This study presents the intercalation into Layered Double Hydroxides (LDHs) of two sulfonated organic molecules featuring the mesoionic triazolium scaffold. These sulfonated fluorophores exhibited ...excellent solubility in aqueous basic solutions, facilitating their compatibility with the synthesis of LDHs through coprecipitation methods. We applied the size-matching interlayer space (SMIS) approach by substituting a portion of a mono- or dianionic surfactant used in LDH preparation by the sulfonated fluorophore, we aimed to match the size of the luminescent interleaved guest effectively. Our investigation focused on two anion spacers: the classic monoanionic dodecyl sulfate (DS) and the dianionic phenylene dipropionate (PPA). Our results indicated that the latter spacer allowed a more efficient insertion of the fluorescent guest. Thermal resistance analysis underscored the robustness of the final hybrid materials, suggesting a promising design strategy for luminescent materials when applied in diverse applications.
Inorganic-organic hybrid materials obtained from mesoionic triazolium fluorophores and layered double hydroxides display highly efficient photoluminescence in the solid state.
Reading is increasingly taking place on digital media, which are vectors of attentional disruption. This manuscript aims to characterize attentional disruption during reading on a computer screen in ...an ecological environment. To this end, we collected information relating to reader interruptions (number, type, duration, position, mental effort, and valence) and
(occurrence, position) throughout the reading session for
and
media multitaskers in their own specific ecological environment, at home. Comprehension of the narrative text was assessed both with surface and inferential questions. In total, 74 participants (
= 22.16, SD = 2.35) took part in the experiment. They reported attentional disruptions on average every 4 mins during reading. Moreover, there were more attentional disruptions during the first half of the text. Most interruptions were short and little mental effort was required to process them. We made a distinction between media-related and media-unrelated related interruptions. Multiple linear regression analyses showed that media-unrelated interruptions were actually related to better performance for both inferential and surface level questions. Furthermore, media-related interruptions were more frequent for
than
media multitaskers. Pleasure experienced when reading the text was also a significant predictor of comprehension. The results are discussed with regard to
and strategies that the readers could have implemented to recover the thread of their reading.
The growing use of digital devices brings about interruptions during reading. The aim of the present study is to observe the consequences of an interruption on reading behavior and text comprehension ...when the information that is evaluated is the information that is being read at the time the interruption occurs. Eye movements (mean number of fixations, regressive fixations and mean fixation duration) were recorded while reading four long texts. Reading was interrupted by an arithmetic verification task either in the middle of a paragraph (intra-paragraph condition) or between two successive paragraphs (inter-paragraph condition). The analysis of the eye movements showed more rereading behaviors when an interruption occurred. The participants who understood the text best were also those who reread the most. The comprehension performances were not affected by the interruption, irrespective of its position (inter- or intra-paragraph). This preservation of performance is discussed in relation to LTWM theory.
•Rereading behaviors following an interruption.•The comprehension of locally interrupted information is not disturbed.•The participants who reread are more successful in comprehending the text.•Auditory-verbal memory span predicts interrupted reading comprehension performance.
Monomeric and dimeric flavanol glycosides were analyzed in
grapes and seeds during ripening. An analytical method using ultra-high performance liquid chromatography coupled with a triple quadrupole ...mass spectrometry (UHPLC-ESI-QQQ-MS/MS) in multiple reaction monitoring (MRM) mode was employed. Three grape varieties (Merlot, Syrah and Tannat) were chosen and grape berries were sampled at different stages of development. Ten monoglycosylated and six diglycosylated flavanol monomers were detected. Twelve monoglycosylated and three diglycosylated flavanol dimers were also detected for all three grape varieties. All diglycosides were detected for the first time in
grapes, though some of these compounds were only detected in skins or seeds. Furthermore, the evolution of all these compounds was studied, and a decrease in monomeric (epi) catechin monoglycosides was observed during ripening for Tannat, Merlot and Syrah grape skins. The dimers would appear to accumulate in skin tissues up to mid-summer (after veraison) and decrease when grape berries reached maturity.
