A27-year-old woman presented with back and abdominal pain. She was diagnosed in infancy with Beckwith-Wiedemann syndrome and bilateral multifocal perilobar nephrogenic rests that progressed to ...diffuse nephroblastomatosis with neoplastic nephroblastomatous rests at 14 months of age and subsequently to a right Wilms tumor at 5 years of age. Computed tomography of the abdomen during the current admission showed multiple obstructed calices. Ureteroscopic inspection of the left kidney revealed severe intrarenal scarring with multiple infundibular stenosis, hydrocalices, and nephrocalcinosis. Renal biopsy showed sclerotic glomeruli with calcification and scarring and persistent subcapsular nodular renal blastema. Electrocautery incision and balloon dilatation provided temporary pain relief. After discharge, the patient has had two or three episodes of recurrent pain associated with new areas of infundibular stenoses and renal cysts. Bilateral nephrectomy and renal transplantation is being considered for management of progressive disease and relief of intractable pain. The potential causes of progressive and severe intrarenal fibrosis, infundibular stenosis and nephrocalcinosis, and renal cysts in this patient may include abnormal renal development secondary to Beckwith-Wiedemann syndrome itself, radiation or chemotherapy damage, or a combination.
Attributions as Inferences and Explanations Zuckerman, Miron; Colwell, Erica L; Darche, Paul R ...
Journal of personality and social psychology,
05/1988, Letnik:
54, Številka:
5
Journal Article
Recenzirano
Observers assessing the probability of an interpretation for a behavioral event may (a) assess the probability that certain inferences can be drawn from the event (inference set) or (b) assess the ...probability that some explanation can cause the event (explanation set). We suggested that inference set subjects would be more likely than explanation set subjects to discount less plausible interpretations in favor of more plausible interpretations. In three studies observers either estimated the probability that some inferences can be drawn from an event or estimated the probability that some explanation can be the cause for the event. As predicted, the inference set produced a higher level of discounting. Studies 1 and 3 also showed that future-oriented observers made attributions similar to those made in the inference set. However, this effect was open to alternative interpretations in Study 1 and failed to reach statistical significance in Study 3. There was also an indication that inference set subjects were more likely to make correspondent attributions. Additional tests of the effects of time orientation and the possible relation between the inference-explanation distinction and actor-observer differences were discussed.
Eighteen patients with residual epithelial ovarian cancer at second-look laparotomy were treated with a combined total of 210 cycles of intraperitoneal cis-platinum. Sixteen patients had previously ...received cis-platinum containing combination chemotherapy systemically. Seven patients had microscopic residual disease at the start of intraperitoneal therapy, eight had macroscopic disease of 5 mm in diameter or less, and three had disease of 6-10 mm in diameter. The drug was administered weekly in 2 L of Ringer's lactate solution via an indwelling Tenckhoff catheter, and the dose ranged from 30-270 mg per cycle (median 120 mg). The dwell time was 20 minutes. After 12 cycles, response was assessed by open laparoscopy (six patients), laparotomy (eight patients), or peritoneal cytology (three patients). One patient developed distant metastases. Local and systemic toxicity was mild. Delays of therapy were necessary for eight of the 210 cycles because of hematologic toxicity. Of the 15 patients available for pathologic evaluation, four (26.6%) had a complete response and two (13.3%) had a partial response. Results of this pilot study suggest a possible role for intraperitoneal cis-platinum in the management of carefully selected patients with epithelial ovarian cancer.
Movement of Surveyor 3 spacecraft Scott, R. F.; Lu, T.‐D.; Zuckerman, K. A.
Journal of Geophysical Research,
10 May 1971, Letnik:
76, Številka:
14
Journal Article
Recenzirano
Odprti dostop
An examination of the position of the Surveyor 3 spacecraft as it appeared in the photographs taken by astronauts C. Conrad and A. Bean of the Apollo 12 lunar mission in November 1969 suggested that ...some changes had occurred in the spacecraft's attitude since the Surveyor operation of April 1967. A detailed study was made by simulating in the laboratory the position of one of the Surveyor spacecraft's footpads and its imprints in the lunar surface. Photographs were taken both from the location of the original Surveyor television camera and from the estimated position of the astronauts. It was found to be impossible to match the footpad and imprint positions and attitude in pictures taken from the two points of view. Consequently, it is tentatively concluded that the Surveyor spacecraft moved a few inches at some time between May 1967 and November 1969. It seems most likely that this movement occurred as a result of a relatively sudden failure of one or two of the shock absorbers on Surveyor's landing gear, since 2 out of the 3 shock absorbers were collapsed at the time of the astronauts' visit.
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