The genus Salvia is one of the largest genera of the Lamiaceae family. In China, about 40 Salvia species have been used as medicinal plants for treatment of various diseases, specifically hepatic and ...renal diseases and those of the cardiovascular and immune systems.
This review aims to provide systematically organized information on the ethnopharmacology, phytochemistry, pharmacology, and toxicology of medicinal Salvia species in China to support their therapeutic potential in the treatment of human diseases.
Relevant information on the Chinese Salvia species was obtained from scientific online databases such as Google Scholar, PubMed, and SciFinder. Additional information was derived from other literature sources (e.g. Chinese Pharmacopoeia 2015 edition, Chinese herbal classic books, PhD and MSc thesis, etc).
Our comprehensive analysis of the scientific literature indicates that many Chinese Salvia species are valuable and popular herbal medicines with therapeutic potentials to cure various ailments. Phytochemical analyses identified diterpenoids and phenolic acids as the major bioactive substances in Chinese Salvia species. Crude extracts and pure compounds isolated from the Chinese Salvia species exhibited various pharmacological activities, typically targeting the cardiovascular and immune systems and hepatic and renal diseases.
This review summarizes the results from current studies about basic properties of medicinal Salvia species in China, such as active constituents and their mechanism of action, pharmacokinetics, underlying molecular mechanisms, toxicology, and efficacy, which are still being studied and explored to achieve integration into medical practice.
With rapid development of lithium ion batteries（LIB） and sodium ion batteries（SIB）, hard carbon（HC） as new anode material has earned much attention. Besides its rich precursor sources and low cost, ...HC has higher Li+storage capacity and better rate performance than graphite for LIB. Furthermore, it is also recognized as the most commercially potential anode material for SIB. However, low initial Coulombic efficiency is a common issue for HC.In addition, it is believed that the specific capacity can be further improved with the clarification of the Li/Na ion storage mechanism. In recent years, many researches on electrochemical mechanism have been conducted with some model assumptions proposed for better understanding the mechanism. This review introduced the structures and preparation approaches of HC as well as its application in LIB and SIB. The advantages, especially in fast charging,coating and other subdivision were discussed, and the different modification strategies such as pore structure design,doping,
The influence of microstructure on slip irreversibility and crack initiation during high-cycle fatigue of a titanium alloy has been explored. The results indicate that the fatigue strength of ...lamellar microstructure is higher than the bimodal microstructure. The underlying microstructure and strain partition below the fatigue crack origins have been revealed through electron backscattered diffraction (EBSD). Furthermore, the slip irreversibility and the corresponding accumulative strain to fracture were calculated and compared for these two microstructures. Finally, a critical parameter about (8.1 ± 2) × 10
–4
·μm
−2
for fatigue crack initiation was achieved with the present titanium alloy, which was found to be independent of microstructural types.
A novel breast ultrasound tomography system based on a circular array of capacitive micromechanical ultrasound transducers (CMUT) has broad application prospects. However, the images produced by this ...system are not suitable as input for the training phase of the super-resolution (SR) reconstruction algorithm. To solve the problem, this paper proposes an improved medical image super-resolution (MeSR) method based on the sparse domain. First, we use the simultaneous algebraic reconstruction technique (SART) with high imaging accuracy to reconstruct the image into a training image in a sparse domain model. Secondly, we denoise and enhance the contrast of the SART images to obtain improved detail images before training the dictionary. Then, we use the original detail image as the guide image to further process the improved detail image. Therefore, a high-precision dictionary was obtained during the testing phase and applied to filtered back projection SR reconstruction. We compared the proposed algorithm with previously reported algorithms in the Shepp Logan model and the model based on the CMUT background. The results showed significant improvements in peak signal-to-noise ratio, entropy, and average gradient compared to previously reported algorithms. The experimental results demonstrated that the proposed MeSR method can use noisy reconstructed images as input for the training phase of the SR algorithm and produce excellent visual effects.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In this study, CoCrFeMnNi (Cantor alloy) high-entropy alloy (HEA) with ultra-fine grained (UFG) structure were prepared using cryogenic (liquid nitrogen, 77 K) rolling followed by short time ...annealing. The deformation behavior and strain rate sensitivity (SRS) of processed material were investigated by tensile test at temperatures ranging from 77 K to 573 K. It was found that the critical twinning stress of the UFG alloy decreased at 77 K, which was attributed to the decrease of stacking fault energy with the temperature. In addition, the UFG alloy exhibited plastic instability and was prominently strengthened with increasing testing temperature from 293 K to 473 K, which was related to obviously grain boundaries relaxation in HEAs. The strain rate jump test revealed that the SRS change of UFG specimen with the decrease of grain size was inversely proportional to the associated strength enhancement, and exhibited a stronger temperature dependence than that of CG specimens especially from 293 K to 473 K. The stronger temperature dependence of SRS of UFG Cantor alloys was due to the increased grain boundary relaxation, which was a thermal activation process and depended on strain rate and temperature.
