Purpose: In this study, the authors evaluated the effect of remote system and acoustic environment on speech perception via telehealth with cochlear implant recipients. Method: Speech perception was ...measured in quiet and in noise. Systems evaluated were Polycom visual concert (PVC) and a hybrid presentation system (HPS). Each system was evaluated in a sound-treated booth and in a quiet office. Results: For speech in quiet, there was a significant effect of environment, with better performance in the sound-treated booth than in the office; there was no effect of system (PVC or HPS). Speech in noise revealed a significant interaction between environment and system. Subjects' performance was poorer for PVC in the office, whereas performance in the sound-treated booth was not significantly different for the two systems. Results from the current study were compared to results for the same group of subjects from an earlier study; these results suggested that poorer performance at remote sites in the previous study was primarily due to environment, not system. Conclusions: Speech perception was best when evaluated in a sound-treated booth. HPS was superior for speech in noise in a reverberant environment. Future research should focus on modifications to non-sound-treated environments for telehealth service delivery in rural areas.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, ODKLJ, OILJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Chromatin modifications at both histones and DNA are critical for regulating gene expression. Mis-regulation of such epigenetic marks can lead to pathological states; indeed, cancer affecting the ...hematopoietic system is frequently linked to epigenetic abnormalities. Here, we discuss the different types of modifications and their general impact on transcription, as well as the polycomb group of proteins, which effect transcriptional repression and are often mis-regulated. Further, we discuss how chromosomal translocations leading to fusion proteins can aberrantly regulate gene transcription through chromatin modifications within the hematopoietic system. PML-RARa, AML1-ETO and MLL-fusions are examples of fusion proteins that mis-regulate epigenetic modifications (either directly or indirectly), which can lead to acute myeloblastic leukemia (AML). An in-depth understanding of the mechanisms behind the mis-regulation of epigenetic modifications that lead to the development and progression of AMLs could be critical for designing effective treatments.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The mouse Polycomb-group gene, embryonic ectoderm development (eed), appears to regulate cellular growth and differentiation in a developmental and tissue specific manner. During embryogenesis, eed ...regulates axial patterning, whereas in the adult eed represses proliferation of myeloid and B cell precursors. The present report demonstrates two novel functional activities of eed: alteration of thymocyte maturation and suppression of thymic lymphoma development. Mice that inherit the viable hypomorphic 17Rn5(1989SB) eed allele sustain a partial developmental block at or before the CD4(-)CD8(-)CD44(-)CD25(+) stage of thymocyte differentiation. Furthermore, mice that are homozygous or heterozygous for the hypomorphic eed allele have an increased incidence and decreased latency of N-methyl-N-nitrosourea-induced thymic lymphoma compared to wild-type littermates. These findings support the notion that Polycomb-group genes exert pleiotropic effects dictated by developmental stage and cellular context.
2012年6月12日．Polycom与北京西城区教委签约仪式在北京举行。Polycom凭借Pdycom Real Presence视频解决方案为西城区教委部署北京首个远程教学与国际教学交流的远程教学系统。该教学系统一期工程将于2012年9月建设完成，包括城域网中心机房、中小学校及200个合作学校的视频教室的全面建设。
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