In this study, silver molybdate was used as a catalyst in different oxidation processes to degrade pantoprazole (PAN) from aqueous suspension. The catalyst was synthesized using a controlled ...precipitation method and characterized by XRD, FTIR spectroscopy, BET analysis, Zeta potential, FEG-SEM/EDS, DRS and EPR. The α- and β-phases of Ag2MoO4 were identified as crystalline structure of the butterfly-shaped particles. The metastable α-phase could be completely converted into β-Ag2MoO4 by thermal treatment at 300 °C. The band gap energy of β-Ag2MoO4 (Eg = 3.25 eV) is slightly higher than for as-prepared catalyst (α-Ag2MoO4 + β-Ag2MoO4) (Eg = 3.09 eV), suggesting that as-prepared catalyst should be active under visible light. PAN is sensible to UV light irradiation, and the addition of H2O2 as electron acceptor enhanced the mineralization rate. In the catalytic UV-based reactions, high PAN oxidation efficiencies were obtained (>85%) but with low mineralization (32-64%). Catalytic peroxidation and photo-catalytic peroxidation under visible light showed the highest PAN oxidation efficiency, leading to its almost complete mineralization (>95%), even under dark conditions (98% in 120 min). Several degradation byproducts were identified and three mechanistic routes of PAN decomposition were proposed. The identified byproducts are less toxic than the parent compound. EPR coupled with the spin trapping method identified •OH radicals as the main ROS species in both photocatalytic and catalytic peroxidation reactions. Ag2MoO4 showed to be a promising catalyst to promote the decomposition of hydrogen peroxide into ROS.1
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•Facile synthesis of Ag2MoO4 with both α and β-phases.•α-Ag2MoO4 + β-Ag2MoO4 catalyst showed photocatalytic activity under visible light.•Efficient oxidation of pantoprazole by catalytic peroxidation with Ag2MoO4.•Mechanistic route for pantoprazole degradation via.•OH radicals is proposed.•Almost complete toxicity removal of PAN and its by-products was observed in 2 h.
Retene is a polycyclic aromatic hydrocarbon (PAH) emitted mainly by biomass combustion, and despite its ubiquity in atmospheric particulate matter (PM), studies concerning its potential hazard to ...human health are still incipient. In this study, the cytotoxicity and genotoxicity of retene were investigated in human HepG2 liver cells. Our data showed that retene had minimal effect on cell viability, but induced DNA strand breaks, micronuclei formation, and reactive oxygen species (ROS) formation in a dose- and time-dependent manner. Stronger effects were observed at earlier time points than at longer, indicating transient genotoxicity. Retene activated phosphorylation of Checkpoint kinase 1 (Chk1), an indicator of replication stress and chromosomal instability, which was in accordance with increased formation of micronuclei. A protective effect of the antioxidant N-acetylcysteine (NAC) towards ROS generation and DNA damage signaling was observed, suggesting oxidative stress as a key mechanism of the observed genotoxic effects of retene in HepG2 cells. Altogether our results suggest that retene may contribute to the harmful effects caused by biomass burning PM and represent a potential hazard to human health.
•Retene induced DNA strand breaks, micronuclei formation, and ROS formation.•Retene activated DNA damage response via Chk1 and H2AX.•Genotoxic effects were dose-dependent and transient.•Oxidative stress is a key mechanism of retene's genotoxicity.
Smoking crack cocaine involves the inhalation of cocaine and its pyrolysis product, anhydroecgonine methyl ester (AEME). Although there is evidence that cocaine is neurotoxic, the neurotoxicity of ...AEME has never been evaluated. AEME seems to have cholinergic agonist properties in the cardiovascular system; however, there are no reports on its effects in the central nervous system. The aim of this study was to investigate the neurotoxicity of AEME and its possible cholinergic effects in rat primary hippocampal cell cultures that were exposed to different concentrations of AEME, cocaine, and a cocaine-AEME combination. We also evaluated the involvement of muscarinic cholinergic receptors in the neuronal death induced by these treatments using concomitant incubation of the cells with atropine. Neuronal injury was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. The results of the viability assays showed that AEME is a neurotoxic agent that has greater neurotoxic potential than cocaine after 24 and 48 h of exposure. We also showed that incubation for 48 h with a combination of both compounds in equipotent concentrations had an additive neurotoxic effect. Although both substances decreased cell viability in the MTT assay, only cocaine increased LDH release. Caspase-3 activity was increased after 3 and 6 h of incubation with 1mM cocaine and after 6 h of 0.1 and 1.0mM AEME exposure. Atropine prevented the AEME-induced neurotoxicity, which suggests that muscarinic cholinergic receptors are involved in AEME's effects. In addition, binding experiments confirmed that AEME has an affinity for muscarinic cholinergic receptors. Nevertheless, atropine was not able to prevent the neurotoxicity produced by cocaine and the cocaine-AEME combination, suggesting that these treatments activated other neuronal death pathways. Our results suggest a higher risk for neurotoxicity after smoking crack cocaine than after cocaine use alone.
