Here, in an analysis of a 2.92 fb–1 data sample taken at 3.773 GeV with the BESIII detector operated at the BEPCII collider, we measure the absolute decay branching fractions to be B(D0 → K–e+νe) = ...(3.505 ± 0.014 ± 0.033)% and B(D0 → π–e+νe) = (0.295 ± 0.004 ± 0.003)%. From a study of the differential decay rates we obtain the products of hadronic form factor and the magnitude of the CKM matrix element $f$ $^{K}_{+}$(0)|Vcs| = 0.7172 ± 0.0025 ± 0.0035 and $f$ $^{π}_{+}$(0)|Vcd| = 0.1435 ± 0.0018 ± 0.0009.
Aim: This study was to determine the roles of inflammatory cytokines in paraventricular nucleus (PVN) in modulating sympathetic activity, blood pressure and cardiac sympathetic afferent reflex ...(CSAR).
Methods: Renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded in anaesthetized rats with bilateral sinoaortic denervation and vagotomy. The CSAR was evaluated by the RSNA response to epicardial application of bradykinin (BK). The levels of inflammatory cytokines were measured with ELISA.
Results: The PVN microinjection of pro‐inflammatory cytokines (PIC), tumour necrosis factor (TNF)‐α or interleukin (IL)‐1β, increased the baseline MAP and RSNA, and enhanced the CSAR. Anti‐inflammatory cytokines (AIC), IL‐4 or IL‐13, in the PVN only increased the baseline MAP. In the rats pretreated with TNF‐α or IL‐1β but not in the rats pretreated with IL‐4 or IL‐13, sub‐response dose of angiotensin II caused significant increases in the MAP and RSNA and enhancement in the CSAR. AT1 receptor antagonist losartan in the PVN attenuated the effects of angiotensin II, TNF‐α and IL‐1β, but not the effects of IL‐4 and IL‐13. Stimulation of cardiac sympathetic afferents with epicardial application of BK increased the levels of TNF‐α, IL‐1β but not IL‐4 in the PVN.
Conclusion: TNF‐α or IL‐1β in the PVN increases blood pressure and sympathetic outflow and enhances the CSAR, which is partially dependent on the AT1 receptors, while IL‐4 or IL‐13 in the PVN only increases blood pressure. There is a synergetic effect of Ang II with TNF‐α or IL‐1β on blood pressure, sympathetic activity and CSAR.
The nodal-line semimetals have attracted immense interest due to the unique electronic structures such as the linear dispersion and the vanishing density of states as the Fermi energy approaching the ...nodes. Here, we report temperature-dependent transport and scanning tunneling microscopy (spectroscopy) STM(S) measurements on nodal-line semimetal ZrSiSe. Our experimental results and theoretical analyses consistently demonstrate that the temperature induces Lifshitz transitions at 80 and 106 K in ZrSiSe, which results in the transport anomalies at the same temperatures. More strikingly, we observe a V-shaped dip structure around Fermi energy from the STS spectrum at low temperature, which can be attributed to co-effect of the spin-orbit coupling and excitonic instability. Our observations indicate the correlation interaction may play an important role in ZrSiSe, which owns the quasi-two-dimensional electronic structures.
From December 2011 to May 2014, about 5 fb^-1 of data were taken with the BESIII detector at center-of- mass energies between 3.810 GeV and 4.600 GeV to study the charmonium-like states and higher ...excited charmonium states. The time-integrated luminosity of the collected data sample is measured to a precision of 1% by analyzing events produced by the large-angle Bhabha scattering process.
Deformation twinning in pure aluminum has been considered to be a unique property of nanostructured aluminum. A lingering mystery is whether deformation twinning occurs in coarse-grained or ...single-crystal aluminum at scales beyond nanotwins. Here, we present the first experimental demonstration of macrodeformation twins in single-crystal aluminum formed under an ultrahigh strain rate (∼10^{6} s^{-1}) and large shear strain (200%) via dynamic equal channel angular pressing. Large-scale molecular dynamics simulations suggest that the frustration of subsonic dislocation motion leads to transonic deformation twinning. Deformation twinning is rooted in the rate dependences of dislocation motion and twinning, which are coupled, complementary processes during severe plastic deformation under ultrahigh strain rates.
Using 6.32 fb–1 of electron-positron collision data recorded by the BESIII detector at center-of-mass energies between 4.178 and 4.226 GeV, we present the first search for the decay $D^{+}_{s}$ → ...a0(980)0e+νe, a0(980)0 → π0η, which could proceed via a0(980) – f0(980) mixing. No significant signal is observed. An upper limit of 1.2 × 10–4 at the 90% confidence level is set on the product of the branching fractions of $D^{+}_{s}$ → a0(980)0e+νe and a0(980)0 → π0η decays.
