Pandemics have become more frequent and more complex during the twenty-first century. Posttraumatic stress disorder (PTSD) following pandemics is a significant public health concern. We sought to ...provide a reliable estimate of the worldwide prevalence of PTSD after large-scale pandemics as well as associated risk factors, by a systematic review and meta-analysis. We systematically searched the MedLine, Embase, PsycINFO, Web of Science, CNKI, WanFang, medRxiv, and bioRxiv databases to identify studies that were published from the inception up to August 23, 2020, and reported the prevalence of PTSD after pandemics including sudden acute respiratory syndrome (SARS), H1N1, Poliomyelitis, Ebola, Zika, Nipah, Middle Eastern respiratory syndrome coronavirus (MERS-CoV), H5N1, and coronavirus disease 2019 (COVID-19). A total of 88 studies were included in the analysis, with 77 having prevalence information and 70 having risk factors information. The overall pooled prevalence of post-pandemic PTSD across all populations was 22.6% (95% confidence interval (CI): 19.9-25.4%, I
: 99.7%). Healthcare workers had the highest prevalence of PTSD (26.9%; 95% CI: 20.3-33.6%), followed by infected cases (23.8%: 16.6-31.0%), and the general public (19.3%: 15.3-23.2%). However, the heterogeneity of study findings indicates that results should be interpreted cautiously. Risk factors including individual, family, and societal factors, pandemic-related factors, and specific factors in healthcare workers and patients for post-pandemic PTSD were summarized and discussed in this systematic review. Long-term monitoring and early interventions should be implemented to improve post-pandemic mental health and long-term recovery.
Chemical modification of electrode materials by heteroatom dopants is crucial for improving storage performance in rechargeable batteries. Electron configurations of different dopants significantly ...influence the chemical interactions inbetween and the chemical bonding with the host material, yet the underlying mechanism remains unclear. We revealed competitive doping chemistry of Group IIIA elements (boron and aluminum) taking nickel‐rich cathode materials as a model. A notable difference between the atomic radii of B and Al accounts for different spatial configurations of the hybridized orbital in bonding with lattice oxygen. Density functional theory calculations reveal, Al is preferentially bonded to oxygen and vice versa, and shows a much lower diffusion barrier than BIII. In the case of Al‐preoccupation, the bulk diffusion of BIII is hindered. In this way, a B‐rich surface and Al‐rich bulk is formed, which helps to synergistically stabilize the structural evolution and surface chemistry of the cathode.
A model study has been performed on Group IIIA element (boron and aluminum) co‐doped high‐nickel layered oxide cathode materials to understand competitive doping chemistry. A notable difference between the atomic radii of B and Al accounts for different spatial configurations of the hybridized orbital in bonding with lattice oxygen, resulting in the formation of a B‐rich surface and an Al‐rich bulk.
Enhanced drug delivery can improve the therapeutic efficacy of drugs and help overcome side effects. However, many reported drug‐delivery systems are too complex and irreproducible for practical use. ...In this work, the design of a hypoxia‐responsive molecular container based on calixarene, called CAC4A, which presents a significant advance in practical, hypoxia‐targeted drug‐delivery, is reported. CAC4A enables a wide variety of clinical drugs to be quantitatively loaded to improve their solubility and stability, as well as enable the administration of reduced doses. Furthermore, as a result of its azo functional groups, which are sensitive to reduction within a hypoxic environment, it is possible to achieve tumor‐targeted drug‐release with reduced side effects. CAC4A fulfils all essential requirements for a drug‐delivery system in addition to multiple advantages, including facile preparation, well‐defined molecular weight, and structure, and universal applicability. Such features collectively enable supramolecular prodrugs to be formulated simply and reproducibly, with potential for bench‐to‐bedside translation. Moreover, CAC4A is amenable to other therapy modalities and can be facilely decorated with functional groups and hybridized with nanomaterials, providing ample possibilities for its role in future drug‐delivery systems.
Carboxylated azocalix4arene is designed as a hypoxia‐responsive molecular container, which affords strong binding toward a series of chemotherapeutic drugs, and improves the drugs’ solubility and stability, demonstrating its universality as a supramolecular drug carrier. Taking one supramolecular prodrug as an example, the efficacy of this hypoxia‐targeted therapy is validated in vitro and in vivo.
