Um dos dilemas recorrentes na sociologia da arte tem sido como balancear abordagens internalistas e externalistas dos fenômenos estéticos (isto é, explicações estéticas e sociais); ou o que este ...artigo caracteriza como a necessidade de sair de um modelo “ou arte ou sociedade” para um modelo de lógica “tanto arte quanto sociedade”. Nos últimos anos, os dilemas conceituais foram intensificados por uma tendência de o capitalismo se tornar um fenômeno mais explicitamente cultural. Ao mesmo tempo, os conhecimentos sobre arte e estética saíram da esfera da grandiosidade e da alta cultura para o mundo prosaico do dia a dia. Este artigo propõe que a solução para os dilemas em curso da sociologia da arte, e para o atual desafio das bases da arte e do conhecimento estético é adotar um paradigma textural, ao invés de um modo de pensar textual. O paradigma textural foi desenvolvido primeiramente no pensamento sobre lugar e é adequado para pensar os problemas da sociologia da arquitetura e do urbanismo – incluindo o problema de como o tecido urbano, às vezes, começa a desemaranhar; ou porque alguns estilos arquitetônicos improváveis voltam à moda (como, por exemplo, o brutalismo pós-guerra).
El presente trabajo revisa los hechos relevantes en la vida infantil del poeta jalisciense Elías Nandino y en el análisis psicológico de sus relaciones con las conductas del padre y de la madre. Se ...busca encontrar una interpretación psicológica que explique la formación heterodoxa de la sexualidad del poeta. El análisis se lleva a cabo dentro de la metodología cualitativa con un diseño narrativo que obtiene sus unidades de significación de la propia autobiografía de Nandino escrita en su libro “Juntando mis pasos” (2000). Se ha hecho el análisis desde un enfoque psicoanalítico y se presentan las conclusiones.
In this article we examine the sonic framing of place. Our theoretical approach combines Goffman’s microsociology (and its sociology of music/sound studies off-shoots) with an account of sound in the ...urban atmospheres literature. Drawing on the work of French urban sociologist Jean-Paul Thibaud and associated work on sound in urban environments by the CRESSON research centre, we propose that sound frames activity in particular ways, including by infusing self and space with a certain tone, and by rendering places more or less hospitable. In the latter part of the article, we examine Quiet Hour shopping as a case study in the sonic constitution and transformation of places. We conclude by reflecting on whether the social and cultural theoretical analysis of sound has suffered from a ‘noise bias’, and whether the ‘resonances’ of public places is a new frontier in both sociological research and in the politics of cities.
Abstract
Problem
Recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) represent distinct clinical conditions with established definitions, both of which have been linked to an ...underlying pro‐inflammatory state. This study aimed to explore the levels of monocytic‐myeloid‐derived suppressor cells (M‐MDSCs) and regulatory T cells (T
Reg
) in a cohort of RPL and RIF women and their potential contribution to RPL and RIF.
Method of study
One hundred and eight non‐pregnant women were evaluated: 40 RPL, 41 RIF, and 27 fertile healthy controls (HC). A multiparametric flow cytometry approach was utilized to measure and quantify the frequency of M‐MDSCs and T
Reg
cells. Cytokine levels in plasma samples were evaluated through a multiplex assay. M‐MDSCs levels were significantly higher in RPL and RIF patients compared to HC.
Results
M‐MDSCs levels were significantly higher in RPL (9.4% 7–11.6) and RIF (8.1% 5.9–11.6) patients compared to HC (6% 4.2–7.6). An optimal cut‐off of 6.1% for M‐MDSCs disclosed a sensitivity of 75.6% and 89.7% and a specificity of 57.7% and 57.7% in RIF and RPL groups, respectively. A significant negative correlation was observed between M‐MDSCs and T
Reg
(
p
= .002,
r
= −.51).
Conclusions
Our preliminary data allowed us to build a predictive model that may aid as a potential diagnostic tool in the clinic. These findings could provide a better understanding of these pathologies and a better definition of patients that could benefit from personalized treatments to promote pregnancy. Additional exploration and confirmation in distinct study groups are needed to fully assess the diagnostic capabilities of this biomarker.
This introduction positions the special issue by highlighting the inherent relationality of place as well as how place is not just an object of analysis but something that shapes thinking, writing ...and experiences of the world. We reflect on why sociology has found it somewhat more difficult than its social science counterparts to give place the centrality it merits, and discuss whether this reflects a problem with dealing with questions of ‘scale’ and thinking the ‘in-betweenness’ of place. We assess important formulations of place in recent place theories, including non-essentialist framings of place such as ‘progressive’ and as ‘assemblage’. We make a case for seeing the articles in this special issue (and Thesis Eleven’s own long history of publishing writing on the topic of place) as resonating with the themes of place as materiality, atmospheres and spaces of belonging.
