Organic semiconductor gas sensor is one of the promising candidates of room temperature operated gas sensors with high selectivity. However, for a long time the performance of organic semiconductor ...sensors, especially for the detection of oxidizing gases, is far behind that of the traditional metal oxide gas sensors. Although intensive attempts have been made to address the problem, the performance and the understanding of the sensing mechanism are still far from sufficient. Herein, an ultrasensitive organic semiconductor NO2 sensor based on 6,13‐bis(triisopropylsilylethynyl)pentacene (TIPS‐petacene) is reported. The device achieves a sensitivity over 1000%/ppm and fast response/recovery, together with a low limit of detection (LOD) of 20 ppb, all of which reach the level of metal oxide sensors. After a comprehensive analysis on the morphology and electrical properties of the organic films, it is revealed that the ultrahigh performance is largely related to the film charge transport ability, which was less concerned in the studies previously. And the combination of efficient charge transport and low original charge carrier concentration is demonstrated to be an effective access to obtain high performance organic semiconductor gas sensors.
An ultrasensitive organic semiconductor NO2 sensor based on crystalline 6,13‐bis(triisopropylsilylethynyl)pentacene films is achieved with a sensitivity over 1000% ppm–1 and fast response/recovery within 200 s/400 s. The relationship between sensor performance and film charge transport is studied. The low original carrier concentration and efficient charge transport are demonstrated to be key factors for the ultrahigh performance.
To obtain stable and ultrafine Pt nanoclusters, a trigonal prismatic coordination cage with the sulfur atoms on the edges was solvothermally synthesized to confine them. In the structure of ...{Ni24(TC4A-SO2)6(TDC)12 (H2O)6} (H4TC4A-SO2 = p-tert-butylsulfonylcalix4arene; H2TDC = 2,5-thiophenedicarboxylic acid), three Ni4-(TC4A-SO2) SBUs are bridged by three TDC ligands into a triangle and two such triangles are pillared by three pairs of TDC ligands to form a trigonal prism. The cage cavity has 12 sulfur atoms on the surface. Because of the porous structure and strong covalent interaction between metal and sulfur, ultrafine Pt nanoclusters composed of less than ∼18 Pt atoms can be facilely confined in the present trigonal prismatic cage (Pt@CIAC-121). The as-synthesized Pt NCs exhibit higher electrocatalytic activity than commercial Pt/C toward hydrogen evolution reaction.
On account of high oxidation ability of sulfate radical-based advanced oxidation processes (AOPs), the eco-friendly catalysts for peroxymonosulfate (PMS) activation have received considerable ...attentions. Previous studies mainly focused on Cobalt-based catalyst due to its high activation efficiency, such as Co3O4/MnO2 and FeCo-layered double hydroxide (LDH), whereas Cobalt-based catalyst usually has serious risk to environment. To avoid this risk, MnFe-LDH was primarily synthesized in this research by simple co-precipitation and subsequently utilized as an effective catalyst for peroxymonosulfate (PMS) activation to degrade organic pollutants. The experimental results demonstrated that MnFe-LDH with a lower dosage (0.20 g/L) could efficiently activate PMS to achieve 97.56% removal of target organic pollutants Acid Orange 7 (AO7). The AO7 degradation process followed the pseudo-first-order kinetic well with an activation energy of 21.32 kJ/mol. The intrinsic influencing mechanism was also investigated. The quenching experiment and electron spin resonance (ESR) indicated that sulfate and hydroxyl radicals were produced by the effective activation of PMS by MnFe-LDH, resulting in a high rate of decolorization. The possible AO7 removal pathway in the constructed MnFe-LDH/PMS system was presented on the basis of UV–vis spectrum analysis and GC–MS, which suggested that the AO7 degradation was firstly initiated by breaking azo linkages, then generated phenyl and naphthalene intermediates and finally presented as ring-opening products. This effective MnFe-LDH/PMS system showed great application potential in the purification of wastewater contaminated by refractory organic pollutants.
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•MnFe-LDH was used as heterogeneous catalyst to active peroxymonosulfate.•The MnFe-LDH/PMS system showed high performance for organic pollutant degradation.•Rreaction parameters of MnFe-LDH/PMS system for AO7 degradation were optimized.•Catalyst showed stable catalytic performance in consecutive runs.•The probable degradation pathways were proposed and discussed.
