Abstract
Background
Lithium carbonate is commonly used in the treatment of bipolar disorder. A spectrum of side effects is associated with lithium, including nephrogenic diabetes insipidus, renal ...tubular acidosis, chronic tubulointerstitial nephropathy, and minimal change disease. Although the former three adverse effects are well-known, minimal change disease is relatively rare.
Case presentation
We herein report a case of lithium therapy-induced minimal change disease with concurrent chronic tubulointerstitial nephropathy. A 66-year old man with bipolar disorder treated by lithium for 20 years, presented to the hospital with anasarca and decreased urine output for 4 weeks. The medical history also included hyperlipidemia, hypertension, and benign prostatic hyperplasia. Further laboratory investigation revealed elevated serum lithium (2.17 mmol/L), potassium (6.0 mmol/L), and creatinine levels (2.92 mg/dL), nephrotic range proteinuria, and hypoalbuminemia. Lithium was discontinued and the patient was treated with intravenous fluids. He underwent a kidney biopsy, which showed findings consistent with minimal change disease with concurrent acute tubular injury and chronic tubulointerstitial nephropathy. The patient was subsequently treated with steroids in an outpatient setting. He did not respond to the treatment, and hemodialysis was started.
Conclusion
Based on the previously reported cases and review of literature, occurrence of lithium-associated minimal change nephropathy is rare. Patients with lithium-associated minimal change disease and acute tubular injury usually respond to discontinuation of lithium therapy and/or steroid treatment. In this case, minimal change nephropathy was steroid-resistant and kidney function of the patient reported here did not recover after 6-month follow-up. We postulated the underlying cause to be minimal change disease with chronic tubulointerstitial nephropathy due to long-term lithium use. This case provides an example of a rare side effect of lithium-induced minimal change nephropathy with chronic tubulointerstitial nephropathy in addition to its well-known complication of interstitial nephritis or diabetes insipidus. In our opinion, these patients likely have much worse clinical outcome.
The Nadanhada terrane is considered to accrete to the eastern end of the Jiamusi Block during the Pacific Plate subduction. Constraints on the deep structure of the Nadanhada terrane and Jiamusi ...Block are essential to study the evolution, transformation and current activity of the eastern Asian continental margin. To reconstruct the accretion processes, two magnetotelluric sounding sections and a seismic reflection section were conducted in the eastern part of Jiamusi Block, the middle, and the southern end of the Nadanhada terrane respectively. Geophysical data revealed resistant stable structures and west-dipping discontinuous reflections with a thickness of around 15 km in the upper crust of Jiamusi Block. In contrast, the lower crust of the Jiamusi block exhibited high conductivity and short sub-horizontal reflections that suggest upwelling of mantle material under Pacific Plate subduction. Moreover, the low resistivity zone observed connecting the shallow crust with the upper mantle in the Tongjiang-Yuejinshan fault was interpreted as the boundary line between the Jiamusi block and Nadanhada terrane. The Nadanhada terrane can be subdivided into the Yuejinshan and Raohe complexes based on their distinct geophysical features. The Yuejinshan Complex is characterized by irregular bodies with high resistivity and short arc reflections with a thickness of about 10 km. In contrast, the Raohe Complex displays high-resistivity blocks and west-dipping thrust nappe strong reflections with a thickness of about 5 km. Additionally, the high-conductivity layer located between the Raohe Complex and the underlying basement is believed to be the detachment zone. Since the Cretaceous, the continuous subduction of the Pacific Plate has caused magmatism that has led to the high conductivity crust. The observation of low-resistivity channels and arcuate reflections within the crust supports the notion of upwelling of mantle-derived materials brought about by the subduction of the Pacific Plate in the Cenozoic era.
•First 2D electrical and seismic image of the Yuejinshan and Raohe complexes.•Geophysical data show the Yuejinshan Fault between the Jiamusi block and Nadanhada terrene.•Conductors and arc reflections in the crust reveal the mantle upwelling by the Pacific subduction since Cenozoic.
