A
bstract
Based on
e
+
e
−
collision samples corresponding to an integrated luminosity of 4.4 fb
−
1
collected with the BESIII detector at center-of-mass energies between 4
.
6 GeV and 4
.
7 GeV, a ...partial wave analysis of the charmed baryon hadronic decay
$$ {\Lambda}_c^{+} $$
Λ
c
+
→
Λ
π
+
π
0
is performed, and the decays
$$ {\Lambda}_c^{+} $$
Λ
c
+
→
Λ
ρ
(770)
+
and
$$ {\Lambda}_c^{+} $$
Λ
c
+
→
Σ(1385)
π
are studied for the first time. Making use of the world-average branching fraction
$$ \mathcal{B}\left({\Lambda}_c^{+}\to \Lambda {\pi}^{+}{\pi}^0\right) $$
B
Λ
c
+
→
Λ
π
+
π
0
, their branching fractions are determined to be
$$ {\displaystyle \begin{array}{c}\mathcal{B}\left({\Lambda}_c^{+}\to \Lambda \rho {(770)}^{+}\right)=\left(4.06\pm 0.30\pm 0.35\pm 0.23\right)\times {10}^{-2},\\ {}\mathcal{B}\left({\Lambda}_c^{+}\to \varSigma {(1385)}^{+}{\pi}^0\right)=\left(5.86\pm 0.49\pm 0.52\pm 0.35\right)\times {10}^{-3},\\ {}\mathcal{B}\left({\Lambda}_c^{+}\to \varSigma {(1385)}^0{\pi}^{+}\right)=\left(6.47\pm 0.59\pm 0.66\pm 0.38\right)\times {10}^{-3},\end{array}} $$
B
Λ
c
+
→
Λ
ρ
770
+
=
4.06
±
0.30
±
0.35
±
0.23
×
10
−
2
,
B
Λ
c
+
→
Σ
1385
+
π
0
=
5.86
±
0.49
±
0.52
±
0.35
×
10
−
3
,
B
Λ
c
+
→
Σ
1385
0
π
+
=
6.47
±
0.59
±
0.66
±
0.38
×
10
−
3
,
where the first uncertainties are statistical, the second are systematic, and the third are from the uncertainties of the branching fractions
$$ \mathcal{B}\left({\Lambda}_c^{+}\to \varLambda {\pi}^{+}{\pi}^0\right) $$
B
Λ
c
+
→
Λ
π
+
π
0
and
$$ \mathcal{B}\left(\Sigma (1385)\to \Lambda \pi \right) $$
B
Σ
1385
→
Λ
π
. In addition, the decay asymmetry parameters are measured to be
α
Λ
ρ
(770)+
= − 0.763 ± 0.053 ± 0.045,
$$ {\alpha}_{\Sigma (1385)+{\pi}^0}=-0.917\pm 0.069\pm 0.056 $$
α
Σ
1385
+
π
0
=
−
0.917
±
0.069
±
0.056
, and
$$ {\alpha}_{\Sigma {(1385)}^0{\pi}^{+}}=-0.789\pm 0.098\pm 0.056 $$
α
Σ
1385
0
π
+
=
−
0.789
±
0.098
±
0.056
.
Using e+e− annihilation data corresponding to an integrated luminosity of 3.19 fb−1 collected at a center-of-mass energy of 4.178 GeV with the BESIII detector, we measure the absolute branching ...fractions BDs+→ηe+νe = (2.323±0.063stat ± 0.063syst)% and BDs+→η′e+νe = (0.824±0.073stat ± 0.027syst)% via a tagged analysis technique, where one Ds is fully reconstructed in a hadronic mode. Combining these measurements with previous BESIII measurements of BD+→η(′)e+νe, the η−η′ mixing angle in the quark flavor basis is determined to be ϕP = (40.1±2.1stat ± 0.7syst)°. From the first measurements of the dynamics of Ds+ → η(′)e+νe decays, the products of the hadronic form factors f+η(′)(0) and the Cabibbo-Kobayashi-Maskawa matrix element |Vcs| are determined with different form factor parametrizations. For the two-parameter series expansion, the results are f+η(0)|Vcs| = 0.4455±0.0053stat±0.0044syst and f+η′(0)|Vcs|=0.477±0.049stat±0.011syst.
miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma (ATC), and is believed to be an important event in thyroid cell transformation. In this study, we ...found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin, a commonly used chemotherapeutic drug for treatment of this neoplasm. Using a mimic of miR-30d, we demonstrated that miR-30d could negatively regulate the expression of beclin 1, a key autophagy gene, leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis. A reporter gene assay demonstrated that the binding sequences of miR-30d in the beclin 1-3′ UTR was the region required for the inhibition of beclin 1 expression by this miRNA. We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro (cell culture) and in vivo (animal xenograft model). These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival. Thus, miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC.
Partial wave analysis of J/ψ → γη′η Ablikim, M.; Adlarson, Patrik; Ikegami Andersson, Walter ...
Physical review. D,
04/2022, Letnik:
105, Številka:
7
Journal Article
Recenzirano
Odprti dostop
Using a sample of (10.09±0.04)×10 9 J/ψ events collected with the BESIII detector, a partial wave analysis of J/ψ→γη′η′ is performed. The masses and widths of the observed resonances and their ...branching fractions are reported. The main contribution is from J/ψ→γf 0 (2020) with f 0 (2020)→η′η′, which is found with a significance of greater than 25σ. The product branching fraction B(J/ψ→γf 0 (2020))⋅B(f 0 (2020)→η′η′) is measured to be (2.63±0.06(stat.) +0.31 −0.46 (syst.))×10 −4 .
