Las miopatías congénitas (MC) son un amplio grupo de trastornos musculares, poco frecuentes, genéticamente heterogéneos con manifestaciones clínicas solapadas. La miopatía miotubular/ centronuclear ...(XL-MTM) es de herencia ligada al cromosoma X, recesiva, debida a variantes patogénicas en MTM1 que codifica miotubularina. Afecta severamente a varones, las mujeres portadoras son asintomáticas o asocian el antecedente de abortos. Con la presentación de un caso buscamos evidenciar la importancia del acceso a estudios moleculares. Se realizó examen físico, genealogía y estudios complementarios. Se trata de un neonato masculino con hipotonía, hiporreactividad, facies miopática, criptorquidia, evento hipóxico isquémico perinatal, CPK y EEG alterados. Se destaca el antecedente de polihidramnios y escasos movimientos fetales. Es el único hijo de pareja sana, no consanguínea, con antecedente materno de un aborto espontáneo. Ante la sospecha de entidad neuromuscular se realizó panel de genes por secuenciación. Se detectó una variante patogénica en hemicigosis en MTM1: c.141_144del (p.Glu48Leufs*24) asociada con XL-MTM. En la madre se halló la variante en heterocigosis. Las MC se sospechan por la clínica y los antecedentes. A menudo el diagnóstico se sustenta en hallazgos histopatológicos no patognomónicos por lo que, actualmente, los estudios genéticos son el Gold Standard. Con el presente caso ilustramos la importancia del acceso a los mismos para acortar el tiempo en arribar al diagnóstico específico, prescindir de estudios cruentos, planificar un correcto abordaje multidisciplinario y un adecuado asesoramiento familiar.
Since the launch of the first consumer grade EEG measuring sensors `NeuroSky Mindset' in 2007, the market has witnessed an introduction of at least one new product every year by competing ...manufacturers, which include NeuroSky, Emotiv, interaXon and OpenBCI. There are numerous variations in the make and versions, but these products clearly share the key selling points of affordability, portability, and ease of use. These features are patently well placed provided one of the main objectives for their development is to attract a new target group of commercial users. Nevertheless, with several decades of traditional EEG usage in clinical and experimental settings, the shift toward commercial and engineering sides has not been achieved without skepticism. With this in mind, researchers in related fields have been tirelessly working to ensure that these putatively novel features were not introduced at the expense of efficiency and accuracy by conducting validation studies to compare the performance of data derived from consumer grade EEG devices with ones from standard research grade counterparts. In this review, we seek to provide the detail of the products supplied by the major players, summarize studies that evaluate consumer product's performance against research grade devices, the key areas of applications that these consumer grade devices have been employed in over the past five years or so, and finally give our perspectives on the limitations and what these innovative tools could offer going forward in terms of research and commercial applications.
This article provides recommendations on the minimum standards for recording routine (“standard”) and sleep electroencephalography (EEG). The joint working group of the International Federation of ...Clinical Neurophysiology (IFCN) and the International League Against Epilepsy (ILAE) developed the standards according to the methodology suggested for epilepsy‐related clinical practice guidelines by the Epilepsy Guidelines Working Group. We reviewed the published evidence using the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) statement. The quality of evidence for sleep induction methods was assessed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) method. A tool for Quality Assessment of Diagnostic Studies (QUADAS‐2) was used to assess the risk of bias in technical and methodological studies. Where high‐quality published evidence was lacking, we used modified Delphi technique to reach expert consensus. The GRADE system was used to formulate the recommendations. The quality of evidence was low or moderate. We formulated 16 consensus‐based recommendations for minimum standards for recording routine and sleep EEG. The recommendations comprise the following aspects: indications, technical standards, recording duration, sleep induction, and provocative methods.
