An interesting procedure for the zinc-catalyzed oxidative transformation of ready available 2-aminobenzamide, 2-aminobenzenesulfonamide with benzyl alcohols has been developed. Various quinazolinones ...and benzothiadiazine 1,1-dioxides were prepared in moderate to good yields under identical conditions. The reactions of both aromatic aldehydes and aliphatic aldehydes with 2-aminobenzamide under catalyst free conditions were described as well. In water media, the products were formed in good yields.
A series of ionic liquids were synthesized and their synergetic effects on the Cu catalyzed one-pot A.sup.3 coupling reactions were investigated for the synthesis of propargylamines. The results ...showed that the combined catalytic system based on ionic liquid MEAH.sub.2PO.sub.4 and CuI had excellent catalytic activity and selectivity for the target propargylamines, a series aromatic aldehyde with electro-withdrawing and donating groups and heteroaromatic aldehyde could all reach good to excellent isolated yields. This catalytic system benefit from mild reaction conditions and simple operation procedures, no volatile organic solvents and other additives were involved, and no inert gas protection were needed. In addition, the ionic liquid utilized in this work was easy to be prepared and its utilization made the catalytic system recyclable. All of these superiorities made this catalytic system efficient and eco-friendly for the synthesis of propargylamines.
Rate coefficients for the reaction of NO.sub.3 radicals with a series of aromatic aldehydes were measured in a 7300 L simulation chamber at ambient temperature and pressure by relative and absolute ...methods. The rate coefficients for benzaldehyde (BA), ortho-tolualdehyde (O-TA), meta-tolualdehyde (M-TA), para-tolualdehyde (P-TA), 2,4-dimethyl benzaldehyde (2,4-DMBA), 2,5-dimethyl benzaldehyde (2,5-DMBA) and 3,5-dimethyl benzaldehyde (3,5-DMBA) were k.sub.1 = 2.6 ± 0.3, k.sub.2 = 8.7 ± 0.8, k.sub.3 = 4.9 ± 0.5, k.sub.4 = 4.9 ± 0.4, k.sub.5 = 15.1 ± 1.3, k.sub.6 = 12.8 ± 1.2 and k.sub.7 = 6.2 ± 0.6, respectively, in the units of 10.sup.-15 cm.sup.3 molec..sup.-1 s.sup.-1 at 298 ± 2 K. The rate coefficient k.sub.13 for the reaction of the NO.sub.3 radical with deuterated benzaldehyde (benzaldehyde-d.sub.1) was found to be half that of k.sub.1 . The end product of the reaction in an excess of NO.sub.2 was measured to be C.sub.6 H.sub.5 C(O)O.sub.2 NO.sub.2 . Theoretical calculations of aldehydic bond energies and reaction pathways indicate that the NO.sub.3 radical reacts primarily with aromatic aldehydes through the abstraction of an aldehydic hydrogen atom. The atmospheric implications of the measured rate coefficients are briefly discussed.
We herein present the synthesis of diversely functionalized pyrimidine fused thiazolino-2-pyridones
K
S
O
-mediated oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-2-pyridones with ...aldehydes. The developed protocol is mild, has wide substrate scope, and does not require transition metal catalyst or base. Some of the synthesized compounds have an ability to inhibit the formation of Amyloid-β fibrils associated with Alzheimer's disease, while others bind to mature amyloid-β and α-synuclein fibrils.
Correction for ‘Synthesis of enantioenriched α-heteroatom functionalised aldehydes by chiral organocatalysis and their synthetic applications’ by Philip J. Chevis et al., Org. Chem. Front., 2021, ...DOI: 10.1039/d1qo00101a.
An air-assisted, functional-group-driven, mild, additive-free, three-component synthetic approach to different 2-oxo acetamidines from 2-oxo aldehydes, secondary amines, and anilines was successfully ...developed. Mechanistically, the transformation proceeds through a highly unstable system (RCOCHN1N2) that rearranges at room temperature and undergoes air-assisted dehydrogenation to different 2-oxo acetamidines.
Reactive aldehydes are common carcinogens. They are also by-products of several metabolic pathways and, without enzymatic catabolism, may accumulate and cause DNA damage. Ethanol, which is ...metabolised to acetaldehyde, is both carcinogenic and teratogenic in humans. Here we find that the Fanconi anaemia DNA repair pathway counteracts acetaldehyde-induced genotoxicity in mice. Our results show that the acetaldehyde-catabolising enzyme Aldh2 is essential for the development of Fancd2(-/-) embryos. Nevertheless, acetaldehyde-catabolism-competent mothers (Aldh2(+/-)) can support the development of double-mutant (Aldh2(-/-)Fancd2(-/-)) mice. However, these embryos are unusually sensitive to ethanol exposure in utero, and ethanol consumption by postnatal double-deficient mice rapidly precipitates bone marrow failure. Lastly, Aldh2(-/-)Fancd2(-/-) mice spontaneously develop acute leukaemia. Acetaldehyde-mediated DNA damage may critically contribute to the genesis of fetal alcohol syndrome in fetuses, as well as to abnormal development, haematopoietic failure and cancer predisposition in Fanconi anaemia patients.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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