Abstract Background Pancreatic fistula (PF) is one of the most common postoperative complications of pancreatoduodenectomy (PD). A recent International Study Group on Pancreatic Fistula (ISGPF) ...definition grades the severity of PF according to the clinical impact on the patient's hospital course. Although PF is generally treated conservatively (grade A), some cases may require interventional procedures (grade B) or may be life-threatening and necessitate emergency reoperation (grade C). The aim of the present study was to evaluate the incidence of postoperative grade C PF after PD and to assess the prognosis and risk factors for this life-threatening condition. Study design Between January 2000 and December 2006, 680 consecutive patients underwent PD in 5 digestive surgery departments in the northwest region of France (Lille, Amiens, Rouen, and Caen). PF was defined as drain output of any measurable volume of fluid on or after postoperative day 3 with amylase content greater than 3 times the serum amylase activity (ISGPF guidelines). To identify possible risk factors for grade C PF, we reviewed the records of 111 (16.3%) patients with postoperative PF and compared grade C cases with grade A+B cases. Results The median age was 59 years (range 22–87). The male-to-female ratio was 1.6:1. Fifty-six (50.4%) PDs were performed via pancreaticogastrostomy and 55 via pancreaticojejunostomy. Overall mortality was 2% (n = 14). Grade C PF was observed in 36 (32%) patients, of whom 17 (47%) had sepsis due to an abdominal collection, 16 (44%) had postoperative bleeding, 10 (27.7%) had bleeding associated with abdominal collection, and 3 (9%) had multi-organ failure due to other causes. Of these 36 patients, 35 (97%) underwent reoperation. The mortality rate in grade C PF patients was 38.8%. The major causes of death were sepsis (n = 6) and recurrent bleeding after reoperation (n = 5). Grade C PF increased the duration of postoperative hospitalization (46 vs 29 days, P < .001). Univariate analysis showed that peroperative soft pancreatic parenchyma, peroperative blood transfusion, and postoperative bleeding were significant risk factors for grade C PF, with P values of .011, .003, and .001, respectively. No risk factors for grade C PF were identified in a multivariate analysis. The sensibility, specificity, positive predictive value, and negative predictive value of the presence of the 3 risk factors for grade C PF were 13.89%, 100%, 100%, and 70.75%, respectively. Conclusion Sixteen percent of patients had PF after PD. Among them, 30% had grade C PF, with a mortality rate of about 40%. Achievement of a 100% predictive positive value for grade C PF after PD in individuals with 3 discriminant risk factors (peroperative soft pancreatic parenchyma, peroperative transfusion, and postoperative bleeding) is a first step towards the identification of high-risk patients who should be managed differently from other patients with PF during or after PD.
Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of patients respond to these immunotherapies. Here, we report that blocking the inhibitory NKG2A receptor enhances ...tumor immunity by promoting both natural killer (NK) and CD8+ T cell effector functions in mice and humans. Monalizumab, a humanized anti-NKG2A antibody, enhanced NK cell activity against various tumor cells and rescued CD8+ T cell function in combination with PD-x axis blockade. Monalizumab also stimulated NK cell activity against antibody-coated target cells. Interim results of a phase II trial of monalizumab plus cetuximab in previously treated squamous cell carcinoma of the head and neck showed a 31% objective response rate. Most common adverse events were fatigue (17%), pyrexia (13%), and headache (10%). NKG2A targeting with monalizumab is thus a novel checkpoint inhibitory mechanism promoting anti-tumor immunity by enhancing the activity of both T and NK cells, which may complement first-generation immunotherapies against cancer.
Display omitted
•Blocking NKG2A unleashes both T and NK cell effector functions•Combined blocking of the NKG2A and the PD-1 axis promotes anti-tumor immunity•Blocking NKG2A and triggering CD16 illustrates the efficacy of dual checkpoint therapy
Blocking of the NKG2A inhibitory receptor unleashes both T and NK cells, and demonstrates anti-tumor efficacy in combination with anti-EGFR or with anti-PD-x antibodies.
