A supercritical Organic Rankine Cycle (ORC) is renowned for higher conversion efficiency than the conventional ORC due to a better thermal match presented in the heat exchanger unit. This improved ...thermal match is a result of the obscured liquid-to-vapor boundary of the organic working fluid at supercritical states. Stand-alone solar thermal power generation and stand-alone geo-thermal power generation using a supercritical ORC have been widely investigated. However, the power generation capability of a single supercritical ORC using combined solar and geothermal energy has not been examined. This paper thus investigates the hybridisation of solar and geothermal energy in a super-critical ORC to explore the benefit from the potential synergies of such a hybrid platform. The figure of merit analysis indicates that the hybrid plant produces a maximum of 15% and 19% more annual electricity than the two stand-alone plants. Economically, the hybrid plant using the supercritical ORC has a solar-to-electricity cost of approximately 1.5-3.3% less than those of the subcritical scenario.
Coumarin compounds represent an important type of naturally occurring and synthetic oxygen-containing heterocycles with typical benzopyrone framework. This type of special benzopyrone structure ...enables its derivatives readily interact with a diversity of enzymes and receptors in organisms through weak bond interactions, thereby exhibit wide potentiality as medicinal drugs. So far, some coumarin-based drugs such as anticoagulant and antineurodegenerative agents have been extensively used in clinic. Coumarin-containing supramolecular medicinal agents as a new increasing expansion of supramolecular chemistry in pharmaceutical science have also been actively investigated in recent years. Coumarin-derived artificial ion receptors, fluorescent probes and biological stains are growing quickly and have a variety of potential applications in monitoring timely enzyme activity, complex biological events as well as accurate pharmacological and pharmacokinetic properties. This review provides a systematic summary and insight of the whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains. Some rational design strategies, structure-activity relationships and action mechanisms are discussed. The perspectives of the future development of coumarinbased medicinal chemistry are also presented.
Peroxisomes account for ~35% of total H2O2 generation in mammalian tissues. Peroxisomal ACOX1 (acyl‐CoA oxidase 1) is the first and rate‐limiting enzyme in fatty acid β‐oxidation and a major producer ...of H2O2. ACOX1 dysfunction is linked to peroxisomal disorders and hepatocarcinogenesis. Here, we show that the deacetylase sirtuin 5 (SIRT5) is present in peroxisomes and that ACOX1 is a physiological substrate of SIRT5. Mechanistically, SIRT5‐mediated desuccinylation inhibits ACOX1 activity by suppressing its active dimer formation in both cultured cells and mouse livers. Deletion of SIRT5 increases H2O2 production and oxidative DNA damage, which can be alleviated by ACOX1 knockdown. We show that SIRT5 downregulation is associated with increased succinylation and activity of ACOX1 and oxidative DNA damage response in hepatocellular carcinoma (HCC). Our study reveals a novel role of SIRT5 in inhibiting peroxisome‐induced oxidative stress, in liver protection, and in suppressing HCC development.
Synopsis
This study reveals a role for SIRT5 in regulating peroxisomal H2O2 and ROS homeostasis and indicates its potential function in liver protection and hepatocellular carcinoma suppression.
SIRT5 is localized in peroxisomes where it controls H2O2 metabolism.
SIRT5‐mediated desuccinylation inhibits ACOX1 activity by suppressing its active dimer formation.
SIRT5 downregulation increases ACOX1 activity and oxidative DNA damage response in HCC.
This study reveals a role for SIRT5 in regulating peroxisomal H2O2 and ROS homeostasis and indicates its potential function in liver protection and hepatocellular carcinoma suppression.
It is of great importance to reinforce electronic and ionic conductivity of Li4Ti5O12 electrodes to achieve fast reaction kinetics and good high‐power capability. Herein, for the first time, a dual ...strategy of combing N‐doped Li4Ti5O12 (N‐LTO) with highly conductive TiC/C skeleton to realize enhanced ultrafast Li ion storage is reported. Interlinked hydrothermal‐synthesized N‐LTO nanosheets are homogeneously decorated on the chemical vapor deposition (CVD) derived TiC/C nanowires forming binder‐free N‐LTO@TiC/C core–branch arrays. Positive advantages including large surface area, strong mechanical stability, and enhanced electronic/ionic conductivity are obtained in the designed integrated arrays and rooted upon synergistic TiC/C matrix and N doping. The above appealing features can effectively boost kinetic properties throughout the N‐LTO@TiC/C electrodes to realize outstanding high‐rate capability at different working temperatures (143 mAh g−1/10 C at 25 °C and 122 mAh g−1/50 C at 50 °C) and notable cycling stability with a capacity retention of 99.3% after 10 000 cycles at 10 C. Moreover, superior high‐rate cycling life is also demonstrated for the full cells with N‐LTO@TiC/C anode and LiFePO4 cathode. The dual strategy may provoke wide interests in fast energy storage areas and motivate the further performance improvement of power‐type lithium ion batteries (LIBs).
