Detection of volatile organic compounds (VOCs) at room temperature (RT) currently remains a challenge for metal oxide semiconductor (MOS) gas sensors. Herein, for the first time, we report on the ...utilization of porous SnO2 thin films for RT detection of VOCs by defect engineering of oxygen vacancies. The oxygen vacancies in the three-dimensional-ordered SnO2 thin films, prepared by a colloidal template method, can be readily manipulated by thermal annealing at different temperatures. It is found that oxygen vacancies play an important role in the RT sensing performances, which successfully enables the sensor to respond to triethylamine (TEA) with an ultrahigh response, for example, 150.5–10 ppm TEA in a highly selective manner. In addition, the sensor based on oxygen vacancy-rich SnO2 thin films delivers a fast response and recovery speed (53 and 120 s), which can be further shortened to 10 and 36 s by elevating the working temperature to 120 °C. Notably, a low detection limit of 110 ppb has been obtained at RT. The overall performances surpass most previous reports on TEA detection at RT. The outstanding sensing properties can be attributed to the porous structure with abundant oxygen vacancies, which can improve the adsorption of molecules. The oxygen vacancy engineering strategy and the on-chip fabrication of porous MOS thin film sensing layers deliver great potential for creating high-performance RT sensors.
Van der Waals p–n junctions of 2D materials present great potential for electronic devices due to the fascinating properties at the junction interface. In this work, an efficient gas sensor based on ...planar 2D van der Waals junctions is reported by stacking n‐type and p‐type atomically thin MoS2 films, which are synthesized by chemical vapor deposition (CVD) and soft‐chemistry route, respectively. The electrical conductivity of the van der Waals p–n junctions is found to be strongly affected by the exposure to NO2 at room temperature (RT). The MoS2 p–n junction sensor exhibits an outstanding sensitivity and selectivity to NO2 at RT, which are unavailable in sensors based on individual n‐type or p‐type MoS2. The sensitivity of 20 ppm NO2 is improved by 60 times compared to a p‐type MoS2 sensor, and an extremely low limit of detection of 8 ppb is obtained under ultraviolet irradiation. Complete and very fast sensor recovery is achieved within 30 s. These results are superior to most of the previous reports related to NO2 detection. This work establishes an entirely new sensing platform and proves the feasibility of using such materials for the high‐performance detection of gaseous molecules at RT.
An entirely new sensor platform is proposed based on an atomically thin van der Waals p–n junction of n‐type and p‐type MoS2. Compared to an n‐ or p‐type MoS2 sensor, the sensor based on the MoS2 p–n junction shows outstanding sensitivity, very fast recovery, and selectivity toward NO2 under UV irradiation at room temperature.
► The protective effect of dioscin against APAP-induced liver damage was investigated. ► Dioscin shows remarkable protective effect against the damage in vitro and in vivo. ► The protective effect of ...dioscin was through adjusting mitochondrial function. ► Dioscin should be developed as a new drug for the treatment of liver injury.
The aim of the study was to investigate the protective effect of dioscin against APAP-induced hepatotoxicity. In the in vitro tests, HepG2 cells were given APAP pretreatment with or without dioscin. In the in vivo experiments, mice were orally administrated dioscin for five days and then given APAP. Some biochemical and morphology parameters were assayed and the possible mechanism was investigated. Dioscin improved AST release, mitochondrial dysfunction, apoptosis and necrosis of HepG2 cells induced by APAP. Following administration of dioscin, APAP-induced hepatotoxicity in mice was significantly attenuated. Furthermore, the liver cell apoptosis and necrosis, and hepatic mitochondrial edema were also prevented. Fifteen differentially expressed proteins were found by using proteomics, and six of them, Suox, Krt18, Rgn, Prdx1, MDH and PNP were validated. These proteins may be involved in the hepatoprotective effect of dioscin and might cooperate with the levels of Ca2+ in mitochondria, decreased expression of ATP2A2, and decreased mitochondrial cardiolipin. In addition, dioscin inhibited APAP-induced activation and expression of CYP2E1, up-regulated the expression of Bcl-2 and Bid, and inhibited the expression of Bax, Bak and p53. Dioscin showed a remarkable protective effect against APAP-induced hepatotoxicity by adjusting mitochondrial function. These results indicated that dioscin has the capability on the treatment of liver injury.
Hierarchical NiCo2O4 microspheres with a p-type response were synthesized and demonstrated for gas sensor application towards TEA detection.
