Display omitted
► Au nanoparticles with sizes distributed at 1–5
nm are prepared on layered double hydroxide (Au/LDH). ► Au/LDH catalyst has superior catalytic activities in aerobic oxidation of ...alcohols. ► Au/LDH catalyst has good stability and recyclability. ► There is an interaction between Au nanoparticles and LDH support.
Extremely small-size Au nanoparticles mainly distributed at 1–5
nm were successfully prepared on layered double hydroxide by ion-exchange and reduction procedures (Au/LDH). This catalyst showed superior catalytic properties in aerobic oxidation of a wide range of secondary and primary alcohols under very mild conditions (e.g. 1
atm pressure of oxygen and even at room temperature). In addition, this catalyst is stable and recyclable during oxidations. These advantages are reasonably attributed to the interaction between Au sites and basic LDH.
To investigate the role of FOXM1, β-catenin and TCF4 in esophageal cancer (EC) and their relationship to VM (Vasculogenic Mimicry).
CCK-8 were performed to examine EC cell proliferation in FOXM1 ...silenced cells. EC cell migration and invasion were investigated through wound healing and Transwell assays, respectively. The formation of pipe like structures were assessed in 3D cultures. The expression of Foxm1, β-catenin, Tcf4 and E-cadherin were investigated through western blot, RT-qPCR and immunohistochemistry (IHC) staining. The relationship between FOXM1 expression, clinic-pathological features, and overall survival (OS) were further analyzed.
A loss of FOXM1 expression correlated with the OS of ESCC patients. FOXM1 silencing led to a loss of cell growth and suppressed cell migration and invasion in ESCC cells. VM structures were identified in ESCC tissues and human EC cell lines. Mechanistically, FOXM1 was found to promote tumorigenesis through the regulation of β-catenin, Tcf4, and E-cadherin in EC cells, leading to the formation of VM structures.
These findings highlight FoxM1 as a novel therapeutic target in ESCC.
A series of imprinted catalysts were obtained by the covalent attachment of a discrete bis(8-quinolinol)oxovanadium(IV) and bis(8-quinolinol)dioxomolybdenum(VI) complexes onto GO through the ...metal-template/metal-exchange method. The imprinted oxovanadium(IV) and dioxomolybdenum(VI) complexes are efficient and recyclable, which exhibit higher activity and better product selectivity than either their homogeneous ones or randomly grafted analogues due to better site-isolation.
•A series of imprinted catalysts were successfully synthesized. through a metal-template/metal-exchange method.•Characterized by XRD, FT-IR, UV–visible, ICP-AES, TEM, TG, Raman, BET and XPS.•The imprinted catalysts were active and showed good recoverability.
A series of imprinted catalysts were obtained by covalent attachment of discrete bis(8-quinolinol)oxovanadium(IV) or bis(8-quinolinol)dioxomolybdenum(VI) complex onto graphene oxide (GO) through the metal-template/metal-exchange method to control the distribution of covalently attached independent ligands, which were examined as catalysts in the epoxidation of alkenes using t-butylhydroperoxide (TBHP) or H2O2 as oxidant in comparison with their homogeneous counterparts and materials synthesized by random grafting of the ligand. The prepared catalysts were characterized by XRD, N2 adsorption/desorption, TEM, FT-IR, diffusion reflection UV–visible, ICP-AES, TG, Raman, EPR, N element analysis and XPS. FT-IR, diffusion reflection UV–visible, ICP-AES, TG, N element analysis, Raman and XPS results showed that oxovanadium(IV) or dioxomolybdenum(VI) complexes were successfully grafted on GO. XRD, N2 adsorption/desorption and TEM results indicated that the structures of the samples were well preserved. EPR results revealed that the materials synthesized by the metal-template method had better site-isolation compared with conventional materials. Furthermore, these imprinted oxovanadium(IV) or dioxomolybdenum(VI) complex catalysts are efficient and recyclable, which exhibit higher activity and higher selectivity to target product than either their homogeneous ones or randomly grafted analogues due to better site-isolation.
