ABSTRACT
We report on multifrequency radio observations of the new magnetar Swift J1818.0−1607, following it for more than one month with high cadence. The observations commenced less than 35 h after ...its registered first outburst. We obtained timing, polarization, and spectral information. Swift J1818.0−1607 has an unusually steep spectrum for a radio emitting magnetar and also has a relatively narrow and simple pulse profile. The position angle swing of the polarization is flat over the pulse profile, possibly suggesting that our line of sight grazes the edge of the emission beam. This may also explain the steep spectrum. The spin evolution shows large variation in the spin-down rate, associated with four distinct timing events over the course of our observations. Those events may be related to the appearance and disappearance of a second pulse component. The first timing event coincides with our actual observations, while we did not detect significant changes in the emission properties that could reveal further magnetospheric changes. Characteristic ages inferred from the timing measurements over the course of months vary by nearly an order of magnitude. A longer-term spin-down measurement over approximately 100 d suggests a characteristic age of about 500 yr, larger than previously reported. Though Swift J1818.0−1607 could still be one of the youngest neutron stars (and magnetars) detected so far, we caution using the characteristic age as a true-age indicator given the caveats behind its calculation.
The study was conducted to evaluate the association between MMP-1 (rs1799750)−1607 1G/2G and MMP-3 (rs3025058)−1612 5A/6A polymorphisms/haplotypes and coronary artery disease (CAD) risk among Iranian ...Turks. Totally, 102 patients with CAD and 102 healthy subjects joined the study. Genomic DNA isolation was carried out using “salting out” method from 3 to 4 mL of whole blood samples. The MMP-1 (−1607 2G/1G) and MMP-3 (−1612 5A/6A) promoter gene polymorphisms were detected via polymerase chain reaction restriction fragment length polymorphism. Our results indicated that the frequencies of the MMP-1 (−1607) 2G alleles and 2G/2G genotypes and the MMP-3 (−1612) 6A alleles and 6A/6A genotypes were higher in CAD patients older than 50 years than in healthy controls (P < 0.05). We failed to show statistically significant differences between the CAD patients younger than 50 years and controls concerning MMP-1 −1607 ins/delG (1G > 2 G, rs1799750) and MMP-3 −1612 ins/delA (5A/6A, rs3025058) polymorphisms (P > 0.05). The frequencies of MMP-3/MMP-1 haplotypes were not statistically different among tested groups (P > 0.05). This examination, as the first study of its own kind in Iranian Turks, reported association between MMP-1 (rs1799750) −1607 2G/2G and MMP-3 (rs3025058) −1612 6A/6A genotypes and CAD risk in patients older than 50 years.
Pericles and the Secret Battell, Sophie Emma
Shakespeare (London, England),
10/2022, Letnik:
18, Številka:
4
Journal Article
Recenzirano
Odprti dostop
This article examines the role of secrecy in William Shakespeare and George Wilkins' Pericles, showing how secrets are used to probe wider questions of sexuality, time and social power. Secrets can ...have a poisonous influence on societal and familial relationships in this play, but they also possess beneficial curative and healing properties that are potentially transformative of the social body. Drawing on the work of modern theorists of secrecy including Georg Simmel, Jacques Derrida and Anne Dufourmantelle, I argue that secrecy in Pericles has a complexity which goes beyond the simple opposition of concealment and revelation. Secrets reveal and conceal at the same time, in ways that may seem paradoxical, just as they simultaneously bind people together and separate them. They are disruptive and unpredictable, pushing past desires for control and order. Political authority, in Shakespeare's day as in our own, often involves keeping secrets. But as my reading of the play demonstrates, secrets can undo power structures and disrupt the orderly temporal patterns of our lives.
