A
bstract
The Schwarzschild wormhole has been interpreted as an entangled state. If Alice and Bob fall into each of the black hole, they can meet in the interior. We interpret this meeting in terms ...of the quantum circuit that prepares the entangled state. Alice and Bob create growing perturbations in the circuit, and we argue that the overlap of these perturbations represents their meeting. We compare the gravity picture with circuit analysis, and identify the post-collision region as the region storing the gates that are not affected by any of the perturbations.
Petz map and Python’s lunch Zhao, Ying
The journal of high energy physics,
11/2020, Letnik:
2020, Številka:
11
Journal Article
Recenzirano
Odprti dostop
A
bstract
We look at the interior operator reconstruction from the point of view of Petz map and study its complexity. We show that Petz maps can be written as precursors under the condition of ...perfect recovery. When we have the entire boundary system its complexity is related to the volume/action of the wormhole from the bulk operator to the boundary. When we only have access to part of the system, Python’s lunch appears and its restricted complexity depends exponentially on the size of the subsystem one loses access to.
A
bstract
We give a quantum circuit interpretation of evaporating black hole geometry. We make an analogy between the appearance of island for evaporating black hole and the transition from two-sided ...to one-sided black hole in the familiar example of perturbed thermofield double. If Alice perturbs thermofield double and waits for scrambling time, she will have a one-sided black hole with interior of her own. We argue that by similar mechanism the radiation gets access to the interior (island forms) after Page time. The growth of the island happens as a result of the constant transitions from two-sided to one-sided black holes.
One great challenge in understanding the history of life is resolving the influence of environmental change on biodiversity. Simulated annealing and genetic algorithms were used to synthesize data ...from 11,000 marine fossil species, collected from more than 3000 stratigraphic sections, to generate a new Cambrian to Triassic biodiversity curve with an imputed temporal resolution of 26 ± 14.9 thousand years. This increased resolution clarifies the timing of known diversification and extinction events. Comparative analysis suggests that partial pressure of carbon dioxide (
co
) is the only environmental factor that seems to display a secular pattern similar to that of biodiversity, but this similarity was not confirmed when autocorrelation within that time series was analyzed by detrending. These results demonstrate that fossil data can provide the temporal and taxonomic resolutions necessary to test (paleo)biological hypotheses at a level of detail approaching those of long-term ecological analyses.
The process for separating and purifying lithium in brines based on electrodialysis with monovalent selective ion exchange membranes was investigated in our previous work. The migration of coexisting ...cations in brines was competitive with lithium ions, especially monovalent cations (Na+ and K+). The aim of this study was to examine the influence of major coexisting cations in brines on lithium recovery in the selective-electrodialysis (S-ED) process. Considering the factors of coexisting cations, such as concentration and type, some migration laws of lithium ion were found as follows: the concentration of coexisting cations had negative effect on the migration of lithium ion; the influence order of coexisting cations on lithium migration was contrary to their hydrated radius sequence: K+>Na+>Ca2+>Mg2+. In order to characterize the migration process of cations through monovalent selective cation exchange membrane in microcosmic theory, a partial dehydration conceptual model based on charge capillary column theory and ionic potential was proposed. And the model was used to characterize the ions migration process. Simultaneously, considering the hydration potential which indicates how strongly an ion would attract water molecules, the influence sequence of coexisting cations was explained legitimately. These observations might provide some theoretical basis and technological support for the relevant research of recovering lithium from brines.
A partial dehydration conceptual model of ion migration in the cation exchange membrane. Display omitted
•Selective-electrodialysis (S-ED) was used to recover lithium from brine.•Effect of coexisting cations concentration on lithium recovery by S-ED was investigated.•The influence sequence of coexisting cations on lithium migration was K+>Na+>Ca2+>Mg2+.•A partial dehydration model was proposed to discuss the separation mechanism of cations in S-ED process.
Chronic kidney disease (CKD) represents a major challenge to public healthcare. Traditional clinical biomarkers of renal function (blood urea nitrogen and serum creatinine) are not sensitive or ...specific enough and only increase significantly after the presence of substantial CKD. Therefore, more sensitive biomarkers of CKD are needed. CKD-specific biomarkers at an early disease stage and early diagnosis of specific renal diseases would enable improved therapeutic treatment and reduced the personal and financial burdens. The goal of metabolomics is to identify non-targeted, global small-molecule metabolite profiles of complex samples, such as biofluids and tissues. This method offers the potential for a holistic approach to clinical medicine, as well as improvements in disease diagnoses and the understanding of pathological mechanisms. This review article presents an overview of the recent developments in the field of metabolomics, followed by an in-depth discussion of its application to the study of CKD (primary, chronic glomerulonephritis such as IgA nephropathy; secondary, chronic renal injury such as diabetic nephropathy; chronic renal failure including end-stage kidney disease with and without undergoing replacement therapies, etc), including metabolomic analytical technologies, chemometrics, and metabolomics in experimental and clinical research. We describe the current status of the identification of metabolic biomarkers in CKD. Several markers have been confirmed across multiple studies to detect CKD earlier than traditional clinical chemical and histopathological methods. The application of metabolomics in CKD studies provides researchers the opportunity to gain new insights into metabolic profiling and pathophysiological mechanisms. Particular challenges in the field are presented and placed within the context of future applications of metabolomic approaches to the studies of CKD.