With the development of clean hydrogen energy, the cost effective and high‐performance hydrogen evolution reaction (HER) electrocatalysts are urgently required. Herein, a green, facile, and ...time‐efficient Ru doping synergistic with air‐plasma treatment strategy is reported to boost the HER performance of CoNi‐layered double hydroxide (LDH) nanotube arrays (NTAs) derived from zeolitic imidazolate framework nanorods. The Ru doping and air‐plasma treatment not only regulate the oxygen vacancy to optimize the electron structure but also increase the surface roughness to improve the hydrophilicity and hydrogen spillover efficiency. Therefore, the air plasma treated Ru doped CoNi‐LDH (P‐Ru‐CoNi‐LDH) nanotube arrays display superior HER performance with an overpotential of 29 mV at a current density of 10 mA cm−2. Furthermore, by assembling P‐Ru‐CoNi‐LDH as both cathode and anode for two‐electrode urea‐assisted water electrolysis, a small cell voltage of 1.36 V is needed at 10 mA cm−2 and can last for 100 h without any obvious activity attenuation that showing outstanding durability. In general, the P‐Ru‐CoNi‐LDH can improve the HER performance from intrinsic electronic structure regulation cooperated with extrinsic surface wettability modification. These findings provide an effective intrinsic and extrinsic synergistic effect avenue to develop high performance HER electrocatalysts, which is potential to be applied to other research fields.
With the Ru‐doping in CoNi‐LDH, the air‐plasma treatment was tend to introduce appropriate O and N filling that can effectively regulate the electronic structure. What's more, the plasma treatment also increases the superwettability of the samples which facilitate the H2 spillover process. The synergistically regulation of the intrinsic electronic structure and interface wettability of CoNi‐LDH can boost the HER process.
Abstract
We present the results from a spectroscopic monitoring campaign to obtain reverberation mapping measurements and investigate the broad-line region (BLR) kinematics for active galactic nuclei ...(AGNs) of Mrk 817 and NGC 7469. This campaign was undertaken with the Lijiang 2.4 m telescope. The median spectroscopic sampling is 2.0 days for Mrk 817 and 1.0 day for NGC 7469. We detect time lags of the broad emission lines, including H
β
, H
γ
, He
ii,
and He
i
for both AGNs, including Fe
ii
for Mrk 817 with respect to the varying AGN continuum at 5100 Å. Investigating the relationship between line widths and time lags of the broad emission lines, we find that the BLR dynamics of Mrk 817 and NGC 7469 are consistent with the virial prediction. We estimate the masses of central supermassive black holes (SMBHs) and the accretion rates of both AGNs. Using the data of this campaign, we construct the velocity-resolved lag profiles of the broad H
γ
, H
β
, and He
i
lines for Mrk 817, which show almost the same kinematic signatures in that the time lags in the red wing are slightly larger than the time lags in the blue wing. For NGC 7469, we only clearly construct the velocity-resolved lag profiles of the broad Hγ and Hβ, which show very similar kinematic signatures to the BLR of Mrk 817. These signatures indicate that the BLR of Keplerian motion in both AGNs seemingly has outflowing components during the monitoring period. We discuss the kinematics of the BLR and the measurements, including SMBH mass and accretion rates.
Developing highly efficient, low‐cost electrocatalysts with long‐time stability at high current density working conditions for hydrogen evolution reaction (HER) remains a great challenge for the ...large‐scale commercialization of hydrogen production from water electrolysis. Herein, the Cr‐doped CoP nanorod arrays on carbon cloth (Cr‐CoP‐NR/CC) is reported as high performance HER catalysts with overpotentials of 38 and 209 mV at the HER current densities of 10 and 500 mA cm−2, respectively, outperforming the performance of the commercial Pt/C at high current density. And its HER performance shows almost no loss after 20 h working at 500 mA cm−2. The high performance is attributed to the Cr doping, which optimizes the hydrogen binding energy of CoP and prevents its oxidation. The nanorod array structure helps the escaping of the generated hydrogen gas, which is suitable for working at high current density. The obtained Cr‐CoP‐NR/CC catalyst shows the potential to replace the costly Pt‐based HER catalysts in the water electrolyzer.
Transition metal phosphides are promising catalysts for hydrogen evolution reaction (HER) but still have the gaps to the commercial noble metal catalysts. This study reports a Cr‐doping method to fabricate high‐active and high‐stability Cr‐doped CoP nanorod arrays for HER at high current density, demonstrating that charge transfer and surface Cr species contribute to the performance enhancement.
Abstract With the rapid development of quantum technology, the growing manipulated Hilbert space makes learning the dynamics of the quantum system a significant challenge. Machine learning technique ...has brought apparent advantages in some learning strategies, therefore, we introduce it to indirect learning in this paper. Based on Choi–Jamiolkowski isomorphism, we propose a protocol that learns the dynamics of an inaccessible quantum system using a quantum device at hand. For an n -qubit system, the learning task can be done iteratively, with operational complexity O ( poly ( n , L ) / ϵ 2 ) in each iteration, where L is the circuit depth and ε is the measurement error. Then we theoretically prove its noise resilience to global depolarization, state preparation and measurement noise, and unitary noise in gates implementation, where we find the learned dynamics stay invariant. Finally, we investigate the protocol experimentally on a nitrogen-vacancy center system with a natural noise source. The results show that the behavior of a relatively intractable nuclear spin can be learned through an easily accessible electron spin under different noise models, demonstrating the protocol’s feasibility.