The reaction of direct transformation of ethanol to ethyl acetate was investigated on reduced Cu/ZrO
2
catalysts prepared by a co-precipitation procedure. The catalytic performances of these Cu–Zr ...mixed oxides were considerably influenced by changing the molar ratio of Cu to Zr. The highest selectivity to ethyl acetate was found over Cu/ZrO
2
(1) catalyst (molar ratio of Cu to Zr was 1). A variety of characterization techniques, such as N
2
adsorption, XRD, XPS, TPR and NH
3
-TPD were carried out on the catalysts. The results revealed that the presence of a certain amount of Cu
+
species may play very important role in improving the selectivity to ethyl acetate of the Cu/ZrO
2
catalysts.
Copper-based titanate intercalation electrode materials (referred as Cu–TO) were achieved by electrochemical reduction of the intercalated cupric ions that were ion exchanged on the layer structured ...titanate films by using n-propylamine as an exfoliating agent. The copper-based titanate intercalation electrode materials were characterized by X-ray diffraction (XRD), electrochemical techniques and inductive coupled plasma-atomic emission spectroscopy (ICP-AES). These copper-based titanate materials were exploited to fabricate the enzymeless glucose sensors, and their assay performances to glucose were evaluated by conventional electrochemical techniques. Cyclic voltammetry (CV) and chronoamperometry (I–t) revealed a high sensitivity, fast response, excellent stability, and good reproducibility in the glucose determination at +0.55V. Under optimal conditions, the electrocatalytic response of the sensor was proportional to the glucose concentration in the range of 2.5×10−7M to 8.0×10−3M with a detection limit of 5.0×10−8M (signal-to-noise=3). Moreover, the intercalated copper electrode materials exhibited high stability and improved selectivity for glucose compared with the more apparently accessible copper. This work also provides a simply controlled test-bed for electrochemical functionalization of layered titanate for sensor applications.
Despite advances in DNA methylome analyses of cells and tissues, current techniques for genome-scale profiling of DNA methylation in circulating cell-free DNA （ccfDNA） remain limited. Here we ...describe a methylated CpG tan- dems amplification and sequencing （MCTA-Seq） method that can detect thousands of hypermethylated CpG islands simultaneously in ccfDNA. This highly sensitive technique can work with genomic DNA as little as 7.5 pg, which is equivalent to 2.5 copies of the haploid genome. We have analyzed a cohort of tissue and plasma samples （n = 151） of hepatocellular carcinoma （HCC） patients and control subjects, identifying dozens of high-performance markers in blood for detecting smaU HCC （≤ 3 cm）. Among these markers, 4 （RGS10, ST8SIA6, RUNX2 and VIM） are mostly specific for cancer detection, while the other 15, classified as a novel set, are already hypermethylated in the normal liver tissues. Two corresponding classifiers have been established, combination of which achieves a sensitivity of 94% with a specificity of 89% for the plasma samples from HCC patients （n = 36） and control subjects including cirrho- sis patients （n = 17） and normal individuals （n = 38）. Notably, all 15 alpha-fetoprotein-negative HCC patients were successfully identified. Comparison between matched plasma and tissue samples indicates that both the cancer and noncancerous tissues contribute to elevation of the methylation markers in plasma. MCTA-Seq will facilitate the development of ccfDNA methylation biomarkers and contribute to the improvement of cancer detection in a clinical setting.
Primary testicular lymphoma (PTL) is a rare type of extranodal non-Hodgkin's lymphoma (NHL). Although data of PTL in patients with diffuse large B-cell lymphoma (DLBCL) are accumulating, there are ...still patients respond poorly to prognosis.
