Human Airway and Alveolar Organoids from BAL Fluid Liu, Monica Yun; Chen, Belinda; Borji, Mehdi ...
American journal of respiratory and critical care medicine,
06/2024, Letnik:
209, Številka:
12
Journal Article
We echo the latest calls that have been made to increase the capacity for antimicrobial susceptibility testing (AST) for bedaquiline for the
Mycobacterium tuberculosis
complex 1, 2. However, we would ...like to highlight the limitations of using insufficiently standardised or validated phenotypic AST methods and breakpoints as the reference standard for bedaquiline AST. Moreover, we advocate for adoption of a composite reference standard that considers genotypic AST results to minimise false-susceptible results for borderline/low-level resistance mechanisms and avoid confusion during clinical decision-making.
A composite reference standard minimises false-susceptible AST results for bedaquiline
https://bit.ly/3wAVvFm
We read with interest the editorial “Clinical remission with biologic therapies in severe asthma: a matter of definition” 1. We absolutely agree that the definition of clinical remission is of ...critical importance, and as with rheumatology, gastroenterology and dermatology, this is likely to be an iterative process. Early intervention with targeted treatments has been associated with an improvement in quality of life and decreased symptom burden in these non-respiratory inflammatory diseases, and certainly the onus to provide prospective evidence showing improved quality of life and disease outcomes with early intervention and sustained remission in severe asthma now lies with the severe asthma community.
There is currently no evidence to support the use of maintenance and reliever therapy (MART) in patients with severe asthma and persistently elevated T2 biomarkers despite adherence to high dose ICS treatment
https://bit.ly/42IOVbA
