Since the turn of the new millennium, 'translational research', the scientific process of bringing disease-targeted knowledge from the laboratory to treat patients in the clinic, has gone mainstream ...and is now practiced by large universities and institutes across the globe. Into this dynamic of the rapidly changing world of translational medical research this book sets the life of one of the discipline's most influential practitioners, Anthony Cerami. His work spans more than five decades and culminated in the discovery, invention and development of diagnostics and therapeutics used daily by millions of people. Students in molecular medicine and investigators pursuing basic science in the hope of improving human health will find inspiration in examining the sacrifices and achievements of Cerami's career in translational medicine. During his three decades at Rockefeller University his cross-disciplinary and laboratory-without-wall approach established 'rational drug design' as the most effective means of advancing the fields of parasitology, hematology, immunology, metabolism, therapeutics and molecular medicine. Cerami's story and that of the evolution of translation are intimately entwined: the contours of Cerami's career shaped by developments in translation, and in exchange, the field itself molded by Cerami's work. To understand one is to understand the other. By examining the life of this often overlooked biochemist it is possible to intimately focus on the ideas and thought processes of a scientist who has helped to define the great acceleration in translational research over the past half century - research that, knowingly or otherwise, has most likely affected the life of almost everyone on the planet. We also gain a better understanding of the febrile creative atmosphere that percolated through the laboratories leading the way in translational medicine, and gain insight into the art, science, successes, failures and providence that underlie major scientific breakthroughs. Anybody interested in the questions of where modern medicines come from, how health outcomes around the globe are affected by research and imagination, and where the future of drug discovery is leading, will be rewarded by exploring Cerami's life in translation. This book is not restricted to those with a professional interest in science, because anyone dedicated to living a life of creativity and discovery will be rewarded by reading this book. In many respects, Cerami's life reflects the modern metaphor of the 'American dream' with his journey from humble beginnings on a chicken farm in rural New Jersey, to occupying a place in the highest echelons of the US scientific establishment. His journey in translational medicine was propelled forward by two obsessions; the idea that he could help people who were sick, and the excitement of discovery. In following his two great passions, he trained a generation of specialists in translational medicine that continue to transform our understanding of, and treatments for, human disease. Anthony Cerami's work has shown how science has become an important force for social change by laying the foundations of modern translational medicine.
Quince Duncan Mosby, Dorothy E
2014, 2014-02-28
eBook
Quince Duncan is a comprehensive study of the published short stories and novels of Costa Rica’s first novelist of African descent and one of the nation’s most esteemed contemporary ...writers.   The grandson of Jamaican and Barbadian immigrants to Limón, Quince Duncan (b. 1940) incorporates personal memories into stories about first generation Afro–West Indian immigrants and their descendants in Costa Rica. Duncan’s novels, short stories, recompilations of oral literature, and essays intimately convey the challenges of Afro–West Indian contract laborers and the struggles of their descendants to be recognized as citizens of the nation they helped bring into modernity.   Through his storytelling, Duncan has become an important literary and cultural presence in a country that forged its national identity around the leyenda blanca (white legend) of a rural democracy established by a homogeneous group of white, Catholic, and Spanish peasants. By presenting legends and stories of Limón Province as well as discussing the complex issues of identity, citizenship, belonging, and cultural exile, Duncan has written the story of West Indian migration into the official literary discourse of Costa Rica. His novels Hombres curtidos (1970) and Los cuatro espejos (1973) in particular portray the Afro–West Indian community in Limón and the cultural intolerance encountered by those of African-Caribbean descent who migrated to San José. Because his work follows the historical trajectory from the first West Indian laborers to the contemporary concerns of Afro–Costa Rican people, Duncan is as much a cultural critic and sociologist as he is a novelist.   In Quince Duncan , Dorothy E. Mosby combines biographical information on Duncan with geographic and cultural context for the analysis of his works, along with plot summaries and thematic discussions particularly helpful to readers new to Duncan.
