•Managing perimenopausal and postmenopausal health is a key issue for all areas of healthcare, not just gynecology.•Training programs for healthcare professionals worldwide should include menopause ...and postmenopausal health in their curriculum.•The curriculum should include assessment, diagnosis and evidence-based management strategies.
The menopause, or the cessation of menstruation, is a stage of the life cycle which will occur in all women. Managing perimenopausal and postmenopausal health is a key issue for all areas of healthcare, not just gynecology.
To provide recommendations for the curriculum of education programs for healthcare professionals worldwide, so that all can receive high quality training on menopause.
Literature review and consensus of expert opinion.
Training programs for healthcare professionals worldwide should include menopause and postmenopausal health in their curriculum. It should include assessment, diagnosis and evidence-based management strategies.
Enterococcus faecalis
(
n
= 15) and
Enterococcus faecium
(
n
= 33) strains isolated from traditional Turkish cheeses were tested for susceptibility to 11 different antimicrobial agents and for the ...presence of selected genes encoding resistance and 13 genes encoding virulence factors using PCR. Furthermore, the plasmid profile of enterococci was examined. All
E. faecium
and
E. faecalis
isolates were resistant to nalidixic acid and kanamycin. The percentages of other resistant
E. faecium
and
E. faecalis
isolates, respectively, were 97 and 100% to streptomycin, 15.1 and 20% to ampicillin, 9.1 and 26.7% to gentamycin, 12.1 and 46.6% to chloramphenicol, 12.1 and 60% to tetracycline, 75.7 and 93.3% to rifampicin, 84.8 and 80% to vancomycin, 97 and 100% to erytromycin and 72.7 and 60% to ciprofloxacin.
efaA
fm
(100%) and ccf (90.1%) genes were the most common virulence genes identified among
E. faecium
isolates while
efaA
fs
(100%),
cpd
(100%),
ccf
(93.3%) and
cob
(86.7%) genes among
E. faecalis
isolates. Cytolysin determinants (
cylM, cylB, cylA
) were not detected among tested strains. Plasmid profile analysis of
Enterococcus
spp. revealed plasmid DNA bands ranging in size from 2.4 to 35.8 kb.
Liver pyruvate kinase (PKL) has recently emerged as a new target for non-alcoholic fatty liver disease (NAFLD), and inhibitors of this enzyme could represent a new therapeutic option. However, this ...breakthrough is complicated by selectivity issues since pyruvate kinase exists in four different isoforms. In this work, we report that ellagic acid (EA) and its derivatives, present in numerous fruits and vegetables, can inhibit PKL potently and selectively. Several polyphenolic analogues of EA were synthesized and tested to identify the chemical features responsible for the desired activity. Molecular modelling studies suggested that this inhibition is related to the stabilization of the PKL inactive state. This unique inhibition mechanism could potentially herald the development of new therapeutics for NAFLD.
PurposeTo evaluate the choroidal thickness in patients with Graves orbitopathy (GO) using enhanced depth imaging-optical coherence tomography (EDI-OCT).MethodsThirty-one patients with GO were ...evaluated prospectively. All subjects underwent ophthalmologic examination including best-corrected visual acuity, intraocular pressure measurement, biomicroscopic, and fundus examination. Choroidal thickness was measured at the central fovea. In addition, visual evoked potential measurement and visual field evaluation were performed.ResultsThe mean choroidal thickness was 377.8±7.4 μ in the GO group, and 334±13.7 μ in the control group. (P=0.004). There was a strong correlation between the choridal thickness and the clinical activity scores (CAS) of the patients (r=0.281, P=0.027). Additionally, there was a correlation between the choroidal thickness and the visual-evoked potential (VEP) P100 latency measurements of the patients (r=0.439, P=0.001).ConclusionsThe results of this study demonstrate that choroid is thicker in patients with GO. The choroidal thickness is also correlated with the CAS and VEP P100 latency measurements in these patients.