Herein, dual “inside and outside” strategies of combing N‐doped Li4Ti5O12 (N‐LTO) with highly conductive TiC/C skeleton is reported to construct integrated N‐LTO@TiC/C core‐branch arrays for ultra‐fast Li ion storage. Positive advantages including large surface area and enhanced electronic/ionic conductivity are obtained in the designed integrated arrays, leading to outstanding high‐rate capability for N‐LTO@TiC/C electrodes.
We have developed a supercapacitor electrode composed of well-aligned CoO nanowire array grown on 3D nickel foam with polypyrrole (PPy) uniformly immobilized onto or firmly anchored to each nanowire ...surface to boost the pseudocapacitive performance. The electrode architecture takes advantage of the high electrochemical activity from both the CoO and PPy, the high electronic conductivity of PPy, and the short ion diffusion pathway in ordered mesoporous nanowires. These merits together with the elegant synergy between CoO and PPy lead to a high specific capacitance of 2223 F g–1 approaching the theoretical value, good rate capability, and cycling stability (99.8% capacitance retention after 2000 cycles). An aqueous asymmetric supercapacitor device with a maximum voltage of 1.8 V fabricated by using our hybrid array as the positive electrode and activated carbon film as the negative electrode has demonstrated high energy density (∼43.5 Wh kg–1), high power density (∼5500 W kg–1 at 11.8 Wh kg–1) and outstanding cycleability (∼20 000 times). After charging for only ∼10 s, two such 4 cm2 asymmetric supercapacitors connected in series can efficiently power 5 mm diameter red, yellow, and green round LED indicators (lasting for 1 h for red LED) and drive a mini 130 rotation-motor robustly.
•The redistribution of asset holdings and the change in asset price are channels.•The central bank adjusts the issuance of CBDC to influence the asset allocation.•Traditional monetary policy and ...legal digital currency policy are complementary.•Price-based fiat digital monetary policy relieves macroeconomic swings.
This paper evaluates the macroeconomic effects of monetary policy for a central bank digital currency rule with traditional monetary policy in an open environment. We build a dynamic stochastic general equilibrium small open model economy with interest-bearing central bank digital currency assets. The redistribution of asset holdings and the change in asset price are the two pathways through which a retail central bank digital currency rule under the traditional monetary policy affects the macroeconomy. Fiat's digital and traditional monetary policies complement one another in lowering macroeconomic fluctuations. As a result, the real exchange rate, current accounts, and consumption are more stable in transmitting foreign shocks. These results occur when price-based or quantitative-based fiat digital monetary policy parallels traditional price-based monetary policy.
The further development of high‐power sodium‐ion batteries faces the severe challenge of achieving high‐rate cathode materials. Here, an integrated flexible electrode is constructed by smart ...combination of a conductive carbon cloth fiber skeleton and N‐doped carbon (NC) shell on Na3V2(PO4)3 (NVP) nanoparticles via a simple impregnation method. In addition to the great electronic conductivity and high flexibility of carbon cloth, the NC shell also promotes ion/electron transport in the electrode. The flexible NVP@NC electrode renders preeminent rate capacities (80.7 mAh g−1 at 50 C for cathode; 48 mAh g−1 at 30 C for anode) and superior cycle performance. A flexible symmetric NVP@NC//NVP@NC full cell is endowed with fairly excellent rate performance as well as good cycle stability. The results demonstrate a powerful polybasic strategy design for fabricating electrodes with optimal performance.
An integrated NVP@NC flexible electrode is constructed by smart combination of a conductive carbon cloth skeleton and N‐doped carbon shell on Na3V2(PO4)3 nanoparticles with superior Na storage performances.
As one of the most induced genes in activated macrophages, immune-responsive gene 1 (IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid (ITA). Although ITA has ...an anti-inflammatory property, the underlying mechanisms are not fully understood. Here we show that ITA is a potent inhibitor of the TET-family DNA dioxygenases. ITA binds to the same site on TET2 as the co-substrate α-ketoglutarate, inhibiting TET2 catalytic activity. Lipopolysaccharide treatment, which induces Irg1 expression and ITA accumulation, inhibits Tet activity in macrophages. Transcriptome analysis reveals that TET2 is a major target of ITA in suppressing lipopolysaccharide-induced genes, including those regulated by the NF-κB and STAT signalling pathways. In vivo, ITA decreases the levels of 5-hydroxymethylcytosine, reduces lipopolysaccharide-induced acute pulmonary oedema as well as lung and liver injury, and protects mice against lethal endotoxaemia, depending on the catalytic activity of Tet2. Our study thus identifies ITA as an immune modulatory metabolite that selectively inhibits TET enzymes to dampen the inflammatory responses.
Summary
By using the adaptive control approach, we solve the error feedback regulator problem for the one‐dimensional wave equation with a general harmonic disturbance anticollocated with control and ...with two types of disturbed measurements, ie, one collocated with control and the other anti‐collocated with control. Different from the classical error feedback regulator design, which is based on the internal mode principle, we give the adaptive servomechanism design for the system by making use of the measured tracking error (and its time derivative) and the estimation mechanism for the parameters of the disturbance and of the unknown reference. Constructing auxiliary systems and observer and applying the backstepping method for infinite‐dimensional system play important roles in the design. The control objective, which is to regulate the tracking error to zero and to keep the states bounded, is achieved.
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