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The morphological and structural design ...provides an efficient protocol to optimize the performance of gas sensing materials. In this work, a gas sensor with high sensitivity for triethylamine (TEA) detection is developed based on p-type NiCo2O4 hierarchical microspheres. The NiCo2O4 microspheres, synthesized by a hydrothermal route, have a three-dimensional (3D) urchin-like structure assembled by nanorod building blocks. The structure-property correlation has been investigated by powder X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscope, scanning electron microscope, N2 adsorption-desorption tests and comprehensive gas sensing experiments. The influence of calcination temperature on the morphological structure and sensing performances has been investigated. Results reveal that the material annealed at 300 °C has a very large specific surface area of 125.27 m2/g, thereby demonstrating the best TEA sensing properties including high response and low limit of detection (145 ppb), good selectivity and stability. The further increase of the calcination temperature leads to the collapse of the 3D hierarchical structure with significantly decreased surface area, which is found to decline the sensing performances. This work indicates the promise of ternary p-type metal oxide nanostructures for application in highly sensitive gas sensors.
With the estimated high prevalence in the population, the two symptoms of pain and depression threaten the well-being of millions worldwide. Researches of the two symptoms increased year by year. ...Top-cited studies will help to understand the achievement and guide researchers toward the direction of the research field. However, it is unclear for researches in the field of pain and depression. In this paper, we reviewed the bibliometric characteristics of the top-cited papers about pain and depression. We will review the evidence of authorship, country of origin, institution, journal, study type, and publication year for the 100 top-cited studies on pain and depression based on the Web of Science Core collection. We also highlight studies with the highest cited times. Our study concluded that pain and depression were correlated, which may share common biological pathways.
•The TFs showed excellent effect against NAFLD in rats.•The TFs inhibited hepatic lipid accumulation.•The TFs prevented mitochondrial membrane potential dysfunctions and ultrastructural ...alterations.•The TFs regulated fatty acid synthesis and promoted fatty acid β-oxidation.•The TFs did not affect cholesterol synthesis.
The effects and mechanisms of the total flavonoids (TFs) from Rosa laevigata Michx fruit on high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) were investigated in this study. Gavage administration of the TFs significantly decreased the relative liver weight, serum AST and ALT activities, the levels of serum lipid, LDL, blood glucose and insulin, suppressed lipid accumulation in liver, and increased serum HDL level. Moreover, the natural product significantly enhanced SOD activity, increased GSH-Px and GSH contents and decreased the concentration of MDA and CYP2E1 expression as well as prevented mitochondrial membrane potential dysfunctions and ultrastructural alterations. Further mechanism investigation indicated that the TFs inhibited hepatic lipid accumulation by suppressing the expressions of some key molecules in fatty acid synthesis pathway and promoting fatty acid β-oxidation, while not by inhibiting cholesterol synthesis. On the base of these, the TFs should be developed as a new drug for treatment of NAFLD.
Background:
This study aims to assess the clinical efficacy and adverse events of delafloxacin for the treatment of acute bacterial infections in adult patients through meta-analysis.
Methods:
The ...PubMed, Embase, Cochrane library, Web of Science, and Clinical trails databases were searched up to 26 March 2022. Only randomized controlled trials (RCTs) that evaluated delafloxacin and comparator antibiotics for treating acute bacterial infections in adult patients were included. The clinical cure rate and microbiological eradication rate at the posttreatment evaluation, while the secondary outcomes included the risk of adverse events (AEs).
Results:
In total, six randomized controlled trials (RCTs) involving 3,019 patients with acute bacterial infection were included. There were no significant differences in the clinical cure rate between delafloxacin and comparators (OR = 1.06%, 95% CI = 0.89–1.26, I
2
= 0%). Overall, the results showed that delafloxacin had a microbiological eradication rate (documented and presumed) similar to the comparators (OR = 1.33%, 95% CI = 0.94–1.88, I
2
= 0%) in the pooled analysis of the six studies. Any treatment-emergent adverse events (TEAEs) did not show significant differences between delafloxacin and the comparators (OR = 0.93%, 95% CI = 0.80–1.08, I
2
= 75%). Serious adverse events (SAEs) did not differ between the delafloxacin and comparators (OR = 0.94%, 95% CI = 0.67–1.32, I
2
= 0%). The results of gastrointestinal disorders were (OR = 1.26%, 95% CI = 1.01–1.56, I
2
= 89%), and nausea, vomiting, and diarrhea were (OR = 0.77%, 95% CI = 0.45–1.34, I
2
= 79%), (OR = 1.00%, 95% CI = 0.74–1.36, I
2
= 72%), and (OR = 2.10%, 95% CI = 1.70–2.96, I
2
= 0%), respectively. The results showed that there was no significant difference in the incidence of nausea and vomiting between delafloxacin and the comparator, but the incidence of diarrhea was higher. The analysis of neurological disorders indicated that the incidence of nervous system disorders was lower in the delafloxacin group (OR = 0.71%, 95% CI = 0.50–1.01, I
2
= 52%).
