Researchers and scientists increasingly find themselves in the position of having to quickly understand large amounts of technical material. Our goal is to effectively serve this need by using ...bibliometric text mining and summarization techniques to generate summaries of scientific literature. We show how we can use citations to produce automatically generated, readily consumable, technical extractive summaries. We first propose C-LexRank, a model for summarizing single scientific articles based on citations, which employs community detection and extracts salient information-rich sentences. Next, we further extend our experiments to summarize a set of papers, which cover the same scientific topic. We generate extractive summaries of a set of Question Answering (QA) and Dependency Parsing (DP) papers, their abstracts, and their citation sentences and show that citations have unique information amenable to creating a summary.
Flow and Turbulence in an Urban Canyon Zajic, D.; Fernando, H. J. S.; Calhoun, R. ...
Journal of applied meteorology and climatology,
01/2011, Letnik:
50, Številka:
1
Journal Article
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Abetter understanding of the interaction between the built environment and the atmosphere is required to more effectively manage urban airsheds. This paper reports an analysis of data from an ...atmospheric measurement campaign in Oklahoma City, Oklahoma, during the summer of 2003 that shows wind flow patterns, turbulence, and thermal effects in the downtown area. Experimental measurements within a street canyon yielded airflow patterns, stability conditions, and turbulence properties as a function of the incoming wind direction and time of the day. Air and surface temperatures at two different sites, one within the downtown urban canyon and the other in a nearby park, were measured. A study of the stability conditions within the urban canyon during the campaign indicates that dynamically stable conditions did not occur within the canyon. This provides evidence that the built environment can strongly influence the thermal characteristics in cities. Mean flow patterns close to the street level are analyzed for two different ranges of incoming wind directions and are compared with those obtained from a previous field experiment featuring idealized building configurations. This paper presents an approach allowing the estimation of wind direction in an urban canyon, given inflow conditions, that shows good agreement with wind patterns in the Oklahoma City street canyon. Turbulence statistics were calculated and normalized using different velocity scales to investigate the efficacy of the latter in specifying turbulence levels in urban canopies. The dependence of turbulence quantities on incoming wind direction and time of the day was investigated.
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BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Colonization of barley roots with the basidiomycete fungus Piriformospora indica (Sebacinales) induces systemic resistance against the biotrophic leaf pathogen Blumeria graminis f. sp. hordei (B. ...graminis). To identify genes involved in this mycorrhiza-induced systemic resistance, we compared the leaf transcriptome of P. indica-colonized and noncolonized barley plants 12, 24, and 96 h after challenge with a virulent race of B. graminis. The leaf pathogen induced specific gene sets (e.g., LRR receptor kinases and WRKY transcription factors) at 12 h postinoculation (hpi) (prepenetration phase) and vesicle-localized gene products 24 hpi (haustorium establishment). Metabolic analysis revealed a progressing shift of steady state contents of the intermediates glucose-1-phosphate, uridinediphosphate-glucose, and phosphoenolpyruvate 24 and 96 hpi, indicating that B. graminis shifts central carbohydrate metabolism in favor of sucrose biosynthesis. Both B. graminis and P. indica increased glutamine and alanine contents, whereas substrates for starch and nitrogen assimilation (adenosinediphosphate- glucose and oxoglutarate) decreased. In plants that were more B. graminis resistant due to P. indica root colonization, 22 transcripts, including those of pathogenesis-related genes and genes encoding heat-shock proteins, were differentially expressed ≥twofold in leaves after B. graminis inoculation compared with non-mycorrhized plants. Detailed expression analysis revealed a faster induction after B. graminis inoculation between 8 and 16 hpi, suggesting that priming of these genes is an important mechanism of P. indica-induced systemic disease resistance.
The Instabilities, Dynamics, and Energetics accompanying Atmospheric Layering (IDEAL) program was conceived to improve understanding of the dynamics of thin strongly stratified “sheet” and deeper ...weakly stratified “layer” (S&L) structures in the lower troposphere under strongly stable conditions. The field portion of the IDEAL program was conducted from 24 October to 15 November 2017 at Dugway Proving Ground, Utah, to target nighttime lower troposphere S&L conditions. It employed a synergistic combination of observations by multiple simultaneous DataHawk-2 (DH2) small unmanned aircraft systems (sUASs) and concurrent ground-based profiling by the NCAR Earth Observing Laboratory Integrated Sounding System (ISS) comprising a wind profiler radar and hourly high-resolution radiosonde soundings. DH2 measurement intervals as well as vertical (∼ 2–4 km) and horizontal (∼ 5–10 km) flight trajectories were chosen based on local high-resolution weather forecasting and guided by near-real-time ISS measurements. These flights combined simultaneous vertical and slant-path profiling, and/or horizontal racetrack sampling, spanning several hours before sunrise. High-spatial- and temporal-resolution data were downlinked in real time to enable near-real-time changes in DH2 flight paths based on observed flow features. The IDEAL field program performed 70 DH2 flights on 16 d, coordinated with 93 high-resolution radiosonde soundings. In this paper, raw and derived measurements from this campaign are outlined, and preliminary analyses are briefly described. This data set, along with “quick look” figures, is available for access by other researchers, as described herein.
THE MATERHORN Fernando, H. J. S.; Pardyjak, E. R.; Di Sabatino, S. ...
