Conservation is a state of harmony between Man and the Earth" is a phrase associated with Aldo Leopold (1887-1948) American environmentalist and with which I wish to approach this important work ...entitled "THE ROLE OF RENEWABLE ENERGIES IN THE COLOMBIAN ENERGY MATRIX" that I am honored to prologue and with whose publication the Master, Eng. René Ramírez Fernández, of notable academic experience, in his role as Coordinator and one of the authors of the book, achieves in the compilation that the researchers show their awareness for the care of the environment and their visible concern for the abuse of non-renewable energies advocating, with scientific argument, for an energy balance for Colombia, promoting an energy transition, for the use of renewable energies and the use of biodigesters for the reduction of the carbon footprint. It should be noted that each of the contributions that you will find in the book are the result of research that has had as a starting point the collection of information, the analysis of real statistical data and the use of a methodology that ensures that the conclusions that are socialized in each of the four chapters of the book are important contributions that have a scientific support.
Conservation is a state of harmony between Man and the Earth" is a phrase associated with Aldo Leopold (1887-1948) American environmentalist and with which I wish to approach this important work ...entitled "THE ROLE OF RENEWABLE ENERGIES IN THE COLOMBIAN ENERGY MATRIX" that I am honored to prologue and with whose publication the Master, Eng. René Ramírez Fernández, of notable academic experience, in his role as Coordinator and one of the authors of the book, achieves in the compilation that the researchers show their awareness for the care of the environment and their visible concern for the abuse of non-renewable energies advocating, with scientific argument, for an energy balance for Colombia, promoting an energy transition, for the use of renewable energies and the use of biodigesters for the reduction of the carbon footprint. It should be noted that each of the contributions that you will find in the book are the result of research that has had as a starting point the collection of information, the analysis of real statistical data and the use of a methodology that ensures that the conclusions that are socialized in each of the four chapters of the book are important contributions that have a scientific support.
Tehnologija sekvenciranja RNK na ravni posameznih celic (scRNAseq) nam omogoča, da z visoko ločljivostjo in natančnostjo naenkrat določimo nabor vseh molekul RNK v vsaki posamezni celici, ki se ...nahaja v določenem vzorcu oz. tkivu. Danes je scRNAseq pomembno orodje predvsem za proučevanje kompleksnih bioloških sistemov in tkiv, kot je tumorsko tkivo, kjer je velika celična raznolikost ključnega pomena. V članku navajamo primer melanoma kože, ki je eden najpogostejših in najbolj agresivnih rakov v razvitem svetu. Čeprav se je v zadnjem času z uvedbo imunske terapije napoved izida melanoma bistveno izboljšala, pa je še vedno približno 30–40 % bolnikov, pri katerih tovrstno zdravljenje ni uspešno. Novi podatki, pridobljeni z uporabo scRNAseq, so razkrili, da je mehanizem odpornosti na zdravljenje z zaviralci imunskih nadzornih točk zelo kompleksen, da na to poleg prisotnosti in fenotipa izčrpanih limfocitov T CD8+ vpliva tudi mutacija v genu BRAF, fenotip melanocitov, prisotnost in fenotip celic mieloičnega izvora, prisotnost fibroblastov različnega fenotipa ter interakcije med vsemi celicami, ki tvorijo tumorsko mikrookolje. V prihodnosti bo torej vse bolj pomemben oseben pristop zdravljenja, ki bo temeljil na molekularni in celični opredelitvi tumorja in njegovega mikrookolja ter na napovednih bioloških označevalcih. Z uporabo tehnologije scRNAseq se bomo lahko cilju osebne medicine zelo približali, saj nam omogoča identifikacijo posameznih celic in celičnih označevalcev, ki bi lahko napovedali odziv bolnika na zdravljenje in omogoča bolj ciljano odločitev za vrsto zdravljenja za posameznega bolnika. Na ta način bi se izognili principu zdravljenja, ki temelji na “poskusu in napaki” ter tako bistveno izboljšali učinkovitost zdravljenja. Zaenkrat pa se tehnologija scRNAseq uporablja zgolj v raziskovalne namene, zato zaradi določenih omejitev ni uvedena v dejansko klinično prakso.
This open access book, written by world experts in aquaponics and related technologies, provides the authoritative and comprehensive overview of the key aquaculture and hydroponic and other ...integrated systems, socio-economic and environmental aspects. Aquaponic systems, which combine aquaculture and vegetable food production offer alternative technology solutions for a world that is increasingly under stress through population growth, urbanisation, water shortages, land and soil degradation, environmental pollution, world hunger and climate change.
This open access book richly illustrates the first, and comprehensive, account of the country’s biomes and ecoregions, the driving forces that account for their diversity and vulnerability, and the ...ecological principles that provide an understanding of the patterns and processes that have shaped landscapes, ecoregions, and ecosystems. Angola encompasses the greatest diversity of terrestrial biomes and is the second richest in terms of ecoregions, of any African country. Yet its biodiversity and the structure and functioning of its ecosystems are largely undocumented. The author draws on personal field observations from over 50 years of involvement in ecological and conservation studies in Angola and across Southern Africa. The vast recent literature published by researchers in neighboring, better resourced countries provides depth to the accounts of ecological principles and processes relevant to Angola and thus contributing to the understanding and sustainable management of its natural resources.
