BackgroundCancer is one of the leading causes of death. The current work aims to investigate the association between C-reactive protein-triglyceride glucose index (CTI) and the risk of incident ...cancer mortality and to evaluate the usefulness of CTI to refine the risk stratification of cancer mortality.MethodsThe study enrolled 19,957 subjects from American National Health and Nutrition Examination Survey. CTI was defined as 0.412*Ln(CRP) + lnT.G. (mg/dL) × FPG (mg/dL)/2. Cox regression was performed to investigate the association.ResultsDuring a follow-up of 215417.52 person-years, 736 subjects died due to malignant tumors, and the incidence of cancer mortality was 3.42 per 1,000 person-years. Kaplan–Meier curve revealed that the fourth quartile group had the lowest cancer mortality-free rate (Log-Rank p < 0.001). After full adjustment, each SD increase of CTI cast a 32.7% additional risk of incident cancer mortality. Furthermore, cancer mortality risk elevated proportionally with the increase of CTI. Finally, ROC and reclassification analyses supported the usefulness of CTI in improving the risk stratification of incident cancer mortality.ConclusionThe study revealed a significant association between CTI and cancer mortality risk, suggesting the value of CTI in improving the risk stratification of incident cancer mortality. KEY MESAGESC-reactive protein-triglyceride glucose index (CTI) is positively associated with cancer mortality risk in the general population.The association was linear in the whole range of CTI.CTI could improve the risk prediction of cancer mortality in the general population.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, OILJ, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK, VSZLJ
The generation of adventitious roots (ARs) is the key to the success of cuttings. The appropriate environment for AR differentiation in tea plants is acidic. However, the mechanism is unclear. In ...this study, pH 4.5 was suitable condition for the differentiation of AR in tea plants. At the base of cuttings, the root primordia differentiated ARs more rapidly at pH 4.5 than pH 7.0, and nine AR differentiation-related genes were found to be differentially expressed in 30 days, the result was also validated by qRT-PCR. The promoter regions of these genes contained auxin and brassinosteroid response elements. The expression levels of several genes which were involved in auxin and brassinosteroid synthesis as well as signaling at pH 4.5 compared to pH 7.0 occurred differential expression. Brassinolide (BL) and indole-3-acetic acid (IAA) could affect the differentiation of ARs under pH 4.5 and pH 7.0. By qRT-PCR analysis of genes during ARs generation, BL and IAA inhibited and promoted the expression of
CsIAA14
gene, respectively, to regulate auxin signal transduction. Meanwhile, the expression levels of
CsKNAT4
,
CsNAC2
,
CsNAC100
,
CsWRKY30
and
CsLBD18
genes were up-regulated upon auxin treatment and were positively correlated with ARs differentiation.This study showed that pH 4.5 was the most suitable environment for the root primordia differentiation of AR in tea plant. Proper acidic pH conditions promoted auxin synthesis and signal transduction. The auxin initiated the expression of AR differentiation-related genes, and promoted its differentiated. BL was involved in ARs formation and elongation by regulating auxin signal transduction.
Key message
Acidic environments promote auxin synthesis and regulate root primordia differentiation to form ARs by initiating AR differentiation-related genes expression in
Camellia sinensis.
It is known to all that mobile ad hoc network (MANET) is more vulnerable to all sorts of malicious attacks which affects the reliability of data transmission because the network has the ...characteristics of wireless, multi-hop, etc. We put forward novel approach of distributed & adaptive trust metrics for MANET in this paper. Firstly, the method calculates the communication trust by using the number of data packets between nodes, and predicts the trust based on the trend of this value, and calculates the comprehensive trust by considering the history trust with the predict value; then calculates the energy trust based on the residual energy of nodes and the direct trust based on the communication trust and energy trust. Secondly, the method calculates the recommendation trust based on the recommendation reliability and the recommendation familiarity; adopts the adaptive weighting, and calculates the integrate direct trust by considering the direct trust with recommendation trust. Thirdly, according to the integrate direct trust, considering the factor of trust propagation distance, the indirect trust between nodes is calculated. The feature of the proposed method is its ability to discover malicious nodes which can partition the network by falsely reporting other nodes as misbehaving and then proceeds to protect the network. Simulation experiments and tests of the practical applications of MANET show that the proposed approach can effectively avoid the attacks of malicious nodes, besides, the calculated direct trust and indirect trust about normal nodes are more conformable to the actual situation.
