The conveyor belt is an indispensable piece of conveying equipment for a mine whose deviation caused by roller sticky material and uneven load distribution is the most common failure during ...operation. In this paper, a real-time conveyor belt detection algorithm based on a multi-scale feature fusion network is proposed, which mainly includes two parts: the feature extraction module and the deviation detection module. The feature extraction module uses a multi-scale feature fusion network structure to fuse low-level features with rich position and detail information and high-level features with stronger semantic information to improve network detection performance. Depthwise separable convolutions are used to achieve real-time detection. The deviation detection module identifies and monitors the deviation fault by calculating the offset of conveyor belt. In particular, a new weighted loss function is designed to optimize the network and to improve the detection effect of the conveyor belt edge. In order to evaluate the effectiveness of the proposed method, the Canny algorithm, FCNs, UNet and Deeplab v3 networks are selected for comparison. The experimental results show that the proposed algorithm achieves 78.92% in terms of pixel accuracy (PA), and reaches 13.4 FPS (Frames per Second) with the error of less than 3.2 mm, which outperforms the other four algorithms.
Objectives
To estimate food insecurity prevalence and develop a statistical prediction model for food insecurity.
Design
Retrospective cohort study.
Setting
Kaiser Permanente Colorado.
Participants
...Adult members who completed a pre‐Medicare Annual Wellness Visit survey.
Measurements
Food insecurity was assessed using a single screening question. Sociodemographic and clinical characteristics from electronic health records and self‐reported characteristics from the survey were used to develop the prediction model.
Results
Of 130,208 older adult members between January 2012 and December 2015, 50,097 (38.5%) completed food insecurity screening, 2,859 of whom (5.7% of respondents) reported food insecurity. The prevalence of food insecurity was 10.0% or greater among individuals who were black or Hispanic, had less than high school education, had Medicaid insurance, were extremely obese, had poor health status or quality of life, had depression or anxiety, had impairments in specific activities of daily living, had other nutritional risk factors, or were socially isolated (all p<.001). A multivariable model based on these and other characteristics showed moderate discrimination (c‐statistic = 0.74) between individuals with food insecurity and those without and 14.3% of individuals in the highest quintile of risk reported food insecurity.
Conclusion
Food insecurity is prevalent even in older adults with private‐sector healthcare coverage. Specific individual characteristics, and a model based on those characteristics, can identify older adults at higher risk of food insecurity. System‐level interventions will be necessary to connect older adults with community‐based food resources.
ABSTRACT PURPOSE Lower continuity of care has been associated with higher rates of adverse outcomes for persons with multiple chronic medical conditions. It is unclear, however, whether this ...relationship also exists within integrated systems that offer high levels of informational continuity through shared electronic health records. METHODS We conducted a retrospective cohort study of 12,200 seniors with 3 or more chronic conditions within an integrated delivery system. Continuity of care was calculated using the Continuity of Care Index, which reflects visit concentration with individual clinicians. Using Cox proportional hazards regression permitting continuity to vary monthly until the outcome or censoring event, we separately assessed inpatient admissions and emergency department visits as a function of primary care continuity and specialty care continuity. RESULTS After adjusting for covariates (demographics; baseline, primary, and specialty care visits; baseline outcomes; and morbidity burden), greater primary care continuity and greater specialty care continuity were each associated with a lower risk of inpatient admission (respective hazard ratios (95% CIs) = 0.97 (0.96, 0.99) and 0.95 (0.93, 0.98)) and a lower risk of emergency department visits (respective hazard ratios = 0.97 (0.96, 0.98) and 0.98 (0.96, 1.00)). For the subgroup with 3 or more primary care and 3 or more specialty care visits, specialty care continuity (but not primary care continuity) was independently associated with a decreased risk of inpatient admissions (hazard ratio = 0.94 (0.92, 0.97)), and primary care continuity (but not specialty care continuity) was associated with a decreased risk of emergency department visits (hazard ratio = 0.98 (0.96, 1.00)). CONCLUSIONS In an integrated delivery system with high informational continuity, greater continuity of care is independently associated with lower hospital utilization for seniors with multiple chronic medical conditions. Different subgroups of patients will benefit from continuity with primary and specialty care clinicians depending on their care needs.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Background
Changes in loneliness are associated with corresponding changes in depression, anxiety, and general health in population surveys, but few studies have assessed these associations through ...repeated screening in clinical settings.
