Abstract
We report the observations of FRB 20220912A using the Five-hundred-meter Aperture Spherical radio Telescope. We conducted 17 observations totaling 8.67 hr and detected a total of 1076 bursts ...with an event rate up to 390 hr
−1
. The cumulative energy distribution can be well described using a broken power-law function with the lower- and higher-energy slopes of −0.38 ± 0.02 and −2.07 ± 0.07, respectively. We also report the
L
-band (1–1.5 GHz) spectral index of the synthetic spectrum of FRB 20220912A bursts, which is −2.6 ± 0.21. The average rotation measure value of the bursts from FRB 20220912A is −0.08 ± 5.39 rad m
−2
, close to 0 rad m
−2
and was relatively stable over 2 months. Most bursts have nearly 100% linear polarization. About 45% of the bursts have circular polarization with Signal-to-Noise ratio > 3, and the highest circular polarization degree can reach 70%. Our observations suggest that FRB 20220912A is located in a relatively clean local environment with complex circular polarization characteristics. These various behaviors imply that the mechanism of circular polarization of FRBs likely originates from an intrinsic radiation mechanism, such as coherent curvature radiation or inverse Compton scattering inside the magnetosphere of the FRB engine source (e.g., a magnetar).
This paper presents the result of the search for pulses from the fast radio burst FRB 20220912A with the LPA LPI antenna at a frequency of 111 MHz during the period of activity in October–November ...2022. As a result of observations, pulses were recorded on October 18, 30 and November 12 with a dispersion measure of
pc/cm
3
and a peak flux density of 626, 354, and 203 Jy, respectively. The registration of the FRB 20220912A radio burst with the FAST radio telescope on October 28 in the frequency range of 1–1.5 GHz is also reported. The data at other frequencies are analyzed, the dependence of the pulse width on the frequency
is obtained.
The coexistence of developed areas and historic buildings is an important topic in urban planning. Our study focuses on this topic from the perspective of urban microclimate. A multi-physics CFD ...simulation is applied to model urban microclimate with anthropogenic heat and buoyancy effects. First, we clarified the impact of new development, i.e., high-rises on pedestrian-level air flow by comparing city structures in Case A (the past, 1960s) and Case B (the current, 2020s). The results showed an average wind speed decrease of 43% over time. Second, we assessed air temperature increments from anthropogenic heat emitted from Case C (high-rises), Case D (historic buildings), and Case E (both). We found that the mean air temperature increased by 0.16 °C for Case C, 0.52 °C for Case D, and 0.87 °C for Case E, respectively. Third, we developed heat mitigation strategies based on the assessment results in the previous steps. The integration of open spaces and building porosity, which create wind corridors together, can promote outdoor ventilation and heat dispersion in the study area. Compared with Case E, the three mitigation cases improve outdoor thermal environment, with mean temperature reductions of 33%, 25%, and 21%, respectively. Finally, we developed new mitigation strategies by considering the constraints in this special region, where modernity and history coexist. Our practical mitigation strategies will aid urban planning and support conservation efforts not only in Singapore, but also in other tropical and subtropical cities.
Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ArLD) constitute the primary forms of chronic liver disease, and their incidence is progressively increasing with changes ...in lifestyle habits. Earlier studies have documented a correlation between the occurrence and development of prevalent mental disorders and fatty liver.
To investigate the correlation between fatty liver and mental disorders, thus necessitating the implementation of a mendelian randomization (MR) study to elucidate this association.
Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog, while information on mental disorders, including Alzheimer's disease, schizophrenia, anxiety disorder, attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, multiple personality disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and schizophrenia was acquired from the psychiatric genomics consortium. A two-sample MR method was applied to investigate mediators in significant associations.
After excluding weak instrumental variables, a causal relationship was identified between fatty liver disease and the occurrence and development of some psychiatric disorders. Specifically, the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD (OR: 5.81, 95%CI: 5.59-6.03,
< 0.01), bipolar disorder (OR: 5.73, 95%CI: 5.42-6.05,
= 0.03), OCD (OR: 6.42, 95%CI: 5.60-7.36,
< 0.01), and PTSD (OR: 5.66, 95%CI: 5.33-6.01,
< 0.01). Meanwhile, NAFLD significantly increased the risk of developing bipolar disorder (OR: 55.08, 95%CI: 3.59-845.51,
< 0.01), OCD (OR: 61.50, 95%CI: 6.69-565.45,
< 0.01), and PTSD (OR: 52.09, 95%CI: 4.24-639.32,
< 0.01).
