The Arithmetical dictum Maffezioli, Paolo; Zanichelli, Riccardo
History and philosophy of logic,
10/2023, Letnik:
44, Številka:
4
Journal Article
Recenzirano
Building on previous scholarly work on the mathematical roots of assertoric syllogistic we submit that for Aristotle, the semantic value of the copula in universal affirmative propositions is the ...relation of divisibility on positive integers. The adequacy of this interpretation, labeled here 'arithmetical dictum', is assessed both theoretically and textually with respect to the existing interpretations, especially the so-called 'mereological dictum'.
Abstract
Self-supervised pretraining on protein sequences has led to state-of-the art performance on protein function and fitness prediction. However, sequence-only methods ignore the rich ...information contained in experimental and predicted protein structures. Meanwhile, inverse folding methods reconstruct a protein’s amino-acid sequence given its structure, but do not take advantage of sequences that do not have known structures. In this study, we train a masked inverse folding protein masked language model parameterized as a structured graph neural network. During pretraining, this model learns to reconstruct corrupted sequences conditioned on the backbone structure. We then show that using the outputs from a pretrained sequence-only protein masked language model as input to the inverse folding model further improves pretraining perplexity. We evaluate both of these models on downstream protein engineering tasks and analyze the effect of using information from experimental or predicted structures on performance.
In this paper, we propose IoTChain, a combination of the OSCAR architecture 1 and the ACE authorization framework 2 to provide an E2E solution for the secure authorized access to IoT resources. ...IoTChain consists of two components, an authorization blockchain based on the ACE framework and the OSCAR object security model, extended with a group key scheme. The blockchain provides a flexible and trustless way to handle authorization while OSCAR uses the public ledger to set up multicast groups for authorized clients. To evaluate the feasibility of our architecture, we have implemented the authorization blockchain on top of a private Ethereum network. We report on several experiments that assess the performance of different architecture components.
It is well known that fretting fatigue promotes crack initiation and propagation in structural components, thus causing the failure of mechanical systems. Nowadays, many palliatives such as shot ...peening are used in order to prevent such ruptures. Nevertheless, when such treatments are applied, the fatigue assessment of the component becomes more complex. In the present paper, a methodology implementing the critical plane‐based criterion by Carpinteri et al. for fretting fatigue is employed in order to estimate both endurance strength and fatigue life of Al 7075‐T651 alloy shot‐peened specimens subject to partial slip fretting fatigue loading.
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) shows the opportunity to treat a diverse array of untreated various genetic and complicated disorders. ...Therapeutic genome editing processes that target disease-causing genes or mutant genes have been greatly accelerated in recent years as a consequence of improvements in sequence-specific nuclease technology. However, the therapeutic promise of genome editing has yet to be explored entirely, many challenges persist that increase the risk of further mutations. Here, we highlighted the main challenges facing CRISPR/Cas9-based treatments and proposed strategies to overcome these limitations, for further enhancing this revolutionary novel therapeutics to improve long-term treatment outcome human health.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In the present paper, a new analytical methodology to estimate both crack path and lifetime of metallic structural components under fretting fatigue elastic partial slip loading condition is ...proposed. Such a methodology consists in the joint application of (a) the criterion by Carpinteri et al for metallic structures under multiaxial constant amplitude fatigue loading in high‐cycle fatigue regime, (b) the critical direction method by Araújo et al, and (c) the critical distance method by Taylor, in the form of the line method. The accuracy of the above methodology is evaluated through experimental tests available in the literature, performed employing two cylindrical fretting pads pressed with a constant normal load against a dog‐bone type test specimen subjected to a cyclic axial load. All these components are made of Al 7075‐T651 aluminium alloy.
Fretting fatigue damage is a typical material damage arising in mechanical components. In such a damage condition, surface cracks can initiate at the surface contact zone, and under a fluctuating ...loading they can grow up to the complete failure of the component, resulting in a catastrophic failure.