Epstein-Barr virus (EBV)-associated epithelial cancers, including nasopharyngeal carcinoma (NPC) and approximately 10% of gastric cancers, termed EBVaGC, represent 80% of all EBV-related ...malignancies. However, the exact role of EBV in epithelial cancers remains elusive. Here, we report that EBV functions in vasculogenic mimicry (VM). Epithelial cancer cells infected with EBV develop tumor vascular networks that correlate with tumor growth, which is different from endothelial-derived angiogenic vessels and is VEGF-independent. Mechanistically, activation of the PI3K/AKT/mTOR/HIF-1α signaling cascade, which is partly mediated by LMP2A, is responsible for EBV-induced VM formation. Both xenografts and clinical samples of NPC and EBVaGC exhibit VM histologically, which are correlated with AKT and HIF-1α activation. Furthermore, although anti-VEGF monotherapy shows limited effects, potent synergistic antitumor activities are achieved by combination therapy with VEGF and HIF-1α-targeted agents. Our findings suggest that EBV creates plasticity in epithelial cells to express endothelial phenotype and provides a novel EBV-targeted antitumor strategy.
Sodium‐ion batteries (SIBs) have been considered as potential candidates for stationary energy storage because of the low cost and wide availability of Na sources. O3‐type layered oxides have been ...considered as one of the most promising cathodes for SIBs. However, they commonly show inevitable complicated phase transitions and sluggish kinetics, incurring rapid capacity decline and poor rate capability. Here, a series of sodium‐sufficient O3‐type NaNi0.5Mn0.5‐
x
Ti
x
O2 (0 ≤ x ≤ 0.5) cathodes for SIBs is reported and the mechanisms behind their excellent electrochemical performance are studied in comparison to those of their respective end‐members. The combined analysis of in situ X‐ray diffraction, ex situ X‐ray absorption spectroscopy, and scanning transmission electron microscopy for NaNi0.5Mn0.2Ti0.3O2 reveals that the O3‐type phase transforms reversibly into a P3‐type phase upon Na+ deintercalation/intercalation. The substitution of Ti for Mn enlarges interslab distance and could restrain the unfavorable and irreversible multiphase transformation in the high voltage regions that is usually observed in O3‐type NaNi0.5Mn0.5O2, resulting in improved Na cell performance. This integration of macroscale and atomicscale engineering strategy might open up the modulation of the chemical and physical properties in layered oxides and grasp new insight into the optimal design of high‐performance cathode materials for SIBs.
Here, a structure optimization of NaNi0.5Mn0.5O2 through a partial Ti substitution strategy is designed, yielding a series of sodium‐sufficient O3‐NaNi0.5Mn0.5‐xTixO2 (0 ≤ x ≤ 0.5) cathodes for sodium‐ion batteries for the first time. The substitution of Ti for Mn could suppress irreversible multiphase transformation in the high voltage regions that is usually observed in O3‐type NaNi0.5Mn0.5O2 and retain a highly reversible O3−P3 phase transition, resulting in improved Na cell performance.
Objective
To investigate the clinical characteristics of systemic lupus erythematosus accompanied by autoimmune liver cirrhosis (SLE‐ALC) patients and differences from the non‐cirrhosis group.
...Methods
Forty‐three patients with SLE‐ALC were enrolled in this study from 2653 patients with SLE in Peking University People's Hospital. A descriptive case–control study was performed between SLE‐ALC patients and the entry time‐matched non‐cirrhosis group.
Results
Among the 43 SLE‐ALC patients, 41 (95.3%) were female. Eight patients (18.6%) were first found to have cirrhosis and then diagnosed with SLE. Eighteen patients (41.9%) had jaundice and 27 (62.8%) had esophageal and gastric varices. The age of SLE‐ALC patients was 51.1 ± 17.2 years, which was significantly older than the non‐cirrhosis group (P < 0.001). Lung involvement was more common as initial manifestations in SLE‐ALC patients during the SLE course (P=0.027). Compared with the non‐cirrhosis group, SLE‐ALC patients had worse liver function. A significantly higher rate of hematological system involvement (anemia, leucopenia, and thrombocytopenia) and a higher level of immunoglobulins were observed in SLE‐ALC patients (P<0.05). Moreover, SLE‐ALC patients displayed a lower positive rate of anti‐double‐stranded DNA and anti‐ribosomal P protein (P<0.05). The most common radiologic manifestations are ascitic fluid (72.1%) and splenomegaly (71.4%) in SLE‐ALC patients. Six SLE‐ALC patients underwent liver biopsy, and interface hepatitis was present in all patients.
Conclusions
Cirrhosis is rare in SLE patients but is manifested as a unique pattern of clinical features characterized by late‐onset age, lung involvement, high immunoglobulins, and impaired liver function.
PDF
