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•The detailed study on synthesis, characterization, and thermal properties of an alkyl-aminopyridine adduct of cobalt(II) chloride.•By adding alkyl-aminopyridine to cobalt(II) ...chloride, the obtained compound exhibits high stability, sufficient volatility, and suitable thermal stability, which is benefit for industrial application.•A promising CVD precursor for preparation of cobalt-based films.
In this study, a 2-isopropyl-aminopyridine adduct of cobalt(II) chloride Co(2-iPrNH-C5H4N)2Cl2 was synthesized and used as a precursor for preparing cobalt-based films through chemical vapor deposition (CVD). This compound was synthesized through a simple coordination reaction and characterized through 1H NMR, elemental analysis, and single-crystal diffraction. The thermal properties (including volatility, vapor pressure, and thermal stability) of the compound were investigated through thermogravimetric analysis (TGA) to determine its feasibility for use in CVD. Moreover, a film deposition experiment was conducted in a low-pressure CVD reactor system, and a Co3O4 film was obtained. This result verified the reported compound’s applicability as a CVD precursor for fabricating cobalt-based films.
•L-proline-based terphenyl ligand was synthesized by using a cross-coupling reaction.•The structure of the synthesized ligand was confirmed by the X-ray crystallography.•A spectroscopic approach is ...used to test the binding interactions with CoCl2.•The molecular docking is used to test the binding interactions with Co-NHase enzyme.•Synthesized ligand has a good binding affinity towards CoCl2 and Co-NHase enzyme.
A molecule having binding coordination with transition metal and metalloenzymes plays a crucial role in medicinal and industrial chemistry. Herein, we synthesize a new l-proline-based terphenyl ligand to investigate the binding interactions with cobalt (II) chloride and cobalt (III) containing nitrile hydratase by spectroscopic and theoretical approach. The formulated compound has been well characterized by elemental analysis, NMR (1H and 13C), FT-IR, Mass spectrometry. Moreover, the complete structure elucidation of synthesized l-proline-based terphenyl ligand was achieved via X-ray crystallography. The UV–visible spectroscopy and computational study reveals that the newly synthesized ligand confers a good binding response towards Cobalt (II) chloride and cobalt (III) containing nitrile hydratase enzyme as supported by calculated spectroscopic results and lower binding energy via molecular docking score, respectively. We hope that the present information can be utilized to develop new metal-coordinated compounds acting as useful metallodrugs or competitive artificial metalloenzymes.
The present work highlights the design, synthesis, and crystal structure of l-proline-based terphenyl ligand 4 for an investigation of binding interaction with CoCl2 and cobalt-containing nitrile Display omitted
This work aims to produce and disseminate videos that follow the microlearning methodology, to explain the physicochemical properties of cobalt (II) chloride hexahydrate through thermal analysis, and ...to determine the reliability of the Portuguese good luck rooster. Temporal and social accelerations due to the growth of the technological world are changing the old teaching-learning methodologies; thus, new methods should be explored. In the microlearning methodology, short segments and specific content can be broadcast to anyone at any time. In addition, relating new information to individual’s experiences can favor the teaching-learning process. The good luck rooster is an ornament of Portuguese origin, which can forecast the weather in a limited way, and is composed of cobalt (II) chloride hexahydrate. This compound was characterized by TG-DTA (Simultaneous Thermogravimetry-Differential Thermal Analysis) and DSC (Differential Scanning Calorimetry), verifying that the salt loses its hydration water when exposed to high temperatures, changing its color from pink color to blue.
