After several hundred years of a closed-door policy, Korea finally opened its ports in 1876. Historians have traditionally claimed that the port-opening was coerced by foreign countries, deteriorated ...the Korean economy, and led to Korea becoming a colony. We examined this view by measuring biological living standards and find the opposite. The height of the male Hangryu Deceased, who died on the street but whose bodies were not claimed, increased by 1.1 cm from the 1880s to the 1910s. This also implies that free trade rather than new institutions might matter more for economic growth during the colonial era.
A worthy tribute to the extraordinary bravery of a remarkable woman.Publishers WeeklyIn World War II's Poland, thirty year old Zofia Sterner and her husbandWacek refuse to be classified as Jews ...destined for extermination.Instead, they evade the Nazis and the Soviets in several dramatic escapes and selflessly rescue many Jews from the Warsaw Ghetto anda labor camp, later becoming active participants in the Warsaw Uprisingwhere they are taken prisoner. This retelling, captured through diaries, interviews, war crime trial testimonies, and letters, detail the Sterners' heroic rescues, escapes, and ultimate survival.A true story of hope amid horrifying tragedy,How We Outwitted and Survived the Nazisillustrates how war brings out the worst and the best in people, and how true humanity and heroism of ordinary people are revealed by their willingness to risk everything and help others. This story is about being human under the most inhumane conditions.
This is the story of a spectacular naval rebellion in which ordinary Brazilian seamen (mostly black and led by a black sailor) overpowered their officers on Dreadnought-class battleships in 1910, to ...abolish flogging and secure civic rights; it also tells how the sailors suffered lethal retribution, although flogging would never return.
Many patients with epilepsy require polytherapy, which increases their antiseizure medication (ASM) drug load, a measure that considers the doses of all ASMs a patient is taking. Changes in ...concomitant ASM drug load after adding cenobamate were evaluated post-hoc in a subset of the open-label, phase 3 study.
Patients 18–70 years old with uncontrolled focal seizures taking 1–3 ASMs were enrolled. Total concomitant ASM drug load (not including cenobamate) was calculated by dividing the patient’s prescribed dose for each ASM by its defined daily dose, per the World Health Organization, then summing the ratios. Changes in concomitant ASM drug load were measured from baseline in 3-month intervals up to 24 months by both total and class-specific ASM drug load. Subgroups of interest included: older adults (65–70 years), prior epilepsy-related surgery vs none, and baseline seizure frequency < 3 vs ≥ 3 seizures/28 days.
Data from 240 patients were available (mean age 41.8 years, mean baseline drug load 3.57). Following cenobamate initiation, the mean concomitant ASM drug load was reduced by 29.4 % at Month 12 % and 31.8 % at Month 24. Reductions occurred in all assessed ASM drug classes, with the largest reduction in benzodiazepines (55.2 % at Month 24). Each assessed subgroup exceeded a 30 % reduction in concomitant ASM drug load at Month 24. Over 24 months, maintenance of ≥ 50 % response occurred in 89.3 %, 86.4 %, and 90.6 % of patients with low (−0.25 to <0), moderate (−0.59 to −0.25), or high (−3.3 to −0.59) numerical reductions in concomitant ASM drug load from baseline, respectively, compared with 86.0 % in patients with no change in drug load; maintenance of 100 % response occurred in 80.7 %, 84.3 %, and 70.0 % of patients with low, moderate, or high numerical reductions in concomitant ASM drug load, compared with 82.0 % in patients with no change.
Adding cenobamate led to reduced mean concomitant ASM drug loads during 1 and 2 years of treatment. Reductions occurred regardless of ASM drug class, patient age, or epilepsy disease characteristics and did not impact maintenance of response rates.
•Concomitant ASM drug load changes were assessed after cenobamate was added.•Mean concomitant ASM drug load (excluding cenobamate) decreased at Years 1 and 2.•Reductions occurred regardless of ASM drug class, patient age, or disease severity.•The largest mean percent reduction was in benzodiazepines (55.2 % at Month 24).•Despite reduced concomitant ASM drug load, response rates were maintained.
