Novel 3D Ni1−xCoxSe2 mesoporous nanosheet networks with tunable stoichiometry are successfully synthesized on Ni foam (Ni1−xCoxSe2 MNSN/NF with x ranging from 0 to 0.35). The collective effects of ...special morphological design and electronic structure engineering enable the integrated electrocatalyst to have very high activity for hydrogen evolution reaction (HER) and excellent stability in a wide pH range. Ni0.89Co0.11Se2 MNSN/NF is revealed to exhibit an overpotential (η10) of 85 mV at −10 mA cm−2 in alkaline medium (pH 14) and η10 of 52 mV in acidic solution (pH 0), which are the best among all selenide‐based electrocatalysts reported thus far. In particular, it is shown for the first time that the catalyst can work efficiently in neutral solution (pH 7) with a record η10 of 82 mV for all noble metal‐free electrocatalysts ever reported. Based on theoretical calculations, it is further verified that the advanced all‐pH HER activity of Ni0.89Co0.11Se2 is originated from the enhanced adsorption of both H+ and H2O induced by the substitutional doping of cobalt at an optimal level. It is believed that the present work provides a valuable route for the design and synthesis of inexpensive and efficient all‐pH HER electrocatalysts.
An integrated electrocatalyst comprising 3D mesoporous Ni0.89Co0.11Se2 nanosheet networks on Ni foam is synthesized, and it demonstrates very high activities and excellent stabilities for hydrogen evolution reaction (HER) in all‐pH conditions. Theoretical calculations verify that electronic structure engineering by optimal Co doping enhances the adsorption of H+ and H2O, leading to the advanced all‐pH HER activity of the catalyst.
Since the outbreak in late December 2019 in Wuhan, China, coronavirus disease-2019 (COVID-19) has become a global pandemic. We analyzed and compared the clinical, laboratory, and radiological ...characteristics between survivors and non-survivors and identify risk factors for mortality.
Clinical and laboratory variables, radiological features, treatment approach, and complications were retrospectively collected in two centers of Hubei province, China. Cox regression analysis was conducted to identify the risk factors for mortality.
A total of 432 patients were enrolled, and the median patient age was 54 years. The overall mortality rate was 5.09% (22/432). As compared with the survivor group (n = 410), those in the non-survivor group (n = 22) were older, and they had a higher frequency of comorbidities and were more prone to suffer from dyspnea. Several abnormal laboratory variables indicated that acute cardiac injury, hepatic damage, and acute renal insufficiency were detected in the non-survivor group. Non-surviving patients also had a high computed tomography (CT) score and higher rate of consolidation. The most common complication causing death was acute respiratory distress syndrome (ARDS) (18/22, 81.8%). Multivariate Cox regression analysis revealed that hemoglobin (Hb) <90 g/L (hazard ratio, 10.776; 95% confidence interval, 3.075-37.766; p<0.0001), creatine kinase (CK-MB) >8 U/L (9.155; 2.424-34.584; p = 0.001), lactate dehydrogenase (LDH) >245 U/L (5.963; 2.029-17.529; p = 0.001), procalcitonin (PCT) >0.5 ng/ml (7.080; 1.671-29.992; p = 0.008), and CT score >10 (39.503; 12.430-125.539; p<0.0001) were independent risk factors for the mortality of COVID-19.
Low Hb, high LDH, PCT, and CT score on admission were the predictors for mortality and could assist clinicians in early identification of poor prognosis among COVID-19 patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•Ni/mesoporous TiO2 photothermal catalyst was prepared and applied for MDR reaction.•Activities of prepared photothermal catalyst were investigated under different conditions.•Synergistic effect of ...photothermal catalysis could improve the performance of catalyst.•Mechanism of photothermal synergistic effect was discussed based on characterization of catalyst.
Developing new highly efficient catalytic technique is critical for solar photo -thermal -chemical conversion. Among kinds of techniques, photothermal catalysis attracts an increasing attention. In this paper, a Ni/mesoporous TiO2 photothermal catalyst was prepared and applied for methane dry reforming reaction under high temperature environment. Catalytic activities of the prepared catalyst were investigated in a homemade fixed bed photothermal reactor under different temperatures and lighting conditions. And mechanism of photothermal synergistic effect was characterized by using scanning electron microscope (SEM), high resolution transmission electron microscope (HR-TEM), BET, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), UV–Vis-Nir spectrophotometer and Photoluminescence spectra. The results shown that (1) Catalytic activity of the prepared photothermal catalyst in present work performs better than the public reported catalysts in literatures. (2) Comparisons of light and dark experiments of different catalysts proved that the synergistic effect of photothermal catalysis could significantly improve the formation rates of products, and increase the conversions of reactants. The reason is attributed to the formation of Ni-TiO2 heterogeneous structure, which can broaden the optical response range of incident light, as well as enhance the separation of excited e−/h+ pairs in the semiconductor TiO2. (3) Increasing lighting intensity could enhance the formation rates of CO/H2 correspondingly. (4) Compared to catalytic performances of the catalyst under ultraviolet and visible-near-infrared conditions, full spectrum incident light could improve the formation rates of products under the cooperative effect of different spectrum. The testing results indicate that utilizing photothermal synergistic effects to realize the process intensification is beneficial and instructive for the future solar photo -thermal -chemical conversion.