Methods
Retrospective cohort study among individuals ≥age 65 in an integrated health care system who completed loneliness screening before two annual wellness visits, separated by a mean of 12.9 (SD 2.0) months, between 2013 and 2018. Their responses identified four subgroups: individuals who were persistently lonely; not lonely; experienced an increase (recently lonely); or decrease (previously lonely) in loneliness. Loneliness was assessed with a single item. Depression was assessed with the Patient Health Questionnaire‐2. Anxiety was assessed with the Generalized Anxiety Disorder‐2. Fair/poor general health was assessed by a single item. Linear mixed effects models assessed changes in outcomes after covariate adjustment.
Results
The cohort comprised 24,666 individuals (19.2% of older adults in the system). Mean age was 73.7 years (SD 6.4); 54.6% were female, and 11.6% were members of racial and ethnic minority groups. Of these individuals, 1936 (7.8%) were persistently lonely, 1687 (6.8%) were recently lonely, 1551 (6.3%) were previously lonely, and 19,492 (79.0%) were not lonely at either time point. After adjustment for sociodemographic, clinical and social variables, recent loneliness was associated with increases in depression (adjusted odds ratio aOR 1.76, 95% confidence interval CI 1.41–2.19) and anxiety (aOR 1.67, 95% CI 1.32–2.10). Previous loneliness was associated with decreases in depression (aOR, 0.46, 95% CI 0.36–0.58) and anxiety (aOR 0.69, 95% CI 0.54–0.90). Changes in loneliness were not associated with changes in general health.
Conclusions
Changes in loneliness identified through screening were associated with corresponding changes in depression and anxiety. These findings support the potential value of identifying social risk factors in clinical settings among older adults.
To examine the relationship between food insecurity and emergency department (ED) visits, hospitalizations, A1c, and diabetes medication adherence over one year of follow-up among individuals ...>65 years with diabetes mellitus.
We conducted a longitudinal cohort study of adults >65 years with diabetes who did (n = 742) or did not (n = 2226) report food insecurity at baseline. We used conditional logistic regression for the ED visits or hospitalization outcomes, and mixed effects models for A1c and non-insulin diabetes medication adherence.
In bivariate analyses, individuals with food insecurity were more likely to have an ED visit (OR = 1.40, 95% CI 1.15–1.72) or hospitalization (OR = 1.41, 95% CI 1.11–1.78) in the year after the food security assessment. In addition, A1c was higher (7.5% vs. 7.2%, p < 0.001). There was no difference in medication adherence. These differences persisted with adjustment for basic demographic and clinical characteristics, but were attenuated with further adjustment for socioeconomic status.
Differences in diabetes outcomes by food insecurity status were attenuated by adjustment for socioeconomic status. Adverse outcomes in individuals with diabetes and food insecurity may be driven by effects of food insecurity per se or be mediated by a constellation of basic resource needs or lower socioeconomic status.
An Eulerian-Lagrangian simulation of the thermobaric explosion and the propagating detonation waves with aluminum particle combustion in a closed chamber is carried out and validated very favorably ...with the pressure histories measured experimentally. A novel numerical framework based on the space-time conservation-element and solution-element method (CE/SE) was employed to simulate the complex detonating flow with detailed chemistry. A discrete particle technique was adopted with either a mono-dispersed or poly-dispersed particle distribution. The results between the experiment and simulation on pressure histories and corresponding impulse forces are compared and showed good agreement. In addition, the effects of metal combustion on afterburning were discussed in detail in terms of the reaction mechanisms and particle dynamics.
The epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic agents. The molecular mechanisms ...responsible for EGFR overexpression are poorly understood.
Gene copy number and protein status of EGFR were investigated in microarrayed tumors from 183 NSCLC patients, including squamous cell carcinoma (SCC; 89 patients) and non-SCC (94 patients) histologies. Protein expression was assessed by immunohistochemistry on a scale from 0 to 400 (percentage of positive cells x staining intensity). Gene and chromosome 7 copy numbers were identified by fluorescent in situ hybridization (FISH).