All patients had disease of the DLBCL subtype and those patients had primary involvement of the testis. In our studies, eleven patients had stage I/II disease, and 3 patients had advanced disease with B symptoms. Four patients exhibited a MYC+, BCL2+, and BCL6- expression pattern, 4 patients had a MYC+, BCL6+, and BCL2- expression pattern, and 3 patients had a MYC+, BCL2+, and BCL6+ expression pattern. Additionally, 43% (7/16) of PT-DLBCL patients had a germinal center B-cell-like (GCB) phenotype, while the others had a non-GCB phonotype.
In our case, most patients presented with unilateral painless scrotal swelling and the enlargement of the testicles in the first examination. After hospitalization, all patients underwent preoperative imageological examination of the testis and epididymis and postoperative revealed that all patients were the diffuse infiltration of a large number of anomalous lymphocytes. In addition, no invasion of other sites was observed within 3 months after diagnosis.
Underwent orchiectomy on the affected side was performed by urologists after all patients were diagnosed with PTL. Meanwhile, some patients received at least one course of chemotherapy, or received postoperative combined RT and chemotherapy. Because of it particularity, nineteen instances of lymph node region involvement were discovered in 12 patients since the operation.
PT-DLBCL has unique biological characteristics, and its treatment modalities are becoming increasingly standardized. In the future, systematic interventions need to be actively considered in the early stages of PTL.
Hierarchical carbon and nitrogen adsorbed PtNiCo nanocomposites with different morphologies and facets were successfully synthesized via a solvothermal method and showed high electrochemical activity ...and long-term stability towards the methanol oxidation reaction (MOR) and oxygen reduction reaction (ORR). Electrochemical results indicated that the (220) facet-terminated PtNiCoatC-N nanocubes manifest superior electro-catalytic activity compared to other morphologies and facets as well as the commercial state-of-the-art Pt/C catalyst (20%). The surface carbon and nitrogen atoms, multiple active surface sites, and synergistic electronic effects of various elements contribute to the high electro-catalytic performance of the electrocatalysts. It is worth mentioning that the carbon and nitrogen atoms were simultaneously adsorbed onto the surface of the catalysts, which can provide more multiple active sites for these nanocomposites. In order to demonstrate this result, a solvent ligand exchange method was explored to demonstrate that these multiple active sites on the surface of the catalysts can be exchanged into n-hexane solution, and thus the catalytic activity dramatically decreased. The present work highlights the carbon and nitrogen adsorbed PtNiCoatC-N nanocomposites as highly active catalysts for polymer electrolyte membrane fuel cells (PEMFCs).
Ternary RuMPt (M=Fe, Co, Ni, and Cu) nanodendrities (NDs) catalysts, are successfully synthesized by using a facile method. The as-obtained ternary catalysts manifest superior catalytic activity and ...stability both in terms of surface and mass specific activities toward the methanol oxidation and oxygen reduction reactions, as compared to the binary catalysts and the commercial Pt/C catalysts.
Display omitted
•Ternary RuMPt catalysts are synthesized by using a facile method.•The catalysts manifest superior catalytic activity towards the MOR and ORR.•High activities are attributed to enhanced electron density and synergistic effects.
The promising Pt-based ternary catalyst is crucial for polymer electrolyte membrane fuel cells (PEMFCs) due to improving catalytic activity and durability for both methanol oxidation reaction and oxygen reduction reaction. In this work, a facile strategy is used for the synthesis ternary RuMPt (M=Fe, Co, Ni, and Cu) nanodendrities catalysts. The ternary RuMPt alloys exhibit enhanced specific and mass activity, positive half-wave potential, and long-term stability, compared with binary Pt-based alloy and the commercial Pt/C catalyst, which is attributed to the high electron density and upshifting of the d-band center for Pt atoms, and synergistic catalytic effects among Pt, M, and Ru atoms by introducing a transition metal. Impressively, the ternary RuCoPt catalyst exhibits superior mass activity (801.59mAmg−1) and positive half-wave potential (0.857V vs. RHE) towards MOR and ORR, respectively. Thus, the RuMPt nanocomposite is a very promising material to be used as dual electrocatalyst in the application of PEMFCs.
PDF