With the continuous expansion of photovoltaic scale, the accurate prediction of photovoltaic power generation is increasingly important for grid dispatching and grid optimization operations. In this ...paper, the photovoltaic power generation mainly uses meteorological factors and historical data as the input and output of the neural network. The input quantity is large, the data is redundant, and the network is difficult to converge, which always has a great adverse effect on the accuracy of photovoltaic output prediction. Firstly, different weather types are classified according to the trend graphs of different weather types. Principal components analysis (PCA) is used to analyze less comprehensive features from multiple meteorological factors and reduce the input of predictive models. At the same time, aiming at the problem that the prediction accuracy of a single prediction model such as the existing neural network and wavelet analysis method is limited, the idea and method of integrated learning are introduced, and a short-term prediction method based on Stacking method combined with SVM and Xgboost is proposed. Compared with the single model of SVM and Xgboost, the results show that the proposed method has a significant improvement compared with the accuracy of a single prediction model.
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Deep bed filtration is commonly used to remove oil from oily wastewater. The wettability of the filter media greatly influences the oil removal efficiency. A filter with a strong ...hydrophobicity and oleophilicity results in a higher oil removal efficiency. To improve the hydrophobicity and oleophilicity, ZnO nanoparticles and octadecyltrichlorosilane (OTS) were coated on quartz sand filter media. SEM, FTIR and XPS were used to study the morphology and chemical composition of the filters, and adsorption capacity and oil removal efficiency experiments were performed to assess the oil removal performance. The results show that the OTS molecules are grafted onto the surface of the quartz sand filter through chemical bonding, and the OTS/ZnO-coated quartz sand filter is superhydrophobic and oleophilic, with a water contact angle of 154.1° and an oil contact angle of 0°. The OTS/ZnO-coated quartz sand filter has very high mechanical stability and acid resistance. The oily wastewater treatment performance is greatly improved after application of the OTS/ZnO coating, and the superhydrophobic quartz sand filter media can potentially be used to filter oily wastewater and achieve high oil removal efficiency.
The gut-liver axis has emerged as a focal point in chronic liver disorders, prompting more research into the role of the gut microbiota in liver cirrhosis. In individuals with liver cirrhosis, ...changes in the structure and function of the gut microbiota are closely tied to clinical prognosis. However, there is a scarcity of bibliometric evaluations conducted in this particular field.
This study is aiming to conduct a complete analysis of the knowledge structure and centers pertaining to gut microbiota in liver cirrhosis using bibliometric methods. Publications on gut microbiota and liver cirrhosis from 2001 to 2023 are sourced from the Web of Science Core Collection. For the bibliometric analysis, we employ VOSviewer, CiteSpace, and the R package "bibliometrix".
Our study encompasses a comprehensive collection of 3109 articles originating from 96 countries, with notable contributions from leading nations such as the United States and China. The quantity of publications concerning the gut microbiota of liver cirrhosis rises annually. The University of California San Diego, Virginia Commonwealth University, Zhejiang University are the primary research institutions. World Journal of Gastroenterology publishes the most papers in this field, while hepatology is the most frequently co-cited journal. These publications come from a total of 15,965 authors, and the most prolific authors are Bajaj Jasmohan S., Schnabl Bernd and Gillevet Patrick M., while the most co-cited authors are Bajaj Jasmohan S., Younossi Zobair M., and Reiner Wiest. In addition, "dysbiosis", "gut microbiota", "intestinal barrier", "fecal microbiota transplantation", and "complement-system" are the primary keywords of research trends in recent years.
This study offering a comprehensive insight into the research dynamics surrounding gut microbiota in patients with liver cirrhosis. It delineates the current research frontiers and hotspots, serving as a valuable guide for scholars.
We report a nonenzymatic wearable sensor for electrochemical analysis of perspiration glucose. Multipotential steps are applied on a Au electrode, including a high negative pretreatment potential ...step for proton reduction which produces a localized alkaline condition, a moderate potential step for electrocatalytic oxidation of glucose under the alkaline condition, and a positive potential step to clean and reactivate the electrode surface for the next detection. Fluorocarbon-based materials were coated on the Au electrode for improving the selectivity and robustness of the sensor. A fully integrated wristband is developed for continuous real-time monitoring of perspiration glucose during physical activities, and uploading the test result to a smartphone app via Bluetooth.