In order to prevent/mitigate fretting fatigue damage, shot peening is widely used in mechanical components. The improvement due to shot peening is related to different factors, but the main one is the compressive residual stress field produced by such a treatment in a region near the contact surface. Unfortunately, both the uncertainty in measurements and stability (relaxation) of residual stress field, make shot peening effects difficult to be included in models aimed to the estimation of fatigue life. Due to this lack in the literature, especially relatively to the fretting fatigue field, in the present paper a new fretting fatigue model, that is able to consider shot peening residual stress and its relaxation, is presented. A 3D elastic-plastic finite element model, which incorporates the shot peening residual stress and its relaxations, is employed. The results obtained, in terms of stress field, are used as input data of a multiaxial stress-based criterion to estimate both fatigue lifetime and crack initiation direction.
•A new fretting fatigue model able to consider shot peening residual stress is presented.•The residual stability of the shot peening residual stress during fretting fatigue life is considered.•Results are compared with those coming from an experimental campaign performed on Al 7075-T651 specimens.•The model estimates well the fatigue life and crack initiation direction.
•Research on sustainable buildings is devoted to lightweight construction materials.•A cement-based mortar reinforced with date-palm mesh fibres is experimentally analysed.•Physical, mechanical and ...fracture properties are examined.•Effectiveness of fibres on the ductility/weight mortar performance is proved.
Nowadays, research on sustainable buildings is devoted to materials which offer advantages in terms of recyclability, low cost, environmentally-friendly features, no toxicity, biodegradability and good mechanical performance. The lightweight construction materials composed by a cement-based matrix reinforced with vegetal fibres are able to satisfy the above statements. In the present paper, the physical, mechanical and fracture properties of a cement-based mortar reinforced with date-palm mesh (DPM) fibres is experimentally analysed. The results obtained show that the positive effect of such fibres on the ductility/weight mortar performance increases by increasing the fibre content.
C1 inhibitor (C1-INH, also known as SERPING1) can be deficient in plasma as a result of genetic or acquired conditions, and this causes an episodic, local increase in vascular permeability in the ...subcutaneous and submucosal layers, identified as angioedema (hereditary or acquired). Bradykinin, the mediator of the increase in vascular permeability, is released on inappropriate activation of the contact system, which is controlled by C1 inhibitor. Therapy aims to reverse or prevent angioedema. Advances in understanding the complex effects of C1-INH deficiency at the molecular level have led to new molecular-targeted approaches. Three new treatments, an inhibitor of kallikrein to prevent bradykinin release, an antagonist of the bradykinin receptor to prevent its action and a recombinant human C1-INH produced in transgenic animals, are under clinical evaluation currently. Here, we review the molecular mechanisms underlying angioedema due to C1-inhibitor deficiency and clinical progress using molecular-targeted interventions.
Abstract
Carbapenem-resistant Enterobacteriaceae (CRE), Acinetobacter baumannii (CRAB), and Pseudomonas aeruginosa (CRPsA) are a serious cause of healthcare-associated infections, although the ...evidence for their control remains uncertain. We conducted a systematic review and reanalysis to assess infection prevention and control (IPC) interventions on CRE-CRAB-CRPsA in inpatient healthcare facilities to inform World Health Organization guidelines. Six major databases and conference abstracts were searched. Before-and-after studies were reanalyzed as interrupted time series if possible. Effective practice and organization of care (EPOC) quality criteria were used. Seventy-six studies were identified, of which 17 (22%) were EPOC-compatible and interrupted time series analyses, assessing CRE (n = 11; 65%), CRAB (n = 5; 29%) and CRPsA (n = 3; 18%). IPC measures were often implemented using a multimodal approach (CRE: 10/11; CRAB: 4/5; CRPsA: 3/3). Among all CRE-CRAB-CRPsA EPOC studies, the most frequent intervention components included contact precautions (90%), active surveillance cultures (80%), monitoring, audit and feedback of measures (80%), patient isolation or cohorting (70%), hand hygiene (50%), and environmental cleaning (40%); nearly all studies with these interventions reported a significant reduction in slope and/or level. The quality of EPOC studies was very low to low.
A systematic review and reanalysis found that infection prevention and control strategies including contact precautions, active surveillance cultures, monitoring, audit and feedback, patient isolation or cohorting, hand hygiene, and environmental cleaning were critical to the control of nosocomial carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa.
PDF