•UFG Cantor alloy was prepared using cryo-rolling and short time annealing.•Tensile and strain rate jump tensile test were conducted from 77 K to 573 K.•UFG alloy exhibited a prominent strengthening from 293 K to 473 K.•Change of SRS in UFG alloy displayed a strong temperature dependence.
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•SNHG11 was overexpressed in NSCLC cells and promoted NSCLC cell growth and migration.•SNHG11 acted as miR-485-5p sponge in NSCLC.•BSG was a target gene of miR-485-5p and played an ...oncogenic role in NSCLC.•SNHG11/miR-485-5p/BSG axis contributed to NSCLC cell growth and migration.
Accumulating studies implied that long noncoding RNAs (lncRNAs) act as essential factors in regulating diverse biological behaviors of cancers. Small nucleolar RNA host gene 11 (SNHG11) has been reported as for its oncogenic properties in several cancer types. However, it is unclear whether SNHG11 exerts functions in non-small cell lung cancer (NSCLC) remains unclear. The aim of this study was to inspect the role and regulatory mechanism of SNHG11 in NSCLC. The expression of SNHG11 in NSCLC cells was analyzed by qRT-PCR. Functional experiments were carried out to determine the effects of SNHG11 silence on the biological behaviors of NSCLC cells, including growth, migration and epithelial-mesenchymal transition. The inhibition of above functions was observed after SNHG11 was silenced. Subcellular fractionation and FISH assays were performed to detect the cellular distribution of SNHG11. Moreover, SNHG11 was found to be a sponge of miR-485-5p that could directly target to Basigin (BSG) mRNA. The interaction between SNHG11 and miR-485-5p as well as between miR-485-5p and BSG was proven by RNA pull down and luciferase reporter assays. Restoration assay confirmed the involvement of miR-485-5p and BSG in SNHG11-mediated NSCLC cellular functions. Conclusively, SNHG11 was overexpressed in NSCLC and functioned as a miR-485-5p sponge to up-regulate BSG.
Alcohol-permselective membranes may play an increasingly important role in bioalcohol production. Developments for this membrane mostly involve hybrid membranes. Obtaining high compatibility and ...nanodispersion of inorganic nanoparticles in the polymer matrix is the key to fabricating hybrid membranes with high pervaporation performance. In this study, a homogeneous, nanodisperse ZIF-8/PDMS membrane was prepared by repeated immersion of a polysulfone supporting membrane in a dilute ZIF-8/PDMS suspension and subsequent removal of defects using a concentrated PDMS solution. To improve the nanoscale dispersion of ZIF-8, the nascent ZIF-8 suspension was directly dispersed in a PDMS solution without drying. This procedure avoids aggregation and redispersion of ZIF-8 nanoparticles after forming a powder. Analyses confirmed that the ZIF-8/PDMS dispersion effectively diminished aggregation between nanoparticles and led to the formation of a well-dispersed ZIF-8/PDMS membrane. A homogeneous and thin ZIF-8/PDMS permselective layer was obtained by adjusting the preparation conditions. The prepared ZIF-8/PDMS membrane exhibited a high separation factor (52.81) and high flux (2800.5 g m super(-2) h super(-1)) in the separation of 5.0 wt% n-butanol-water solution at 80 degree C. By comparing the powder-dispersed ZIF-8/PDMS hybrid membrane with the suspension-dispersed ZIF-8/PDMS membrane, we found that the latter showed much higher performance in butanol separation. Therefore, the nanodisperse ZIF-8/PDMS membrane has great potential applications for in siturecovery of biobutanol.