We demonstrate the coherent creation of a single NaCs molecule in its rotational, vibrational, and electronic (rovibronic) ground state in an optical tweezer. Starting with a weakly bound Feshbach ...molecule, we locate a two-photon transition via the |c^{3}Σ_{1},v^{'}=26⟩ excited state and drive coherent Rabi oscillations between the Feshbach state and a single hyperfine level of the NaCs rovibronic ground state |X^{1}Σ,v^{''}=0,N^{''}=0⟩ with a binding energy of D_{0}=h×147044.63(11) GHz. We measure a lifetime of 3.4±1.6 s for the rovibronic ground state molecule, which possesses a large molecule-frame dipole moment of 4.6D and occupies predominantly the motional ground state. These long-lived, fully quantum-state-controlled individual dipolar molecules provide a key resource for molecule-based quantum simulation and information processing.
Mobile-edge computing (MEC) is an emerging paradigm to meet the ever-increasing computation demands from mobile applications. By offloading the computationally intensive workloads to the MEC server, ...the quality of computation experience, e.g., the execution latency, could be greatly improved. Nevertheless, as the on-device battery capacities are limited, computation would be interrupted when the battery energy runs out. To provide satisfactory computation performance as well as achieving green computing, it is of significant importance to seek renewable energy sources to power mobile devices via energy harvesting (EH) technologies. In this paper, we will investigate a green MEC system with EH devices and develop an effective computation offloading strategy. The execution cost, which addresses both the execution latency and task failure, is adopted as the performance metric. A low-complexity online algorithm is proposed, namely, the Lyapunov optimization-based dynamic computation offloading algorithm, which jointly decides the offloading decision, the CPU-cycle frequencies for mobile execution, and the transmit power for computation offloading. A unique advantage of this algorithm is that the decisions depend only on the current system state without requiring distribution information of the computation task request, wireless channel, and EH processes. The implementation of the algorithm only requires to solve a deterministic problem in each time slot, for which the optimal solution can be obtained either in closed form or by bisection search. Moreover, the proposed algorithm is shown to be asymptotically optimal via rigorous analysis. Sample simulation results shall be presented to corroborate the theoretical analysis as well as validate the effectiveness of the proposed algorithm.
Diabet. Med. 28, 652–657 (2011)
Aims To investigate the trend in the prevalence of gestational diabetes mellitus during 1999–2008 in women living in urban Tianjin, China.
Methods A universal ...screening for gestational diabetes mellitus has become an integral part of the antenatal care in Tianjin, China from 1998. A total of 105 473 pregnant women living in the six urban districts of Tianjin, China, participated in the gestational diabetes mellitus screening programme between December 1998 and December 2008. The screening test consisted of a 50‐g 1‐h glucose test. Women who had a glucose reading ≥ 7.8 mmol/l at the initial screening were invited to undergo the standard 2‐h oral glucose tolerance test with a 75‐g glucose load. Gestational diabetes mellitus was confirmed using the World Health Organization’s diagnostic criteria.
Results The adjusted prevalence of gestational diabetes mellitus increased by 2.8 times during 1999–2008, from 2.4 to 6.8% (P < 0.0001 for linear trend). In 2008, the age‐specific prevalence of gestational diabetes mellitus was the highest among women aged 30–34 years (11.3%) and lowest among women aged 25 and under (1.2%). In women aged 35 years and more, the prevalence was 5.3%.
Conclusions The prevalence of gestational diabetes mellitus has markedly been increasing in a universally screened urban Chinese female population and has become an important public health problem in China.
Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, ...http://bidd.nus.edu.sg/group/ttd/ttd.asp) has been developed to provide comprehensive information about efficacy targets and the corresponding approved, clinical trial and investigative drugs. Since its last update, major improvements and updates have been made to TTD. In addition to the significant increase of data content (from 1894 targets and 5028 drugs to 2025 targets and 17 816 drugs), we added target validation information (drug potency against target, effect against disease models and effect of target knockout, knockdown or genetic variations) for 932 targets, and 841 quantitative structure activity relationship models for active compounds of 228 chemical types against 121 targets. Moreover, we added the data from our previous drug studies including 3681 multi-target agents against 108 target pairs, 116 drug combinations with their synergistic, additive, antagonistic, potentiative or reductive mechanisms, 1427 natural product-derived approved, clinical trial and pre-clinical drugs and cross-links to the clinical trial information page in the ClinicalTrials.gov database for 770 clinical trial drugs. These updates are useful for facilitating target discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations.
A measurement of the energy dependence of antineutrino disappearance at the Daya Bay reactor neutrino experiment is reported. Electron antineutrinos (ν¯(e)) from six 2.9 GW(th) reactors were ...detected with six detectors deployed in two near (effective baselines 512 and 561 m) and one far (1579 m) underground experimental halls. Using 217 days of data, 41 589 (203 809 and 92 912) antineutrino candidates were detected in the far hall (near halls). An improved measurement of the oscillation amplitude sin(2)2θ(13)=0.090(-0.009)(+0.008) and the first direct measurement of the ν¯(e) mass-squared difference |Δm(ee)2|=(2.59(-0.20)(+0.19))×10(-3) eV2 is obtained using the observed ν¯(e) rates and energy spectra in a three-neutrino framework. This value of |Δm(ee)2| is consistent with |Δm(μμ)2| measured by muon neutrino disappearance, supporting the three-flavor oscillation model.
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