Objective
To investigate the relationship between pretreatment plasma D-dimer levels and survival in Chinese patients with small cell lung cancer (SCLC).
Methods
This retrospective study enrolled 82 ...patients with SCLC treated at Beijing Chaoyang Hospital, Capital Medical University, from January 2012 to January 2015. All patients were followed up. Associations between pretreatment plasma D-dimer levels measured by immunoturbidimetric assay and clinical outcomes were analyzed by Kaplan–Meier and multivariate analyses, using a cut-off level of 0.55 mg/L fibrinogen equivalent units (FEU).
Results
Median progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with low D-dimer levels (≤0.55 mg/L FEU; 8.0 and 17.0 months, respectively) compared with patients with high levels (>0.55 mg/L FEU; 5.0 and 9.0 months, respectively). Plasma D-dimer levels, Karnofsky performance status, N stage, TNM stage, treatment, and neuron-specific enolase (NSE) levels were significantly associated with PFS, while D-dimer levels, N stage, TNM stage, and treatment were significantly associated with OS. Multivariate analysis revealed that TNM stage, treatment, and NSE levels were independently associated with PFS, while D-dimer levels and treatment were independently associated with OS.
Conclusions
Pretreatment plasma D-dimer levels were independently associated with OS in patients with SCLC.
At present, the research on flotation separation of cassiterite and gangue minerals is mainly focused on the development of new collectors or depressants, while the research on combined depressants ...is rare. In this study, the flotation separation of cassiterite and the typical gangue mineral, calcite, was investigated using the metal-inorganic complex depressant AlSS, composed of aluminum sulfate (Al2(SO4)3) and water glass (Na2SiO3·4H2O). The flotation results indicated that, with the assistance of Al3+, the inhibition effect of SS (water glass) on calcite is significantly enhanced, while the inhibition effect on cassiterite is almost unchanged. The zeta potential and adsorption measurements proved that the formation of the negatively charged colloidal particles composed of Alm(OH)n3m−n and SiOm(OH)n4−2m−n tended to adsorb on the positively charged calcite surface, inhibiting the adsorption of sodium oleate (NaOL), while the adsorption of the colloidal particles on the negatively charged cassiterite surface is relatively less. The contact angle measurements indicate that the contact angle of cassiterite in the NaOL + AlSS solution is obviously larger than that of calcite, which indicates that cassiterite has better floatability in this system. The X-ray photoelectron spectroscopy (XPS) analysis confirms the Al and Si species are adsorbed on the surface of calcite, but not on the cassiterite. In addition, the adsorption of AlSS on cassiterite and calcite changes the chemical environment on the calcite surface, indicating that the adsorption of AlSS on the mineral surface is more inclined to be through a chemical reaction.
Due to the optimum dissolution of the hydroxyl ion, serpentine is positively charged and tends to cover the sulfide mineral surface as a slime coating through electrostatic attraction, which ...intensively worsens sulfide flotation. To handle this problem, the sodium of polyaspartic acid (PASP) was employed as the selective depressant for the flotation of pyrite from serpentine in this work. Micro-flotation results showed that the fine serpentine of −10 µm could intensively hinder pyrite flotation, with a maximum decrease of about 75.8% in pyrite recovery at pH 9. However, at this pH, pyrite recovery remarkably increased from 20.17% to 92.68% when 15 mg/L PASP was introduced. Zeta potential results depicted that the addition of PASP overcompensated the positive charge on the serpentine surface and rendered it negative, while it had little impact on that of pyrite. Hence, the hetero-coagulation between serpentine and pyrite was broken due to the electrostatic repulsion, which was further confirmed by turbidity results. After that, the adsorption of PAX on the pyrite surface was restored, and the selective flotation of pyrite from serpentine was obtained. XPS analyses revealed that the chelation interaction between the carboxylate groups in PASP and the magnesium cations that remained on the serpentine surface were the main driving forces for the adsorption of PASP on the serpentine surface.
Nostolachma jenkinsii (Hook.f.) Deb & J.Lahiri, a member of the Rubiaceae family, is an endangered wild plant species with potential economic value. In this research, the complete chloroplast genome ...of N. jenkinsii was sequenced to gain insight into its genome feature and better understand the phylogenetic relationships among the Rubiaceae species. The chloroplast genome, with a total length of 155,036 bp, comprises two inverted repeats (IR) regions spanning 25,692 bp each, a large single-copy (LSC) region measuring 85,437 bp, and a short single-copy (SSC) region measuring 18,215 bp. There is an overall 37% GC content in the chloroplast genome. By annotation analysis,. 54 tRNA genes, 10 rRNA genes, and 107 protein-coding genes were all annotated in N. jenkinsii. Furthermore, we applied phylogenetic analysis that revealed a close relationship between N. jenkinsii, D. fruticosa and D. dubia, placing them together within the Rubiaceae family.