Bulletin of the American Meteorological Society,
11/2015, Letnik:
96, Številka:
11
Journal Article
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Emerging application areas such as air pollution in megacities, wind energy, urban security, and operation of unmanned aerial vehicles have intensified scientific and societal interest in mountain ...meteorology. To address scientific needs and help improve the prediction of mountain weather, the U.S. Department of Defense has funded a research effort—the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) Program—that draws the expertise of a multidisciplinary, multiinstitutional, and multinational group of researchers. The program has four principal thrusts, encompassing modeling, experimental, technology, and parameterization components, directed at diagnosing model deficiencies and critical knowledge gaps, conducting experimental studies, and developing tools for model improvements. The access to the Granite Mountain Atmospheric Sciences Testbed of the U.S. Army Dugway Proving Ground, as well as to a suite of conventional and novel high-end airborne and surface measurement platforms, has provided an unprecedented opportunity to investigate phenomena of time scales from a few seconds to a few days, covering spatial extents of tens of kilometers down to millimeters. This article provides an overview of the MATERHORN and a glimpse at its initial findings. Orographic forcing creates a multitude of time-dependent submesoscale phenomena that contribute to the variability of mountain weather at mesoscale. The nexus of predictions by mesoscale model ensembles and observations are described, identifying opportunities for further improvements in mountain weather forecasting.
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BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
SUPPLEMENT Fernando, H. J. S.; Pardyjak, E. R.; Di Sabatino, S. ...
Bulletin of the American Meteorological Society,
11/2015, Letnik:
96, Številka:
11
Journal Article
Recenzirano
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The evolution of ozone (O^sub 3^) in the nocturnal and morning-transitional planetary boundary layer (PBL) of the Phoenix valley was measured as a part of the 'Phoenix Sunrise Experiment 2001' of the ...U.S. Department of Energy conducted in June 2001. The goal of the field program was to study the transport, distribution and storage of ozone and its precursors in the urban boundary layer over a diurnal cycle. The ground level O^sub 3^ as well as mean meteorological variables and turbulence were measured over the entire period, and vertical profiling (using a tethered balloon) was made during the morning transition period. Approximately half of the observational days showed the usual diurnal cycle of high O^sub 3^ during the day and low O^sub 3^ at night, with nitrogen oxides (NO^sub x^ = NO^sub 2^ + NO) showing an out of phase relationship with O^sub 3^. The rest of the days were signified by an anomalous increase of O^sub 3^ in the late evening ( 2200 LST), concomitant with a sudden drop of temperature, an enhancement of wind speed and Reynolds stresses, a positive heat flux and a change of wind direction. NO^sub x^ measurements indicated the simultaneous arrival of an 'aged' air mass, which was corroborated by the wind predictions of a mesoscale numerical model. In all, the results indicate that the recirculation of O^sub 3^ rich air masses is responsible for the said high-O^sub 3^ events. Such air masses are produced during the transport of O^sub 3^ precursors by the upslope flow toward mountainous suburbs during the day, and they return back to the city at night via downslope winds (i.e. mountain breeze). The corresponding flow patterns, and hence the high-O^sub 3^ events, are determined by background meteorological conditions. The vertical profiling of O^sub 3^ and flow variables during the morning transition points to a myriad of transport, mixing and chemical processes that determine the fate of tropospheric O^sub 3^. How well such processes are incorporated and resolved in predictive O^sub 3^ models should determine the accuracy of their predictions.PUBLICATION ABSTRACT
Targeting tumors with antibody-based therapeutics is a complex task presenting multiple kinetic barriers. Antibody internalization and clearance inhibit uptake both in solid tumors, limited by tumor ...vascular permeability, and in micrometastases, limited by diffusion.
A modeling exercise is used to introduce 2 simple criteria that must be less than unity for saturation of both tumors and micrometastases. The clearance modulus and the Thiele modulus are ratios of the plasma clearance rate and antibody catabolism, respectively, to the tumor tissue penetration rate.
Even low rates of antigen internalization from constitutive membrane turnover can significantly retard antibody penetration. Rapid clearance of single-chain variable fragments also hinders uptake, often more than counterbalancing their more rapid extravasation and diffusion.
The model illustrates that with the large resistance from the tumor capillary, antibodies may be more suitable for targeting micrometastases than vascularized tumors.
Inhibition of cathepsin K (CatK) is a potential new treatment for osteoporosis. In two double‐blind, randomized, placebo‐controlled phase I studies, postmenopausal female subjects received odanacatib ...(ODN), an orally active, potent, and selective CatK inhibitor, once weekly for 3 weeks or once daily for 21 days. Bone turnover biomarkers, safety monitoring, and plasma ODN concentrations were assessed. These studies showed ODN to be well tolerated. Pharmacokinetic (PK) analysis revealed a long half‐life (t1/2; 66–93 h) consistent with once‐weekly dosing. Pronounced reductions in C‐terminal telopeptide of type I collagen (~62%) and N‐terminal telopeptide of type I collagen normalized to creatinine (NTx/Cr) (~62%) at trough (C168 h) were seen following weekly administration. Robust reductions in CTx (up to 81%) and NTx/Cr (up to 81%) were seen following daily administration. ODN exhibits robust and sustained suppression of bone resorption biomarkers (CTx and NTx/Cr) at weekly doses ≥25 mg and daily doses ≥2.5 mg.
Clinical Pharmacology & Therapeutics (2009); 86, 2, 175–182 doi:10.1038/clpt.2009.60
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