The purposes are to manage human resource data better and explore the association between Human Resource Management (HRM), data mining, and economic management. An Ensemble Classifier-Decision Tree ...(EC-DT) algorithm is proposed based on the single decision tree algorithm to analyze HRM data. The involved single decision tree algorithms include C4.5, Random Tree, J48, and SimpleCart. Then, an HRM system is established based on the designed algorithm, and the evaluation management and talent recommendation modules are tested. Finally, the designed algorithm is compared and tested. Experimental results suggest that C4.5 provides the highest classification accuracy among the single decision tree algorithms, reaching 76.69%; in contrast, the designed EC-DT algorithm can provide a classification accuracy of 79.97%. The proposed EC-DT algorithm is compared with the Content-based Recommendation Method (CRM) and the Collaborative Filtering Recommendation Method (CFRM), revealing that its Data Mining Recommendation Method (DMRM) can provide the highest accuracy and recall, reaching 35.2% and 41.6%, respectively. Therefore, the data mining-based HRM system can promote and guide enterprises to develop according to quantitative evaluation results. The above results can provide a reference for studying HRM systems based on data mining technology.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Efficacy and safety of chemotherapeutic drugs constitute two major criteria in tumor chemotherapy. Nanomedicines with tumor‐targeted properties hold great promise for improving the efficacy and ...safety. To design targeted nanomedicines, the pathological characteristics of tumors are extensively and deeply excavated. Here, the rationale, principles, and advantages of exploiting these pathological characteristics to develop targeted nanoplatforms for tumor chemotherapy are discussed. Homotypic targeting with the ability of self‐recognition to source tumors is reviewed individually. In the meanwhile, the limitations and perspective of these targeted nanomedicines are also discussed.
Nanomedicines with tumor‐targeted properties hold great potential for improved efficacy and safety of tumor chemotherapy. This review summarizes the recent advances in exploiting tumor‐associated pathological features to elaborate tumor targeting nanomedicines. Homotypic targeting strategies are also discussed due to the self‐recognition to source tumors.
The clinical outcomes of conventional mono-chemotherapy of cancers are usually far from satisfactory due to some issues such as tumor heterogeneity and resistance to chemotherapeutic drugs. With the ...increasing knowledge of molecular signal pathways and pathological mechanisms involved in the initiation and progression of cancers, collaborative strategies have been elaborated to optimize therapeutic outcomes. This review surveys the most recent advances in combination therapy including combination chemotherapy, chemotherapy plus gene therapy, chemotherapy plus phototherapy, as well as chemotherapy plus immunotherapy. Additionally, chemotherapy-involved multiple therapy that merges various therapeutic modalities is also presented. We try to elicit the rationales of applying these combinational formulations for cancer chemotherapy, which might provide new guidelines for high-performance cancer treatments.
Combinational therapy, including combination chemotherapy, chemotherapy plus gene therapy, chemotherapy plus phototherapy, chemotherapy plus immunotherapy, as well as chemotherapy-involved multiple therapy, are confirmed to be the robust choices for high-performance cancer chemotherapy due to their abilities of conquering tumor heterogeneity and complexity, reversing multidrug resistance (MDR), and decreasing unwanted side effects, etc. Display omitted
Metabolomics is the systematic study of all the metabolites present within a biological system, which consists of a mass of molecules, having a variety of physical and chemical properties and ...existing over an extensive dynamic range in biological samples. Diverse analytical techniques are needed to achieve higher coverage of metabolites. The application of mass spectrometry (MS) in metabolomics has increased exponentially since the discovery and development of electrospray ionization and matrix-assisted laser desorption ionization techniques. Significant advances have also occurred in separation-based MS techniques (gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, capillary electrophoresis-mass spectrometry, and ion mobility-mass spectrometry), as well as separation-free MS techniques (direct infusion-mass spectrometry, matrix-assisted laser desorption ionization-mass spectrometry, mass spectrometry imaging, and direct analysis in real time mass spectrometry) in the past decades. This review presents a brief overview of the recent advanced MS techniques and their latest applications in metabolomics. The software/websites for MS result analyses are also reviewed.
Metabolomics is the systematic study of all the metabolites present within a biological system, supply functional information and has received extensive attention in the field of life sciences.
Abstract Carrier-assistant drug delivery systems (DDSs) have been rapidly established for cancer therapy and great strides have been made in recent years. However, further development of DDSs is ...retarded by the aspects such as the low drug carrying capacity, carrier-induced toxicity and immunogenicity, complex synthesis manipulation. Drug self-delivery systems (DSDSs), in which active drugs exhibit nanoscale characteristic to realize intracellular delivery by themselves without the help of nanocarriers, have been rapidly developed to address these issues. In this review, we present a comprehensive summary of the recent advances in DSDSs for cancer therapy. After a brief introduction to the major types of DSDSs and their fabrication strategies, we emphatically discuss some representative achievements of these DSDSs for passive or/and positive targeting therapy, combinational therapy as well as theranostics. The design principle is explained and justified, which can cast a new light on developing drug delivery systems for cancer treatments.
