Purpose
Glioblastoma Multiforme (GBM) is the most common and lethal primary brain tumor in adults. The goal of this study was to test the predictive value of MR parameters in relation to the survival ...of patients with newly diagnosed GBM who were scanned prior to receiving adjuvant radiation and chemotherapy.
Methods
The study population comprised 68 patients who had surgical resection and were to be treated with fractionated external beam radiation therapy and chemotherapy. Imaging scans included anatomical MRI, diffusion and perfusion weighted imaging and
1
H MRSI. The MR data were acquired 3–5 weeks after surgery and approximately 1 week before treatment with radiation therapy. The diffusion, perfusion and spectroscopic parameter values were quantified and subjected to proportional hazards analysis that was adjusted for age and scanner field strength.
Results
The patients with larger lesion burden based upon volumes of anatomic lesions, volume of CNI2 (number of voxels within the T2 lesion having choline to NAA index >2), volume of CBV3 (number of pixels within the T2 lesion having relative cerebral blood volume >3), and volume of nADC1.5 (number of pixels within the T2 lesion having normalized apparent diffusion coefficient <1.5) had a higher risk for poor outcome. High intensities of combined measures of lactate and lipid in the T2 and CNI2 regions were also associated with poor survival.
Conclusions
Our study indicated that several pre-treatment anatomic, physiological and metabolic MR parameters are predictive of survival. This information may be important for stratifying patients to specific treatment protocols and for planning focal therapy.
IL-33, a member of the IL-1 cytokine family has been shown to play a dual role within the body. First IL-33, similar to other IL-1 family members, is a secreted cytokine that binds to the cell ...surface receptor ST2 to induce a number of cell signaling pathways. Second, IL-33 enters the nucleus where it binds chromatin and directs transcriptional control of an array of growth factors and cytokines. Consistent with its complex cellular regulation, IL-33 mediates an array of biological functions by acting on a wide range of innate and adaptive immune cells. Recently, we found that IL-33 is expressed in a large number of human glioma patient specimens where its expression within the tumor correlates with the increased presence of Iba+ cells that include both resident microglia and recruited monocyte and macrophages. Strikingly, glioma derived expression of IL-33 correlates with a dramatic decrease in overall survival of tumor-bearing animals and thus supports its role as an influential factor in gliomagenesis. Notably however, when the nuclear localization function of IL-33 is crippled, the tumor microenvironment is programmed to be anti-tumorigenic and results in prolonged overall survival suggesting that when educated appropriately this could represent a novel therapeutic strategy for glioma (De Boeck
(2020), Nat Commun, doi: 10.1038/s41467-020-18569-4).
Cilj: Upotrebom standardnih psihometrijskih testova utvrditi razinu umora, boli, funkcionalne neovisnosti i kvalitetu života u ljudi oboljelih od multiple skleroze (MS) u odnosu na neoboljele na ...malom broju ispitanika, te utvrditi povezanost umora i boli s percipiranom kvalitetom života vezanom za umor, bol, emocionalno i fizičko funkcioniranje.
Ispitanici i metode: Grupa ljudi oboljelih od MS (N = 17), pretežno ženskog spola, u dobi od 21 - 70 g, EDSS (Expanded Disability Status Scale) vrijednosti 0.0 - 8.0, bez relapsa i kortikosteroidne terapije proteklih 4 tjedna te bez težih kroničnih oboljenja, bila je podvrgnuta sljedećim testovima: Barthelov indeks, Functional Independence Measure, Visual Analogue Scale, Modified Fatigue Impact Scale i Medical Outcomes Study 36-Item Short-Form Health Survey. Kontrolna grupa (N = 17) bez težih akutnih i kroničnih oboljenja također je podvrgnuta istim testovima.
Rezultati: Utvrđene su statistički značajne razlike među grupama (P<0.05 - P<0.001) te statistički značajna (P<0.05) povezanost između razine umora i percipirane kvalitete života vezane za umor, te nepostojanje veze između razine boli i percipirane kvalitete života vezane za bol. Korelacijom razine umora i boli s kvalitetom života vezanom za fizičko funkcioniranje utvrđene su statistički značajne (P<0.05) veze, za razliku od korelacije s kvalitetom života vezanom za emocionalno funkcioniranje.
Zaključak: Odabrana kombinacija psihometrijskih testova pokazala je jasne razlike u razini umora, boli, funkcionalne neovisnosti te kvaliteti života kod oboljelih od MS u odnosu na neoboljele na malom broju ispitanika te utvrdila povezanost razine umora s percipiranom kvalitetom života vezanom za umor kao i razine umora i boli s kvalitetom života vezanom za fizičko funkcioniranje.