Equality is not something that we must expect from state institutions. It is something that we must both presuppose and create through collective action. Todd May investigates in depth the ...philosophical grounds, ethical implications and practical consequences of the view of active equality. Much more than a commentary, his book is a powerful analysis of what politics means and how we can recover the project of political action.Jacques RanciereThis is the first single-authored book in any language devoted entirely to the thought of Jacques Rancière. It focuses on his central political idea that a democratic politics emerges from the presupposition of equality. Todd May examines and extends this presupposition, offering a framework for understanding it, placing it in the current political context, and showing how it challenges traditional political philosophy and opens up neglected political paths.May aims to show that Rancière's view offers both hope and perspective for those who seek to think about and engage in progressive political action.Key Features* offers a thorough discussion of Rancière's concept of equality* provides an ethical framework in which to ground his politics* shows why Rancière is crucial for political reflection today* both translated and untranslated works are referred to
During the Second World War, the British movie industry produced a number of films concerning the war, all of which were, by necessity, heavily myth-laden and propagandised. Foremost among these ...productions was _The First of the Few_, which was the biggest grossing film of 1942\. In the immediate post-war period, to start with there were no British aviation war films. The first to be released was _Angels One Five_ in 1952\. It was well-received, confirming that the Battle of Britain was a commercial commodity. Over the next few years, many famous war heroes published their memoirs, or had books written about them, including the legless Group Captain Douglas Bader, whose story, _Reach for the Sky_, told by Paul Brickhill, became a best-seller in 1956\. It was followed a year later by the film of the same name, which, starring Kenneth More, dominated that year's box office. The early Battle of Britain films had tended to focus upon the story of individuals, not the bigger picture. That changed with the release of the star-studded epic _Battle of Britain_ in 1969\. Using real aircraft, the film, produced in colour and on a far larger scale than had been seen on film before, was notable for its spectacular flying sequences. Between the release of _Reach for the Sky_ and _Battle of Britain_, however, much had changed for modern Britain. For a variety of reasons many felt that the story of the nation's pivotal moment in the Second World War was something best buried and forgotten. Indeed, the overall box office reaction to Battle of Britain reinforced this view - all of which might explain why it was the last big screen treatment of this topic for many years. It was during the Battle of Britain's seventieth anniversary year that the subject returned to the nation's screens when Matthew Wightman's docudrama _First Light_ was first broadcast. Essentially a serialisation of Spitfire pilot Geoffrey Wellum's best-selling memoir of the same title, Wightman cleverly combined clips of Wellum as an old man talking about the past with his new drama footage. The series is, in the opinion of the author, the best portrayal of an individual's Battle of Britain experience to have been made. In this fascinating exploration of the Battle of Britain on the big screen, renowned historian and author Dilip Sarkar examines the popular memory and myths of each of these productions and delves into the arguments between historians and the filmmakers. Just how true to the events of the summer of 1940 are they, and how much have they added to the historical record of 'The Finest Hour'?
In acknowledgement "for the courage and clinical acuity with which she uncovers the roots, estrangements and collective restraints of personal memory," the 2022 Nobel Prize in Literature was awarded ...to Annie Ernaux. Fall is a season when the air cools; the leaves display vibrant colors; apples and pumpkins are everywhere; and the Nobel Committee announces the new laureates. A bit of something for everyone. Now the fun starts. Finding a piece of the new Laureate's work to read is always an adventure. Fortunately for me the Internet provides a rich source of background, book purchasing sites, and reviews. I'm always intrigued with the "reason" for the award featured on the Nobel Prize website. Will I see that reason when I read one of the author's works?
Hawk of the mind Yang, Mu; Yeh, Michelle
2018, 20180327, 2018-04-10
eBook
Yang Mu is a towering figure in modern Chinese poetry. His poetic voice is subtle and lyrical, and his work is rich with precise images and crystalline thoughts invoking temporality and remembrance. ...A bold innovator and superb craftsman, he elegantly combines cosmopolitan experimentation with poetic forms and an allusive reverence for classical Chinese poetry while remaining rooted in his native Taiwan and its colonial history.Hawk of the Mindis a comprehensive collection of Yang Mu's poetry that presents crucial works from the many stages of his long creative career, rendered into English by a team of distinguished translators. It conveys the complexity and beauty of Yang Mu's work in a stately and lucid English poetic register that displays his ability to range from meditative to playful and colloquial to archaic. The volume includes an editor's introduction and definitive commentary that offer insights into the poet's major themes and motifs, explaining how he draws on deep engagement with Chinese and Western literary traditions, history, and art as well as mythology, philosophy, and music and a profound love for the natural world to create a nuanced and multifaceted artistic universe. It also contains translations of prefaces and afterwords written by Yang Mu for collections of his poetry.Hawk of the Minddemonstrates the breadth and depth of Yang Mu's oeuvre, illustrating the distinctive style and affective power of a great poet.
Mina (Anna Maria Mazzini, born Lombardy, 1940) is an Italian popular music icon who throughout her sixty-year-long career has come to represent a range of diverse meanings. She is one of the ...best-loved popular music stars in Italy and abroad, with a large fan base across Europe, Asia, and South America. Her career began in the late 1950s and reached its peak in the 1960s and 1970s. Despite having retired from public appearances at the end of the 1970s, Mina remains popular and successful today, and continues to release new albums that consistently debut in the number one spot of the Italian charts. As an Italian popular music star, she is exemplary of the way in which stardom is constructed by different media and has come to represent different local and global identities, values, ideologies, and ways of behaving. This is because whilst Mina is first and foremost a popular music star, she has also been a film star and a television personality during different phases of her career. She has advertised successful Italian brands on television, and she has been a magazine writer and agony aunt. Her star persona is the product of her work in many different areas, as well as of the promotional materials and commentaries that are produced in response to her work. This book explores these different 'mediums' that Mina has been involved in and which have shaped her career and significance. It traces the process by which she has come to embody a diverse range of meanings that reveal something of the values and ideals at work within contemporary Italian society. Rachel Haworth is a researcher of Italian popular music and culture of the twentieth century, and Senior Lecturer in Italian at the University of Hull, UK. The primary market for this book is students and academics in the following subject areas: Italian Studies; Popular Music Studies; Stardom and Celebrity Studies; Media Studies; Cultural History. Also scholars and researchers working on music divas. The book is suitable for use on courses and modules at all undergraduate and postgraduate levels, which deal with Italian cultural studies, Italy's post- war history, and the role of women in Italy, as well as the wider study of popular music and the construction of stardom and celebrity. The secondary audience for this book will be fans of Mina around the world, accessibly written, this will appeal to fans in Italy who are able to read in English.
