Twelve cases of spiradenocylindromas, which revealed features of both spiradenoma and cylindroma in the same tumor mass, are presented. Nine female patients had multiple neoplasms occurring mostly on ...the scalp, and two female and one male patient had a solitary cutaneous lesion. Three of the female patients with multiple cutaneous tumors had a familial history of similar cutaneous neoplasms. In one of the patient’s family, the multiple cutaneous tumors were known to occur in multiple family members in four consecutive generations. One patient with multiple cutaneous lesions was known to have associated multiple kidney cysts as confirmed by computed tomography. Histologically, spiradenocylindromas are composed of intermixed areas that are either of typical spiradenoma in appearance or of typical cylindroma appearance. Apocrine and trichoepitheliomatous differentiation seen in two cases in the present series points to spiradenomas, as well as cylindromas, having complex hair follicle (folliculo‐ sebaceous apocrine) rather than eccrine differentiation. The presence of lymphoid tissue was a histological feature in the present series, which was prominent in all the spiradenomatous parts of the tumors and which was scanty or practically absent in all the cylindromatous parts. The selective presence of lymphocytes in spiradenoma and an absence in cylindroma suggest that spiradenomas have the unique property of attracting lymphocytes. The malignant tumors arising in three patients in the present series had the morphology of a poorly differentiated epithelioid neoplasm. Three patients died of the disease and the other patients were either free of disease or alive with disease 1–30 years on follow up.
Congenital cystic adenomatoid malformation (CCAM) of the lung is characterized by an excessive overgrowth of the terminal respiratory bronchioles, probably of hamartomatous origin. The absence of ...inflammation has generally been considered obligatory for the diagnosis of CCAM of the lung in the infantile period. Furthermore, it has been argued that chronic inflammation itself may influence the development of cystic lesions within lung parenchyma. We report a case of an 11-month-old infant with CCAM malformation of the lung type III associated with a super-impossed purulent inflammation and abscess formation. In conclusion, our case clearly demonstrates that CCAM may even in infantile period become inflamed, manifesting itself with different clinical symptoms and signs, such as respiratory distress or recurrent pneumonia.
A case of a child with the hyperplastic callus formation in association with osteogenesis imperfecta is presented. The soft tissue mass arising at the site of femoral fracture was clinically and ...radiologically suspected to be a hyperplastic callus, although a possibility of osteosarcoma could not be completely excluded. A drill biopsy of the soft tissue mass was performed which showed osteocartilaginous callus. The soft tissue mass disappeared following biopsy. This occurrence is also reported in previously described cases.
Acinic cell-like carcinoma of the breast Roncaroli, F; Lamovec, J; Zidar, A ...
Virchows Archiv : an international journal of pathology,
09/1996, Letnik:
429, Številka:
1
Journal Article
Recenzirano
A case of infiltrating carcinoma of the breast with features similar to those seen in acinic cell carcinoma of the parotid gland is described in a 42-year-old woman. The neoplastic cells were ...immunoreactive with anti-lysozyme- and anti-salivary-type amylase antisera and contained electron-dense cytoplasmic globules similar to those seen in acinic cell carcinoma of salivary glands. One lymph node out of 18 was found to contain a metastatic deposit. The patient is alive and well 1 year after mastectomy. This appears to be the first case of carcinoma with acinic cell-like features reported in the breast.
We report three cases of epithelioid hemangioma of small tubular bones in women aged 20, 24, and 50 years. In two patients, the tumor appeared during or shortly after pregnancy. We studied clinical ...data, radiographs, and hematoxylin- and eosin-stained slides, and we performed immunohistochemical and flow cytometric DNA analysis. The tumor was in distal phalanges of the fingers in two patients and in metatarsal bone in one. Cortical bone destruction with infiltration of the surrounding soft tissue was seen in all of the patients. Light microscopic examination showed characteristic morphology, highlighted by epithelioid endothelial cells with different degrees of vasoformativity. Immunohistochemically, the epithelioid cells showed strong positive reaction for Factor VIII in all three patients, for CD31 in two, and for CD34 in one. Ulex europaeus antigen and keratins were negative. Laminin and collagen IV delineated innumerable predominantly abortive vascular structures, which were encircled by cells that presumably were pericytic and that were positive for smooth muscle actin. A relatively high degree of immunostaining for proliferating cell nuclear antigen and Ki67 contrasted with the low mitotic rate and low percentage of cells in S phase. Progesterone and estrogen receptors were negative. Epithelioid hemangiomas of small tubular bones are rare lesions that are characterized by early bone destruction and infiltration of soft tissues. Their association with pregnancy may be fortuitous; if any gestation-related proliferative stimulation exists, it does not seem to be mediated through steroid receptors.