It is difficult to separate molybdenite and chalcopyrite by froth flotation due to the good floatability of the two minerals. In this paper, the separation of copper–molybdenum sulfide minerals was ...realized by using pullulan polysaccharide (PU) as the depressant. The flotation test results showed that the copper concentrate grade increased from 16.24 to 29.86%, and the copper concentrate recovery reached 83.55% under low alkali conditions. The selective separation mechanism of the two minerals by PU was revealed through contact angle measurements, ζ-potential measurements, Fourier transform infrared (FTIR) spectroscopy analyses, and X-ray photoelectron spectroscopy (XPS) analyses. The ζ-potential and contact angle results showed that PU is more easily adsorbed on molybdenite to strengthen the hydrophilicity of molybdenite. The FTIR and XPS results showed that PU is adsorbed on molybdenite by physical interactions, and hydrophobic interactions and hydrogen bonding play a major role.
Multiple myeloma (MM) is an incurable malignancy of mature B-lymphoid cells, and its pathogenesis is only partially understood. Previous studies have demonstrated that a number of Non-Hodgkin ...Lymphoma (NHL) associated genes also show susceptibility to MM, suggesting malignancies originating from B cells may share similar genetic susceptibility. Several recent large-scale genome-wide association studies (GWAS) have identified HLA-I, HLA-II, CXCR5, ETS1, LPP and NCOA1 genes as genetic risk factors associated with NHL, and this study aimed to investigate whether these genes polymorphisms confer susceptibility with MM in the Chinese Han population. In 827 MM cases and 709 healthy controls of Chinese Han, seven single nucleotide polymorphisms (SNPs) in the HLA-I region (rs6457327), the HLA-II region (rs2647012 and rs7755224), the CXCR5 gene (rs4938573), the ETS1 gene (rs4937362), the LPP gene (rs6444305), and the NCOA1 region (rs79480871) were genotyped using the Sequenom platform. Our study indicated that genotype and allele frequencies of rs79480871 showed strong associations with MM patients (pa = 3.5×10-4 and pa = 1.5×10-4), and the rs6457327 genotype was more readily associated with MM patients than with controls (pa = 4.9×10-3). This study was the first to reveal the correlation between NCOA1 gene polymorphisms and MM patients, indicating that NCOA1 might be a novel susceptibility gene for MM patients in the Chinese Han population.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The mechanism of electrochemical interaction between chalcopyrite and hexagonal pyrrhotite was analyzed via electrochemical interaction, copper ion concentration testing, and X-ray photoelectron ...spectroscopy (XPS) characterization. Besides, the effect of electrochemical interaction between the two minerals on the flotation separation was investigated using the mineral flotation tests, adsorption capacity tests, and a microcalorimetric test. Our research results showed that chalcopyrite had higher electrochemical activity than hexagonal pyrrhotite, and when the former acted as an anode during the electrochemical interaction of the two, the corrosion current density was three times higher than that when it acted alone, and the surface oxidation corrosion was intensified. At the same time, the interaction between the two minerals was accompanied by a large number of copper ions dissolved and adsorbed on the surface of the hexagonal pyrrhotite, so that adsorption of butyl xanthate intensified, adsorption increased, and flotation recovery increased by 5%–20%. However, owing to the increase in metal defects and the generation of hydrophilic sulfate, the surface of chalcopyrite hindered the adsorption of butyl xanthate on its surface, and the flotation recovery decreased by nearly 10% compared with that before the occurrence of the electrochemical interaction. This action also significantly weakened the inhibition effect of lime on hexagonal pyrrhotite and increased the difficulty of the flotation separation of the two minerals. The research results of this study provide theoretical guidance for the flotation separation of copper–sulfur ores containing pyrrhotite.
A new species, Uncifera motuoensis (Orchidaceae: Epidedroideae: Aeridinae) from Xizang Autonomous Region, China is described and illustrated with detailed photos and scientific illustration. Detailed ...morphological comparisons indicate that U. motouensis is similar to U. obtusifolia, but differs in having entire mid-lobe of lip, narrower leaf blade and wider pollinarium stipe. For the identification, a key to the known seven species of Uncifera is presented.
Cinnamomum glanduliferum (Wall) Meissn is a commercially important timber tree and wild spice plants of the genus Cinnamomum Trew in the family Lauraceae. To determine its phylogenetic location with ...respect to the other Cinnamomum species, the complete plastid genome of C. glanduliferum was sequenced. The whole plastome is 152,715 bp in length, consisting of a pair of inverted repeat (IR) regions of 20,114 bp, one large single copy (LSC) region of 93,617 bp, and one small single copy (SSC) region of 18,870 bp. The overall GC content of the whole plastome is 39.1%. Further, maximum likelihood phylogenetic analyse was conducted using 13 complete plastomes of the Lauraceae, which support close relationship between C. glanduliferum and C. bodinieri.
Alseodaphne petiolaris Hook.f. is a valuable timber tree of the genus Alseodaphne Nees in the family Lauraceae. To better determine its phylogenetic location with respect to the other Alseodaphne ...species, the complete plastid genome of A. petiolaris was sequenced. The whole plastome is 152,986 bp in length, consisting of a pair of inverted repeat (IR) regions of 20,108 bp, one large single copy (LSC) region of 93,863 bp, and one small single copy (SSC) region of 18,907 bp. The overall GC content of the whole plastome is 39.1%. Further, maximum-likelihood phylogenetic analyse was conducted using 15 complete plastomes of the Lauraceae, which support the close relationship between A. petiolaris and the species of Machilus and Phoebe.
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