Tamamen insana ozgu bir kavram olan kultur, zaman icinde toplumsal degisimle birlikte donusen, zaman zaman da toplumu donusturen bir yapi olarak karsimiza cikmaktadir. Toplumlar farkli kultur ...alanlarinda cok ve cesitli kulturel urunler ortaya cikarir. Ideolojik, antropolojik, toplumsal ve artistik olmak uzere dort basamakta incelenebilecek kultur alanlarinin en ustunde yer alan artistik alan muzik, tiyatro, opera, resim gibi sanat dallarinin yani sira sinemayi da kapsamaktadir. Sinema hem bir sanat dali olarak, hem bir kitle iletisim araci olarak genis kitlelere ulasmakta ve filmler araciligiyla hem icine dogdugu toplumu yansitmakta hem de izleyicisine yon vermektedir. Bu noktadan hareketle, bu calismada Turk sinemasinda ilkogretim duzeyinde okul, ogretmen ve ogrencilerin nasil temsil edildikleri arastirilacaktir. Bunun icin amacli ornekleme yoluyla Turk sinemasindan Hakkari'de Bir Mevsim(Erden Kiral/1982), Kasaba(Nuri Bilge Ceylan/1996) ve Iki Dil Bir Bavul(Ozgur Dogan-Orhan Eskikoy/2008) olmak uzere uc ornek ele alinmis, bu filmlerdeki okul, ogrenci, ogretmen ve yoksunluk temsilleri betimsel analiz yoluyla incelenmistir. Boylece, bu konuya iliskin toplumsal gercekligimizle, sinemamiz arasinda bir ortusmenin olup olmadigi sorgulanmaya calisilmistir.// web URL: http://globalmediajournaltr.yeditepe.edu.tr/makaleler/GMJ_11 ._sayi_ guz_2015/pdf/1.pdf
Background
In Turkey, several changes have been made in the vaccination schedule. Vaccines against diphtheria, tetanus, pertussis and poliomiyelitis were applied as DTwP and OPV until the end of ...2006. Hib vaccine was added to the schedule and was administered as a separate injection in 2007 as DPT + OPV + Hib. DTaP-IPV/Hib combined vaccine replaced them in 2008. The aim of this study was to evaluate the alterations in the frequency of adverse reactions of these different schedules in the consecutive three years.
Methods
A total of 2401 infants who were vaccinated in Gazi University Well Child Clinics during the first 3 months of each schedule were enrolled in the study. Local and systemic adverse events were recorded in diaries by the parents for the next three days.
Results
No significant differences existed between infants vaccinated with DPT + OPV and DPT + OPV + Hib regarding all adverse events detected. Frequency of local and systemic reactions were lower in infants vaccinated with DTaP-IPV/Hib combined vaccine (p < 0.001). Frequency of adverse events in infants vaccinated with DPT + OPV or DPT+ OPV + Hib were highest at booster doses.
Conclusions
The original experience of the study is the demonstration of the adverse event profile for three different schedules which allowed us to draw the profile of the adverse events in a country with changing national schedules. Implementation of Schedule 3 reduced the adverse events of vaccination. Thus reduction in the number of injections and reactogenicity of pertussis vaccine contributed to an increase in the compliance to the vaccination program.
We summarize the studies carried out in Turkish Atomic Energy Authority Proton Accelerator Facility (TAEA PAF) R&D irradiation vault in order to design an in-vacuum fully automated irradiation system ...capable of adjusting proton beam energy between 2–30 MeV with beam currents down to picoamperes. The low current beam may be used for a wide range of research covering radiation damage testing and non-destructive material analysis such as PIXE, PIGE and RBS. The energy and current of the beam extracted TAEA-PAF cyclotron are not suitable to perform aforementioned applications since the accelerator was primarily designed for radioisotope production. Additional systems such as an energy degrader system, a collimator, an irradiation chamber and a Faraday Cup was designed in order to adjust beam parameters. The effects of different degrader foil materials, thicknesses, configurations and different collimator apertures on the beam energy and current at the target plane were investigated in the design of the energy degrader system. The temperature increase and activation of degrader foils were calculated depending on beam current and irradiation time. The design includes an energy measurement system with a Si(Li) detector. The design of the irradiation chamber includes equipment for beam characterization and sample manipulation and connection ports for detectors, pneumatic cylinders, motors and vacuum components. A Faraday Cup and related low noise electronics were designed, manufactured and tested. Picoampere range beam current was measured successfully with the Faraday Cup and related electronics for design validation.
Serum nitrite/nitrate (NOx) and malondialdehyde (MDA) levels of 40 male alcoholic patients and 14 healthy male controls were investigated. Severity of alcohol withdrawal in alcoholic patients was ...evaluated by using the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale just before taking the blood samples. NOx levels in serum samples were determined based on the reduction of nitrate to nitrite by vanadium chloride. MDA levels were also determined spectrophotometrically at 540 nm. The total CIWA-Ar score of alcohol-withdrawn patients was found to be 17.7. NOx and MDA levels were significantly increased in alcoholics during alcohol withdrawal as compared to control subjects. In conclusion, we observed increased serum NOx levels and lipid peroxidation during alcohol withdrawal in alcoholic patients.
To report clinically symptomatic and angiographically documented cystoid macular edema (CME) associated with the use of latanoprost in two pseudophakic eyes after uncomplicated cataract surgery.
...Retrospective review of two patients who had history of latanoprost use and uncomplicated cataract surgery and described blurred vision in the first postoperative month.
Ocular examination revealed CME, which was confirmed by fluorescein angiography. The visual acuities of patients improved and the CME was angiographically resolved after discontinuation of latanoprost and the initiation of nonsteroidal anti-inflammatory eye-drops and oral acetazolamide.
Until a causal relationship between CME and latanoprost is proved or disproved, caution in its use in pseudophakic patients would be prudent.
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