Background The modulation of perioperative inflammation seems crucial to improve postoperative morbidity and cancer-related outcomes in patients undergoing oncological surgery. Data from the ...literature suggest that perioperative corticosteroids decrease inflammatory markers and might be associated with fewer complications in esophageal, liver, pancreatic and colorectal surgery. Their benefit on cancer-related outcomes has not been assessed. Methods The CORTIFRENCH trial is a phase III multicenter randomized double-blind placebo-controlled trial to assess the impact of a flash dose of preoperative corticosteroids versus placebo on postoperative morbidity and cancer-related outcomes after elective curative-intent surgery for digestive cancer. The primary endpoint is the frequency of patients with postoperative major complications occurring within 30 days after surgery (defined as all complications with Clavien-Dindo grade > 2). The secondary endpoints are the overall survival at 3 years, the disease-free survival at 3 years, the frequency of patients with intraabdominal infections and postoperative infections within 30 days after surgery and the hospital length of stay. We hypothesize a reduced risk of major complications and a better disease-survival at 3 years in the experimental group. Allowing for 5% of drop-out, 1 200 patients (600 per arm) should be included. Discussion This will be the first trial focusing on the impact of perioperative corticosteroids on cancer related outcomes. If significant, it might be a strong improvement on oncological outcomes for patients undergoing surgery for digestive cancers. Trial registration ClinicalTrials.gov, NCT03875690, Registered on March 15, 2019, URL: Keywords: Perioperative corticosteroids, Digestive surgical oncology, Randomized placebo-controlled trial, Postoperative morbidity, cancer-related outcomes
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The severity and course of sepsis-associated acute kidney injury (SA-AKI) are correlated with the mortality rate. Early detection of SA-AKI subphenotypes might facilitate the rapid provision of ...individualized care.
In this
analysis of a multicenter prospective study, we combined conventional kidney function variables with serial measurements of urine (tissue inhibitor of metalloproteinase-2 TIMP-2)* (insulin-like growth factor-binding protein IGFBP7) at 0, 6, 12, and 24 h) and then using an unsupervised hierarchical clustering of principal components (HCPC) approach to identify different phenotypes of SA-AKI. We then compared the subphenotypes with regard to a composite outcome of in-hospital death or the initiation of renal replacement therapy (RRT).
We included 184 patients presenting SA-AKI within 6 h of the initiation of catecholamines. Three distinct subphenotypes were identified: subphenotype A (99 patients) was characterized by a normal urine output (UO), a low SCr and a low TIMP-2*IGFBP7 level; subphenotype B (74 patients) was characterized by existing chronic kidney disease (CKD), a higher SCr, a low UO, and an intermediate TIMP-2*IGFBP7 level; and subphenotype C was characterized by very low UO, a very high TIMP-2*IGFBP7 level, and an intermediate SCr level. With subphenotype A as the reference, the adjusted hazard ratio (aHR) 95%CI for the composite outcome was 3.77 1.92-7.42 (
< 0.001) for subphenotype B and 4.80 1.67-13.82 (
= 0.004) for subphenotype C.
Combining conventional kidney function variables with urine measurements of TIMP-2*IGFBP7 might help to identify distinct SA-AKI subphenotypes with different short-term courses and survival rates.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
High-resolution manometry (HRM) might be superior to conventional manometry (CM) to diagnose esophageal motility disorders. We aimed to compare the diagnosis performed with HRM and CM and confirmed ...at 6 months in a multicenter randomized trial.
Patients with unexplained dysphagia were randomized to undergo either CM or HRM. Motility disorders were diagnosed using the Castell and Spechler classification for CM and the Chicago classification for HRM. Diagnosis confirmation was based on clinical outcome and response to treatment after 6-month follow-up. The initial diagnosis and percentage of confirmed diagnoses were compared between the two arms (CM and HRM).
In total, 247 patients were randomized and 245 analyzed: 122 in the CM arm and 123 in the HRM arm. A manometric diagnosis was more frequently initially achieved with HRM than with CM (97% vs. 84%; P<0.01). Achalasia was more frequent in the HRM arm (26% vs. 12% in the CM arm; P<0.01) while normal examinations were more frequent in the CM arm (52% vs. 28% in the HRM arm; P<0.05). After follow-up, the initial diagnosis was confirmed in 89% of patients in the HRM arm vs. 81% in the CM arm (P=0.07). Finally, overall procedure tolerance was better with CM than with HRM (P<0.01).
This randomized trial demonstrated an improved diagnostic yield for achalasia with HRM compared with CM. Diagnoses tended to be more frequently confirmed in patients who underwent HRM, suggesting that esophageal motility disorders could be identified earlier with HRM than with CM (ClinicalTrial.gov, NCT01284894).
PDF
