A
bstract
We introduce a new information-theoretic measure of multipartite correlations Δ
P
, by generalizing the entanglement of purification to multipartite states. We provide proofs of its various ...properties, focusing on several entropic inequalities, in generic quantum systems. In particular, it turns out that the multipartite entanglement of purification gives an upper bound on multipartite mutual information, which is a generalization of quantum mutual information in the spirit of relative entropy. After that, motivated by a tensor network description of the AdS/CFT correspondence, we conjecture a holographic dual of multipartite entanglement of purification Δ
W
, as a sum of minimal areas of codimension-2 surfaces which divide the entanglement wedge into multi-pieces. We prove that this geometrical quantity satisfies all properties we proved for the multipartite entanglement of purification. These agreements strongly support the Δ
P
= Δ
W
conjecture. We also show that the multipartite entanglement of purification is larger than multipartite squashed entanglement, which is a promising measure of multipartite quantum entanglement. We discuss potential saturation of multipartite squashed entanglement onto multipartite mutual information in holographic CFTs and its applications.
A
bstract
We study mixed anomaly between
G
1
and
G
2
of one-form finite symmetry
G
1
×
G
2
in 3
d
Chern-Simons theories. We assign a quantum entanglement structure to two linked
G
-symmetry lines ...(Wilson loops) and compute the entanglement entropy
S
G
. We find a measure of the mixed anomaly by computing
S
G
1
×
G
2
−
S
G
1
−
S
G
2
.
Governments, militaries, and aid organizations all rely on economic interventions to shape civilian attitudes toward combatants during wartime. We have, however, little individual-level evidence that ...these “hearts and minds” programs actually influence combatant support. We address this problem by conducting a factorial randomized control trial of two common interventions—vocational training and cash transfers—on combatant support among 2,597 at-risk youth in Kandahar, Afghanistan. We find that training only improved economic livelihoods modestly and had little effect on combatant support. Cash failed to lift incomes, producing a boom-and-bust dynamic in which pro-government sentiment initially spiked and then quickly reversed itself, leaving a residue of increased Taliban support. Conditional on training, cash failed to improve beneficiaries’ livelihoods but did increase support for the Afghan government for at least eight months after the intervention. These findings suggest that aid affects attitudes by providing information about government resolve and competence rather than by improving economic livelihoods.
A large literature suggests that the presence of refugees is associated with greater risk of conflict. We argue that the positive effects of hosting refugees on local conditions have been overlooked. ...Using global data from 1990 to 2018 on locations of refugee communities and civil conflict at the subnational level, we find no evidence that hosting refugees increases the likelihood of new conflict, prolongs existing conflict, or raises the number of violent events or casualties. Furthermore, we explore conditions where provinces are likely to experience substantively large decreases in conflict risk due to increased development. Analysis examining nighttime lights as a measure of development, coupled with expert interviews, support our claim. To address the possibility of selection bias, we use placebo tests and matching. Our research challenges assertions that refugees are security risks. Instead, we show that in many cases, hosting refugees can encourage local development and even conflict reduction.
•NLRP3 inducers leads to externalization or release of mitochondria-derived molecule, which activate the NLRP3 inflammasome.•Ubiquitination/deubiquitination regulates NLRP3 inflammasome ...activation.•Ca2+-mediated mitochondrial damage contributes to NLRP3 inflammasome activation.•Knockdown of dynamin-related protein 1 (Drp1) induces mitochondrial elongation to promote NLRP3 inflammasome assembly.
The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory cytokines like interleukin-1β (IL-1β) and IL-18, and an inflammatory form of cell death termed as pyroptosis. Recent studies have unveiled the pivotal roles of mitochondria in initiation and regulation of the NLRP3 (nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3) inflammasome. NLRP3 activators induce mitochondrial destabilization, NLRP3 deubiquitination, linear ubiquitination of ASC, and externalization or release of mitochondria-derived molecules such as cardiolipin and mitochondrial DNA. These molecules bind to NLRP3 that is translocated on mitochondria and activate the NLRP3 inflammasome. Here we review recently described mechanisms by which mitochondria regulate NLRP3 inflammasome activation.
Even though the power conversion efficiency (PCE) of rigid perovskite solar cells is increased to 22.7%, the PCE of flexible perovskite solar cells (F‐PSCs) is still lower. Here, a novel dimethyl ...sulfide (DS) additive is developed to effectively improve the performance of the F‐PSCs. Fourier transform infrared spectroscopy reveals that the DS additive reacts with Pb2+ to form a chelated intermediate, which significantly slows down the crystallization rate, leading to large grain size and good crystallinity for the resultant perovskite film. In fact, the trap density of the perovskite film prepared using the DS additive is reduced by an order of magnitude compared to the one without it, demonstrating that the additive effectively retards transformation kinetics during the thin film formation process. As a result, the PCE of the flexible devices increases to 18.40%, with good mechanical tolerance, the highest reported so far for the F‐PSCs. Meanwhile, the environmental stability of the F‐PSCs significantly enhances by 1.72 times compared to the device without the additive, likely due to the large grain size that suppresses perovskite degradation at grain boundaries. The present strategy will help guide development of high efficiency F‐PSCs for practical applications.
