Human Airway and Alveolar Organoids from BAL Fluid Liu, Monica Yun; Chen, Belinda; Borji, Mehdi ...
American journal of respiratory and critical care medicine,
06/2024, Letnik:
209, Številka:
12
Journal Article
We echo the latest calls that have been made to increase the capacity for antimicrobial susceptibility testing (AST) for bedaquiline for the
Mycobacterium tuberculosis
complex 1, 2. However, we would ...like to highlight the limitations of using insufficiently standardised or validated phenotypic AST methods and breakpoints as the reference standard for bedaquiline AST. Moreover, we advocate for adoption of a composite reference standard that considers genotypic AST results to minimise false-susceptible results for borderline/low-level resistance mechanisms and avoid confusion during clinical decision-making.
A composite reference standard minimises false-susceptible AST results for bedaquiline
https://bit.ly/3wAVvFm
