It is the challenging goal in cancer biomedicine to search novel cancer-therapeutic modality with concurrent high therapeutic efficiency on combating cancer and low side effects to normal ...cells/tissues. The recently developed nanocatalytic cancer therapy based on catalytic Fenton reaction represents one of the promising paradigms for potential clinical translation, which has got fast progress very recently. This progress report discusses the rational design and fabrication of Fenton reaction-based nanocatalysts for triggering the in-situ Fenton chemical reaction within tumor microenvironment to generate highly toxic hydroxyl radicals (•OH), which is highly efficient for killing the cancer cells and suppressing the tumor growth. Several strategies for optimizing the nanocatalytic cancer-therapeutic efficiency of Fenton reaction have been highlighted, including screening high-performance Fenton nanocatalysts, increasing peroxide-hydrogen amounts as the reactants, changing the Fenton-reaction conditions (e.g., temperature, acidity and photo-triggering), and Fenton reaction-based synergistic cancer therapy such as some sequential nanocatalytic reactions with improved therapeutic outcome. The facing challenges and future developments of Fenton reaction-based nanocatalytic cancer therapy are also discussed for further promoting the clinical translation of this emerging cancer-therapeutic modality to benefit the cancer patients.
Display omitted
Microbially induced calcite precipitation (MICP) is used increasingly to improve the engineering properties of granular soils that are unsuitable for construction. This shows MICP technique ...significant advantages such as low energy consumption and environmentally friendly feature. The objective of the present study is to assess the strength behaviour of bio-cemented sand with varying cementation levels, and to provide an insight into the mechanism of MICP treatment. A series of isotropic consolidated undrained compression tests, calcite mass measurement and scanning electron microscopy tests were conducted. The experimental results show that the strength of bio-cemented sand depends heavily on the cementation level (or calcite content). The variations of strength parameters, i.e. effective friction angle
φ
′ and effective cohesion
c
′, with the increase in calcite content can be well evaluated by a linear function and an exponential function, respectively. Based on the precipitation mechanism of calcite crystals, bio-clogging and bio-cementation of calcite crystals are correlated to the amount of total calcite crystals and effective calcite crystals, respectively, and contributed to the improvement in the effective friction angle and effective cohesion of bio-cemented sand, separately.
DNA modifications such as 5-methylcytosine （5mC） and 5-hydroxymethylcytosine （5hmC） are epigenetic marks known to affect global gene efpression in mammals. Given their prevalence in the human genome, ...close correlation with gene expression and high chemical stability, these DNA epigenetic marks could serve as ideal biomarkers for cancer diagnosis. Taking advantage of a highly sensitive and selective chemical labeling technology, we report here the genome-wide profiling of 5hmC in circulating cell-free DNA （cfDNA） and in genomic DNA （gDNA） of paired tumor and adjacent tissues collected from a cohort of 260 patients recently diagnosed with colorectal, gastric, pancreatic, liv- er or thyroid cancer and normal tissues from 90 healthy individuals. 5hmC was mainly distributed in transcriptionally active regions coincident with open chromatin and permissive histone modifications. Robust cancer-associated 5hmC signatures were identified in cfDNA that were characteristic for specific cancer types. 5hmC-based biomarkers of cir- culating cfDNA were highly predictive of colorectal and gastric cancers and were superior to conventional biomarkers and comparable to 5hmC biomarkers from tissue biopsies. Thus, this new strategy could lead to the development of effective, minimally invasive methods for diagnosis and prognosis of cancer from the analyses of blood samples.
Ultra-high temperature ceramics (UHTCs) are generally referred to the carbides, nitrides, and borides of the transition metals, with the Group IVB compounds (Zr & Hf) and TaC as the main focus. The ...UHTCs are endowed with ultra-high melting points, excellent mechanical properties, and ablation resistance at elevated temperatures. These unique combinations of properties make them promising materials for extremely environmental structural applications in rocket and hypersonic vehicles, particularly nozzles, leading edges, and engine components, etc. In addition to bulk UHTCs, UHTC coatings and fiber reinforced UHTC composites are extensively developed and applied to avoid the intrinsic brittleness and poor thermal shock resistance of bulk ceramics. Recently, highentropy UHTCs are developed rapidly and attract a lot of attention as an emerging direction for ultra-high temperature materials. This review presents the state of the art of processing approaches, microstructure design and properties of UHTCs from bulk materials to composites and coatings, as well as the future directions.
Abstract
The novel coronavirus pneumonia (COVID-19) epidemic has brought serious social psychological impact to the Chinese people, especially those quarantined and thus with limited access to ...face-to-face communication and traditional social psychological interventions. To better deal with the urgent psychological problems of people involved in the COVID-19 epidemic, we developed a new psychological crisis intervention model by utilizing internet technology. This new model, one of West China Hospital, integrates physicians, psychiatrists, psychologists and social workers into Internet platforms to carry out psychological intervention to patients, their families and medical staff. We hope this model will make a sound basis for developing a more comprehensive psychological crisis intervention response system that is applicable for urgent social and psychological problems.
