Measures aimed at conservation or restoration of ecosystems are often seen as net‐cost projects by governments and businesses because they are based on incomplete and often faulty cost‐benefit ...analyses. After screening over 200 studies, we examined the costs (94 studies) and benefits (225 studies) of ecosystem restoration projects that had sufficient reliable data in 9 different biomes ranging from coral reefs to tropical forests. Costs included capital investment and maintenance of the restoration project, and benefits were based on the monetary value of the total bundle of ecosystem services provided by the restored ecosystem. Assuming restoration is always imperfect and benefits attain only 75% of the maximum value of the reference systems over 20 years, we calculated the net present value at the social discount rates of 2% and 8%. We also conducted 2 threshold cum sensitivity analyses. Benefit‐cost ratios ranged from about 0.05:1 (coral reefs and coastal systems, worst‐case scenario) to as much as 35:1 (grasslands, best‐case scenario). Our results provide only partial estimates of benefits at one point in time and reflect the lower limit of the welfare benefits of ecosystem restoration because both scarcity of and demand for ecosystem services is increasing and new benefits of natural ecosystems and biological diversity are being discovered. Nonetheless, when accounting for even the incomplete range of known benefits through the use of static estimates that fail to capture rising values, the majority of the restoration projects we analyzed provided net benefits and should be considered not only as profitable but also as high‐yielding investments. Beneficios de Invertir en la Restauración de Ecosistemas
Decoding the information in mRNA during protein synthesis relies on tRNA adaptors, the abundance of which can affect the decoding rate and translation efficiency. To determine whether cells alter ...tRNA abundance to selectively regulate protein expression, we quantified changes in the abundance of individual tRNAs at different time points in response to diverse stress conditions in
We found that the tRNA pool was dynamic and rearranged in a manner that facilitated selective translation of stress-related transcripts. Through genomic analysis of multiple data sets, stochastic simulations, and experiments with designed sequences of proteins with identical amino acids but altered codon usage, we showed that changes in tRNA abundance affected protein expression independently of factors such as mRNA abundance. We suggest that cells alter their tRNA abundance to selectively affect the translation rates of specific transcripts to increase the amounts of required proteins under diverse stress conditions.
In recent years, environmental indicators have become a vital component of environmental impact assessments and “state of the environment” reporting. This has increased the influence of environmental ...indicators on environmental management and policy making at all scales of decision making. However, the scientific basis of the selection process of the indicators used in environmental reporting can be significantly improved. In many studies no formal selection criteria are mentioned and when selection criteria are used they are typically applied to indicators individually. Often, no formal criteria are applied regarding an indicator's analytical utility within the total constellation of a selected set of indicators. As a result, the indicator selection process is subject to more or less arbitrary decisions, and reports dealing with a similar subject matter or similar geographical entities may use widely different indicators and consequently paint different pictures of the environment. In this paper, a conceptual framework for environmental indicator selection is proposed that puts the indicator set at the heart of the selection process and not the individual indicators. To achieve this objective, the framework applies the concept of the causal network that focuses on the inter-relation of indicators. The concept of causal networks can facilitate the identification of the most relevant indicators for a specific domain, problem and location, leading to an indicator set that is at once transparent, efficient and powerful in its ability to assess the state of the environment.
We describe and reflect on seven recurring critiques of the concept of ecosystem services and respective counter‐arguments. First, the concept is criticized for being anthropocentric, whereas others ...argue that it goes beyond instrumental values. Second, some argue that the concept promotes an exploitative human–nature relationship, whereas others state that it reconnects society to ecosystems, emphasizing humanity's dependence on nature. Third, concerns exist that the concept may conflict with biodiversity conservation objectives, whereas others emphasize complementarity. Fourth, the concept is questioned because of its supposed focus on economic valuation, whereas others argue that ecosystem services science includes many values. Fifth, the concept is criticized for promoting commodification of nature, whereas others point out that most ecosystem services are not connected to market‐based instruments. Sixth, vagueness of definitions and classifications are stated to be a weakness, whereas others argue that vagueness enhances transdisciplinary collaboration. Seventh, some criticize the normative nature of the concept, implying that all outcomes of ecosystem processes are desirable. The normative nature is indeed typical for the concept, but should not be problematic when acknowledged. By disentangling and contrasting different arguments we hope to contribute to a more structured debate between opponents and proponents of the ecosystem services concept.
Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases. On the biotechnological side, protein ...production is often hampered by the accumulation of recombinant proteins into aggregates. Thus, the development of methods to anticipate the aggregation properties of polypeptides is receiving increasing attention. AGGRESCAN is a web-based software for the prediction of aggregation-prone segments in protein sequences, the analysis of the effect of mutations on protein aggregation propensities and the comparison of the aggregation properties of different proteins or protein sets.
AGGRESCAN is based on an aggregation-propensity scale for natural amino acids derived from in vivo experiments and on the assumption that short and specific sequence stretches modulate protein aggregation. The algorithm is shown to identify a series of protein fragments involved in the aggregation of disease-related proteins and to predict the effect of genetic mutations on their deposition propensities. It also provides new insights into the differential aggregation properties displayed by globular proteins, natively unfolded polypeptides, amyloidogenic proteins and proteins found in bacterial inclusion bodies.
