pesticides fighting against root-rot of
.
.
Zizhines V, W, Y, Z, (±)‐zizhines X, and Z1−Z3, and (±)‐ganosinensol L, thirteen new compounds including four pairs of enantiomers and a known compound (−)‐ganosinensol L, were isolated from the ...fruiting bodies of Ganoderma sinensis. Their structures were identified by spectroscopic, computational methods, and CD (circular dichroism spectroscopy) comparisons. Zizhines V−Z and Z1−Z3 are meroterpenoids consisting of the phenolic and the terpenoidal parts. All the compounds except zizhine Z3 bear a common trans‐p‐hydroxycinnamoyl group. Biological evaluation shows that (−)‐zizhine Z1 inhibits cell migration in the MDA‐MB‐231 cell lines. The present study discloses the chemical profiling of G. sinensis and paves the way for its development as functional products to benefit chronic disorders.
Five new meroterpenoids, zizhines P-S and U (
-
,
), together with two known meroterpenoids (
and
) were isolated from
. Their structures including absolute configurations were assigned by using ...spectroscopic, computational, and chemical methods. Racemics zizhines P and Q were purified by HPLC on chiral phase. Biological evaluation found that
,
and
are cytotoxic toward human cancer cells (A549, BGC-823, Kyse30) with IC
values in the range of 63.43-80.83 μM towards A549, 59.2 ± 2.73 μM and 64.25 ± 0.37 μM towards BGC-823, 76.28 ± 1.93 μM and 85.42 ± 2.82 μM towards Kyse30.
We performed a two-stage genome-wide association study of IgA nephropathy (IgAN) in Han Chinese, with 1,434 affected individuals (cases) and 4,270 controls in the discovery phase and follow-up of the ...top 61 SNPs in an additional 2,703 cases and 3,464 controls. We identified associations at 17p13 (rs3803800, P = 9.40 × 10(-11), OR = 1.21; rs4227, P = 4.31 × 10(-10), OR = 1.23) and 8p23 (rs2738048, P = 3.18 × 10(-14), OR = 0.79) that implicated the genes encoding tumor necrosis factor (TNFSF13) and α-defensin (DEFA) as susceptibility genes. In addition, we found multiple associations in the major histocompatibility complex (MHC) region (rs660895, P = 4.13 × 10(-20), OR = 1.34; rs1794275, P = 3.43 × 10(-13), OR = 1.30; rs2523946, P = 1.74 × 10(-11), OR = 1.21) and confirmed a previously reported association at 22q12 (rs12537, P = 1.17 × 10(-11), OR = 0.78). We also found that rs660895 was associated with clinical subtypes of IgAN (P = 0.003), proteinuria (P = 0.025) and IgA levels (P = 0.047). Our findings show that IgAN is associated with variants near genes involved in innate immunity and inflammation.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with ...schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 × 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 × 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 × 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 × 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 × 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 × 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
A template-free strategy was designed to prepare hierarchical porous carbons (HPCs) using fluid catalytic cracking oil modified a coal tar pitch (CTP). The resulting HPCs possess large specific ...surface areas, reasonable pore size distributions, and wrinkled structures, which could improve the overall electrochemical performance. They exhibit a specific capacitance value of 329 F g
−1
at 0.5 A g
−1
and still maintain 220 F g
−1
at 20 A g
−1
, manifesting the remarkable rate capability. Additionally, the assembled symmetrical supercapacitor delivers a highest energy density of 23.6 Wh kg
−1
at a power density of 500 W kg
−1
and outstanding cycle stability of 92.8% capacitance retention after 10000 cycles. This work paves a new way to fabricate advanced carbon materials from low-cost CTP and provides a promising approach for value-added utilization of CTP.
