Due to the large variety of Internet of Things (IoT) platforms, selecting the right one to implement an IoT solution is a tough task. To mitigate right selection by the developer, this paper presents ...a Systematic Multivocal Mapping Study on IoT platforms and its main software elements, to define their anatomy considering how they were studied by the market analysts and academia. By using a precise protocol defined on this work, it was possible to select 63 academic articles and industry reports that perform IoT platform descriptions, evaluations and comparisons. As results, this paper identified the most important IoT platforms are AWS IoT, Azure IoT, Watson IoT, PTC ThingWorx and Google IoT. Its main capabilities are Interoperability, Security & Privacy, Developer Support, Data Management, Device Management and Services Management. It was also defined an architectural model with the main platform components highlighted according to their relevance, the main communication models (Publish/Subscribe and REST APIs) and the common API that should be implemented by the IoT platforms.
A design of experiments was conducted to study the transesterification of tris(p-nitrophenyl) phosphate with sodium methoxide. The factorial design was performed to check the experimental conditions ...that favored ths yield of bis(p-nitrophenyl) methyl phosphate in a semi-batch process. The experiments were performed using a Mettler RC1 calorimeter. The reaction temperature, the addition order of reagents and the time spent in those additions were analyzed at two different levels. The results showed the addition order of reagents as the most important factor to guarantee the improvement of the reaction yielding bis(p-nitrophenyl) methyl phosphate. It was demonstrated that the temperature has a small effect on the reaction yield between 5 and 30
ˆ
C. An important effect was observed with regard to the addition time of reagents and yield: when the tris(p-nitrophenyl)phosphate is added to the methoxide solution (58% on average) while no effect was observed when the methoxide solution was added to the phosphate (87% on average). Theses results indicated that the addition could be made in times shorter than five minutes under the latter condition.
The objective of this study was to evaluate the effect of low-dose naltrexone (LDN) as a carboplatin chemotherapy-associated drug in female dogs with mammary carcinoma in benign mixed tumors (MC-BMT) ...after mastectomy and to assess its association with quality of life and survival rates. Sixty female dogs were included in this study, all of which had histopathological diagnosis of MC-BMT and were divided into three groups: G1 (control), consisting of animals submitted only to mastectomy with or without regional metastasis; G2, composed of treated animals that did not present with metastasis; and G3, treated dogs that presented with metastasis. G2 and G3 were also subdivided according to the treatment administered: chemotherapy alone (MC-BMT(-) C/MC-BMT(+) C) or LDN and chemotherapy (MC-BMT(-) C+LDN/MC-BMT(+) C+LDN). All animals were subjected to clinical evaluation, mastectomy, peripheral blood lymphocyte immunophenotyping, beta-endorphin and met-enkephalin quantification, and evaluation of survival rates and quality of life scores. The results showed higher serum concentrations of beta-endorphin and met-enkephalin, fewer chemotherapy-related side effects, and better quality of life and survival rates in the LDN-treated groups than in LDN-untreated groups (P < 0.05). Evaluation of clinical and pathological parameters indicated a significant association between the use of LDN and both prolonged survival and enhanced quality of life. These results indicate that LDN is a viable chemotherapy-associated treatment in female dogs with MC-BMT, maintaining their quality of life and prolonging survival rates.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling ...is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin reuptake inhibitor, in a small molecule screen of FDA-approved drugs that rescued neuronal dysfunction and reduced aggregation using a Caenorhabditis elegans model of mutant ataxin 3-induced neurotoxicity. MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Moreover, chronic treatment of CMVMJD135 mice with citalopram significantly reduced ataxin 3 neuronal inclusions and astrogliosis, rescued diminished body weight and strikingly ameliorated motor symptoms. These results suggest that small molecule modulation of serotonergic signalling represents a promising therapeutic target for Machado-Joseph disease.
Acute lung injury (ALI) is an important public health problem. The present work investigated whether dehydrodieugenol B treatment, a compound isolated from Brazilian plant
(Lauraceae), modulates ...experimental ALI and compared the observed effects to eugenol. Effects of dehydrodieugenol B
in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were evaluated. The lung and systemic inflammatory profile, lung function, and possible mechanisms involved in BALB/C male mice (6-8 weeks) with ALI induced by LPS instillation (5 mg/kg) was assayed. Dehydrodieugenol B did not affect the cell viability and inhibited the increase in NO release and IL-1β and IL-6 gene expression induced by LPS.
, both compounds reduced lung edema, inflammatory cells, and the IL-6 and IL-1 β levels in bronchoalveolar lavage fluid, as well as reduced inflammatory cell infiltration and those positive to iNOS, MMP-9, and TIMP-1, and reduced the collagen content and the 8-isoprostane expression in lung tissue. Eugenol and dehydrodieugenol B also inhibited the phosphorylation of Jc-Jun-NH2 terminal Kinase (JNK), a signaling protein involved in the MAPKinase pathway. There was no effect of these compounds in lung function. Therefore, eugenol and dehydrodieugenol B ameliorates several features of experimental ALI and could be considered as a pharmacological tool to ameliorate acute lung inflammation.