Time-reversal invariant topological insulator is widely recognized as one of the fundamental discoveries in condensed matter physics, for which the most fascinating hallmark is perhaps a spin-based ...topological protection, the absence of scattering of conduction electrons with certain spins on matter surface. Recently, it has created a paradigm shift for topological insulators, from electronics to photonics, phononics and mechanics as well, bringing about not only involved new physics but also potential applications in robust wave transport. Despite the growing interests in topologically protected acoustic wave transport, T-invariant acoustic topological insulator has not yet been achieved. Here we report experimental demonstration of anomalous Floquet topological insulator for sound: a strongly coupled metamaterial ring lattice that supports one-way propagation of pseudo-spin-dependent edge states under T-symmetry. We also demonstrate the formation of pseudo-spin-dependent interface states due to lattice dislocations and investigate the properties of pass band and band gap states.
As a cathode for sodium‐ion batteries (SIBs), Na3V2(PO4)2F3 (NVPF) with 3D open framework is a promising candidate due to its high working voltage and large theoretical capacity. However, the severe ...capacity degradation and poor rate capability hinder its practical applications. The present study demonstrated the optimization of Na‐storage performance of NVPF via delicate lattice modulation. Aliovalent substitution of V3+ at Na+ in NVPF induces the generation of electronic defects and expansion of Na+‐migration channels, resulting in the enhancement in electronic conductivity and acceleration of Na+‐migration kinetics. It is disclosed that the formed stronger NaO bonds with high ionicity than VO bonds lead to the significant increase in structural stability and ionicity in the Na+‐substituted NVPF (NVPF‐Nax). The aforementioned effects of Na+ substitution achieve the unprecedented electrochemical performance in the optimized Na3.14V1.93Na0.07(PO4)2F3 (NVPF‐Na0.07). As a result, NVPF‐Na0.07 delivers a high‐rate capability (77.5 mAh g−1 at 20 C) and ultralong cycle life (only 0.027% capacity decay per cycle over 1000 cycles at 10 C). Sodium‐ion full cells are designed using NVPF‐Na0.07 as cathode and Se@reduced graphene oxide as anode. The full cells exhibit excellent wide‐temperature electrochemical performance from −25 to 25°C with an outstanding rate capability (96.3 mAh g−1 at 20 C). Furthermore, it delivered an excellent cycling performance over 300 cycles with a capacity retention exceeding 90% at 0.5 C under different temperatures. This study demonstrates a feasible strategy for the development of advanced cathode materials with excellent electrochemical properties to achieve high‐efficiency energy storage.
An advanced Na3.14V1.93Na0.07(PO4)2F3 cathode with high ionicity and excellent energy‐storage performance is prepared via aliovalent substitution of V3+ at Na+ sites. It exhibits the higher structural stability and improved electron/ion‐transport kinetics than the pristine Na3V2(PO4)2F3 owing to the stronger NaO and VO bonds, thereby extending the cycle life of NASICON cathode materials.
Flexible power sources featuring high-performance, prominent flexibility and raised safety have received mounting attention in the area of wearable electronic devices. However, many great challenges ...remain to be overcome, notably the design and fabrication of flexible electrodes with excellent electrochemical performance and matching them with safe and reliable electrolytes. Herein, a facile approach for preparing flexible electrodes, which employs carbon cloth derived from commercial cotton cloth as the substrate of cathode and a flexible anode, is proposed and investigated. The promising cathode (NVPOF@FCC) with high conductivity and outstanding flexibility is prepared by efficiently coating Na
3
V
2
(PO
4
)
2
O
2
F (NVPOF) on flexible carbon cloth (FCC), which exhibits remarkable electrochemical performance and the significantly improved reaction kinetics. More importantly, a novel flexible quasi-solid-state sodium-ion full battery (QSFB) is feasibly assembled by sandwiching a P(VDF-HFP)-NaClO
4
gel-polymer electrolyte film between the advanced NVPOF@FCC cathode and FCC anode. And the QSFBs are further evaluated in flexible pouch cells, which not only demonstrates excellent energy-storage performance in aspect of great cycling stability and high-rate capability, but also impressive flexibility and safety. This work offers a feasible and effective strategy for the design of flexible electrodes, paving the way for the progression of practical and sustainable flexible batteries.