We show that gravitational floating orbits may exist for black holes with rotating hairs. These black hole hairs could originate from the superradiant growth of a light axion field around the ...rotating black holes. If a test particle rotates around the black hole, its tidal field may resonantly trigger the dynamical transition between a corotating state and a dissipative state of the axion cloud. A tidal bulge is generated by the beating of modes, which feeds angular momentum back to the test particle. Following this mechanism, an extreme-mass-ratio-inspiral (EMRI) system, as a source for LISA, may face delayed merger as the EMRI orbit stalls by the tidal response of the cloud, until the cloud is almost fully dissipated. If the cloud depletes slower than the average time separation between EMRI mergers, it may lead to interesting interaction between multiple EMRI objects at comparable radii. Inclined EMRIs are also expected to migrate towards the black hole equatorial plane due to the tidal coupling and gravitational-wave dissipation. Floating stellar-mass back holes or stars around the nearby intermediate-mass black holes may generate strong gravitational-wave emission detectable by LISA.
Yield-driven optimization is important in microwave design due to the uncertainties introduced in the manufacturing process. For the first time, we extend in this paper the use of polynomial chaos ...(PC) approach from electromagnetic (EM)-based yield estimation to EM-based yield optimization of microwave structures. We first formulate a novel objective function for yield-driven EM optimization. By incorporating the PC coefficients into the formulation, the objective function is analytically related to yield optimization variables, which are the nominal point. We then derive the sensitivity formulas of the PC coefficients with respect to the nominal point, following which we derive the sensitivities of the optimization objective function with respect to yield optimization variables. These sensitivities are then used in gradient-based optimization algorithms to find the optimal yield solution iteratively. The proposed objective function requires fewer EM simulations to provide reliable yield representation than that in the conventional Monte Carlo-based yield optimization approach. As a result, the number of EM simulations required to find the update direction and suitable step size for the change of the nominal point is reduced at each iteration of optimization. This allows the proposed approach to achieve similar yield increase using much fewer EM simulations or greater yield increase using similar number of EM simulations compared to the conventional yield optimization approach. The advantages of our proposed approach are demonstrated by yield-driven EM optimization of three waveguide filter examples.
Controlling the growth of high-activity anatase TiO2 exposed {001} facets improves greatly the adsorption and electronic and photocatalytic properties and has been attractive for various ...environmental and energy-related applications. In this paper, we introduced a novel approach for quantitatively measuring the percentage of exposed {001} facets in anatase TiO2 by using Raman spectroscopy. Comparing to XRD, Raman peaks originate from the vibration of molecular bonds, that is, vibrational mode Eg and A1g peaks, which are related to different crystal planes. Therefore, it provided a high sensitivity and accuracy for measuring the percentage of the exposed facets from the micro perspective of molecular bonding with less measurement errors. With the photocatalytic experiments, we found that 50% was the optimal percentage of the exposed {001} facets for the highest efficiency, which seemed more reasonable than the value of 70% obtained from XRD.
Rhizosphere microorganisms play important roles in plant health and growth. The diversity and composition of rhizosphere microbial communities have been well studied, but little is known about their ...co-occurrence patterns, especially at a continental scale. Herein, we performed a network-based analysis using integrated bacterial and fungal community datasets to delineate the co-occurrence patterns of bulk soil and rhizosphere microbiome and the geographic patterns of network topological features in 51 soybean fields across China. Results showed that the microbial networks differed between bulk soil and rhizosphere in terms of structure and composition. Compared with the bulk soil networks, the rhizosphere networks had fewer links between bacteria and fungi, lower modularity, and smaller average path length; the global, southern and northern networks of rhizosphere showed similar, higher and lower complexity, respectively. The southern-specific networks of both bulk soil and soybean rhizosphere had more links between bacteria and fungi compared with the northern-specific networks. Additionally, the geographic patterns of network topological features differed between bulk soil and rhizosphere habitats, northern and southern regions. Bacterial sub-networks of both bulk soil and rhizosphere were most influenced by soil pH; fungal sub-networks were related to fewer environmental factors and most influenced by soil Mg content. Given that microbial networks may reflect interactions or niches shared among microorganisms, these results provide new insights into the organization of rhizosphere microbial communities.
•We compared bulk soil and rhizosphere microbial networks at a continental scale.•The rhizosphere networks had fewer bacteria-fungi links than the bulk soil networks.•Soil pH was the strongest predictor of bacterial sub-networks topological features.•Soil Mg was the strongest predictor of fungal sub-networks topological features.
We study massive scalar field perturbation on Kerr black holes in dynamical Chern–Simons gravity by performing a
(
2
+
1
)
-dimensional simulation. Object pictures of the wave dynamics in time domain ...are obtained. The tachyonic instability is found to always occur for any nonzero black hole spin and any scalar field mass as long as the coupling constant exceeds a critical value. The presence of the mass term suppresses or even quench the instability. The quantitative dependence of the onset of the tachyonic instability on the coupling constant, the scalar field mass and the black hole spin is given numerically.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
PDF