Pedro de Valencia, humanista cristiano y exégeta bíblico, la Inquisición se sirvió de él como calificador cuando el Índice de 1607 (Roma) se revisaba. Su comentario sobre los Actos de los Apóstoles y ...la Epístola a los Gálatas examina el conflicto entre Pablo, Pedro y Santiago sobre los nuevos convertidos de la gentilidad. ¿Deberían circuncidarse y seguir las leyes y los ritos judaicos? El Concilio de Jerusalén quitó estos pesos de la cerviz de los nuevos convertidos. Sin embargo, esta nueva época había de introducirse paulatinamente. Valencia parece identificar a los Moriscos con los cristianos primitivos convertidos de la gentilidad. Esos se encontraban marginalizados por los estatutos de limpieza de sangre; en cambio, como con los convertidos de la gentilidad, había que tratarlos con paciencia, tolerancia y amor.
A partir de la reforma tributaria Ley 1607 de 2012, el Estado colombiano reformó el sistema tributario de las personas naturales y se realizó una separación entre los nacionales y extranjeros, y ...residentes y no residentes. Sin embargo, los cambios no se implementaron en todo el Estatuto Tributario (et), lo que ocasionó problemas jurídicos a los nacionales colombianos no residentes que vienen a trabajar a su país de origen, los cuales corresponde analizar en el presente escrito. En este sentido, para llevar a cabo el análisis planteado, es necesario abordar de manera crítica las siguientes situaciones: la obligación formal de declarar, las retenciones en la fuente, la ley de trabajador migratorio, los convenios para evitar la doble imposición y la forma de depurar la renta de los no residentes. Además de los resultados del análisis, se plantea una propuesta para solucionar estas situaciones. Ahora bien, el presente artículo aborda la problemática en cuestión antes de la reforma tributaria de 2012 (Ley 1607), después de la misma y luego de las modificaciones de la Ley 1819 de 2016, por medio del análisis de caso.
The sixteenth-century reckoning with extra-European peoples and cultures occurred at precisely the same moment that humanists were increasingly preoccupied with the daily life, material culture, and ...lived religion of classical antiquity. Leading figures in sixteenth-century antiquarianism took an abiding interest in ethnographic accounts of contemporary peoples and even produced such accounts. This article examines how sixteenth-century readers and scholars placed bodies of literature on ancient and modern customs in dialogue with one another. While scholars have long appreciated that ethnographic and travel writing were deeply mediated by the study of antiquity, that mediation cut both ways. This article addresses the question of how ethnographic descriptions of modern peoples shaped sixteenth-century understandings of the customs and lived religion of antiquity. The writings of merchants and humanists testify to the ways in which the practices of ethnographic writing helped to shape travellers' and readers' appreciation of the cultural alterity of classical antiquity.
Growing evidences show that matrix metalloproteinase 1 (MMP1) plays important roles in tumorigenesis and cancer metastasis.
MMP1
−1607 1G>2G is a single nucleotide polymorphism in the promoter region ...of MMP1 and affects MMP1 production. Analysis of previous studies on the association of −1607 1G>2G polymorphism with different cancer types remained to be illustrated. To further assess the effect of −1607 1G>2G polymorphism on cancer risk, we performed this meta-analyses, up to September 8, 2014, of 10,640 cases and 10,915 controls from 42 published case–control designed studies. Statistical analyses were performed using STATA 11.0 software. Crude odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. ORs with 95 % CIs for the polymorphism
MMP1
−1607 1G>2G and cancer were estimated using fixed and random effects models when appropriate. Significantly increased risks were found in overall under the models of 2G vs.1G, 2G2G vs. 1G1G, 2G2G/1G2G vs. 1G1G, and 2G2G vs. 2G1G/1G1G. Significantly elevated risks were observed in colorectal adenoma under the models of 2G vs. 1G, 2G2G vs. 1G1G, 2G2G/1G2G vs. 1G1G, and 2G2G vs. 2G1G/1G1G and lung cancer and head and neck cancer under the models of 2G vs. 1G. We found that significantly elevated risks were observed in Asian population and hospital-based studies in most comparison models tested. Thus, this meta-analysis indicates that the polymorphism
MMP1
−1607 1G>2G is significantly associated with a significantly increased risk of cancers and may provide evidence-based medical certificate to study the cancer susceptibility.
PDF