The Schrödinger equation is a fundamental equation to describe the wave function of a quantum-mechanical system. The similar forms between the Schrödinger equation and the paraxial wave equation ...allow a paradigm shift from the quantum mechanics to classical fields, opening up a plethora of interesting phenomena including the optical super-oscillatory behavior. Here, we propose an ultrasonic meta-lens for generating super-oscillation acoustic wave-packets with different spatial momenta and then superimposing them to a diffraction-limit-broken spot, visually represented by the ring-shaped trapping of tiny particles. Moreover, based on the focused super-oscillation packets, we experimentally verify proof-of-concept super-resolution ultrasound imaging, opening up the arena of super-oscillation ultrasonics for advanced acoustic imaging, biomedical applications, and versatile far-field ultrasound control.
The combination of small organic molecules and a base serves as a unique system for the activation carbon-halogen bonds in haloarenes by single electron transfer (SET). However, most of the molecules ...employed as promoters only allow for the activation of aryl iodides, and efficient activation of aryl bromides and chlorides under this mode is still rather challenging. Herein, we report the discovery of a structurally simple yet powerful promoter molecule, indoline, which exhibits unusually high activity in promoting the activation of haloarenes by SET. In the presence of
-BuOK and a trace amount of oxygen, indoline promotes the formation of aryl radicals not only from aryl iodides and bromides, but also from unactivated aryl chlorides (
, chlorobenzene) under relatively mild conditions. Mechanistic studies reveal the molecular basis for its high activity, for which the aromatization process plays a key role in modulating the electron transfer process.
Peptide deformylase can catalyse the removal of formyl groups from the N-terminal formyl methionine of the primary polypeptide chain. The peptide deformylase genes of a few herbaceous plants have ...been studied to some extent, but the peptide deformylase genes of woody plants have not been studied. In this study, we isolated EuPDF1B from Eucommia ulmoides Oliv. The full-length sequence of EuPDF1B is 1176 bp long with a poly-A tail and contains an open reading frame of 831 bp that encodes a protein of 276 amino acids. EuPDF1B was localized to the chloroplast. qRT‒PCR analysis revealed that this gene was expressed in almost all tissues tested but mainly in mature leaves. Moreover, the expression of EuPDF1B was enhanced by ABA, MeJA and GA and inhibited by shading treatment. The expression pattern of EuPDF1B was further confirmed in EuPDF1Bp: GUS transgenic tobacco plants. Among all the transgenic tobacco plants, EuPDF1Bp-3 showed the highest GUS histochemical staining and activity in different tissues. This difference may be related to the presence of enhancer elements in the region from - 891 bp to - 236 bp of the EuPDF1B promoter. In addition, the expression of the chloroplast gene psbA and the net photosynthetic rate, fresh weight and height of tobacco plants overexpressing EuPDF1B were greater than those of the wild-type tobacco plants, suggesting that EuPDF1B may promote the growth of transgenic tobacco plants. This is the first time that PDF and its promoter have been cloned from woody plants, laying a foundation for further analysis of the function of PDF and the regulation of its expression.
•The influence of beam span on the impact responses are investigated using a validated FE model.•Characteristics of local shear failure mechanisms under impact are investigated.•A simplified model ...for shear damage evaluation of RC beams under impact is proposed.
High-fidelity finite element models of drop weight tests on reinforced concrete (RC) beams conducted previously by the authors are developed and validated by comparing the numerically simulated results with measured experimental data. The validated models are then utilized to examine the influence of beam span on the impact responses of typical beams. It is shown that the beam response is characterized by localization at an early stage during the impact process. By employing a modified span to characterize this response localization, the characteristics of local shear failure mechanisms under impact are investigated. Finally, a simplified three-degree-of-freedom model considering response characteristics of both local shear and overall flexural deformation modes is proposed and shown to perform comparably to the finite element simulations. The concept of a mass-velocity interaction diagram is proposed for shear damage evaluation of RC beams under impact.
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