The
Astragalus
polysaccharide is an important bioactive component derived from the dry root of
Astragalus membranaceus
. This review aims to provide a comprehensive overview of the research progress ...on the immunomodulatory effect of
Astragalus
polysaccharide and provide valuable reference information. We review the immunomodulatory effect of
Astragalus
polysaccharide on central and peripheral immune organs, including bone marrow, thymus, lymph nodes, spleen, and mucosal tissues. Furthermore, the immunomodulatory effect of
Astragalus
polysaccharide on a variety of immune cells is summarized. Studies have shown that
Astragalus
polysaccharide can promote the activities of macrophages, natural killer cells, dendritic cells, T lymphocytes, B lymphocytes and microglia and induce the expression of a variety of cytokines and chemokines. The immunomodulatory effect of
Astragalus
polysaccharide makes it promising for the treatment of many diseases, including cancer, infection, type 1 diabetes, asthma, and autoimmune disease. Among them, the anticancer effect is the most prominent. In short,
Astragalus
polysaccharide is a valuable immunomodulatory medicine, but further high-quality studies are warranted to corroborate its clinical efficacy.
Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to ...investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia.
This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO
/FiO
ratio were used to assess lung injury.
106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO
/FiO
were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO
/FiO
(β = - 0.434, p = 0.003).
Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Herein, an electrochemical oxidative cross‐coupling reaction between terminal alkynes and sulfonylhydrazides has been developed. Tetrabutylammonium iodide is used as the electrolyte and redox medium. ...The significant advantages of this method are high atom efficiency, functional group tolerance, and transition metal‐ and oxidant‐free conditions. Most of the compounds exhibit good inhibitory activity on tumor cell lines, and one of the compounds can inhibit cell migration and induce apoptosis in HeLa cells.
IMPORTANCE: Blood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal and nonfatal outcomes. It is uncertain which BP index is most strongly associated ...with these outcomes. OBJECTIVE: To evaluate the association of BP indexes with death and a composite CV event. DESIGN, SETTING, AND PARTICIPANTS: Longitudinal population-based cohort study of 11 135 adults from Europe, Asia, and South America with baseline observations collected from May 1988 to May 2010 (last follow-ups, August 2006-October 2016). EXPOSURES: Blood pressure measured by an observer or an automated office machine; measured for 24 hours, during the day or the night; and the dipping ratio (nighttime divided by daytime readings). MAIN OUTCOMES AND MEASURES: Multivariable-adjusted hazard ratios (HRs) expressed the risk of death or a CV event associated with BP increments of 20/10 mm Hg. Cardiovascular events included CV mortality combined with nonfatal coronary events, heart failure, and stroke. Improvement in model performance was assessed by the change in the area under the curve (AUC). RESULTS: Among 11 135 participants (median age, 54.7 years, 49.3% women), 2836 participants died (18.5 per 1000 person-years) and 2049 (13.4 per 1000 person-years) experienced a CV event over a median of 13.8 years of follow-up. Both end points were significantly associated with all single systolic BP indexes (P < .001). For nighttime systolic BP level, the HR for total mortality was 1.23 (95% CI, 1.17-1.28) and for CV events, 1.36 (95% CI, 1.30-1.43). For the 24-hour systolic BP level, the HR for total mortality was 1.22 (95% CI, 1.16-1.28) and for CV events, 1.45 (95% CI, 1.37-1.54). With adjustment for any of the other systolic BP indexes, the associations of nighttime and 24-hour systolic BP with the primary outcomes remained statistically significant (HRs ranging from 1.17 95% CI, 1.10-1.25 to 1.87 95% CI, 1.62-2.16). Base models that included single systolic BP indexes yielded an AUC of 0.83 for mortality and 0.84 for the CV outcomes. Adding 24-hour or nighttime systolic BP to base models that included other BP indexes resulted in incremental improvements in the AUC of 0.0013 to 0.0027 for mortality and 0.0031 to 0.0075 for the composite CV outcome. Adding any systolic BP index to models already including nighttime or 24-hour systolic BP did not significantly improve model performance. These findings were consistent for diastolic BP. CONCLUSIONS AND RELEVANCE: In this population-based cohort study, higher 24-hour and nighttime blood pressure measurements were significantly associated with greater risks of death and a composite CV outcome, even after adjusting for other office-based or ambulatory blood pressure measurements. Thus, 24-hour and nighttime blood pressure may be considered optimal measurements for estimating CV risk, although statistically, model improvement compared with other blood pressure indexes was small.
Lower crusts of oceanic plateaus have been rarely studied and their nature remains unclear, due to low probability in preservation. Here we demonstrate that cumulates of the Pengco Complex in central ...Tibet represent the lower crust of an oceanic plateau generated at ~188 Ma. Mineral crystallization order and geochemistry support their formation via low‐P fractionation from anhydrous basaltic melts. The Pengco cumulates are more magnesium rich and more depleted in rare earth elements than the mid‐ocean ridge cumulates, supporting a mantle source more refractory than the depleted MORB mantle (DMM). However, the extrusive rocks outcropped in the Pengco Complex are younger (161–166 Ma) and have a subducted‐related genesis. Such a temporal and genetical decoupling between the lower and upper crustal rocks in the Pengco Complex resulted from the subduction re‐initiation that was triggered by the oceanic plateau‐continent collision at ~164 Ma.
An efficient electrochemical transformation of structurally diverse sulfonyl hydrazides and thiols into thiosulfonates in the presence of ammonium iodide as redox catalyst and electrolyte in ...acetonitrile at ambient temperature is reported. Transition metal- and oxidant-free conditions are the striking features of this protocol. The in vitro cytotoxicity of all compounds is evaluated by MTT assay against four human cancer cell lines. The results reveal that 3ac and 3ag exhibit potential inhibitory activity against tumor cells. Furthermore, 3ag inhibits cell migration ability and tubulin polymerization in T-24 cells, leading to cell cycle arrest and apoptosis.
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