•Application of geophysical methods in new uranium bearing strata in Odors basin.•First application of the constrained inversion of seismic and residual gravity data in uranium exploration.•The ...geophysical characteristics of uranium bearing sandstones are summarized.
We present the seismic and 3-D gravity study to define the ore-controlling structures of sandstone-hosted uranium deposits in the southwestern Ordos Basin, the second largest sedimentary basin in China. The instantaneous amplitude and frequency are extracted from seismic reflection data, and the seismic impedance is obtained by joint inversion of well-log and post-stack seismic data. Results of the seismic attributes and inversion show that the uranium-bearing deposits exhibit low instantaneous frequencies, low instantaneous amplitudes and medium–low seismic impedances. The scratch analysis method is employed on the residual gravity anomaly generated from the gravity bouguer anomaly by using the potential field separation. The edge coefficient image of the residual gravity anomaly shows that the fault structures are composed of NE-trending faults in the west and EW-trending faults in the east of the study area. The 3-D gravity inversion constrained by the seismic data was performed to reveal that uranium-bearing deposits are characterized by low gravity anomaly, which is related to the larger porosity of the uranium-bearing sandstones. Geophysical results show that the uranium-bearing deposits are controlled by flower structures, EW-trending normal faults and NW-trending thrust faults. Flower structures are produced by the tectonic inversion as a result of the uplift and NE-directed growth of the Tibetan Plateau. Ore-controlling faults cut crossing the floor of the ore-bearing strata as channels, along which the ore-forming fluids move upward and are enriched in the sandstone strata with high permeability and porosity in Luohe Formation. In addition, the roof and floor of the ore-bearing strata in Luohe Formation are characterized by high impedance and gravity anomaly, which has a sealing effect on uranium deposits. Then we predicted the thickness of the sandstones in Luohe Formation, as the sandstone is a prerequisite for mineralization.
To improve the accuracy of numerical control machine tools error, this paper studies the application of laser testing technology in numerical control machine tool, and put forward a laser ...interferometer automatic aiming system which can conduct space error measurement. The system, in the process of the NC machine tool operating, can measure the machine tool space curve through changing the direction of the laser. The principle of laser interferometer and matlab analysis are adopted, through the experiment of laser interference technology in the numerical control machine tool, the law curve of error in NC machine tools is obtained, getting the method of error of NC machine tools. When conducting laser testing error experiment in NC machine tool, the results show that the laser testing can measure aggregated error and thermal error of NC machine tool better, with small control of environment and high accuracy of measurement.
This study investigated the influence of different linearly polarized spectrum lights on locusts polartactic response characteristics linearly polarized vector sensitivity mode and polartactic ...response) by using linearly polarized spectrum vector light module and experimental device. The objective was to clarify the vector sensitivity characteristics and functional effect of linearly polarized light spectrum intensity on locusts polartactic response, determine the influence specificity of linearly polarized spectrum illumination properties on locusts polarization-related behavior. When spectrum and illumination were constant, locusts polartactic response, presenting the response feature of sine and cosine function change specificity, was related to spectrum attribute. The visual acuity effect stimulated by violet spectrum was the best, whereas the optical distance modulation effect induced by orange spectrum was the strongest. When illumination was enhanced, locusts vector sensitivity mode shifted to present the specific sensitivity prompted by light intensity at long distance and inhibited by light intensity at short distance. Moreover, the regulating function of violet spectrum was the strongest, and the regulatory mutation effect of orange spectrum was the least significant. Simultaneously, locusts polartactic sensitivity to 300° vector at 100 lx, whereas to 240° vector at 1000 lx of linearly polarized violet light was the strongest. Locusts polartactic aggregation and visual tendency sensitivity to 90° vector at 100 lx, whereas to 270° vector at 1000 lx of linearly polarized violet light was the strongest. The heterogeneous regulation function of different linearly polarized spectrum couplings with light intensity led to significant variations in locusts vector sensitivity mode. This was derived from the antagonistic and specific tuning characteristics of locusts polartactic vision, reflecting the integrated output effect of locusts vector dependence regulated by linearly polarized spectrum intensity attribute. The findings were significant for the construction of pest polarization induction light sources and the investigation of the sensitive physiology pathway of locusts polarization vision.