Systemic sclerosis (SSc) is a rare chronic autoimmune disease characterized by vascular abnormalities and connective tissue disorders. In 2021, the multidisciplinary team of the university hospital ...recognized a demand for oral health information among SSc patients. This study aims to describe the development of an SSc oral health booklet and its validation by people with SSc.
For the development of the booklet, the project creators employed the action research methodology involving ten stages. SSc patients evaluated the material by filling out a digital form.
One hundred and thirty-one people with SSc evaluated the booklet. It received an average score of 9.73 (SD: 0.80) in relevance, 9.82 (SD: 0.47) in explicitness, and 9.49 (SD: 0.93) in aesthetics. The final version was emailed to the participants and posted on social media.
This is the first booklet that deeply addresses these issues in Portuguese and constitutes a soft technology to instruct and assist patients with SSc.
The production of high-quality educational materials on oral health for patients with SSc is necessary. The online distribution increased its reach and had great importance in the context of the COVID-19 pandemic.
•Systemic sclerosis orofacial abnormalities impose challenges to health professionals.•Health education enables patients to self-manage systemic sclerosis.•Educational booklets must use simple language and illustrations to improve patients' understanding.•Patients' suggestions are essential to improve educational booklets.•The online distribution of educational materials improves their reach.
Resumo A jaca é um fruto exótico presente na região Nordeste do Brasil, apresentando um grande potencial econômico para região em face da comercialização interna e externa do seu fruto. Sua semente é ...rica em carboidratos, proteína, minerais e vitaminas, constituindo fonte alternativa de amido para alimentação. A germinação é uma tecnologia barata de fácil acesso para produção de brotos, melhorando a biodisponibilidade de nutrientes na semente para o consumo, a exemplo das proteínas e compostos bioativos. O objetivo do trabalho foi avaliar os parâmetros químicos, físicos e físico-químicos das sementes de jaca in natura e germinadas. A germinação das sementes de jaca proporcionou o aumento nos teores de água, proteínas, ácido ascórbico, compostos fenólicos e açúcares totais, além de reduzir os conteúdo de amido, lipídios, taninos e os parâmetros de cor, a luminosidade, intensidade de vermelho (+a*) e de amarelo (+b*). Em relação às propriedades físicas da semente, ocorreu acréscimo na massa específica real e na massa unitária. Para massa específica aparente houve redução. A germinação das sementes proporcionou aumento nos teores de magnésio, ferro e sódio, consequentemente ocorrendo redução de potássio, fósforo, cálcio, zinco, cobre e manganês.
OBJETIVOS: Avaliar a qualidade de vida (QV) na doença venosa crônica (DVC) e analisar a relação entre QV e severidade da doença. MÉTODOS: Trata-se de um estudo transversal com uma amostra de ...conveniência de 50 pacientes com DVC diagnosticada. Os pacientes foram classificados quanto à severidade da DVC pela classificação clínica da Clinical manifestations, Etiologic factors, Anatomic distribuition of disease, Pathophysiologic findings (CEAP) e agrupados em: CEAP 1, 2, 3 (menos comprometidos clinicamente) e CEAP 4, 5, 6 (mais comprometidos clinicamente). A QV foi avaliada pelo questionário SF-36. Para comparação dos escores do SF-36 entre os grupos foi utilizado o teste Mann-Whitney U e para verificar associação entre QV e CEAP, o coeficiente de correlação de Spearman. Foi considerada diferença estatisticamente significativa p<0,05. O programa estatístico SPSS, versão 16.0 foi utilizado para as análises. RESULTADOS: 74% da amostra eram mulheres e a média de idade foi significativamente maior (p<0,001) entre os indivíduos CEAP 4, 5, 6 (56,6±10,3) do que entre os CEAP 1, 2, 3 (40,6±10,7). Todos os domínios do Componente Saúde Física (CSF) do SF-36 apresentaram escores significativamente menores no grupo CEAP 4, 5, 6 (p<0,05), representando maior comprometimento físico e funcional. Apenas os domínios do CSF apresentaram correlação negativa e estatisticamente significativa com a CEAP. CONCLUSÕES: Os aspectos físicos e funcionais foram mais comprometidos, sobretudo nas formas mais graves da DVC. Estes achados podem contribuir para melhor compreensão dos efeitos da DVC na QV e melhor direcionamento das intervenções terapêuticas nessa população.