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The synthesis of materials on magnetic activated carbon is of concern, with a simple and environmentally friendly. The research used pecan shell (Aleurites moluccana) as a carbon ...source. The breakthrough made in this research is to make magnetic activated carbon electrodes in supercapacitors. Obtained on the XRD diffractograms show the graphite lattice, respectively. Also, a sharp, narrow peak is seen at 2θ = 26° in the carbon samples spectrum, showing a highly graphitized fraction. FESEM-EDX showed AC20/80 that the shape of the particles was like plates indicating that the particles had been formed. AC80/20 is the surface morphology in which particles with irregular shapes indicate that particles have been formed, where the shape of the particles is irregular. The composition between C and O is also balanced. AC80/20 has lower Co content than AC20/80, AC40/60, AC60/40, and AC50/50 and it appears that AC80/20 is better than the others. The magnitude of the coercivity states that AC20/80, AC80/20, AC40/60, AC60/40, and AC50/50 are strong magnets. The lower the value of the open circuit potential, it will show electrochemical stability. The Nyquist plots of magnetic activated carbon show a straight vertical indicating the process of charge transfer resistance at the low electrode. Obtained specific capacitance AC80/20 at 150F/g.
Fibrinopeptide B (GluFib) is one of the factors of thrombosis. Normal soluble blood protein, fibrinogen (fibrinopeptide A and fibrinopeptide B), is transformed into the insoluble fibrin, which in the ...form of filaments adheres to the vessel wall at the site of injury, forming a grid. In the literature, it is noted that a violation of blood coagulation under the influence of cobalt and lanthanides compounds has been established. It is possible that the reason is the change in the structure of the molecules of fibrin fibers under the influence of cobalt and lanthanides influences. In this paper the spatial structure of GluFib was investigated with manganese (II) chloride, cobalt (II) chloride and gadolinium (III) chloride by NMR spectroscopy. The spatial structures were obtained by applying 1D and 2D 1H–1H NMR spectroscopy (TOCSY, ROESY). The chemical shifts of some 1H NMR signals of GluFib in complex with cobalt and gadolinium salts have changed. The changing chemical shifts belong to betta-group atoms of 7 and 8 glutamic acid. Analyzing spectra, it was found that ions of cobalt and gadolinium interact with GluFib, integrating between the amino acid residues of the seventh and eighth glutamic acids. Manganese ions don’t interact with fibrinopeptide B molecule. In our work we were received the spatial structure of GluFib peptide in aqueous solution in complex with cobalt (II) chloride and gadolinium (III) chloride. The interaction of the peptide with the ions of these metals leads to backbone bending.
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•Spatial structure of the peptide in water with metal ions (Co, Gd) revealed.•Co and Gd ions interact with GluFib, embedding between the 7th and 8th Glu acids.•Manganese ions do not have isolated sites of interaction with fibrinopeptide B.
Hypoxia‐induced apoptosis of cementoblasts (OCCM‐30) may be harmful to orthodontic treatment. Hypoxia‐inducible factor 1‐alpha (HIF‐1α) mediates the biological effects during hypoxia. Little is known ...about the survival mechanism capable to counteract cementoblast apoptosis. We aimed to investigate the potential roles of HIF‐1α, as well as the protein‐protein interactions with ERK1/2, using an in‐vitro model of chemical‐mimicked hypoxia and adipokines. Here, OCCM‐30 were co‐stimulated with resistin, visfatin or ghrelin under CoCl2‐mimicked hypoxia. In‐vitro investigations revealed that CoCl2‐induced hypoxia triggered activation of caspases, resulting in apoptosis dysfunction in cementoblasts. Resistin, visfatin and ghrelin promoted the phosphorylated ERK1/2 expression in OCCM‐30 cells. Furthermore, these adipokines inhibited hypoxia‐induced apoptosis at different degrees. These effects were reversed by pre‐treatment with ERK inhibitor (FR180204). In cells treated with FR180204, HIF‐1α expression was inhibited despite the presence of three adipokines. Using dominant‐negative mutants of HIF‐1α, we found that siHIF‐1α negatively regulated the caspase‐8, caspase‐9 and caspase‐3 gene expression. We concluded that HIF‐1α acts as a bridge factor in lengthy hypoxia‐induced apoptosis in an ERK1/2‐dependent pathway. Gene expressions of the caspases‐3, caspase‐8 and caspase‐9 were shown to be differentially regulated by adipokines (resistin, visfatin and ghrelin). Our study, therefore, provides evidence for the role of ERK1/2 and HIF‐1α in the apoptotic response of OCCM‐30 cells exposed to CoCl2‐mimicked hypoxia, providing potential new possibilities for molecular intervention in obese patients undergoing orthodontic treatment.
