Scientists' understanding of two central problems in neuroscience, psychology, and philosophy has been greatly influenced by the work of David Hubel and Torsten Wiesel: What is it to see? This ...relates to the machinery that underlies visual perception, How do we acquire the brain's mechanisms for vision? This is the nature-nurture question as to whether the nerve connections responsible for vision are innate or whether they develop through experience in the early life of an animal or human. This is a book about the collaboration between Hubel and Wiesel, which began in 1958, lasted until about 1982, and led to a Nobel Prize in 1981. It opens with short biographies of both men, describes the state of the field when they started, and talks about the beginnings of their collaboration. It emphasizes the importance of various mentors in their lives, especially Stephen W. Kuffler, who opened up the field by studying the cat retina in 1950, and founded the department of neurobiology at Harvard Medical School, where most of their work was done. The main part of the book consists of Hubel and Wiesel's most important publications. Each reprinted paper is preceded by a foreword that tells how they went about the research, what the difficulties and the pleasures were, and whether they felt a paper was important and why. Each is also followed by an afterword describing how the paper was received and what developments have occurred since its publication. The reader learns things that are often absent from typical scientific publications, including whether the work was difficult, fun, personally rewarding, exhilarating, or just plain tedious. The book ends with a summing-up of the present state of the field.
Multipla skleroza najčešće je kronična bolest središnjeg živčanog sustava i pripada širokoj i važnoj skupini bolesti koje obilježuju razaranje mijelinskih ovojnica živčanih vlakana u mozgu, ...kralježničkoj moždini i vidnim putovima. Posljedica oštećenja ovojnice živca je uporenje ili blokada prijenosa živčanog impulsa između živčanih stanica, a samim time i poremećaj različitih funkcija u središnjem živčanom sustavu među kojima su vrlo očiti motorni poremećaji. Klinički napadaji i fizička onesposobljenost u MS-i predstavljaju temeljno obilježje tijeka bolesti. Napadajem se smatra javljanje novih simptoma, ponovno javljanje nekih starih simptoma te pojačanje prisutnih simptoma u vremenskom razdoblju duljem od 24 sata. Ne postoji mnogo testova za procjenu fine motorike gornjih ekstremiteta. Cilj provedenog istraživanja bio je dokazati da je ne toliko poznat 20 cents test vjerodostojan, precizan i pouzdan kao i 9 hole peg test koji se već koristi i poznat je svim zdravstvenim ustanovama u ispitivanju fine motorike gornjih ekstremiteta kod pacijenata s multiplom sklerozom te se postavlja pitanje postoji li dobra korelacija motorike desne i lijeve, odnosno dominantne i nedominantne ruke s obzirom na iznosi zbroja onesposobljenosti (EDSS) desne i lijeve ruke u bolesnika s multiplom sklerozom u oba testa. Nakon završetka obrade, analize i prikaza podataka rezultati su pokazali da je 20 cents test adekvatan i precizan u testiranju fine motorike gornjih ekstremiteta kao i 9 hole peg test, ali je dostupniji u primjeni i korištenju u odnosu na 9 hole peg spravu.
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