Background Esophageal stenosis is one of the major complications of aggressive endoscopic resection. Tissue-engineered epithelial cell grafts have demonstrated effectiveness in promoting ...re-epithelialization and suppressing inflammation causing esophageal scarring and stenosis after endoscopic submucosal dissection (ESD) in an animal model. Objective To confirm the reproducibility and efficacy of a human oral mucosal epithelial cell (hOMEC) sheet cultured on temperature-responsive surface in conformity with Good Manufacturing Practice guidelines. Design A preclinical study. Setting Good Manufacturing Practice grade cell-processing center, animal laboratory. Subjects Canine esophageal ulcer models, which were made by ESD. Interventions Oral mucosal specimens were obtained from 7 healthy volunteers. Main Outcome Measurement Fabricated and transplanted hOMEC sheets were subjected to histological analysis. Results The reproducibility of the fabrication of hOMEC sheets was confirmed. In this method, animal-derived materials such as 3T3 feeder layer and fetal bovine serum were successfully excluded from the culture condition. Furthermore, the environment of the culture room and safety cabinet in the cell-processing center was maintained for obtaining sterility assurances during the fabrication. Transplanted hOMEC sheets after ESD were observed to graft onto canine esophageal ulcer surfaces. Limitations Small number of subjects, animal model. Conclusions Cultured hOMEC sheets were fabricated without animal-derived materials and demonstrated efficacy as a medical device that promotes re-epithelialization of an esophageal ulcer after ESD.
Of the Gothic church which was erected at Homec after the miraculous apparition of the Blessed Virgin in 1419 only the lower part of the free-standing bell-tower has been preserved up to this day~in ...the times of Turkish incursions around 1500 it was adapted to serve as a defence tower as well. Since the condition of the old church had worsened and the building had also become too small, a new sanctuary was built on its northern side in 1723, and the next year the church was pulled down and a new nave was begun on its site~the building was completed in 1728.
Provider: - Institution: - Data provided by Europeana Collections- Homec in Homčani s svojo nošo v začetku 20. stoletja. Razglednica je bila odposlana okoli leta 1930.- All metadata published by ...Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Homški hrib s travnika ob vznožju s kozolci.- All metadata published by Europeana are available free of restriction under the ...Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Otroci in odrasli zbrani na travniku ob vznožju Homškega hriba.- All metadata published by Europeana are available free of ...restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Homški hrib z Društvenim domom, slikan iz vznožja hriba, okoli leta 1920.- All metadata published by Europeana are available free of ...restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Razglednica je bila poslana leta 1936.- All metadata published by Europeana are available free of restriction under the Creative ...Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- Panorama s Pikelna na Homškem hribu okoli leta 1910. Pogled proti Kamniku in Kamniško Savinjskim Alpam.Fotografija je sestavljena iz ...treh posnetkov.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Valley Animal Clinic and Valley Kennel opened at 46-920 Jefferson in Indio May 14. The 12,500 square-foot facility is the largest of its kind in Southern California.
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