This article shows the geometric modeling and virtual reconstruction of the optical telegraph by Agustín de Betancourt and Abraham Louis Breguet developed at the end of the 18th century. Autodesk ...Inventor Professional software has been used to obtain the three-dimensional (3D) model of this historical invention and its geometric documentation. The material for the research is available on the website of the Betancourt Project of the Canary Orotava Foundation for the History of Science. Thanks to the three-dimensional modeling performed, it has been possible to explain in detail both its operation and the assembly system of this invention in a coherent way. After carrying out its 3D modeling and functional analysis, it was discovered that the transmissions in the telegraph were not performed by hemp ropes but rather by metal chains with flat links, considerably reducing possible error. Similarly, it has also been found that the use of the gimbal joint facilitated the adaptability of the invention to geographical areas where there was a physical impediment to the alignment of telegraph stations. In addition, it was not now necessary for the telescope frames to be located parallel to the mast frame (frame of the indicator arrow) and therefore they could work in different planes.
Common variable immunodeficiency (CVID) represents the largest group of primary immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and cancer, mainly B-cell ...non-Hodgkin’s lymphoma (NHL). Indeed, NHL may result from chronic or recurrent infections and has, therefore, been recognized as a clinical phenotype of CVID, although rare. The more one delves into the mechanisms involved in CVID and cancer, the stronger the idea that both pathologies can be a reflection of the same primer events observed from different angles. The potential effects of germline variants on specific somatic modifications in malignancies suggest that it might be possible to anticipate critical events during tumor development. In the same way, a somatic alteration in NHL could be conditioning a similar response at the transcriptional level in the shared signaling pathways with genetic germline alterations in CVID. We aimed to explore the genomic substrate shared between these entities to better characterize the CVID phenotype immunodeficiency in NHL. By means of an
in-silico
approach, we interrogated the large, publicly available datasets contained in cBioPortal for the presence of genes associated with genetic pathogenic variants in a panel of 50 genes recurrently altered in CVID and previously described as causative or disease-modifying. We found that 323 (25%) of the 1,309 NHL samples available for analysis harbored variants of the CVID spectrum, with the most recurrent alteration presented in NHL occurring in PIK3CD (6%) and STAT3 (4%). Pathway analysis of common gene alterations showed enrichment in inflammatory, immune surveillance, and defective DNA repair mechanisms similar to those affected in CVID, with PIK3R1 appearing as a central node in the protein interaction network. The co-occurrence of gene alterations was a frequent phenomenon. This study represents an attempt to identify common genomic grounds between CVID and NHL. Further prospective studies are required to better know the role of genetic variants associated with CVID and their reflection on the somatic pathogenic variants responsible for cancer, as well as to characterize the CVID-like phenotype in NHL, with the potential to influence early CVID detection and therapeutic management.
This review considers the book Anko Itosu. The Man. The Master. The Myth. Biography of a Legend, published in 2021 by Thomas Feldmann. The volume is a thorough biographical study of Anko Itosu ...(1831–1915), Okinawan born and essential figure to interpret initial developments of karate history during the 20th century. Approximately two decades before this indigenous martial art was to be popularized in mainland Japan by Funakoshi Gichin (1868–1957) and Mabuni Kenwa (1889–1952), and officially recognized by the Dainippon Butokukai Greater Japan Martial Arts Virtue Society (1933), Itosu consolidated important technical and discursive changes for karate. This novel way to practice and describe karate, still molding the perception of the art today, had the intention, among others, to further support its inclusion in the school system of Okinawa. Using a huge amount of written and oral sources, historical documents, and scholarly studies on Okinawa, this text offers a vivid picture of Itosu's life. In a manner unusual among the publications on the topic, the text not only explores the early days of modern karate through the existential vicissitudes of the master, but even more importantly it does so against the background of how the cultural, social, and political life was articulated in Okinawa at the time. Such a remarkable effort bears a value that should not go unnoticed among martial arts researchers and the interested reader alike.
This article analyzes the first self-propelled floating dredging machine designed and executed by Agustín de Betancourt in 1810 to dredge the port of Kronstadt (Russia). With this objective, a study ...of computer-aided engineering (CAE) has been carried out using the parametric software Autodesk Inventor Professional, consisting of a static analysis using the finite element method, of the 3D model which is reliable under operating conditions. The results have shown that the system of inertia drums proposed by Betancourt manages to dissipate the tensions between the different elements, locating the highest stresses in the links of the bucket rosary, specifically at the point of contact between links. Similarly, the maximum displacements and the greatest deformations (always associated with these points of greater stress), are far from reaching the limits of breakage of the material used in its construction, as well as the safety coefficient of the invention, confirming that the mechanism was oversized, as was generally the case at the time. This analysis highlights the talent of the Spanish engineer and his mastery of mechanics, in an invention, the first of its kind worldwide, which served the Russian Empire for many years.
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