With the rapid growth of science and technology, the Internet of Things (IoT) technology has matured and attracted the attention of many researchers. The development of agricultural modernization ...leads to the gradual emergence of intelligent management gradually taking root in agricultural production. Among many technologies in the IoT technologies, low-power Wide Area Network (WAN) technology has the characteristics of reliable and stable transmission with long distance and low power consumption. This is very useful for data transmission in special environments, especially for orchards in mountainous areas. This paper proposed a new agricultural Internet of Things in orchard management based on multi-sensors, such as DHT11 for temperature/humidity and GY-30 for illumination, the Long Range (LoRa) technology for transmitting the collected data or control command between the terminal and data cloud center, etc. Setting a low-power IoT sensor network in the orchard can remotely measure the parameters in the orchard. LoRa WAN is used to transmit data to the central node. In order to reduce power consumption and cost, a single monitoring node selects two power supplies, a solar power supply and a power supply, and the power supply can be turned on remotely by users in special circumstances. Experiments in different environments in the peach orchard show that the monitoring system has enough reliability and accuracy, and is suitable for environmental monitoring in orchards in remote areas or areas with complex terrain.
Immunoglobulin light chain amyloidosis is the most frequent type of renal amyloidosis in the United States, accounting for 81% of cases. Accurate typing is crucial for early diagnosis and treatment ...of immunoglobulin-derived amyloidosis and to avoid treating other amyloidoses with potentially toxic chemotherapy. Immunofluorescence is the first step to type renal immunoglobulin-derived amyloidosis but the performance characteristics of this method are largely unknown. Here, we establish the sensitivity and specificity of immunofluorescence for diagnosing immunoglobulin-derived amyloidosis in patients whose amyloid typing was performed by the current gold standard of laser microdissection/mass spectrometry. Renal biopsy pathology reports originating from several institutions with a diagnosis of amyloidosis and which had amyloid typing by laser microdissection/mass spectrometry performed at our center were reviewed. Reported immunofluorescence staining for kappa or lambda of 2+ or more, with weak or no staining for the other light chain was considered positive for light chain amyloidosis by immunofluorescence. Based on microdissection/mass spectrometry results, of the 170 cases reviewed, 104 cases were typed as immunoglobulin-derived amyloidosis and 66 were typed as non-immunoglobulin-derived amyloidosis. Immunofluorescence sensitivity for diagnosing immunoglobulin-derived amyloidosis was 84.6%. The remaining 16 cases could not be diagnosed by immunofluorescence due to reported weak staining for all antigens or reported lack of preferential staining for one antigen. Immunofluorescence specificity was 92.4%. Five cases, all amyloid A amyloidosis, were misdiagnosed as immunoglobulin-derived amyloidosis by immunofluorescence. Immunofluorescence failed to accurately differentiate immunoglobulin-derived from non-immunoglobulin-derived amyloidosis in 12.3% of cases of renal amyloidosis. Relying on immunofluorescence alone for determining immunoglobulin-derived vs. non-immunoglobulin-derived amyloidosis may lead to misdiagnosis. Thus, immunofluorescence has inferior sensitivity and specificity compared with laser microdissection/mass spectrometry in the typing of immunoglobulin-derived amyloidosis.
