ABSTRACT
We present a large, homogeneous catalogue of molecular clouds within 4 kpc from the Sun at low Galactic latitudes (|b| < 10°) with unprecedented accurate distance determinations. Based on ...the 3D dust reddening map and estimates of colour excesses and distances of over 32 million stars presented in Chen et al., we have identified 567 dust/molecular clouds with a hierarchical structure identification method and obtained their distance estimates by a dust model fitting algorithm. The typical distance uncertainty is less than 5 per cent. As far as we know, this is the first large catalogue of molecular clouds in the Galactic plane with distances derived in a direct manner. The clouds are seen to lie along the Sagittarius, Local and Perseus Arms. In addition to the known structures, we propose the existence of a possible spur, with a pitch angle of about 34°, connecting the Local and the Sagittarius Arms in the fourth quadrant. We have also derived the physical properties of those molecular clouds. The distribution of cloud properties in different parameter spaces agrees grossly with the previous results. Our cloud sample is an ideal starting point to study the concentration of dust and gas in the solar vicinity and their star formation activities.
Neurotransmitters play essential roles in regulating neural circuit dynamics both in the central nervous system as well as at the peripheral, including the gastrointestinal tract
. Their real-time ...monitoring will offer critical information for understanding neural function and diagnosing disease
. However, bioelectronic tools to monitor the dynamics of neurotransmitters in vivo, especially in the enteric nervous systems, are underdeveloped. This is mainly owing to the limited availability of biosensing tools that are capable of examining soft, complex and actively moving organs. Here we introduce a tissue-mimicking, stretchable, neurochemical biological interface termed NeuroString, which is prepared by laser patterning of a metal-complexed polyimide into an interconnected graphene/nanoparticle network embedded in an elastomer. NeuroString sensors allow chronic in vivo real-time, multichannel and multiplexed monoamine sensing in the brain of behaving mouse, as well as measuring serotonin dynamics in the gut without undesired stimulations and perturbing peristaltic movements. The described elastic and conformable biosensing interface has broad potential for studying the impact of neurotransmitters on gut microbes, brain-gut communication and may ultimately be extended to biomolecular sensing in other soft organs across the body.
Abstract
We present a detailed analysis of the selection function of the LAMOST Spectroscopic Survey of the Galactic Anti-centre (LSS-GAC). LSS-GAC was designed to obtain low-resolution optical ...spectra for a sample of more than 3 million stars in the Galactic anti-centre. The second release of value-added catalogues of the LSS-GAC (LSS-GAC DR2) contains stellar parameters, including radial velocity, atmospheric parameters, elemental abundances, and absolute magnitudes deduced from 1.8 million spectra of 1.4 million unique stars targeted by the LSS-GAC between 2011 and 2014. For many studies using this data base, such as those investigating the chemodynamical structure of the Milky Way, a detailed understanding of the selection function of the survey is indispensable. In this paper, we describe how the selection function of the LSS-GAC can be evaluated to sufficient detail and provide selection function corrections for all spectroscopic measurements with reliable parameters released in LSS-GAC DR2. The results, to be released as new entries in the LSS-GAC value-added catalogues, can be used to correct the selection effects of the catalogue for scientific studies of various purposes.
A nasopharyngeal carcinoma (NPC) mass screening trial using a combination of immunoglobulin A antibodies to Epstein-Barr virus capsid antigen and nuclear antigen-1 by enzyme-linked immunosorbent ...assay in addition to indirect mirror examination in the nasopharynx and/or lymphatic palpation (IMLP) was conducted in southern China. Cantonese aged 30-59 years residing in 2 cities randomly selected by cluster sampling, Sihui and Zhongshan, were invited to participate in this screening from May 2008 through May 2010. Participants were offered fiberoptic endoscopy examination and/or pathologic biopsy if their serologic tests reached our predefined level of high risk or if results from the physical examination indicated possible cancer (i.e., were IMLP positive). A total of 28,688 individuals were voluntarily screened in the initial round. The overall NPC detection rate was 0.14% (41/28,688) with an early diagnosis rate of 68.3% (28/41) during the first year of follow-up. Thirty-eight of 41 cases (92.7%) were detected among the high-risk group, and 7 of 41 cases (17.1%) were detected among the IMLP-positive group. The 2 Epstein-Barr virus serologic tests by enzyme-linked immunosorbent assay could be a feasible alternative for NPC screening in endemic areas. Further follow-up is needed to examine whether screening has an effect on decreasing mortality from NPC in these areas.
Patches of ionization are common in the polar ionosphere, where their motion and associated density gradients give variable disturbances to high-frequency (HF) radio communications, over-the-horizon ...radar location errors, and disruption and errors to satellite navigation and communication. Their formation and evolution are poorly understood, particularly under disturbed space weather conditions. We report direct observations of the full evolution of patches during a geomagnetic storm, including formation, polar cap entry, transpolar evolution, polar cap exit, and sunward return flow. Our observations show that modulation of nightside reconnection in the substorm cycle of the magnetosphere helps form the gaps between patches where steady convection would give a "tongue" of ionization (TOI).