The aim of the present study was to compare the recurrence rates of solid multicystic ameloblastomas after segmental resection or marginal resection.
PubMed, ScienceDirect, Web of Science, Scopus, ...Embase were searched for studies published up to July 2022. The gray literature was also searched. Meta-analysis was performed using OpenMeta Software,
< 0.05 considered significant.
Among the search, 8 studies met all eligibility criteria. The group that underwent marginal resection was 1.1 times more likely to present recurrence of the lesion compared to the group that underwent segmental resection. There was no statistically significant difference between the two groups (segmental resection and marginal resection) in all eight studies regarding reducing ND (95% Confidence interval, 0.339 - 3.705; heterogeneity: Q value= 3.105; I2= 0%).
The results showed that there was no statistically significant difference between segmental and marginal resection for the treatment of solid multicystic ameloblastomas; however, prospective studies with more rigorous methodological procedures are needed to better compare the surgical techniques.
Ameloblastoma, solid multicystic ameloblastoma, treatment, recurrence.
Background: sarcopenia is a progressive and generalized clinical condition associated with loss of mass, strength, and/or muscle function, impairing physical performance. The definition of ...sarco-penia is a dilemma, as several studies have been published in the last ten years by different socie-ties. One of the most used definitions is the Guideline created by the European Working Group on Sarcopenia in Older People (EWGSOP) and updated in 2019 (EWGSOP2) to facilitate the under-standing of sarcopenia and improve treatment proposals. This is the only definition supported by several international scientific societies for clinical practice and research in patients with sarcope-nia. Treatment can be divided into non-pharmacological and pharmacological. There are no spe-cific drugs approved for the treatment of sarcopenia. As for non-pharmacological interventions, physical exercise is the most effective intervention, especially resistance exercises. Nutritional in-tervention has a low level of evidence. Objectives: The objective of this article is to review data on the effect of physical exercise in the treatment of sarcopenia. Method: Reviews and systematic re-views were searched in different data sources, including PubMed, between the years 2010 and 2024, with the keywords (sarcopenia and non-pharmacological treatment; sarcopenia and exercise and sarcopenia). Conclusions: Physical exercise is the first-line treatment for sarcopenia. There is no drug released for the specific treatment of sarcopenia, and nutritional interventions have little clinical evidence in improving the quantitative and functional aspects of the muscular system in sarcopenic patients. Among the exercise modalities, resistive exercises alone showed the most sig-nificant benefit in the muscular rehabilitation of sarcopenic patients. Despite this, when evaluated with resistive exercise, aerobic and balance exercises brought additional benefits in some muscular functions. Nutritional intervention also appears to improve muscle strength when associated with resistive exercises. More studies are needed to elucidate the best physical activity program and whether other nutritional interventions could benefit the patient more.
Introduction: Existing literature presents varying perspectives on the impact of COVID-19 on liver transplant recipients. However, no research has specifically investigated the role of gender ...differences in the manifestation of COVID-19 among liver transplant recipients. This study aims to examine the effects of COVID-19 on liver transplant recipients, with a focus on gender differences in disease presentation and progression. Methods: Conducted as a multicenter historical cohort study, this research collected patient records through an online questionnaire. Assessing COVID-related mortality was the main objective. Additionally, demographic, clinical, and laboratory data pertaining to disease presentation and progression were collected. Results:The study included a total of 283 patients, of whom 76 were female and 206 were male. The median follow-up period for males was 99 days (IQR 38-283), while for females, it was 126 days (IQR 44-291). A higher prevalence of cardiovascular disease was observed in males (p=0.002). Females frequently experienced a loss of smell (p=0.021), whereas males commonly exhibited fever (p=0.031). Levels of ALT and gamma-glutamyl transferase were significantly elevated in males (p=0.008 and 0.004, respectively). Although there was a trend towards increased mortality in males, it did not reach statistical significance.Conclusion: This study is the first attempt to investigate gender differences in COVID-19 among liver transplant recipients. Our findings highlight the need for a comprehensive and personalised approach to treating this patient population and underscore the importance of further elucidating the disease presentation in these individuals
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