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A Magnetotelluric profile stretching northward from the Wulungu Depression (on the northern margin of the Junggar Basin) to the Dulate arc (crossing the Zhaheba–Aermantai ophiolite belt) was carried ...out in an attempt to probe the crustal structure and properties of the East Junggar, NW China. Along the profile, the inversion model was used to determine the electrical structure of the crust and uppermost mantle. The results revealed that the crust of the eastern Junggar Basin is composed of the shallow low resistivity layer and underlying high resistivity bodies. There is a crustal detachment in the basement: the upper layer is a Hercynian folded basement and the lower is a Precambrian basement. The Zhaheba complex is characterized by relatively high resistivity, with a thickness of ~5 km, the bottom controlled by the Zhaheba–Aermantai fault. The crust of the Yemaquan arc is composed of the residual continental crust, characterized by stable resistance. The exposed intrusive rocks are characterized by irregular resistors. The crust of the Dulate arc is characterized by relatively low resistivity. The shallow low resistivity layers represent the Zhaheba depression composed of the Devonian-Permian volcanic and sedimentary rocks. The crustal conductive anomalies are related to the magmatism and mechanism of metal deposits in the post-collision period.
As an essential step in the restoration of Terracotta Warriors, the results of fragments classification will directly affect the performance of fragments matching and splicing. However, most of the ...existing methods are based on traditional technology and have low accuracy in classification. A practical and effective classification method for fragments is an urgent need. In this case, an attention-based multi-scale neural network named AMS-Net is proposed to extract significant geometric and semantic features. AMS-Net is a hierarchical structure consisting of a multi-scale set abstraction block (MS-BLOCK) and a fully connected (FC) layer. MS-BLOCK consists of a local-global layer (LGLayer) and an improved multi-layer perceptron (IMLP). With a multi-scale strategy, LGLayer can parallel extract the local and global features from different scales. IMLP can concatenate the high-level and low-level features for classification tasks. Extensive experiments on the public data set (ModelNet40/10) and the real-world Terracotta Warrior fragments data set are conducted. The accuracy results with normal can achieve 93.52% and 96.22%, respectively. For real-world data sets, the accuracy is best among the existing methods. The robustness and effectiveness of the performance on the task of 3D point cloud classification are also investigated. It proves that the proposed end-to-end learning network is more effective and suitable for the classification of the Terracotta Warrior fragments.
Background and purpose: Circular RNA (circRNA) plays an important regulatory role in the development of a variety of tumors. However, the abnormal expression and biological function of circRNA in ...nasopharyngeal carcinoma remain unclear. This study aimed to explore the effect of hsa_circ_0012779 on the biological behavior of nasopharyngeal carcinoma cells and its molecular mechanism. Methods: The expression of hsa_circ_0012779 in human immortalized nasopharyngeal epithelial cell line NP69 and nasopharyngeal carcinoma cell lines CNE2, 5-8F, HNE1 and SUNE1 was detected by real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR). Cell counting kit-8 (CCK-8) assay and transwell invasion assay were used to detect the effect of hsa_circ_0012779 on the proliferation and invasion ability of nasopharyngeal carcinoma cells. The protein level of ELAV like protein 1 (ELAVL1) in NPC cells with hsa_circ_0012779 knockdown was detected by Western blot. The binding of hsa_circ_0012779 and ELAVL1 was verified by RNA pull-down assay. Results: hsa_circ_0012779 was highly expressed in nasopharyngeal carcinoma tissues and cells. Knockdown hsa_circ_0012779 could inhibit the proliferation and invasion of nasopharyngeal carcinoma cells. hsa_circ_0012779 bound to RNA-binding protein ELAVL1 to promote its expression and colocalization in cytoplasm. In the meanwhile, the effect of knockdown hsa_circ_0012779 on nasopharyngeal carcinoma cells could be reversed by the overexpression of ELAVL1. Conclusion: hsa_circ_0012779 promote the expression of ELAVL1 and thus promote the proliferation and invasion of nasopharyngeal carcinoma, and influence the occurrence and development of nasopharyngeal carcinoma.
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