Using a 3.19fb-1 data sample collected at the s=4.178GeV with the BESIII detector, we search for the rare decay Ds+ → p p ¯ e+νe . No significant signal is observed, and an upper limit of B ( Ds+ → p ...p ¯ e+νe ) <2.0×10-4 is set at the 90% confidence level. This measurement is useful input in understanding the baryonic transition of Ds+ mesons.
HIAF (High Intensity heavy ion Accelerator Facility) is the new generation heavy ion accelerator under construction in China. The HFRS (FRagment Separator of HIAF) is a fragment separator and also a ...transfer-line between the Booster Ring and the Spectrometer ring, which has magnetic rigidity up to 25 Tm. HFRS magnet system is composed of 11 superconducting dipoles and 13 sets of triplets. Several multipole magnets (an octupole coil, a quadrupole coil, and a sextupole coil) are nested together to compact the length of the HFRS-line. All of them feature high field gradients (13 T/m, 25 T/m 2 , 105 T/m 3 ) and large bores (320 mm). To reduce the cold mass and ensure the field quality, the whole multipole magnets are all designed with coil-dominated magnets of CCT (Canted Cosine Theta) and DCT (Discrete Cosine Theta). This paper will introduce the general design process of an HFRS multipole module. The development process and test results of the prototype will be presented.
The singly Cabibbo-suppressed decay D$^+_s$ → K+π+π-π0 is observed by using a data set corresponding to an integrated luminosity of 6.32 fb-1 recorded by the BESIII detector at the centre-of-mass ...energies between 4.178 and 4.226 GeV. The first amplitude analysis of D$^+_s$ → K+π+π-π0 reveals the sub-structures in this decay and determines the fractions and relative phases of different intermediate processes. The dominant intermediate process is D$^+_s$ → K*0ρ+, with a fit fraction of (40.5 ± 2.8stat. ± 1.5syst.)%. With the detection efficiency based on our amplitude analysis, the absolute branching fraction for D$^+_s$ → K+π+π-π0 is measured to be (9.75 ± 0.54stat. ± 0.17syst.) x 10-3.
The aim of this study was to analyze the setup error of the electronics portal image device (EPID) in intensity-modulated radiation therapy (IMRT) for thoracic tumors and the influence on the outward ...expansion distance of the target area.
A total of 202 patients with chest tumors admitted to our hospital from March 2016 to March 2018 were selected as the observation subjects. All patients were treated with IMRT. The original plan was developed based on the SM90 obtained by the planning target volume (PTV) expansion method, and the new plan was obtained by shifting the isocenter coordinates of the treatment plan according to the positioning error value obtained by EPID. Before the treatment, EPID scans were performed. The electronic radiation field images (ERIs) were registered with the digitally reconstructed radiographic images (DRRs) generated by the treatment planning system using the image registration software, and the setup errors in the X, Y, and Z directions were further measured. The PTV was developed according to ERIs, and the setup error was simulated to obtain the PTV with 95% internal target volume (ITV) reaching the prescribed dose under the condition of a setup error. The outward expansion distance of clinical target volume (CTV) → PTV was calculated.
In this experiment, the setup errors in X, Y, and Z directions were (-2.00±1.16) mm, (0.16±1.14) mm, and (-0.55±1.16) mm, respectively. The systematic error in the Z direction was -3.00 mm, and the random error in the X direction was 3.30 mm. The CTV → PTV outward expansion distance was set as 7, 8 and 7 mm in the X direction, Y direction and Z direction, respectively. At this time, under the presence of setup error, the PTV D95 and the ITV V100 in the new plan were (62.23±3.85) Gy and (97.51±1.56) %, respectively, effectively ensuring that 95% ITV of 90% patients reached the prescribed dose. In contrast, the ITV D95 and ITV V100 in the presence of setup error were (56.11±5.26) Gy and (90.15±3.12) %, respectively, at a CTV → PTV outward expansion distance of 5 mm, which could not guarantee that 95% ITV of 90% patients reached the prescribed dose. In the presence of a setup error, the double-lung 5 Gy irradiation of the total heart volume (V5), the double-lung 20 Gy irradiation of the total heart volume (V20), mean lung dose (MLD), mean heart dose (MHD), and D1 cm3 of the new plan increased by 0.89%, 0.29%, 0.13%, 0.06%, and 5 Gy, respectively, compared with the original plan.
In general, the first treatment of radiotherapy in thoracic tumors mostly has a certain degree of setup error, which is most evident in the X direction. When the CTV → PTV outward expansion distance is set at 7, 8, and 7 mm in the X direction, Y direction, and Z direction, respectively, it can effectively ensure that 95% ITV reach the prescribed dose in 90% of patients in the presence of a setup error. EPID helps to achieve the desired effect of radiotherapy, improves the efficacy of radiotherapy, and reduces the side effects caused by radiotherapy errors.
Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSC). Here, we show that GSCs, differentiated glioblastoma cells (DGC), and nonmalignant brain cultures all ...displayed robust circadian rhythms, yet GSCs alone displayed exquisite dependence on core clock transcription factors, BMAL1 and CLOCK, for optimal cell growth. Downregulation of
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in GSCs induced cell-cycle arrest and apoptosis. Chromatin immunoprecipitation revealed that BMAL1 preferentially bound metabolic genes and was associated with active chromatin regions in GSCs compared with neural stem cells. Targeting
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attenuated mitochondrial metabolic function and reduced expression of tricarboxylic acid cycle enzymes. Small-molecule agonists of two independent BMAL1-CLOCK negative regulators, the cryptochromes and REV-ERBs, downregulated stem cell factors and reduced GSC growth. Combination of cryptochrome and REV-ERB agonists induced synergistic antitumor efficacy. Collectively, these findings show that GSCs co-opt circadian regulators beyond canonical circadian circuitry to promote stemness maintenance and metabolism, offering novel therapeutic paradigms. SIGNIFICANCE: Cancer stem cells are highly malignant tumor-cell populations. We demonstrate that GSCs selectively depend on circadian regulators, with increased binding of the regulators in active chromatin regions promoting tumor metabolism. Supporting clinical relevance, pharmacologic targeting of circadian networks specifically disrupted cancer stem cell growth and self-renewal.
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Glioblastoma ranks among the most aggressive and lethal of all human cancers. Functionally defined glioma stem cells (GSC) contribute to this poor prognosis by driving therapeutic resistance and ...maintaining cellular heterogeneity. To understand the molecular processes essential for GSC maintenance and tumorigenicity, we interrogated the superenhancer landscapes of primary glioblastoma specimens and
GSCs. GSCs epigenetically upregulated ELOVL2, a key polyunsaturated fatty-acid synthesis enzyme. Targeting ELOVL2 inhibited glioblastoma cell growth and tumor initiation. ELOVL2 depletion altered cellular membrane phospholipid composition, disrupted membrane structural properties, and diminished EGFR signaling through control of fatty-acid elongation. In support of the translational potential of these findings, dual targeting of polyunsaturated fatty-acid synthesis and EGFR signaling had a combinatorial cytotoxic effect on GSCs. SIGNIFICANCE: Glioblastoma remains a devastating disease despite extensive characterization. We profiled epigenomic landscapes of glioblastoma to pinpoint cell state-specific dependencies and therapeutic vulnerabilities. GSCs utilize polyunsaturated fatty-acid synthesis to support membrane architecture, inhibition of which impairs EGFR signaling and GSC proliferation. Combinatorial targeting of these networks represents a promising therapeutic strategy.
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Poly(ethylene oxide) (PEO) nanofiber mats were produced by electrospinning. Biobased cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) as reinforcement nanofillers were also added to the ...polymer to produce composite nanofiber mats. The effects of the two cellulose nanofillers on the rheological properties of the PEO solutions and the microstructure, crystallization, and mechanical properties of the mats were systematically compared. The microstructural disparity between the CNCs and CNFs led to significant differences in the solution viscosity, nanofiber morphology and microstructure of the composite nanofiber mats. A unique shish-kebab-like crystalline structure was discovered in both pure and filled PEO nanofibers. Both CNCs and CNFs showed strong reinforcing effects on the nanofiber mats.
Partial wave analysis of J / ψ → γ η η Ablikim, M.; An, F. F.; Ban, Y. ...
Physical review. D, Particles, fields, gravitation, and cosmology,
05/2013, Letnik:
87, Številka:
9
Journal Article
We report on the observation of the accreting pulsar GRO J1008-57 performed by Insight-Hard X-ray Modulation Telescope (HXMT) at the peak of the source's 2017 outburst. Pulsations are detected with a ...spin period of 93.283(1) s. The pulse profile shows double peaks at soft X-rays, and only one peak above 20 keV. The spectrum is well described by the phenomenological models of X-ray pulsars. A cyclotron resonant scattering feature (CRSF) is detected with very high statistical significance at a centroid energy of keV, for the reference continuum and line models, HIGHECUT and GABS, respectively. Detection is very robust with respect to different continuum models. The line energy is significantly higher than what is suggested from previous observations, which provided very marginal evidence for the line. This establishes a new record for the centroid energy of a fundamental CRSF observed in accreting pulsars. We also discuss the accretion regime of the source during the Insight-HXMT observation.
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