Conclusion:
The clinical efficacy, microbiological eradication rate and the incidence of AEs of delafloxacin in the treatment of acute bacterial infections were similar to those of the comparators, as an alternative therapeutic agent.
Our previous works showed that dioscin, a natural product, could protect liver from acute liver damages induced by dimethylnitrosamine, ethanol, carbon tetrachloride and acetaminophen. However, the ...effect of dioscin on thioacetamide (TAA)-induced acute liver injury still remained unknown. The purpose of this study was to investigate whether dioscin confers a protective effect against TAA-induced acute liver injury in rats and mice. The results showed that dioscin decreased the serum levels of ALT, AST, and rehabilitated histopathological changes compared with the model groups. In addition, dioscin obviously increased the levels of GSH, GSH-Px, SOD, and significantly reduced MDA levels compared with the model groups. Mechanistic study showed that dioscin significantly up-regulated the expression levels of FXR, p-AMPKα, and then increased the expression levels of Nrf2, HO-1, NQO-1, GCLM and GST. Furthermore, dioscin obviously down-regulated the expression levels of NF-κB (p65), ICAM-1, HMGB1, COX-2, TNF-α, IL-1β and IL-6. Taken together, dioscin showed protective effect against TAA-induced acute liver injuries in rats and mice and the effects might be obtained through inhibiting oxidative stress and inflammation via FXR/AMPK signal pathway. These findings provided a new insight on the role of doscin in the treatment of acute liver injury.
The expressions of three types of stress sensitivity coefficients (S, α, β) are obtained on the basis of analysis of the empirical models and theoretical models on the relationships between ...permeability and effective stress, and the stress sensitivity evaluation standard is proposed considering experiment data and rock micro-structural features. Then the empirical models and theoretical models were used to fit experiment data of low-permeability and tight sandstones and different types of granites, which promotes the understanding of the empirical models and the physical meanings of the stress sensitivity coefficients. According to the study of the three types of stress sensitivity coefficients and the relationship of effective stress and permeability, it is found that the stress sensitive coefficient S is suitable for evaluating the stress sensitivity (strong stress sensitivity: S>0.40; low stress sensitivity: S<0.25; medium stress sensitivity: 0.25≤S≤0.4). Meanwhile, it is also found that strong-stress-sensitivity cores are more suitable to be characterized by the logarithmic model, while the exponential model (or binomial model) occurred more frequently in low-stress-sensitivity cores, and medium-stress-sensitivity cores are more likely to be described with the power model. Finally, the evaluation standard is discussed based on the micro-structure in the low-permeability and tight sandstones. The results show that the crack-like pores in the strong-stress-sensitivity cores are obvious, but low-stress-sensitivity cores have the characteristics of porous rocks; moreover, the types of cemented clay minerals, the size of rock grain and lithology have impact on stress sensitivity.
Waterflooding experiments were conducted in micro-models (microscopic scale) and on plunger cores from low permeability, extra-low permeability and ultra-low permeability reservoirs in the Ordos ...Basin under different displacement pressures using the NMR techniques to find out pore-scale oil occurrence state, oil production characteristics and residual oil distribution during the process of waterflooding and analyze the effect of pore structure and displacement pressure on waterflooding efficiency. Under bound water condition, crude oil mainly occurs in medium and large pores in the low-permeability sample, while small pores and medium pores are the main distribution space of crude oil in extra-low permeability and ultra-low permeability samples. During the waterflooding, crude oil in the medium and large pores of the three types of samples are preferentially produced. With the decrease of permeability of the samples, the waterflooding front sequentially shows uniform displacement, network displacement and finger displacement, and correspondingly the oil recovery factors decrease successively. After waterflooding, the residual oil in low-permeability samples is mainly distributed in medium pores, and appears in membranous and angular dispersed phase; but that in the extra-low and ultra-low permeability samples is mainly distributed in small pores, and appears in continuous phase formed by a bypass flow and dispersed phase. The low-permeability samples have higher and stable oil displacement efficiency, while the oil displacement efficiency of the extra-low permeability and ultra-low permeability samples is lower, but increases to a certain extent with the increase of displacement pressure.
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