”Clevetici” de Vasile Alecsandri, secvențe din emisiunea ”Antologia umorului românesc”, regia artistică Alexandru Tocilescu, interpretează Florian Pittiș.
4:3
”Clevetici” de Vasile Alecsandri.
color
...720x576
SAŽETAK: Korištenjem samo klasičnih metoda zasnovanih na izračunu objektivnog statističkog rizika nakon ekspertiza prometnih nesreća vrlo je teško pouzdano izdvojiti one za koje je mogući uzrok umor ...vozača cestovnih vozila. IRAP metodologija može bitno pomoći u boljem izdvajanju prometnih nesreća za koje je vjerojatni uzrok umor vozača, jer se iRAP metodologijom može brzo i objektivno procijeniti statička sigurnost prometne infrastrukture, a onda i isključiti kao mogući uzrok. Prema dinamičkom otvorenom Fullerovom TCI modelu „zahtjev zadaće-sposobnost vozača“, vozači dominantno određuju željenu razinu težine zadaće tijekom vožnje odabirom brzine, što u slučaju odabira nedopuštene brzine ili brzine neprilagođene uvjetima na cesti između ostaloga može ovisiti i o tome je li vozač umoran ili ne. Na primjeru šest prometnih nesreća na autocestama u Republici Hrvatskoj, izdvojenih statističkom obradom prema karakterističnim kriterijima iz recentne znanstvene literature, pokazat će se kako se primjenom iRAP metodologije odrednice prometne infrastrukture iz skupine čimbenika „prometni okoliš“ mogu potpuno isključiti kao uzrok prometne nesreće. Što točnije izdvajanje prometnih nesreća cestovnih vozila za koje je mogući uzrok umor pomoći će kolegama istraživačima iz ostalih znanstvenih područja istražiti karakteristične čimbenike prometnih nesreća povezanih s umorom, a zbog predlaganja mjera za smanjivanje utjecaja umora na izvedbu vozača.
SUMMARY: Using only classical methods based on the calculation of objective statistical risk after the traffic accident expertise, it is very difficult to select the traffic accidents that were probably caused
by fatigue of road vehicle drivers. The iRAP methodology can significantly assist in the selection of road traffic accidents which were probably caused by the driver's fatigue, because by using the iRAP methodology the static safety of road infrastructure elements can be quickly and objectively evaluated, and then excluded as a possible cause
of a traffic accident. According to dynamic and open TCI Fuller's model
“task demand - driver's capability”, drivers dominantly influence the desired level of task demand while driving by choosing the speed, which in the case of choosing the unacceptable speed or speed unsuited for the
environmental conditions on the road, among the rest, may depend on whether the driver is under the influence of fatigue. On the example of six traffic accidents that occurred on motorways in the Republic of Croatia and were selected for statistical analysis by characteristic criteria from the recent scientific literature, it will be presented how
by using the iRAP methodology the factors of road infrastructure from the group of “traffic environment” factors can be completely excluded as
the cause of traffic accidents. The more accurate selection of road traffic accidents that were caused by driver’s fatigue will help researchers from other scientific fields to select and explore the characteristic factors of fatigue-related traffic accidents in order to suggest measures to reduce the fatigue effect on the driver's performance.
fragment Alexandru Bocăneț
28.05.1905
Video Recording
Odprti dostop
Fragment din piesa de teatru ”Bună seara, domnule Wilde! De Eugen mirea Și H. Mălineanu. Regia artistică Alexandru Bocăneț. Interpretează Carmen Stănescu, Ștefan Iordache, Emil Hossu, melania Cârje, ...Anda caropol, Ștefan Radof.
4:3
Fragment din piesa de teatru ”Bună seara, domnule Wilde!
alb / negru
720x576
fragment Grigore Pop; Octavian Sava; Tudor Vornicu ...
07.06.1905
Video Recording
Odprti dostop
Fragment din schița ”Care de dame”, adaptare după Gheorghe Brăescu, de Octavian Sava. Interpretează Leopoldina Bălănuță. Regia sergiu Ionescu.
4:3
Fragment din schița ”Care de dame”.
alb / negru
...720x576
U članku je definirano naprezanje materijala pri toplinskom umoru i izveden teorijski životno (radno) vrijeme materijala te uspoređene sa izmjerenim vrijednostima. Opisana su važna svojstva ...materijala, kao što je toplinska vodljivost, koefi cijent toplinske rastegljivosti, modul elastičnosti i mehanička svojstva. U nastavku su analizirani materijali kao što su ugljični čelici te krom-volframovi čelici. Kao perspektivni materijal za tlačno lijevanje željeznih slitina se pojavljuje molibdan sa prestižnim svojstvima.
PDF