Eight cases of primary non‐Hodgkin's lymphoma of the breast found in the pathology files of the Institute of Oncology, Ljubljana, Yugoslavia, for a period of 25 years (from 1961 to 1985) were ...analyzed. During the same period 5711 cases of breast carcinoma were seen. Seven cases were diffuse lymphomas, and one case was nodular. Five cases were high‐grade large cell lymphomas and three cases were of low‐grade type. One case of the latter group was associated with elevated IgA in the serum and showed monoclonal reaction of plasmacytic lymphoma cells for kappa light chain and IgA. In this case amyloid deposits were seen in the breast tumor. In six cases, focal infiltration of ductal/Iobular epithelium by lymphoma cells was found. This so‐called lymphoepithelial lesion appears to be an important characteristic of various mucosa‐associated lymphoid tissue lymphomas which have been described in different extranodal sites (e.g. gastrointestinal tract, and respiratory tract). They may show different behavior from nodal counterparts, especially in terms of their spread to other mucosal sites which may appear before or without nodal dissemination. The breast appears to be yet another location for these lymphomas.
Background. Inflammatory pseudotumor or inflammatory myofibroblastic tumor is a benign, tumor forming proliferation of myofibroblasts with a potential for recurrence and persistent local growth, in ...some respects similar to fibromatosis. The lesion does not metastasize except exceedingly rarely. Though inflammatory pseudotumor is not a malignant lesion, it may occasionally behave aggressively, like fibromatosis or fibrosarcoma, and threatens patient’s life.Patients and methods. Patient D. E., born in 1974, in the second month of pregnancy, was admitted to our Clinic in 1996 because of the protrusion of the left eye. She has often had evening headaches for the last 5 years. She has previously been treated for epistaxis. CT showed a tumorous formation in the ethmoidal labyrinth, which grew into adjacent structures, destroyed the neighboring bones and extended into extradural space of cranial cavity.The patient was operated upon at the ENT clinic where a tumor of a »woman’s fist« size was excised. It showed expansive, non-infiltrative growth. Microscopically, it was an inflammatory pseudotumor. For one year after the operation the patient was in good health, without protrusion. After that period, she had repeated recurrences, reoperations, she was irradiated and received chemotherapy. In spite of all treatment, the tumor locally progressed and the patient died in December 2000. Conclusions. Although repeated histopathologic examinations showed a benign inflammatory pseudotumor, because of the proximity of vital structures the course of disease was malignant just like in a malignant neoplasm.
Metastatic medulloblastoma to the breast LAMOVEC, Janez; POGAENIK, Ana
Virchows Archiv : an international journal of pathology,
08/2001, Letnik:
439, Številka:
2
Journal Article
Recenzirano
We present a case of metastatic medulloblastoma to the breast in a 33-year-old woman who had a cerebellar medulloblastoma excised 2 years previously. Upon presentation, she had a bilateral breast ...tumor, which was diagnosed as a malignant small cell tumor by means of fine needle aspiration biopsy. An excisional biopsy of the tumor was performed, showing metastatic medulloblastoma, morphologically identical with a cerebellar primary. Eighteen months following breast surgery, the patient developed unilateral ovarian and peritoneal metastases and died of the disease 57 months after the cerebellar tumor was excised. Metastatic medulloblastoma to the breast is an extremely rare form of a secondary breast tumor, which may be easily diagnosed when both primary and secondary tumors are cytologically or histologically compared. If this is not possible, considerable problems may be encountered to get to the correct diagnosis.
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