Sabri Cemil Yalkut (1882-1957), Öğretmen ve yazar, İstanbul Darülfünun Edebiyat Fakültesini bitirmiştir. II. Meşrutiyet Döneminde Üsküp Orta Öğretmen Okul Müdürlüğü yapmıştır. Üsküp’te bir meslek ...dergisi yayınlamış ve Mütareke Döneminde İlköğretim Dairesi Müdürlüğü yapmıştır. Cumhuriyetin ilk yıllarında da mesleki dergilerde çeşitli yazılar yazmıştır. Üsküp’te Okul Müdürlüğü yaptığı sırada büyük bir gereksinimi karşılayacak olan “Ameli Fen-ni Tedris”(Pratik Pedagoji) adını taşıyan bir eser yazdı. 21 Ağustos 1326 (Miladi 3 Eylül 1910) yılında yazılan bu kitap, bir özel öğretim kitabı niteliği taşımaktadır. Fransız Gabriel Compaire’nin bir eserini esas alarak yazmıştır. Kitaptaki bütün konular 14 ders(bölüm) halinde toplamıştır. Bu çeviri yazıda ise “Ameli Fen-ni Tedris” kitabının 6. Bölümü olan Tarih Öğretimi kısmı çevrilmiştir. Bu bölümde; Tarih öğretiminin amaçları, Tarihin zihin gelişimine etkisi; bu öğretimin vasıfları ve hududu; yakın zamandan başlayarak eski zamanlara doğru gitme metodu ve mukayese; derebeylik hakkında bir ders; kitap, hülasalar ve nakiller, öğretmen ve öğrencilerin vazifeleri; Tarih ve medeni bilgiler; Tarih ve coğrafya konularından bahsetmiştir.
Expatriation, the sense of being "outside" or exposed, is a central theme in the life and work of Paul Bowles. Beginning with Bowles' account of a frightening childhood memory, A World Outside ...explores how the dichotomies of inside and outside, safety and danger, enclosure and exposure—fundamental dualities in Bowles' fiction—have their deepest origin in the fabric of Bowles' own life and also mark his kinship with other twentieth-century writers. Like V. S. Naipaul, Paul Bowles is one of those writers who have an uncanny grasp of what it is like never to feel "at home." In this much-needed study, Richard Patteson explores how this sense of "outsidedness" characterizes one's experience in a world in which many of the traditional shelters—social, familial, religious—seem to have lost their ability to protect. He discovers that storytelling is the vehicle by which both Bowles and his characters attempt to domesticate inchoate experience, bringing it into the familiar interior of human comprehension. The music world has for decades recognized Paul Bowles' stature as a composer, but his fiction is only recently receiving the close attention it has long deserved from students of American and contemporary literature. Bowles is an author who neither sought nor received the kind of publicity often lavished on his contemporaries but one whom an ever-growing audience regards as a commanding figure of twentieth-century American literature.
Taking Power analyzes the causes behind some three dozen revolutions in the Third World between 1910 and the present. It advances a theory that seeks to integrate the political, economic, and ...cultural factors that brought these revolutions about, and links structural theorizing with original ideas on culture and agency. It attempts to explain why so few revolutions have succeeded, while so many have failed. The book is divided into chapters that treat particular sets of revolutions including the great social revolutions of Mexico 1910, China 1949, Cuba 1959, Iran 1979, and Nicaragua 1979, the anticolonial revolutions in Algeria, Vietnam, Angola, Mozambique, and Zimbabwe from the 1940s to the 1970s, and the failed revolutionary attempts in El Salvador, Peru, and elsewhere. It closes with speculation about the future of revolutions in an age of globalization, with special attention to Chiapas, the post-September 11 world, and the global justice movement.
The Race with No Finish Line offers a framework for understanding the strategies of states engaged in competition for regional hegemony. Employing insights drawn from business strategy, the author ...argues for an essentially asymmetric understanding of fundamental policy goals for states engaged in competition for control of a region of the globe, with one state attempting to maintain a dominant position and another attempting, by focusing limited resources, to supplant it.
Background. To evaluate macro and microscopic changes of veins in the immediate and remote period after endovasal laser coagulation using a wavelength of 1910 nm and a power of 3 Watts. Materials and ...methods. Experiments on endovasal laser coagulation of subcutaneous veins (EVLC) with analgesia xylazine hydrochloride 20 mg/ml were carried out on 4 sheep (12 saphenous veins of limbs). EVLC was carried out at a rate of 2 mm/sec and a power of 3 Watts. 40 days after EVLC vein excision was performed for histological evaluation. Results. EVLC with a wavelength of 1910 nm and a power of 3 Watts is sufficient for thermal damage of the vein wall. Histological analysis in the near postcompletion period indicated thermal damage of the vein wall, accompanied by a reduction in the diameter of veins and their clearance, the violation of differentiation of the layers of the venous wall. The study of veins 40 days after coagulation indicates the preservation of thermal disorders with leukocyte infiltration of the wall, the presence of thrombotic masses in their lumen, the growth of connective tissue. Conclusions. The nearest changes of the venous wall after laser coagulation are accompanied by its thickening against the background of a decrease in the lumen of the veins and their diameter, a violation of the differentiation of the wall layers. Long-term results (after 40 days) indicate the presence of blood clots in the lumen of veins, leukocyte infiltration of the wall and the appearance of granulation tissue, contributing to the subsequent obliteration of veins.
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