Ciljevi: Svrha ovoga rada bila je odrediti postotak perzistentnih apikalnih lezija pozitivnih na bakterijske nukleinske kiseline, zatim s pomoću lančane reakcije polimeraze detektirati mikroorganizme ...u periapikalnim lezijama koje je teško kultivirati te ih povezati s endodontskim neuspjehom, kliničkih simptomima i dijabetesom. Materijali i postupci: Uzorci perzistentnih apikalnih lezija skupljani su tijekom apikotomije. Bakterijska ubikvitarna početnica 16S rRNK rabljena je za otkrivanje 16S ribosomskog RNK u 36 uzoraka. PCR usmjeren na pojedine vrste proveden je s pomoću početnica za 16S rRNK gene Prevotelle nigrescens, Pseudoramibactera alactolyticusa i Propionobacterium propionicum. Rezultati: Šest uzoraka (16,67 %) bilo je pozitivno na bakterijski ribosomski RNK. Pseudoramibacter alactolyticus detektiran je u trima uzorcima. Propionibacterium propionicum i Prevotella nigrescens detektirani su svaki u po jednom uzorku. Prevalencija infekcije ovih lezija P. intermedia, P. propionicum i P. alactolyticusom niska je. Provedeno istraživanje nije dalo dostatne podatke o povezanosti ekstraradikularne infekcije s dijabetesom melitusom i kliničkim simptomima. Zaključci: Apikalne lezije koje perzistiraju nakon endodontskog liječenja mogu, uz Actinomyces i Propionicum species, sadržavati i druge mikroorganizme.
Grupirane pravilno razmaknute kratke ponavljajuće palindromske sekvence (CRISPR)/CRISPR-povezani sustav (Cas) je sustav koji osigurava imunost većine prokariotskih organizama na napade virusa i ...drugih stranih tijela. CRISPR sustavi se sastoje od bjelančevine nalik škarama naziva Cas9 i genetskog GPS vodiča „vodičke RNK“. Međutim, istraživači su preorijentirali i prenamijenili iskonski imunološki sustav za preciznu manipulaciju genomom u većini organizama uvodeći dvolančane lomove na DNK na određenim lokacijama genoma radi uvođenja specifičnih izmjena DNK.
Od njegova otkrića CRISPR ima sve više primjena; od onemogućavanja parazita do ispravljanjamutacijaipoboljšavanjaprinosa u poljoprivredi. Ovo istraživanje provedeno je da bi poslužilo kao vodič za CRISPR tehnologiju, od povijesti njegova otkrića do najnovijih saznanja. Nadamo se da će ova studija osigurati općeniti pregled ove tehnologije koja mijenja živote, a i inspirirati znanstvenike da nastave istraživanja s CRISPR-om, za bolji život.
This open access book is one in a series of four volumes introducing peatland conservation and restoration in Indonesia. It focuses on local governance, in particular on regional and local ...perspectives in Riau, the most peat-destructed province of Indonesia. The book fills a vital gap in the existing literature that overlooks social science and humanities perspectives. Written by authors from different disciplines and backgrounds (including scholars and NGO activists), the approaches to the topic are various and unique, including analysis of GPS logs, social media, geospatial assessments, online interviews (conducted due to the Covid-19 pandemic), and more conventional questionnaires and surveys of community members. The chapters cover an interdisciplinary understanding of peatland destruction and broadly offer insights into environmental governance. While presenting combined studies of established fieldwork methodologies and contemporary technology such as drones and geospatial information, the book also explores the potential of long-distance research with rural communities through online facilitation, which was brought about by Covid-19, but that may have longterm implications. Readers will gain a comprehensive understanding of the complexities surrounding peatland conservation and restoration and recognize the significance of locally inclusive approaches that use contemporary but accessible technologies to sustainably govern the globally important resource of peatland. That approach would be useful for other environmentally fragile but important regions and give some ideas to achieve the United Nations’ SDGs for 1)No Poverty, 5)Gender Equality, 13)Climate Action, 15)Life of Land.
This book delivers a realistic and feasible framework for creating resilient landscapes in an era of anthropogenic climate change.From across six continents, this book presents fifteen case studies ...of differing sociocultural, economic, and biophysical backgrounds that showcase opportunities and limitations for creating resilient landscapes throughout the world. The potential to create socio-ecological resilience is examined across a wide range of landscapes, including agricultural, island, forest, coastal, and urban landscapes, across sixteen countries: Argentina, Australia, Brazil, Denmark, Finland, Greece, Guatemala, Japan, Mexico, Norway, Samoa, South Africa, the United States, Turkey, Uruguay, and Vanuatu. Chapters discuss current and future issues around creating a sustainable food system, conserving biodiversity, and climate change adaptation and resilience, with green infrastructure, nature-based architecture, green-tech, and ecosystem services as just a few of the approaches discussed. The book emphasizes solution-oriented approaches for an "ecological hope" that can support landscape resiliency in this chaotic era, and the chapters consider the importance of envisioning an unpredictable future with numerous uncertainties. In this context, the key focus is on how we all can tackle the intertwined impacts of climate change, biodiversity loss, and large-scale land-cover conversion in urban and non-urban landscapes, with particular attention to the concept of landscape resiliency. The volume provides that much-needed link between theory and practice to deliver forward-thinking, practical solutions.This book will be of great interest to students, researchers, practitioners and policymakers who are interested in the complex relationship between landscapes, climate change, biodiversity loss, and land-based conversion at local, national and global scales.
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