Nd0.2Ce0.8O3-δ (NDC) is one of the most common solid electrolyte materials used in solid oxide fuel cells (SOFCs). However, the densification temperature of NDC electrolyte is above 1400 °C. In this ...work, Bi2O3 and CoO sintering aids were individually or synergistically added to Nd0.2Ce0.8O3-δ (NDC) electrolytes through the sol-gel method to lower its sintering temperature. Effects of Bi2O3-CoO dual sintering aid on the sintering behavior, phase composition, microstructure, and electrochemical properties of NDC electrolyte were all investigated. The data revealed that Bi2O3-CoO dual-sintering aid doped-NDC (labeled as NDC-CB) possessed high density and superior conductivity at low temperatures, better than that of Bi2O3 or CoO single sintering aid. NDC electrolyte doped with Bi2O3-CoO dual-sintering aid achieved highest relative density of 95.3% at 1100 °C and total conductivity of 5.765 × 10-2 S cm-1 at 800 °C. Furthermore, NDC-CB displayed excellent physical and chemical compatibility with La0.6Sr0.4Co0.8Fe0.2O3-δ (LSCF) cathode and NiO-NDC anode. Oxygen reduction reaction at LSCF/NDC-CB interface was improved by about 40% when compared to NDC. In sum, Bi2O3-CoO looks promising as dual-sintering additive for lowing sintering temperature and increasing electrical conductivity of NDC. Therefore, NDC-CB might be potential electrolyte for future intermediate-temperature solid oxide fuel cells (IT-SOFCs).
•The density and properties of NDC samples with sintering aids were improved.•NDC with Bi2O3-CoO dual-sintering aid exhibited the excellent performance.•Dual-sintering aid enhancement was superior to single sintering aids.•NDC co-doped with Bi2O3-CoO achieved the highest relative density of 95.3%.•The total conductivity of NDC-CB was 5.765 × 10-2 S cm-1 at 800 °C.•1–24.
Both the epidermal growth factor receptor (EGFR) and insulin-like growth factor 1 receptor (IGF-1R) have been implicated in the development of cancers, and the increased expression of both receptors ...has been observed in esophageal cancer. However, the tyrosine kinase inhibitors of both receptors have thus far failed to provide clinical benefits for esophageal cancer patients. Studies have confirmed the complicated crosstalks that exist between the EGFR and IGF-1R pathways. The EGFR and IGF-1R signals act as mutual compensation pathways, thereby conveying resistance to EGFR or IGF-1R inhibitors when used alone. This study evaluated the antitumor efficacy of the EGFR/HER2 inhibitors, gefitinib and lapatinib, in combination with the IGF-1R inhibitor, linsitinib, on the esophageal squamous cell carcinoma (ESCC). Gefitinib or lapatinib, in combination with linsitinib, synergistically inhibited the proliferation, migration, and invasion of ESCC cells, caused significant cell cycle arrest, and induced marked cell apoptosis. Their combination demonstrated stronger inhibition on the activation of EGFR, HER2, and IGF-1R as well as the downstream signaling molecules. In vivo, the addition of linsitinib to gefitinib or lapatinib also potentiated the inhibition effects on the growth of xenografts. Our results suggest the next clinical exploration of the combination of gefitinib or lapatinib with linsitinib in the treatment of ESCC patients.
It was well-known that Berberine, a major bioactive compound extracted from natural plants Coptis chinensis, has anti-diabetic effects for decades in china. Other types of pharmacological activities, ...such as anti-inflammatory, antimicrobial, hypolipidemic, and anti-cancer effects, have also been examined. At cellular level, these pharmacological activities were mostly an inhibitory effect. However, the cytoprotective effect of berberine was also observed in various types of cells, such as neurons, endothelial cells, fibroblasts, and β-cells. The paradoxical result may be closely associated with characteristics and distribution of berberine within cells, and they can be explained mechanically by mitohormesis, one particular form of hormesis. Here, we reviewed the mitohormetic response and assessed the berberine-induced effects and the possible signaling pathway involved. These findings may contribute to better clinical applications of berberine and indicate that some mitochondria-targeted conventional drugs should be considered carefully in clinical application.
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