Associations were found between genetic predisposition to fatty liver disease and an increased risk of a broad range of psychiatric disorders, namely bipolar disorder, OCD, and PTSD, highlighting the significance of preventive measures against psychiatric disorders in patients with fatty liver disease.
Hypertriglyceridemia is the third leading cause of acute pancreatitis (AP), and its incidence is increasing. Due to its relatively insidious etiology, it is easy to be ignored in the early stages. In ...China, Chaiqin Chengqi Decoction (CQCQD) has long been employed for treating AP.
To evaluate the effectiveness of CQCQD in patients diagnosed with mild/ moderately severe hypertriglyceridemic AP (HTG-AP).
In this study, the clinical data of 39 patients with HTG-AP admitted from January 2019 to November 2022 were collected. The changes of blood lipids, gastrointestinal symptoms, and abdominal pain before and after treatment were analyzed and compared between the two groups.
Twenty patients were treated with the conventional HTG-AP regimen, and 19 patients were additionally treated with CQCQD. After receiving treatment, the triglycerides (TG) level of the CQCQD group was lower than that of the CQCQD group (3.14 ± 0.25 mmol/L
4.96 ± 0.47 mmol/L,
< 0.01). After 3 d of treatment, the patients in the CQCQD group had more bowel movements than the control group (2.51 ± 0.25 times
1.00 ± 0.17 times,
= 0.01). The gastrointestinal function of most patients returned to normal, and the acute gastrointestinal injury score was significantly lower than that of the control group (0.11 ± 0.07
0.42 ± 0.11,
< 0.01).
In patients with HTG-AP, CQCQD can significantly reduce the TG level, shorten the recovery time of defecation, significantly improve the gastrointestinal function.
Magnesium and its alloys as biodegradable implant materials can be potentially used in cardiovascular and orthopedic devices. However, few studies have focused on its application in esophageal ...stents. In this paper, time-lapse degradation characteristics of pure Mg were analyzed by scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, hydrogen evolution, pH and electrochemical measurements after immersion in artificial saliva for different times. Results revealed that a dense degradation product film formed on samples, which mainly consisted of two kinds of layers： one was calcium phosphate compounds with different structures; the other was thin magnesium hydrate layer close to the substrate. Less pH increase and low degradation rate were ob- served in the first 5 days of immersion, which can be ascribed to the formation of a thicker and denser layer on the sample surface with increasing immersion time. And then there was an increase in degradation rate and pH values; the deposition layer remained almost intact after immersion for 6 and 8 days. After 10 days of immersion, the degradation rate and pH value remained stable, and the calcium phosphate layer was delaminated and the inner magnesium hydrate layer was exposed. This study indicated that pure Mg exhibited desirable degradation resistance in artificial saliva, which provided magnesiumbased materials with the potential to be used as esophageal stents.
Earthworms, one of the most important macroinvertebrates in terrestrial ecosystems of temperate zones, exert important influ- ences on soil functions. A laboratory microcosm study was conducted to ...evaluate the influence of the earthworm Eisenia fetida on wheat straw decomposition and nutrient cycling in an agricultural soil in a reclaimed salinity area of the North China Plain. Each microcosm was simulated by thoroughly mixing wheat straw into the soil and incubated for 120 d with earthworms added at 3 different densities as treatments： control with no earthworms, regular density （RD） with two earthworms, and increased density （ID） with six earthworms. The results showed that there was no depletion of carbon and nitrogen pools in the presence of the earthworms. Basal soil respiration rates and metabolic quotient increased with the increase in earthworm density during the initial and middle part of the incubation period. In contrast, concentrations of microbial biomass carbon and microbial biomass quotient decreased in the presence of earthworms. Earthworm activity stimulated the transfer of microbial biomass carbon to dissolved organic carbon and could lead to a smaller, but more metabolically active microbial biomass. Concentrations of inorganic nitrogen and NO~-N increased significantly with the increase in earthworm density at the end of the incubation （P ~ 0.05）, resulting in a large pool of inorganic nitrogen available for plant uptake. Cumulative net nitrogen mineralization rates were three times higher in the ID treatment than the RD treatment.