The decays ψ2(3823 ) → γχc0,1,2, π+π− J/ψ, π0π0J/ψ , ηJ/ψ, and π0J/ψ are searched for using the reaction e+e− → π+π− ψ2 (3823) in a 19 fb−1 data sample collected at center-of-mass energies between ...4.1 and 4.7 GeV with the BESIII detector. The process ψ2(3823) → γχc1 is observed in a 9 fb−1 data sample in the center-of-mass energy range 4.3–4.7 GeV, which confirms a previous observation but with a higher significance of 11.8 σ , and evidence for ψ2(3823) → γχc2 is found with a significance of 3.2 σ for the first time. The branching-fraction ratio ... is determined. No significant ψ2 (3823) signals are observed for any of the other decay channels. Upper limits of branching-fraction ratios for ψ2(3823 ) → π+π− J/ψ , π0π0 J/ψ, ηJ/ψ , π0 J/ψ, γ χc0 relative to ψ2 (3823) → γχc1 are reported. The process e+e− → π0π0ψ2 (3823) is also searched for, and we find evidence for the process with a significance of 4.3 σ . The average cross-section ratio σ (e+e− → π0π0ψ2 (3823)) σ (e+e− → π+π− ψ2 (3823)) is also determined. (ProQuest: ... denotes formula omited.).
Adenosquamous carcinoma (ASC) of the lung is a heterogeneous disease that is composed of both adenocarcinoma components (ACC) and squamous cell carcinoma components (SCCC). Their genomic profile, ...genetic origin, and clinical management remain controversial.
Resected ASC and metastatic tumor in regional lymph nodes (LNs) were collected. The ACC and SCCC were separated by microdissection of primary tumor. The 1021 cancer-related genes were evaluated by next-generation sequencing independently in ACC and SCCC and LNs. Shared and private alterations in the two components were investigated. In addition, genomic profiles of independent cohorts of adenocarcinomas and squamous cell carcinomas were examined for comparison. We have also carried out a retrospective study of ASCs with known EGFR mutation status from 11 hospitals in China for their clinical outcomes.
The most frequent alterations in 28 surgically resected ASCs include EGFR (79%), TP53 (68%), MAP3K1 (14%) mutations, EGFR amplifications (32%), and MDM2 amplifications (18%). Twenty-seven patients (96%) had shared variations between ACC and SCCC, and pure SCCC metastases were not found in metastatic LNs among these patients. Only one patient with geographically separated ACC and SCCC had no shared mutations. Inter-component heterogeneity was a common genetic event of ACC and SCCC. The genomic profile of ASC was similar to that of 170 adenocarcinomas, but different from that of 62 squamous cell carcinomas. The incidence of EGFR mutations in the retrospective analysis of 517 ASCs was 51.8%. Among the 129 EGFR-positive patients who received EGFR-TKIs, the objective response rate was 56.6% and the median progression-free survival was 10.1 months (95% confidence interval: 9.0–11.2).
The ACC and SCCC share a monoclonal origin, a majority with genetically inter-component heterogeneity. ASC may represent a subtype of adenocarcinoma with EGFR mutation being the most common genomic anomaly and sharing similar efficacy to EGFR TKI.
•The adenocarcinoma component and squamous cell carcinoma component of adenosquamous carcinoma share a common clonal origin.•High incidence of trunk EGFR and TP53 mutation were noted in adenosqumous cell carcinoma, while the overall genomic profile of adenosqumous cell carcinoma is more similar to adenocarcinoma than squmous cell carcinoma.•EGFR-TKIs should be the standard first-line therapy for advanced stage adenosquamous carcinoma with EGFR mutation.
It is difficult to accurately visualize internal structure and characterize progressive fracture process during rock failure due to the heterogeneous and opaque features of rock. This paper focuses ...on providing two methods, i.e., 3D printing (3DP) and 3D numerical modelling, to replicate internal defects and study the mechanical and fracture behaviours of rock in combination with X-ray computerized tomography (micro-CT). On one hand, Stereolithography 3DP combined with the X-ray micro-CT and 3D reconstruction techniques were applied to replicate natural volcanic rocks using 3DP resin. Uniaxial compression and Brazilian disc tests were, subsequently, performed to characterize and visualize the mechanical and fracture properties of the 3DP rock. On the other hand, the digital image processing technique was adopted to integrate the microstructures of the natural volcanic rock into the rock failure process analysis code (RFPA3D-digital) for characterizing the failure behaviour of rock under uniaxial compression and tension. The results showed that both the 3DP samples and the 3D numerical models can successfully replicate the internal defects and micro-structures identical to those of the natural prototype volcanic rock. The mechanical properties of the 3DP samples and the 3D numerical models, including compressive and tensile strength and the Poisson's ratio, and fracture properties are testified to be similar to those of the prototype rocks. Visualization analysis of the progressive fracture process demonstrated that the initial internal voids and cracks dominate the spatial fracture evolution and failure patterns within the rock. The proposed methods provide a promising means to quantify, replicate and visualize the pre-existing defects and mirco-structures, and to understand their influences on the mechanical and fracture behaviour of rock under different loading conditions, facilitating better understanding of failure mechanism of rocks.
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