The determination of cholesterol concentration in the blood is an important characteristic of the state of health. Modern methods for the detection of cholesterol involve the use of enzymes or ...expensive and complicated equipment. In this study, an enzymeless electrochemical method for the quantitative determination of cholesterol using cobalt (II) chloride as an electrocatalyst has been proposed. An analytical signal was peak current of cobalt (II) chloride faradaic oxidation on a platinum disk electrode in acetonitrile media in the presence of cholesterol via linear sweep voltammetry. A possible path of the electrocatalytic oxidation of cholesterol on the electrode surface was proposed. The catalytic constant kcat and the Michaelis constant Km calculated for the electrocatalytic oxidation process of cholesterol on the electrode surface are comparable in magnitude to the natural enzyme cholesterol oxidase, indicating the high efficiency of CoCl2 as an electrocatalyst for oxidation and, therefore, the determination of cholesterol. The highest value and the best reproducibility of analytical signal are reached at a CoCl2 concentration of 25mM and a scan rate of 100mV·s−1. The linear region of the calibration curve “current-cholesterol concentration” obtained using a developed method in a solution of 0.1M LiClO4 and 25mM CoCl2 in acetonitrile is 25–200μM (R2=0.971) with a detection limit of 2μM.
•An enzymeless electrochemical cholesterol determination method has been proposed.•Cobalt (II) chloride was used as electrocatalyst for cholesterol oxidation.•Analytical characteristics of the proposed method were calculated.•Cobalt (II) chloride as cholesterol oxidation catalyst is comparable to cholesterol oxidase.
Binary complexes of general formula CoCl2L2, where L = triphenylphosphine oxide (TPPO), benzyldiphenylphosphine oxide (BDPPO), dibenzylphenylphosphine oxide (DBPPO) and tribenzylphosphine oxide ...(TBPO) were considered concerning X-ray structural data for the complexes in the solid state and their stability constants in acetone solution. Compatibility between structural data and stability constants are pointed out. Previous investigations showed that in acetone medium, with CoCl2 as reference acceptor, the following basicity order is obeyed: TBPO > DBPPO > BDPPO > TPPO. This sequence is supported by X-ray diffraction data of the solid complexes and by electrolytic conductance values for these complexes both in acetone and in nitromethane media.
A simple and efficient method for the convenient synthesis of 2-arylbenzimidazole has been described on reaction with o-phenylenediamine and various aromatic aldehydes using cobalt(II) chloride ...hexahydrate as a catalyst. The method is cost-effective, high-yielding, clean, and selective.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Moisture content is one of the parameters of transformer oil that determine its quality. This parameter is one of the most critical, which is closely monitored. During the operation of transformer ...oil in the power equipment of electric power systems, about 10 grams of water per ton of oil is allowed, i.e. the permissible proportion of water is 10 ppm (ppm). The aim of the work is to develop a new method for determining the permissible proportion of water in transformer oil in small quantities. This goal is achieved by performing spectral studies of transformer oil samples in the UV and visible range with the addition of cobalt (II) chloride (CoCl2) powder. Сobalt (II) chloride has the ability to change its color depending on the amount of water of crystallization. The most significant result of the article is the conclusion, obtained on the basis of the recorded spectra, about the relationship between the optical density of the spectrum in the range of 360-490 nm and the moisture content of transformer oil when adding cobalt chloride powder. The significance of the results obtained is that the authors have proposed a new optical method for determining small values of the proportion of water in transformer oils, based on the dependence of the optical properties of cobalt (II) chloride on moisture content.This method has a very high sensitivity, low cost for determining the proportion of water and is very promising for solving problems of power energy.
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