Graphical abstract
Nitrogen and sulfur co-doped porous carbon (NSCDPC) was prepared using a one-step method using a purple-leaf plum kernel shell, potassium benzoate, and
N
,
N
′-diphenylthiourea (DPTU) as the carbon ...precursor, the activator and the nitrogen and sulfur source, respectively. The use of potassium benzoate with weak alkalinity and causticity facilitates obtaining abundant microporous structures and heteroatoms. Meanwhile, the dopant
N
,
N
′-diphenylthiourea plays a synergic activation role. The optimal layer-stacked NSCDPC
750-1
exhibits abundant ultramicropores and defect sites, developed interconnected channels, a large specific surface area, and rich nitrogen and sulfur contents, resulting in excellent electrochemical performance. As expected, NSCDPC
750-1
exhibits a high specific capacitance of 338 F g
−1
at 0.5 A g
−1
in 6 M KOH electrolyte, an outstanding rate performance with 280 F g
−1
at 20 A g
−1
, and remarkable durability with 92.3% retention after 10 000 cycles. In addition, a symmetric supercapacitor assembled with NSCDPC
750-1
as the electrode and 6 M KOH as the electrolyte possesses an outstanding specific capacitance of 111 F g
−1
at 0.5 A g
−1
, an excellent rate capability, and a high energy density of 30.22 W h kg
−1
. The impressive electrochemical performance makes NSCDPC
750-1
a promising supercapacitor electrode material.
Nitrogen and sulfur co-doped porous carbon materials with excellent electrochemical performance were prepared using a one-step carbonization and activation method.
Atopic dermatitis is a chronic, relapsing form of inflammatory skin disorder that is affected by genetic and environmental factors. We performed a genome-wide association study of atopic dermatitis ...in a Chinese Han population using 1,012 affected individuals (cases) and 1,362 controls followed by a replication study in an additional 3,624 cases and 12,197 controls of Chinese Han ethnicity, as well as 1,806 cases and 3,256 controls from Germany. We identified previously undescribed susceptibility loci at 5q22.1 (TMEM232 and SLC25A46, rs7701890, Pcombined = 3.15 × 10−9, odds ratio (OR) = 1.24) and 20q13.33 (TNFRSF6B and ZGPAT, rs6010620, Pcombined = 3.0 × 10−8, OR = 1.17) and replicated another previously reported locus at 1q21.3 (FLG, rs3126085, Pcombined = 5.90 × 10−12, OR = 0.82) in the Chinese sample. The 20q13.33 locus also showed evidence for association in the German sample (rs6010620, P = 2.87 × 10−5, OR = 1.25). Our study identifies new genetic susceptibility factors and suggests previously unidentified biological pathways in atopic dermatitis.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Display omitted
•N/O self-doped HPCs were successfully prepared by modifying a coal tar pitch.•The HPCs own hierarchical porous architecture and high conductivity.•The HPCs show high specific ...capacitance, good rate performance, and cycle stability.•The assembled supercapacitors exhibit high energy density and power density.
Carbon materials with hierarchical porous architecture and high conductivity are highly desired for supercapacitors (SCs), but there is a daunting challenge to prepare them via an ecofriendly and economic route. Herein, a co-activation/graphitization strategy with the aid of KOH and Ni is proposed to fabricate the N/O self-doped hierarchical porous carbons (HPCs), employing coal tar pitch (CTP) modified by fluid catalytic cracking oil as a low-cost precursor. The as-prepared HPCs with a large specific surface area of 2254 m2 g−1 and appropriate heteroatom doping exhibit a specific capacitance of 368 F g−1 of specific capacitance at 0.5 A g−1 and still retain 270 F g−1 at 20 A g−1 (73.3% capacitance retention rate) in 6 M KOH electrolyte. Besides, the symmetrical SC achieves a maximum energy density of 27.45 Wh kg−1 at a power density of 253 W kg−1 in 1 M Na2SO4 electrolyte. This work designs a novel route for preparing electrode materials with excellent electrochemical performance and provides a feasible way for the value-added utilization of low-cost CTP.
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