Bacterial infections of the wound surface can be painful for patients, and traditional dressings do not effectively address this problem. In this study, an antimicrobial wound dressing is prepared ...using a novel antimicrobial peptide, HX‐12C. This hydrogel system is based on the natural biomaterials sodium alginate and gelatin, utilizing calcium carbonate as a source of Ca2+, and ionic cross‐linking is facilitated by lowering the solution pH. The resulting sodium alginate/gelatin HX‐12C‐loaded hydrogel (CaAGEAM) has good mechanical and adhesion properties, biocompatibility and in vitro degradability. Its extraordinary antibacterial efficacy (>98%) is verified by an antibacterial experiment. More importantly, in vivo experiments further demonstrate its healing‐promotion effect, with a 95% wound healing rate by day 9. Tissue staining demonstrates that the hydrogel containing antimicrobial peptides is effective in suppressing inflammation. The dressing promotes wound healing by stimulating the deposition of skin appendages and collagen. The results of this study suggest that composite hydrogels containing antimicrobial peptides are a promising new type of dressing to promote the healing of infected wounds.
To address the problems of chronic wound infection and antibiotic resistance, a novel antimicrobial hydrogel dressing is designed based on sodium alginate/gelatin/antimicrobial peptide HX‐12C. The usability, safety, and efficient antibacterial properties of the dressing are verified. In vivo animal experiments demonstrate that the hydrogel is a promising wound dressing with faster healing rate better than infected wounds in rats.
A double-water-in-oil-emulsion procedure was designed to synthesize cadmium, lead and copper alginate nanobeads less than 200nm diameter under mild conditions. The cadmium, lead and copper alginate ...nanobeads can be activated to immobilize biomacromolecules and can directly produce distinctive electrochemical signals. Using the novel alginate nanobeads labeled with antibodies as electrochemical probes, a sandwich-type immunosensor was constructed using AFP, CEA and PSA as model analytes. This proposed immunosensor shows wide linear range with detection limits of 0.01, 0.0086 and 0.0075ngmL−1 for AFP, CEA and PSA, respectively. Analysis of clinical serum samples using this immunosensor was well consistent with the data determined by the enzyme-linked immunosorbent assay (ELISA). It suggested that the alginate nanobeads electrochemical probes could be generally extended to other multiple analytes detection.
•A double-water-in-oil-emulsions method was used to synthesize alginate nanobeads under 200nm.•Cadmium, lead and copper alginate nanobeads can produce distinctive electrical signals.•Triple tumor biomarkers can be simultaneously detected in a single run.
A bioadhesive hydrogel system based on OMA/PEG has been developed. The single- or dual-crosslinked OMA/PEG hydrogel system with tunable physical properties and adhesion strength developed in this ...study may be a promising bioadhesive for a wide range of biomedical applications, such as wound closure and healing, drug delivery and biomedical device implantation.
A degradable, cytocompatible bioadhesive can facilitate surgical procedures and minimize patient pain and post-surgical complications. In this study a bioadhesive hydrogel system based on oxidized methacrylated alginate/8-arm poly(ethylene glycol) amine (OMA/PEG) has been developed, and the bioadhesive characteristics of the crosslinked OMA/PEG hydrogels evaluated. Here we demonstrate that the swelling behavior, degradation profiles, and storage moduli of crosslinked OMA/PEG hydrogels are tunable by varying the degree of alginate oxidation. The crosslinked OMA/PEG hydrogels exhibit cytocompatibility when cultured with human bone marrow-derived mesenchymal stem cells. In addition, the adhesion strength of these hydrogels, controllable by varying the alginate oxidation level and measured using a porcine skin model, is superior to commercially available fibrin glue. This OMA/PEG hydrogel system with controllable biodegradation and mechanical properties and adhesion strength may be a promising bioadhesive for clinical use in biomedical applications, such as drug delivery, wound closure and healing, biomedical device implantation, and tissue engineering.
•All recognized antibacterial and wound remedy mechanisms of ZnONPs are presented.•Comparison of antibacterial and wound healing capacities of chitosan, cellulose, alginate.•Micro/nano formulations ...of ZnONPs with chitosan, cellulose, and alginate.•Challenges and future viewpoints of ZnO nanoparticles with polysaccharides.
Release of Zn2+ ions from zinc oxide nanoparticles (ZnO NPs) is a major mechanism for oligodynamic activities of these metal oxide NPs against eukaryotic and prokaryotic microorganisms. In addition to this mechanism, ZnO NPs can form reactive oxygen species (ROSs) resulted from electron-hole formation under certain light wavelength. These properties with suitable biocompatibility and biodegradability of ZnO NPs compared to other metal NPs have caused higher applications of these nanomaterials in therapeutic and cosmetic fields. Recently, natural polymers including cellulose, chitosan, and alginate polymers have gained more attention as safe and cost-effective scaffold for wound healing. Both ZnO NPs and these polymers have not been able to satisfy related patients. In this way, the coupling of these materials and nanomaterials as nanocomposites (NCs) is an alternative way to increase the mechanical and antibacterial properties of wound-healing tissue scaffolds. Controllable release of Zn2+ ions in physiological medium should be considered as an indispensable factor to obtain appropriate industrial formulation. Therefore, in this review, attempts were made to highlight particularly important antibacterial results of these NCs in recent investigations.