(2013) Neural Processes Underlying the“Same”-“Different” Judgment of Two Simultaneously Presented Objects- An EEG Study. The correct abbreviation of the third author's name in the Author ...Contributions statement is: DR. Citation: Zhang R, Hu Z, Roberson D, Zhang L, Li H, Liu Q (2014) Correction: Neural Processes Underlying the“Same”-“Different” Judgment of Two Simultaneously Presented Objects- An EEG Study.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
An abstract of a study by Noe et al evaluating noninvasive diagnostic test results and their association with excellent surgical outcomes in a group of patients with medically resistant nonlesional ...extratemporal epilepsy is presented. Based on the noninvasive diagnostic test results, a clear hypothesis for seizure origin was possible for 47 of the 85 patients (55%), and 31 of these 47 patients (66%) proceeded to intracranial EEG monitoring. For 24 of these 31 patients undergoing long-term intracranial EEG (77%), a seizure focus was identified and surgically resected. Of these 24 patients, 9(38%) had an excellent outcome after resective epilepsy surgery. All patients with an excellent surgical outcome had at least 10 years of follow-up. Univariate analysis showed that localized interictal epileptiform discharges on scalp EEGs were associated with an excellent surgical outcome.
Electroencephalography (EEG) is an important clinical tool and frequently used to study the brain-behavior relationship in humans noninvasively. Traditionally, EEG signals are recorded by positioning ...electrodes on the scalp and keeping them in place with glue, rubber bands, or elastic caps. This setup provides good coverage of the head, but is impractical for EEG acquisition in natural daily-life situations. Here, we propose the transparent EEG concept. Transparent EEG aims for motion tolerant, highly portable, unobtrusive, and near invisible data acquisition with minimum disturbance of a user's daily activities. In recent years several ear-centered EEG solutions that are compatible with the transparent EEG concept have been presented. We discuss work showing that miniature electrodes placed in and around the human ear are a feasible solution, as they are sensitive enough to pick up electrical signals stemming from various brain and non-brain sources. We also describe the cEEGrid flex-printed sensor array, which enables unobtrusive multi-channel EEG acquisition from around the ear. In a number of validation studies we found that the cEEGrid enables the recording of meaningful continuous EEG, event-related potentials and neural oscillations. Here, we explain the rationale underlying the cEEGrid ear-EEG solution, present possible use cases and identify open issues that need to be solved on the way toward transparent EEG.
Neurofeedback is a promising approach for non-invasive modulation of human brain activity with applications for treatment of mental disorders and enhancement of brain performance. Neurofeedback ...techniques are commonly based on either electroencephalography (EEG) or real-time functional magnetic resonance imaging (rtfMRI). Advances in simultaneous EEG–fMRI have made it possible to combine the two approaches. Here we report the first implementation of simultaneous multimodal rtfMRI and EEG neurofeedback (rtfMRI–EEG-nf). It is based on a novel system for real-time integration of simultaneous rtfMRI and EEG data streams. We applied the rtfMRI–EEG-nf to training of emotional self-regulation in healthy subjects performing a positive emotion induction task based on retrieval of happy autobiographical memories. The participants were able to simultaneously regulate their BOLD fMRI activation in the left amygdala and frontal EEG power asymmetry in the high-beta band using the rtfMRI−EEG-nf. Our proof-of-concept results demonstrate the feasibility of simultaneous self-regulation of both hemodynamic (rtfMRI) and electrophysiological (EEG) activities of the human brain. They suggest potential applications of rtfMRI–EEG-nf in the development of novel cognitive neuroscience research paradigms and enhanced cognitive therapeutic approaches for major neuropsychiatric disorders, particularly depression.
•We report the first implementation of simultaneous rtfMRI and EEG neurofeedback.•A novel integration of simultaneous rtfMRI and EEG data streams is described.•Subjects can self-regulate their left amygdala fMRI activation and frontal EEG asymmetry.•Hemodynamic and electrophysiological processes can be regulated simultaneously.•rtfMRI–EEG neurofeedback holds promise for improved treatment of mental disorders.
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