Asthma allergic disease is caused by airway chronic inflammation. Some intracellular signaling pathways, such as MAPK and STAT3-SOCS3, are involved in the control of airway inflammation in asthma. ...The flavonoid sakuranetin demonstrated an anti-inflammatory effect in different asthma models. Our aim was to clarify how sakuranetin treatment affects MAPK and STAT3-SOCS3 pathways in a murine experimental asthma model. Mice were submitted to an asthma ovalbumin-induction protocol and were treated with vehicle, sakuranetin, or dexamethasone. We assayed the inflammatory profile, mucus production, and serum antibody, STAT3-SOCS3, and MAPK levels in the lungs. Morphological alterations were also evaluated in the liver. LPS-stimulated RAW 264.7 cells were used to evaluate the effects of sakuranetin on nitric oxide (NO) and cytokine production. In vivo, sakuranetin treatment reduced serum IgE levels, lung inflammation (eosinophils, neutrophils, and Th2/Th17 cytokines), and respiratory epithelial mucus production in ovalbumin-sensitized animals. Considering possible mechanisms, sakuranetin inhibits the activation of ERK1/2, JNK, p38, and STAT3 in the lungs. No alterations were found in the liver for treated animals. Sakuranetin did not modify in vitro cell viability in RAW 264.7 and reduced NO release and gene expression of IL-1β and IL-6 induced by LPS in these cells. In conclusion, our data showed that the inhibitory effects of sakuranetin on eosinophilic lung inflammation can be due to the inhibition of Th2 and Th17 cytokines and the inhibition of MAPK and STAT3 pathways, reinforcing the idea that sakuranetin can be considered a relevant candidate for the treatment of inflammatory allergic airway disease.
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Eugenol, a common phenylpropanoid derivative found in different plant species, has well-described anti-inflammatory effects associated with the development of occupational ...hypersensitive asthma. Dehydrodieugenol, a dimeric eugenol derivative, exhibits anti-inflammatory and antioxidant activities and can be found in the Brazilian plant species Nectandra leucantha (Lauraceae). The biological effects of dehydrodieugenol on lung inflammation remain unclear.
This study aimed to investigate the effects of eugenol and dehydrodieugenol isolated from N. leucantha in an experimental model of asthma.
In the present work, the toxic effects of eugenol and dehydrodieugenol on RAW 264.7 cells and their oxidant and inflammatory effects before lipopolysaccharide (LPS) exposure were tested. Then, male BALB/c mice were sensitized with ovalbumin through a 29-day protocol and treated with vehicle, eugenol, dehydrodieugenol or dexamethasone for eight days beginning on the 22nd day until the end of the protocol. Lung function; the inflammatory profile; and the protein expression of ERK1/2, JNK, p38, VAChT, STAT3, and SOCS3 in the lung were evaluated by immunoblotting.
Eugenol and dehydrodieugenol were nontoxic to cells. Both compounds inhibited NO release and the gene expression of IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. In OVA-sensitized animals, dehydrodieugenol reduced lung inflammatory cell numbers and the lung concentrations of IL-4, IL-13, IL-17, and IL-10. These anti-inflammatory effects were associated with inhibition of the JNK, p38 and ERK1/2, VAChT and STAT3/SOCS3 pathways. Moreover, treatment with dehydrodieugenol effectively attenuated airway hyperresponsiveness. Conclusion: The obtained data demonstrate, for the first time, that dehydrodieugenol was more effective than eugenol in counteracting allergic airway inflammation in mice, especially its inhibition of the JNK, p38 and ERK1/2, components of MAPK pathway. Therefore, dehydrodieugenol can be considered a prototype for the development of new and effective agents for the treatment of asthmatic patients.
Precision agriculture requires accurate methods for classifying crops and soil cover in agricultural production areas. The study aims to evaluate three machine learning-based classifiers to identify ...intercropped forage cactus cultivation in irrigated areas using Unmanned Aerial Vehicles (UAV). It conducted a comparative analysis between multispectral and visible Red-Green-Blue (RGB) sampling, followed by the efficiency analysis of Gaussian Mixture Model (GMM), K-Nearest Neighbors (KNN), and Random Forest (RF) algorithms. The classification targets included exposed soil, mulching soil cover, developed and undeveloped forage cactus, moringa, and gliricidia in the Brazilian semiarid. The results indicated that the KNN and RF algorithms outperformed other methods, showing no significant differences according to the kappa index for both Multispectral and RGB sample spaces. In contrast, the GMM showed lower performance, with kappa index values of 0.82 and 0.78, compared to RF 0.86 and 0.82, and KNN 0.86 and 0.82. The KNN and RF algorithms performed well, with individual accuracy rates above 85% for both sample spaces. Overall, the KNN algorithm demonstrated superiority for the RGB sample space, whereas the RF algorithm excelled for the multispectral sample space. Even with the better performance of multispectral images, machine learning algorithms applied to RGB samples produced promising results for crop classification.
The electronic transport in a metal/semiconductor/metal (MSM) structure, consisting of cobalt oxide films with aluminum (Al) contacts, was investigated. The cobalt oxides were grown by direct current ...(DC) magnetron sputtering using different oxygen gas flow rates. The behavior of the electric conductivity in the 200 K–350 K temperature range, the Schottky barrier heights (
∅
B
) and specific contact resistances (
R
c
)
were investigated. The analysis shows that small oxygen flow variations produce significant changes in electrical characteristics of the MSM structure.
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