EGFR protein overexpression was observed in 62% of the NSCLC (25% scored 201 to 300; 37% scored 301 to 400), more frequently in SCC than non-SCC (82% v 44%; P <.001), and in 80% of the bronchioloalveolar carcinomas. The prevalent FISH patterns were balanced disomy (40%) and trisomy (38%) for EGFR gene and chromosome 7 (40%), whereas balanced polysomy was seen in 13% and gene amplification was seen in 9% of the patients. Gene copy number correlated with protein expression (r = 0.4; P <.001). EGFR overexpression or high gene copy numbers had no significant influence on prognosis.
EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. High gene copy numbers per cell showed a trend toward poor prognosis. It will be important to evaluate EGFR gene and EGFR protein status and signal protein expression to properly interpret future clinical trials using EGFR inhibitors.
The epidermal growth factor receptor (EGFR) is overexpressed in the majority of non-small cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors, such as gefitinib and erlotinib, produce 9% to ...27% response rates in NSCLC patients. E-Cadherin, a calcium-dependent adhesion molecule, plays an important role in NSCLC prognosis and progression, and interacts with EGFR. The zinc finger transcriptional repressor, ZEB1, inhibits E-cadherin expression by recruiting histone deacetylases (HDAC). We identified a significant correlation between sensitivity to gefitinib and expression of E-cadherin, and ZEB1, suggesting their predictive value for responsiveness to EGFR-tyrosine kinase inhibitors. E-Cadherin transfection into a gefitinib-resistant line increased its sensitivity to gefitinib. Pretreating resistant cell lines with the HDAC inhibitor, MS-275, induced E-cadherin along with EGFR and led to a growth-inhibitory and apoptotic effect of gefitinib similar to that in gefitinib-sensitive NSCLC cell lines including those harboring EGFR mutations. Thus, combined HDAC inhibitor and gefitinib treatment represents a novel pharmacologic strategy for overcoming resistance to EGFR inhibitors in patients with lung cancer.
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•Simultaneous identification and determination of three bioactive compounds in Amomum villosum samples.•After comparison of different spectra pretreatments, 2-Der with SNV was ...demonstrated as an optimum pretreatment.•The results show that the coefficients of determination are all above 0.96. PI approaching 100, RMSEC, RMSEP and RMSECV are under 0.6.•Excellent correlation between the GC determined value as well as the model-predicted value proved the feasibility of quantification and quality control of Amomum villosum with NIR models.
A method is described using rapid and sensitive Fourier transform near-infrared spectroscopy combined with Gas Chromatograpy internal standard method detection for the simultaneous identification and determination of three bioactive compounds in Amomum villosum samples. Partial least squares regression is selected as the analysis type and multiplicative scatter correction, second derivative, and SNV were adopted for the spectral pretreatment. The correlation coefficients (R) of the calibration models were above 0.95 and the root mean square error of predictions were under 0.8. The developed models were applied to unknown samples with satisfantory results. The established method was validated and can be applied to the intrinsic quality control of Amomum villosum.
The simulation of the liquid- and gas-phase properties of aerated-liquid jets in various quiescent and cross flow conditions are presented in the study. For simplicity, water is used as the liquid ...for all test conditions. The effect of various air-to-liquid ratios under super-sonic cross flow conditions are simulated and compared to experimental conditions, which is taken in the supersonic wind tunnel with a dimension of 762 × 152 × 127 mm. An injector with an orifice diameter of 0.5 mm is used both in a non-aerated and aerated injection into a supersonic cross flow prescribed by the momentum flux ratio of the liquid jet to free stream air,
q
0
. The initial conditions of the spray calculation were estimated from internal flow simulation using VOF and X-ray data. The conservation-element and solution-element (CE/SE) method, a novel numerical framework for general conservation law, is applied to simulate the compressible flow. The effect of degree of aeration, breakup, and mixing of the liquid spray are demonstrated. The spray penetration height and average droplet size along with a spray penetration axis are quantitatively compared with data. The shock train flow structures induced by the presence of a liquid jet are further discussed.
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