Numerous studies have explored the drivers and consequences of the expansion of urban areas. However, limited research has been conducted on the land development of cities based on the different ...developmental stages. Therefore, using land transaction records obtained by Python in the land market of China during the 2011–2015 period, this study explores the factors affecting the land development process in 289 cities at five different stages of economic development. The development stages are identified by combing per capita GDP and the industrial structure in the 289 cities in 2015. The stages of economic development are the primary production stage (PPS), primary industrialization stage (PIS), middle industrialization stage (MIS), later industrialization stage (LIS), and developed stage (DS). The results reveal that with the advance of regional development stage, the scale of land development increases. We also find that, in general, the proportions of residential and public management-service land development projects increases, whereas the proportion of transportation land development projects decreases. The proportions of industrial-mining-warehouse land development projects first increases and then decreases, and there is no significant change in the proportion of land used for commercial land development projects. Regression analyses of panel data indicate that various factors have different effects on land development at five developmental stages, although the positive effects of domestic fixed asset investment on land development are always strongest. The results can contribute to our understanding of land development patterns in different stages of development and local governments in China, and thus to the formulation of reasonable annual land development plans.
•With the development of regional economy, the demand for construction land is increasing.•The differences of land development structure in different stages of economic development are also significant.•The impact of non-agricultural industrial development, capital accumulation and population growth on land development in different stages of economic development is also significantly different.
Urban agglomerations are fundamental regional units of development and attract large-scale migrant population. Previous studies have only focused on migrant population distribution in major urban ...agglomerations. Therefore, this study analysed the spatiotemporal characteristics of migrant population distribution in China during 2000-2010 at city level from the perspective of urban agglomerations. The results indicate that urban agglomerations were accumulation areas of migrant population. Numerous people have migrated into 19 urban agglomerations, which has enlarged regional differences in migrant population distribution. The interprovincial migrant population dominated within urban agglomerations, whereas the intraprovincial migrant population dominated outside urban agglomerations. In the future, intraprovincial migration will become the dominant migration mode. The evolution of migrant population distribution pattern in urban agglomerations agrees with classic theories of unbalanced regional development. The determinants of migration in different regions were compared. Results revealed that economic and government driving forces jointly influenced migration; however, economic forces exceeded government forces. Economic forces were more influential within urban agglomerations, whereas government forces played more important roles outside urban agglomerations. Increased income and job opportunities were the core attractions of urban agglomerations. Moreover, with an increase in the urban agglomeration development level, the influence of economic forces increased, whereas that of government forces decreased. The findings provide a deeper understanding of migrant population distribution in China, which will benefit population management across various regions.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Non-small cell lung cancer (NSCLC) is a threat to human health. Circular RNAs (circRNAs) have been proved to function in NSCLC development. In this study, the role of circRNA hsa_circ_0010235 in ...NSCLC progression and the possible molecular mechanism were explored.
Expression of hsa_circ_0010235, miRNA (miR)-433-3p and TOR signaling pathway regulator-like (TIPRL) was examined by quantitative real-time PCR (qRT-PCR). Cell viability and clonogenicity were detected by cell counting kit-8 (CCK-8) assay and colony formation assay, respectively. Flow cytometry was performed to monitor cell apoptosis and cell cycle distribution. Western blot assay was employed to evaluate the protein levels of TIPRL, light chain 3 (LC3)-II/I and p62. Cell metastasis was assessed by Transwell and wound healing assays. The targeted relationship between miR-433-3p and hsa_circ_0010235 or TIPRL was confirmed by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. Furthermore, the role of hsa_circ_0010235 in vivo was investigated by xenograft assay.
Hsa_circ_0010235 and TIPRL were highly expressed in NSCLC tissues and cells, while miR-433-3p was downregulated. Depletion of hsa_circ_0010235 or gain of miR-433-3p repressed proliferation and autophagy but promoted apoptosis in NSCLC cells. Hsa_circ_0010235 sponged miR-433-3p to upregulate TIPRL expression, so as to affect NSCLC development. Hsa_circ_0010235 knockdown also blocked tumor growth in vivo.
Hsa_circ_0010235 knockdown suppressed NSCLC progression by regulating miR-433-3p/TIPRL axis, affording a novel mechanism of NSCLC progression.
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