Spontaneous corrosion and uncontrolled dendrite accumulation of Zn rapidly degrades zinc–metal battery performance. Artificial interfaces have been widely fabricated on Zn metal anodes, yet most ...interfaces are detrimental to ion transfer and adapt poorly to spatial changes during Zn plating/stripping. Herein, a hybrid interface, consisting of a thermoplastic polyurethane (TPU) fiber matrix and Zn‐alginate (ZA) filler, is designed, which serves as a physical barrier between anode and electrolyte to inhibit side reactions. Encouragingly, ZA regulates Zn2+ transport and endows uniform Zn deposition by inducing plating/stripping underneath the hybrid interface. At the same time, the TPU frame acts as a super‐elastic constraint to further suppress rampant dendrite evolution and accommodate a large amount of deposited Zn. Consequently, the interface‐protected Zn anode delivers high cycling stability (1200 h at 5 mA cm–2/5 mA h cm–2; 500 h at 10 mA cm–2/10 mA h cm–2), realizing an exceptional cumulative capacity of over 6000 mA h cm–2. This enhancement is well maintained in the full cell when coupled with a vanadium‐based cathode. The unique matrix‐filler architecture and mechanistic insights unraveled in this study are expected to provide a general principle in designing functional interfaces for metal anodes.
A matrix‐filler hybrid interface is designed on a Zn metal surface by infiltrating alginate into a super‐elastic elastomer framework. The protected Zn delivers a prolonged lifespan when applied in Zn metal batteries. It provides a new approach toward Zn metal protection and may also benefit the development of functional interfaces for other metal anodes.
Extensive research on marine algae, especially on their health-promoting properties, has been conducted. Various ingredients with potential biomedical applications have been discovered and extracted ...from marine algae. Alginate oligosaccharides are low molecular weight alginate polysaccharides present in cell walls of brown algae. They exhibit various health benefits such as anti-inflammatory, anti-microbial, anti-oxidant, anti-tumor and immunomodulation. Their low-toxicity, non-immunogenicity, and biodegradability make them an excellent material in biomedicine. Alginate oligosaccharides can be chemically or biochemically modified to enhance their biological activity and potential in pharmaceutical applications. This paper provides a brief overview on alginate oligosaccharides characteristics, modification patterns and highlights their vital health promoting properties.
•Alginate oligosaccharide has good biosafety, biocompatibility and bioavailability.•Composition and structure of oligosaccharide affects its final biological activity.•Alginate oligosaccharides are potential biomedicines with promising prospects.
Various composite scaffolds with different fabrication techniques have been applied in cartilage tissue engineering. In this study, poly ɛ‐caprolactone (PCL) was printed by fused deposition modeling ...method, and the prepared scaffold was filled with Alginate (Alg): Alginate‐Sulfate (Alg‐Sul) hydrogel to provide a better biomimetic environment and emulate the structure of glycosaminoglycans properly. Furthermore, to enhance chondrogenesis, different concentrations of decellularized extracellular matrix (dECM) were added to the hydrogel. For cellular analyses, the adipose‐derived mesenchymal stem cells were seeded on the hydrogel and the results of MTT assay, live/dead staining, and SEM images revealed that the scaffold with 1% dECM had better viscosity, cell viability, and proliferation. The study was conducted on the optimized scaffold (1% dECM) to determine mechanical characteristics, chondrogenic differentiation, and results demonstrated that the scaffold showed mechanical similarity to the native nasal cartilage tissue along with possessing appropriate biochemical features, which makes this new formulation based on PCL/dECM/Alg:Alg‐Sul a promising candidate for further in‐vivo studies.
•Preparation of ZnO nanoparticles by in situ generated in carboxymethyl chitosan.•ZnO was incorporated into chitosan multilayer films to improve properties.•Water vapor resistance was improved by the ...addition of ZnO and sodium alginate.•Mechanical properties and antibacterial activity were improved.•The film with prepared ZnO (0.05 g/g sodium alginate) had a better preservation effect.
To deal with serious environmental pollution resulting from plastic packaging materials, biodegradable films using chitosan (CS) are gaining considerable increase gradually. However, chitosan films lack important properties to meet the preserved demands. This study aimed to develop new bio-based films incorporated with carboxymethyl chitosan-ZnO (CMCS-ZnO) nanoparticles and sodium alginate (SA) to overcome the weakness of CS films. CMCS-ZnO nanoparticles were successfully synthesized in the matrix of CMCS through direct precipitation method, which showed an average diameter of 100 nm. Multilayer films with CS film as the outer layer and SA film as the inner layer were prepared by solution casting method. The addition of CMCS-ZnO nanoparticles led to enhanced tensile strength, and to better water vapor resistance. The as-prepared films exhibited distinctive antibacterial activity against S. aureus and E. coli. The results suggested that the as-prepared film is expected to be a promising material for food packaging.
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