The problem of metal-composite wing structural optimization is discussed and a strategy is presented. Topology optimization method is applied to provide load transferring path of structure for ...concept design. Size, shape and other optimization method are used to provide detailed design for individual components. A three-phase optimization method is discussed for fiber reinforced composite laminate skin. Optimal parameters include ply angle, percentage, thickness, layer shape and sequence. The design of laminate for ease of manufacture is based on a set of manufacturing constraints. This paper deals with a total optimal design solution for aileron structure of an aircraft. The result satisfies all the requirements of strength and stability, and has obvious effect of weight loss.
AIM: To assess the safety and feasibility of peroral esophageal myotomy(POEM) in patients with achalasia.METHODS: From January 2012 to March 2014, 50 patients(28 men, 22 women; mean age: 42.8 years, ...range: 14-70 years) underwent POEM. Pre- and postoperative symptoms were quantified using the Eckardt scoring system. Barium swallow and esophagogastroscopy were performed before and after POEM, respectively. Esophageal motility was evaluated in all patients, both preoperatively and one month after POEM treatment, using a high-resolution manometry system. Manometry data, Eckardt scores, lower esophageal sphincter pressure and barium swallow results were used to evaluate the effect of the procedure.RESULTS: POEM was successfully completed for all patients. The mean procedure time was 55.4 ± 17.3 min and the mean total length of myotomy of the circular esophagus was 10.5 ± 2.6 cm. No specific complications occurred, with the exception of two patients that developed as ymptomatic pneumomediastinum and subcutaneous emphysema. Clinical improvement in symptoms was achieved in all patients. Approximately 77.5% of patients experienced weight gain 6 mo after POEM, with an average of 4.78 kg(range: 2-15 kg). The lower esophageal sphincter resting pressure, four second integrated relaxation pressure and Eckardt scores were all significantly reduced after POEM(Ps < 0.05). A small segment of proximal esophageal peristalsis appeared postoperatively in two patients, but without normal esophageal peristalsis. The average diameter of the esophageal lumen decreased significantly from 4.39 to 3.09 cm(P < 0.01). CONCLUSION: POEM can relieve achalasia symptoms, improve gastroesophageal junction relaxation and restore esophageal body motility function, but not normal esophageal peristalsis.
AIM To investigate the impact of cigarette smoking on the recurrence rate and recurrence-free survival in patients with hyperlipidemic acute pancreatitis(HLAP).METHODS A total of 863 patients were ...admitted to our hospital for acute pancreatitis(AP) from January 2013 to March2016, of whom 88 diagnosed with HLAP were enrolled in this retrospective study. Demographic data, medical history, previous episodes of pancreatitis, consumption of alcohol and cigarettes, as well as biochemical and hematological data were carefully recorded for univariate and multivariate analyses. During followup, the information on current smoking status and recurrent AP was gathered. Recurrence-free survival(RFS) was calculated using the Kaplan-Meier method, and the differences between groups were compared using the log-rank test.RESULTS No significant differences were observed between the three groups in age or medical history of hyperlipidemia, fatty liver, diabetes mellitus, hypertension, or AP. The current smokers had a remarkably higher recurrence rate and a greater incidence of repeated episodes of AP(50.0% and 77.8%, respectively) than non-smokers(9.8% and 39.0%), and these two percentages were reduced to 9.1% and 36.4% for patients who gave up smoking. The median follow-up time was 13.5 mo and HLAP recurred after hospital discharge in 23(26.1%) patients. Multivariate analysis identified current smoking(HR = 6.3, P = 0.020) as an independent risk factor contributing to HLAP recurrence. Current smokers had significantly worse RFS than non-smokers(23 mo vs 42 mo), but no significant difference was documented between ex-smokers(34 mo) and non-smokers. The RFS was not significantly different between light and heavy smokers.CONCLUSION Smoking is associated with worse RFS and an increased rate of HLAP recurrence. Continued smoking correlates with a compromised survival and smoking cessation should be recommended.
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