We report on the analysis of the 10-1000 TeV large-scale sidereal anisotropy of Galactic cosmic rays (GCRs) with the data collected by the Tibet Air Shower Array from 1995 October to 2010 February. ...In this analysis, we improve the energy estimate and extend the decl. range down to −30°. We find that the anisotropy maps above 100 TeV are distinct from that at a multi-TeV band. The so-called tail-in and loss-cone features identified at low energies get less significant, and a new component appears at ∼100 TeV. The spatial distribution of the GCR intensity with an excess (7.2 pre-trial, 5.2 post-trial) and a deficit (−5.8 pre-trial) are observed in the 300 TeV anisotropy map, in close agreement with IceCube's results at 400 TeV. Combining the Tibet results in the northern sky with IceCube's results in the southern sky, we establish a full-sky picture of the anisotropy in hundreds of TeV band. We further find that the amplitude of the first order anisotropy increases sharply above ∼100 TeV, indicating a new component of the anisotropy. All these results may shed new light on understanding the origin and propagation of GCRs.
Abstract The purpose of this study was to clarify the correlation between pre-treatment anterior disc displacement and mandibular stability after orthognathic and orthodontic treatment among patients ...with a skeletal class II malocclusion and without pre-treatment condylar resorption. Thirty-seven patients were included (7 male, 30 female). The mean length of follow-up was 6.76 ± 3.06 years. Patients with condylar resorption before treatment were excluded. Magnetic resonance images and lateral cephalometric radiographs were taken before treatment (T0), after treatment (T1), and at follow-up (T2). Patients were classified according to the degree of disc displacement: −10–10° ‘normal’, 11–50° ‘slight to mild’, ≥51° ‘moderate to severe’. Results showed the condyle moved posterosuperiorly after treatment, and then moved anteriorly to a more concentric location during the long follow-up period. Condylar movement was found not to correlate with disc displacement. The degree of disc displacement before treatment did not correlate with the post-surgical mandibular positional change in either the sagittal or vertical direction. To conclude, the mandibular bilateral sagittal split ramus osteotomy was stable in the long-term after orthognathic and orthodontic treatment. In the absence of pre-treatment condylar resorption, the degree of initial anterior disc displacement did not have a significant influence on the stability of mandibular advancement.
Abstract
Proper regulation of genome architecture and activity is essential for the development and function of multicellular organisms. Histone modifications, acting in combination, specify these ...activity states at individual genomic loci. However, the methods used to study these modifications often require either a large number of cells or are limited to targeting one histone mark at a time. Here, we developed a new method called Single Cell Evaluation of Post-TRanslational Epigenetic Encoding (SCEPTRE) that uses Expansion Microscopy (ExM) to visualize and quantify multiple histone modifications at non-repetitive genomic regions in single cells at a spatial resolution of ∼75 nm. Using SCEPTRE, we distinguished multiple histone modifications at a single housekeeping gene, quantified histone modification levels at multiple developmentally-regulated genes in individual cells, and evaluated the relationship between histone modifications and RNA polymerase II loading at individual loci. We find extensive variability in epigenetic states between individual gene loci hidden from current population-averaged measurements. These findings establish SCEPTRE as a new technique for multiplexed detection of combinatorial chromatin states at single genomic loci in single cells.
Graphical Abstract
Graphical Abstract
Single cell evaluation of post-translational epigenetic encoding (SCEPTRE) uses expansion microscopy to combine DNA in situ labeling with immunofluorescence and quantify histone mark levels at individual loci within cells.
ABSTRACT
We perform analysis of the 3D kinematics of Milky Way disc stars in mono-age populations. We focus on stars between Galactocentric distances of R = 6 and 14 kpc, selected from the combined ...LAMOST Data Release 4 (DR4) red clump giant stars and Gaia DR2 proper motion catalogue. We confirm the 3D asymmetrical motions of recent works and provide time tagging of the Galactic outer disc asymmetrical motions near the anticentre direction out to Galactocentric distances of 14 kpc. Radial Galactocentric motions reach values up to 10 km s−1, depending on the age of the population, and present a north–south asymmetry in the region corresponding to density and velocity substructures that were sensitive to the perturbations in the early 6 Gyr. After that time, the disc stars in this asymmetrical structure have become kinematically hotter, and are thus not sensitive to perturbations, and we find the structure is a relatively younger population. With quantitative analysis, we find stars both above and below the plane at R ≳ 9 kpc that exhibit bending mode motions of which the sensitive duration is around 8 Gyr. We speculate that the in-plane asymmetries might not be mainly caused by a fast rotating bar, intrinsically elliptical outer disc, secular expansion of the disc, or streams. Spiral arm dynamics, out-of-equilibrium models, minor mergers or others are important contributors. Vertical motions might be dominated by bending and breathing modes induced by complicated inner or external perturbers. It is likely that many of these mechanisms are coupled together.
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