•Chronic kidney disease (CKD) is becoming a worldwide public health problem.•Metabolomics provides a powerful platform for CKD.•The identification of novel clinical biomarkers for CKD is needed.•Biomarkers promise to improve clinical CKD diagnosis.
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•A recovery system with LiMn2O4/Li1-xMn2O4 as electrodes was used to extract lithium.•The influence sequence of coexisting ions on lithium extraction was Mg2+> Na+> Ca2+> K+.•The ...values of αLi-Na, αLi-Mg and αLi-Ca were more than 300, 70 and 110, respectively.•The specific energy consumption was between 18 and 19W h·mol−1.
Lithium rechargeable batteries have been used for lithium extraction in recent years. Here, we report on a highly selective lithium recovery system that consists of a LiMn2O4 positive electrode, a Li1-xMn2O4 negative electrode and a monovalent selective anion-exchange membrane. The effect of potential, temperature and coexisting ions on lithium extraction were investigated in this paper, and the lithium recovery system was applied to extract lithium from brine and concentrated seawater. The extraction capacity of Li+ reached 34.31 mg· (1g LiMn2O4) −1 at 1.2V. With higher reaction rate and lower energy consumption, 25°C (room temperature) was considered as the appropriate temperature. The system still remained high selective for Li+ even in the presence of impurity ions (K+, Na+, Mg2+, Ca2+). With simulated brine and concentrated seawater as source solutions, the concentrations of Na+, Mg2+ and Ca2+ were reduced more than 300, 70 and 100 times, consuming 18–19W h per mole of lithium recovered. And the electrodes still had high separation coefficients of Li+ and Men+ (Na+, Mg2+, Ca2+) after five cycles although a slight drop was existing.
Plant secondary metabolites (SMs) are not only a useful array of natural products but also an important part of plant defense system against pathogenic attacks and environmental stresses. With ...remarkable biological activities, plant SMs are increasingly used as medicine ingredients and food additives for therapeutic, aromatic and culinary purposes. Various genetic, ontogenic, morphogenetic and environmental factors can influence the biosynthesis and accumulation of SMs. According to the literature reports, for example, SMs accumulation is strongly dependent on a variety of environmental factors such as light, temperature, soil water, soil fertility and salinity, and for most plants, a change in an individual factor may alter the content of SMs even if other factors remain constant. Here, we review with emphasis how each of single factors to affect the accumulation of plant secondary metabolites, and conduct a comparative analysis of relevant natural products in the stressed and unstressed plants. Expectantly, this documentary review will outline a general picture of environmental factors responsible for fluctuation in plant SMs, provide a practical way to obtain consistent quality and high quantity of bioactive compounds in vegetation, and present some suggestions for future research and development.
Background and Purpose
Tubulo‐interstitial fibrosis is the final pathway in the progression of chronic kidney disease (CKD) to kidney failure. The renin‐angiotensin system (RAS) plays a major role in ...CKD progression. Hence, we determined the efficacy of novel RAS inhibitors isolated from Poria cocos against renal fibrosis.
Experimental Approach
Effects of three novel tetracyclic triterpenoid compounds, poricoic acid ZC (PZC), poricoic acid ZD (PZD) and poricoic acid ZE (PZE), were investigated on TGFβ1‐ and angiotensin II (AngII)‐treated HK‐2 cells and unilateral ureteral obstruction (UUO) in mice. Immunofluorescence staining, quantitative real‐time PCR, siRNA, co‐immunoprecipitation and Western blot analyses were used to evaluate expression of key molecules in RAS, Wnt/β‐catenin and TGFβ/Smad pathways.
Key Results
Addition of the above compounds to culture media and their administration to UUO mice: (i) significantly attenuated epithelial‐to‐mesenchymal transition and extracellular matrix production in TGFβ1‐ and AngII‐treated HK‐2 cells and UUO mice by inhibiting Wnt/β‐catenin pathway activation and Smad3 phosphorylation; (ii) selectively inhibited Smad3 phosphorylation by blocking the interaction of TGFBR1 with Smad3; and (iii) specifically inhibited Smad3 activation. PZC and PZD showed a strong inhibitory effect on all RAS components, and PZE showed a strong inhibitory effect on renin. Furthermore, the secolanostane tetracyclic triterpenoids, PZC and PZD, showed a stronger inhibitory effect than the lanostane tetracyclic triterpenoid PZE. Therefore, compounds with secolanostance skeleton showed stronger bioactivity than those with lanostance skeleton.
Conclusion and Implications
The secolanostane tetracyclic triterpenoids effectively blocked RAS by simultaneously targeting multiple RAS components and lanostane tetracyclic triterpenoids inhibited renin and protected against tubulo‐interstitial fibrosis.
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