A method for the synthesis of 3‐acyl quinoxalin‐2(1H)‐ones through visible‐light promoted decarboxylative acylation of α‐oxo‐carboxylic acids with quinoxalin‐2(1H)‐ones was developed. The reaction ...was performed in aqueous phase and photoredox catalyst was not required to run the process.
Shengmai San (SMS), a Chinese classic herbal formula, has been widely used for the treatment of Qi-Yin deficiency syndrome in Asia. Modern pharmacological studies have shown that SMS improves the ...cognitive function. However, the quality markers (Q-markers) for SMS still need further research.
Using chinmedocmics strategy to systematically evaluate the efficacy of SMS in the treatment of APPswe/PS1dE9 (APP/PS1) transgenic model of Alzheimer's disease (AD) and to discover the efficacy-related Q-markers.
The effect of SMS on APP/PS1 mice was evaluated by behavioral test, immunohistochemistry and urine metabolic profile, and the urine marker metabolites associated with SMS treatment of AD were characterized using metabolomics method. In the premise of efficacy, Serum Pharmacochemistry of Traditional Chinese Medicine was applied to investigate the in vivo constituents of SMS. A correlation analysis between marker metabolites of therapeutic effects and serum constituents was completed by chinmedomics approach.
SMS had a therapeutic effect on APP/PS1 mice, and 34 potential urine biomarkers were reversed by SMS treatment. A total of 17 in vivo constituents were detected, including 14 prototype components and 3 metabolites. The correlation analysis showed that eight constituents were extremely correlated with protective effects of SMS in AD, and considered as potential Q-markers of SMS, including schisandrin, isoschisandrin, angeloylgomisin Q, gomisin D, angeloylgomisin H, gomisin M2, ginsenoside F1, 20(R)-ginsenoside Rg3.
This study has demonstrated that chinmedomics is novel strategy for discovering the potential effective constituents from herbal formula, which are recognized as Q-markers.
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Removal of six phenolic endocrine disrupting compounds (EDCs) (estrone, 17β-estradiol, 17α-ethinylestradiol, estriol, bisphenol A, and 4-nonylphenols) from waste activated sludge (WAS) was ...investigated using ultraviolet light (UV), hydrogen peroxide (H2O2), and the combined UV/H2O2 processes. Effects of initial EDC concentration, H2O2 dosage, and pH value were investigated. Particularly, the effects of 11 metal ions and humic acid (HA) contained in a sludge matrix on EDC degradation were evaluated. A pseudo-first-order kinetic model was used to describe the EDC degradation during UV, H2O2, and UV/H2O2 treatments of WAS. The results showed that the degradation of the 6 EDCs during all the three oxidation processes fitted well with pseudo-first-order kinetics. Compared with the sole UV irradiation or H2O2 oxidation process, UV/H2O2 treatment was much more effective for both EDC degradation and WAS solubilization. Under their optimal conditions, the EDC degradation rate constants during UV/H2O2 oxidation were 45–197 times greater than those during UV irradiation and 11–53 times greater than those during H2O2 oxidation. High dosage of H2O2 and low pH were favorable for the degradation of EDCs. Under the conditions of pH=3, UV wavelength=253.7nm, UV fluence rate=0.069mWcm−2, and H2O2 dosage=0.5molL−1, the removal efficiencies of E1, E2, EE2, E3, BPA, and NP in 2min were 97%, 92%, 95%, 94%, 89%, and 67%, respectively. The hydroxyl radical (OH) was proved to take the most important role for the removal of EDCs. Metal ions in sludge could facilitate the removal of EDCs during UV/H2O2 oxidation. Fe, Ag, and Cu ions had more obvious effects compared with other metal ions. The overall role of HA was dependent on the balance between its competition as organics and its catalysis/photosensitization effects. These indicate that the sludge matrix plays an important role in the degradation of EDCs.
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•UV/H2O2 is effective in removing EDCs from WAS and improve sludge solubilization.•EDC degradation in sludge fitted well with pseudo-first-order kinetics.•OH takes the most important role in UV/H2O2 oxidation of EDCs in sludge.•Metal ions in sludge facilitate the removal of EDCs during UV/H2O2 oxidation.•Effect of HA in sludge on EDC removal during UV/H2O2 oxidation is observed.
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