An efficiency of flexible perovskite solar cells (F‐PSCs) is achieved of 18.40% with small area and 13.35% with large area using effective dimethyl sulfide (DS) additive; both are the highest reported for the F‐PSCs. The F‐PSCs show high efficiency and good stability due to the large grain size and good crystallinity of perovskite when DS is used.
Background N6-Methyladenosine (m6A) modification has been implicated in multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A reader, whereas its role in colon cancer ...remains unclear. Methods The expression of m6A associated enzymes and total m6A level were measured by Western Blotting analysis and m6A RNA Methylation Quantification Kit respectively. Cell cycle was analyzed by flowcytometry. The interaction of IGF2BP3 and related targets was analyzed by RNA immunoprecipitation (RIP) and m6A RNA immunoprecipitation (MeRIP) assays. Results We investigated all m6A regulated enzymes in colon cancer and found only the overexpression of IGF2BP3 was associated with cancer progression and survival based on The Cancer Genome Atlas (TCGA) databases. Additionally, we also demonstrated IGF2BP3 was associated with DNA replication in the cell cycle. Knockdown of IGF2BP3 significantly repressed percentage of S phase of cell cycle as well as cell proliferation. Further research demonstrated IGF2BP3 bound to the mRNA of Cyclin D1 (CCND1, checkpoint of G1/S phase of cell cycle) and reduced its mRNA stability via reading m6A modification in the CDS region. Overexpression of Cyclin D1 in IGF2BP3 down-regulated cells completely rescued the inhibited percentage of S phase in cell cycle as well as cell proliferation. Additionally, we also demonstrated a similar role of IGF2BP3 at VEGF. IGF2BP3 bound to the mRNA of VEGF and reads m6A modification, thus regulated both expression and stability of VEGF mRNA. Knockdown of IGF2BP3 repressed angiogenesis in colon cancer via regulating VEGF. Conclusion Knockdown of IGF2BP3 repressed DNA replication in the S phase of cell cycle and angiogenesis via reading m6A modification of CCND1 and VEGF respectively. IGF2BP3 was a possible prognosis marker and potential therapeutic target of colon cancer. Keywords: IGF2BP3, N6-Methyladenosine, Angiogenesis, Cell cycle, DNA replication
•Exopolysaccharide biosynthesis process and genetic modules are relatively conserved.•Both structures and functions of exopolysaccharide are diverse.•Functional mechanisms of exopolysaccharide lie in ...vitro or vivo or both of them.•The bioactivities are influenced by backbones, chain length and substitution of EPS.
The ability to exhibit various bioactivities is widespread in exopolysaccharide (EPS) of lactic acid bacteria (LAB), and it has been admittedly associated with large structural variability of these polymers. Exceptional bioactivities such as cholesterol-lowering, immunomodulating, antioxidant, antiviral and anticoagulant effects render these biopolymers vast commercial value for global market and application potentials in medicine sector. Therefore, an elaborate understanding of structure-to-function associations will be prerequisite to search natural and artificial EPSs for new applications in functional food, health and medicine fields. In this review, it is presented a significant overview of the latest advances in the field of EPS from genes to application. This review emphasized in the general biosynthesis pathway together with genetic modules, multiple structures, functions, and respective functional mechanisms of LAB-derived EPSs, and the relationships between their structure and bioactivity, which will help to exploit new bioactive drugs from LAB-derived EPS.
Recently, acceptor–donor–acceptor (A–D–A) small molecules have emerged as promising nonfullerene acceptors (NFAs) for organic solar cells and have attracted great attention. The carbon‐bridged ...(C‐bridged) ladder‐type D unit plays a crucial role in developing high‐performance A–D–A NFAs. However, the medium electron‐donating capability of C‐bridged units is unfavorable for making NFAs with strong light‐harvesting capability. In this regard, carbon–oxygen‐bridged (CO‐bridged) ladder‐type units present advantages in developing strong light‐absorbing NFAs. Here, recent progress in the newly emerging CO‐bridged NFAs is highlighted. The synthetic methods for the polycyclic CO‐bridged building blocks are introduced. The photovoltaic performance for CO‐bridged NFAs is summarized and discussed. Perspectives on developing high‐performance CO‐bridged‐NFA‐based solar cells are made.
Thanks to the strong electron‐donating capability of carbon–oxygen‐bridged (CO‐bridged) ladder‐type building blocks, CO‐bridged nonfullerene acceptors (NFAs) present low bandgaps and strong light‐harvesting capability, delivering high short‐circuit current density (>28 mA cm−2) and high power conversion efficiency (>14% for single‐junction and >17% for tandem) in organic solar cells.
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