By identifying aggregation-prone segments in proteins, AGGRESCAN http://bioinf.uab.es/aggrescan/ shall facilitate (i) the identification of possible therapeutic targets for anti-depositional strategies in conformational diseases and (ii) the anticipation of aggregation phenomena during storage or recombinant production of bioactive polypeptides or polypeptide sets.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Background and AimsDespite differences in physiology between dry and relative moist seeds, seed ageing tests most often use a temperature and seed moisture level that are higher than during dry ...storage used in commercial practice and gene banks. This study aimed to test whether seed ageing under dry conditions can be accelerated by storing under high-pressure oxygen.MethodsDry barley (Hordeum vulgare), cabbage (Brassica oleracea), lettuce (Lactuca sativa) and soybean (Glycine max) seeds were stored between 2 and 7 weeks in steel tanks under 18 MPa partial pressure of oxygen. Storage under high-pressure nitrogen gas or under ambient air pressure served as controls. The method was compared with storage at 45 °C after equilibration at 85 % relative humidity and long-term storage at the laboratory bench. Germination behaviour, seedling morphology and tocopherol levels were assessed.Key ResultsThe ageing of the dry seeds was indeed accelerated by storing under high-pressure oxygen. The morphological ageing symptoms of the stored seeds resembled those observed after ageing under long-term dry storage conditions. Barley appeared more tolerant of this storage treatment compared with lettuce and soybean. Less-mature harvested cabbage seeds were more sensitive, as was the case for primed compared with non-primed lettuce seeds. Under high-pressure oxygen storage the tocopherol levels of dry seeds decreased, in a linear way with the decline in seed germination, but remained unchanged in seeds deteriorated during storage at 45 °C after equilibration at 85 % RH.ConclusionsSeed storage under high-pressure oxygen offers a novel and relatively fast method to study the physiology and biochemistry of seed ageing at different seed moisture levels and temperatures, including those that are representative of the dry storage conditions as used in gene banks and commercial practice.
Introduction
The finding of left atria diverticula (LAD) on cardiac computed tomography images obtained from patients with atrial fibrillation (AF) referred for pulmonary vein isolation is not ...uncommon. Prior studies reporting on LAD do not always provide definitions of LAD resulting in confusion with other anatomical structures such as left atrial accessory appendages (LAAA) and atrial aneurysms. The aim of this review is to identify an accurate definition of LAD and to describe distinctive properties between LAD and other left atrial structures, such as LAAA and aneurysms. Also, the relation between LAD and development of atrial tachyarrhythmias is discussed.
Methods
PubMed was searched for studies reporting on atrial aneurysms, left atrial diverticula, left atrial accessory appendages and atrial congenital aneurysms, resulting in 36 papers.
Results
LAD can be distinguished from LAAA by taking into account embryologic origins of the left atrium and their locations, resulting in the following definitions: (a) LAAA are contractile, trabeculated structures with circumscriptive ostia and narrow necks, originating from the primitive atria, (b) LAD are contractile, sac like structures with either smooth or trabeculated inner surfaces, circumscriptive ostia, narrow necks, and variable morphologies, originating from the embryologic common pulmonary vein, that incorporates into the LA, and (c) atrial aneurysms are non‐contractile structures with wide necks and sac like bodies. There are no differences in prevalences of LAD between patients with sinus rhythm and AF.
Conclusion
The pathophysiology of LAD is not yet fully understood. It is unlikely, that LAD are related to the development of atrial tachycardia's and AF by either being a source of ectopic activity or being part of an arrhythmogenic substrate. No differences in LAD prevalences between patients with sinus rhythm and AF have been found. Thus, it is unlikely that LAD could potentially be wolves in sheep's clothing.
Since the late 1960s, the valuation of ecosystem services has received ample attention in scientific literature. However, to date, there has been relatively little elaboration of the various spatial ...and temporal scales at which ecosystem services are supplied. This paper analyzes the
spatial scales of ecosystem services, and it examines how stakeholders at different spatial scales attach different values to ecosystem services. The paper first establishes an enhanced framework for the valuation of ecosystem services, with specific attention for stakeholders. The framework includes a procedure to assess the value of regulation services that avoids double counting of these services. Subsequently, the paper analyses the spatial scales of ecosystem services: the ecological scales at which ecosystem services are generated, and the institutional scales at which stakeholders benefit from ecosystem services. On the basis of the proposed valuation framework, we value four selected ecosystem services supplied by the De Wieden wetlands in The Netherlands, and we analyze how these services accrue to stakeholders at different institutional scales. These services are the provision of reed for cutting, the provision of fish, recreation, and nature conservation. In the De Wieden wetland, reed cutting and fisheries are only important at the municipal scale, recreation is most relevant at the municipal and provincial scale, and nature conservation is important in particular at the national and international level. Our analysis shows that stakeholders at different spatial scales can have very different interests in ecosystem services, and we argue that it is highly important to consider the scales of ecosystem services when valuation of services is applied to support the formulation or implementation of ecosystem management plans.
An increasing amount of information is being collected on the ecological and socio-economic value of goods and services provided by natural and semi-natural ecosystems. However, much of this ...information appears scattered throughout a disciplinary academic literature, unpublished government agency reports, and across the World Wide Web. In addition, data on ecosystem goods and services often appears at incompatible scales of analysis and is classified differently by different authors. In order to make comparative ecological economic analysis possible, a standardized framework for the comprehensive assessment of ecosystem functions, goods and services is needed. In response to this challenge, this paper presents a conceptual framework and typology for describing, classifying and valuing ecosystem functions, goods and services in a clear and consistent manner. In the following analysis, a classification is given for the fullest possible range of 23 ecosystem functions that provide a much larger number of goods and services. In the second part of the paper, a checklist and matrix is provided, linking these ecosystem functions to the main ecological, socio–cultural and economic valuation methods.
Highlights • In DMD problems with mastication are found in the early stages of the disease. • Masseter muscle weakness and malocclusions were responsible for hampered chewing. • Early detection is ...essential and can lead to timely intervention.
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